Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P27574 (PYP1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase 1

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 1
Short name=PTPase 1
Gene names
Name:pyp1
ORF Names:SPAC26F1.10c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Tyrosine-protein phosphatase 1
PRO_0000094858

Regions

Domain260 – 539280Tyrosine-protein phosphatase

Sites

Active site4701Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue3181Phosphoserine Ref.5
Modified residue3201Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
P27574 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 5DB770AEAAA59F03

FASTA55061,588
        10         20         30         40         50         60 
MNFSNGSKSS TFTIAPSGSC IALPPQRGVA TSKYAVHASC LQEYLDKEAW KDDTLIIDLR 

        70         80         90        100        110        120 
PVSEFSKSRI KGSVNLSLPA TLIKRPAFSV ARIISNLHDV DDKRDFQNWQ EFSSILVCVP 

       130        140        150        160        170        180 
AWIANYVTNA EVIGEKFRKE SYSGDFGILD LDYSKVSGKY PSVIDNSPVK SKLGALPSAR 

       190        200        210        220        230        240 
PRLSYSAAQT APISLSSEGS DYFSRPPPTP NVAGLSLNNF FCPLPENKDN KSSPFGSATV 

       250        260        270        280        290        300 
QTPCLHSVPD AFTNPDVATL YQKFLRLQSL EHQRLVSCSD RNSQWSTVDS LSNTSYKKNR 

       310        320        330        340        350        360 
YTDIVPYNCT RVHLKRTSPS ELDYINASFI KTETSNYIAC QGSISRSISD FWHMVWDNVE 

       370        380        390        400        410        420 
NIGTIVMLGS LFEAGREMCT AYWPSNGIGD KQVYGDYCVK QISEENVDNS RFILRKFEIQ 

       430        440        450        460        470        480 
NANFPSVKKV HHYQYPNWSD CNSPENVKSM VEFLKYVNNS HGSGNTIVHC SAGVGRTGTF 

       490        500        510        520        530        540 
IVLDTILRFP ESKLSGFNPS VADSSDVVFQ LVDHIRKQRM KMVQTFTQFK YVYDLIDSLQ 

       550 
KSQVHFPVLT 

« Hide

References

« Hide 'large scale' references
[1]"A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases."
Ottilie S., Chernoff J., Hannig G., Hoffman C.S., Erikson R.L.
Proc. Natl. Acad. Sci. U.S.A. 88:3455-3459(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast."
Millar J.B.A., Russell P., Dixon J.E., Guan K.L.
EMBO J. 11:4943-4952(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[4]"Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast."
Millar J.B.A., Buck V., Wilkinson M.G.
Genes Dev. 9:2117-2130(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63257 mRNA. Translation: AAA35328.1.
CU329670 Genomic DNA. Translation: CAA97367.1.
PIRA40449.
RefSeqNP_594885.1. NM_001020314.2.

3D structure databases

ProteinModelPortalP27574.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279130. 239 interactions.
MINTMINT-4687977.
STRING4896.SPAC26F1.10c-1.

Proteomic databases

MaxQBP27574.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC26F1.10c.1; SPAC26F1.10c.1:pep; SPAC26F1.10c.
GeneID2542677.
KEGGspo:SPAC26F1.10c.

Organism-specific databases

PomBaseSPAC26F1.10c.

Phylogenomic databases

eggNOGCOG5599.
KOK01104.
OMAPAWIANY.
OrthoDBEOG7JMGNZ.
PhylomeDBP27574.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00581. Rhodanese. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803725.

Entry information

Entry namePYP1_SCHPO
AccessionPrimary (citable) accession number: P27574
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names