Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P27574

- PYP1_SCHPO

UniProt

P27574 - PYP1_SCHPO

Protein

Tyrosine-protein phosphatase 1

Gene

pyp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei470 – 4701Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine phosphatase activity Source: PomBase
    2. protein tyrosine phosphatase activity Source: PomBase

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
    3. negative regulation of mitotic cell cycle Source: PomBase
    4. negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
    5. negative regulation of transcription by glucose Source: PomBase
    6. peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 1
    Short name:
    PTPase 1
    Gene namesi
    Name:pyp1
    ORF Names:SPAC26F1.10c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC26F1.10c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Tyrosine-protein phosphatase 1PRO_0000094858Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei318 – 3181Phosphoserine1 Publication
    Modified residuei320 – 3201Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP27574.

    Interactioni

    Protein-protein interaction databases

    BioGridi279130. 240 interactions.
    MINTiMINT-4687977.
    STRINGi4896.SPAC26F1.10c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP27574.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini260 – 539280Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    KOiK01104.
    OMAiPAWIANY.
    OrthoDBiEOG7JMGNZ.
    PhylomeDBiP27574.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00581. Rhodanese. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27574-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFSNGSKSS TFTIAPSGSC IALPPQRGVA TSKYAVHASC LQEYLDKEAW    50
    KDDTLIIDLR PVSEFSKSRI KGSVNLSLPA TLIKRPAFSV ARIISNLHDV 100
    DDKRDFQNWQ EFSSILVCVP AWIANYVTNA EVIGEKFRKE SYSGDFGILD 150
    LDYSKVSGKY PSVIDNSPVK SKLGALPSAR PRLSYSAAQT APISLSSEGS 200
    DYFSRPPPTP NVAGLSLNNF FCPLPENKDN KSSPFGSATV QTPCLHSVPD 250
    AFTNPDVATL YQKFLRLQSL EHQRLVSCSD RNSQWSTVDS LSNTSYKKNR 300
    YTDIVPYNCT RVHLKRTSPS ELDYINASFI KTETSNYIAC QGSISRSISD 350
    FWHMVWDNVE NIGTIVMLGS LFEAGREMCT AYWPSNGIGD KQVYGDYCVK 400
    QISEENVDNS RFILRKFEIQ NANFPSVKKV HHYQYPNWSD CNSPENVKSM 450
    VEFLKYVNNS HGSGNTIVHC SAGVGRTGTF IVLDTILRFP ESKLSGFNPS 500
    VADSSDVVFQ LVDHIRKQRM KMVQTFTQFK YVYDLIDSLQ KSQVHFPVLT 550
    Length:550
    Mass (Da):61,588
    Last modified:August 1, 1992 - v1
    Checksum:i5DB770AEAAA59F03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63257 mRNA. Translation: AAA35328.1.
    CU329670 Genomic DNA. Translation: CAA97367.1.
    PIRiA40449.
    RefSeqiNP_594885.1. NM_001020314.2.

    Genome annotation databases

    EnsemblFungiiSPAC26F1.10c.1; SPAC26F1.10c.1:pep; SPAC26F1.10c.
    GeneIDi2542677.
    KEGGispo:SPAC26F1.10c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63257 mRNA. Translation: AAA35328.1 .
    CU329670 Genomic DNA. Translation: CAA97367.1 .
    PIRi A40449.
    RefSeqi NP_594885.1. NM_001020314.2.

    3D structure databases

    ProteinModelPortali P27574.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279130. 240 interactions.
    MINTi MINT-4687977.
    STRINGi 4896.SPAC26F1.10c-1.

    Proteomic databases

    MaxQBi P27574.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC26F1.10c.1 ; SPAC26F1.10c.1:pep ; SPAC26F1.10c .
    GeneIDi 2542677.
    KEGGi spo:SPAC26F1.10c.

    Organism-specific databases

    PomBasei SPAC26F1.10c.

    Phylogenomic databases

    eggNOGi COG5599.
    KOi K01104.
    OMAi PAWIANY.
    OrthoDBi EOG7JMGNZ.
    PhylomeDBi P27574.

    Miscellaneous databases

    NextBioi 20803725.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00581. Rhodanese. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases."
      Ottilie S., Chernoff J., Hannig G., Hoffman C.S., Erikson R.L.
      Proc. Natl. Acad. Sci. U.S.A. 88:3455-3459(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast."
      Millar J.B.A., Russell P., Dixon J.E., Guan K.L.
      EMBO J. 11:4943-4952(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. "Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast."
      Millar J.B.A., Buck V., Wilkinson M.G.
      Genes Dev. 9:2117-2130(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPYP1_SCHPO
    AccessioniPrimary (citable) accession number: P27574
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3