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Protein

Tyrosine-protein phosphatase 1

Gene

pyp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei470Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • MAP kinase tyrosine phosphatase activity Source: PomBase
  • protein tyrosine phosphatase activity Source: PomBase

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cellular response to sodium arsenite Source: PomBase
  • inactivation of MAPK activity involved in osmosensory signaling pathway Source: PomBase
  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
  • negative regulation of transcription by glucose Source: PomBase
  • peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 1
Short name:
PTPase 1
Gene namesi
Name:pyp1
ORF Names:SPAC26F1.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26F1.10c.
PomBaseiSPAC26F1.10c. pyp1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948581 – 550Tyrosine-protein phosphatase 1Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318Phosphoserine1 Publication1
Modified residuei320Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP27574.
PRIDEiP27574.

PTM databases

iPTMnetiP27574.

Interactioni

Protein-protein interaction databases

BioGridi279130. 244 interactors.
MINTiMINT-4687977.
STRINGi4896.SPAC26F1.10c.1.

Structurei

3D structure databases

ProteinModelPortaliP27574.
SMRiP27574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 539Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST280

Sequence similaritiesi

Phylogenomic databases

InParanoidiP27574.
KOiK01104.
OMAiDDYFNGN.
OrthoDBiEOG092C26OL.
PhylomeDBiP27574.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00581. Rhodanese. 1 hit.
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

P27574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSNGSKSS TFTIAPSGSC IALPPQRGVA TSKYAVHASC LQEYLDKEAW
60 70 80 90 100
KDDTLIIDLR PVSEFSKSRI KGSVNLSLPA TLIKRPAFSV ARIISNLHDV
110 120 130 140 150
DDKRDFQNWQ EFSSILVCVP AWIANYVTNA EVIGEKFRKE SYSGDFGILD
160 170 180 190 200
LDYSKVSGKY PSVIDNSPVK SKLGALPSAR PRLSYSAAQT APISLSSEGS
210 220 230 240 250
DYFSRPPPTP NVAGLSLNNF FCPLPENKDN KSSPFGSATV QTPCLHSVPD
260 270 280 290 300
AFTNPDVATL YQKFLRLQSL EHQRLVSCSD RNSQWSTVDS LSNTSYKKNR
310 320 330 340 350
YTDIVPYNCT RVHLKRTSPS ELDYINASFI KTETSNYIAC QGSISRSISD
360 370 380 390 400
FWHMVWDNVE NIGTIVMLGS LFEAGREMCT AYWPSNGIGD KQVYGDYCVK
410 420 430 440 450
QISEENVDNS RFILRKFEIQ NANFPSVKKV HHYQYPNWSD CNSPENVKSM
460 470 480 490 500
VEFLKYVNNS HGSGNTIVHC SAGVGRTGTF IVLDTILRFP ESKLSGFNPS
510 520 530 540 550
VADSSDVVFQ LVDHIRKQRM KMVQTFTQFK YVYDLIDSLQ KSQVHFPVLT
Length:550
Mass (Da):61,588
Last modified:August 1, 1992 - v1
Checksum:i5DB770AEAAA59F03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63257 mRNA. Translation: AAA35328.1.
CU329670 Genomic DNA. Translation: CAA97367.1.
PIRiA40449.
RefSeqiNP_594885.1. NM_001020314.2.

Genome annotation databases

EnsemblFungiiSPAC26F1.10c.1; SPAC26F1.10c.1:pep; SPAC26F1.10c.
GeneIDi2542677.
KEGGispo:SPAC26F1.10c.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPYP1_SCHPO
AccessioniPrimary (citable) accession number: P27574
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 5, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families