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Protein

Tyrosine-protein phosphatase 1

Gene

pyp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei470Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • MAP kinase tyrosine phosphatase activity Source: PomBase
  • protein tyrosine phosphatase activity Source: PomBase

GO - Biological processi

  • carbon catabolite repression of transcription by glucose Source: PomBase
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • negative regulation of stress-activated MAPK cascade Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 1
Short name:
PTPase 1
Gene namesi
Name:pyp1
ORF Names:SPAC26F1.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26F1.10c
PomBaseiSPAC26F1.10c pyp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948581 – 550Tyrosine-protein phosphatase 1Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318Phosphoserine1 Publication1
Modified residuei320Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP27574
PaxDbiP27574
PRIDEiP27574

PTM databases

iPTMnetiP27574

Interactioni

Protein-protein interaction databases

BioGridi279130, 244 interactors
STRINGi4896.SPAC26F1.10c.1

Structurei

3D structure databases

ProteinModelPortaliP27574
SMRiP27574
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 539Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST280

Sequence similaritiesi

Phylogenomic databases

InParanoidiP27574
KOiK01104
OMAiDDYFNGN
OrthoDBiEOG092C26OL
PhylomeDBiP27574

Family and domain databases

Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00581 Rhodanese, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

P27574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSNGSKSS TFTIAPSGSC IALPPQRGVA TSKYAVHASC LQEYLDKEAW
60 70 80 90 100
KDDTLIIDLR PVSEFSKSRI KGSVNLSLPA TLIKRPAFSV ARIISNLHDV
110 120 130 140 150
DDKRDFQNWQ EFSSILVCVP AWIANYVTNA EVIGEKFRKE SYSGDFGILD
160 170 180 190 200
LDYSKVSGKY PSVIDNSPVK SKLGALPSAR PRLSYSAAQT APISLSSEGS
210 220 230 240 250
DYFSRPPPTP NVAGLSLNNF FCPLPENKDN KSSPFGSATV QTPCLHSVPD
260 270 280 290 300
AFTNPDVATL YQKFLRLQSL EHQRLVSCSD RNSQWSTVDS LSNTSYKKNR
310 320 330 340 350
YTDIVPYNCT RVHLKRTSPS ELDYINASFI KTETSNYIAC QGSISRSISD
360 370 380 390 400
FWHMVWDNVE NIGTIVMLGS LFEAGREMCT AYWPSNGIGD KQVYGDYCVK
410 420 430 440 450
QISEENVDNS RFILRKFEIQ NANFPSVKKV HHYQYPNWSD CNSPENVKSM
460 470 480 490 500
VEFLKYVNNS HGSGNTIVHC SAGVGRTGTF IVLDTILRFP ESKLSGFNPS
510 520 530 540 550
VADSSDVVFQ LVDHIRKQRM KMVQTFTQFK YVYDLIDSLQ KSQVHFPVLT
Length:550
Mass (Da):61,588
Last modified:August 1, 1992 - v1
Checksum:i5DB770AEAAA59F03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63257 mRNA Translation: AAA35328.1
CU329670 Genomic DNA Translation: CAA97367.1
PIRiA40449
RefSeqiNP_594885.1, NM_001020314.2

Genome annotation databases

EnsemblFungiiSPAC26F1.10c.1; SPAC26F1.10c.1:pep; SPAC26F1.10c
GeneIDi2542677
KEGGispo:SPAC26F1.10c

Similar proteinsi

Entry informationi

Entry nameiPYP1_SCHPO
AccessioniPrimary (citable) accession number: P27574
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health