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P27573

- MYP0_MOUSE

UniProt

P27573 - MYP0_MOUSE

Protein

Myelin protein P0

Gene

Mpz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell junction maintenance Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin protein P0
    Alternative name(s):
    Myelin peripheral protein
    Short name:
    MPP
    Myelin protein zero
    Gene namesi
    Name:Mpz
    Synonyms:P0
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:103177. Mpz.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929By similarityAdd
    BLAST
    Chaini30 – 248219Myelin protein P0PRO_0000019301Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 127PROSITE-ProRule annotation
    Glycosylationi122 – 1221N-linked (GlcNAc...) (complex)Sequence Analysis
    Modified residuei210 – 2101Phosphoserine; by PKCBy similarity
    Modified residuei226 – 2261Phosphoserine1 Publication
    Modified residuei228 – 2281Phosphoserine1 Publication
    Modified residuei233 – 2331Phosphoserine; by PKCBy similarity
    Modified residuei237 – 2371Phosphoserine1 Publication
    Modified residuei243 – 2431Phosphoserine1 Publication

    Post-translational modificationi

    N-glycosylated; contains sulfate-substituted glycan.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP27573.

    PTM databases

    PhosphoSiteiP27573.

    Expressioni

    Tissue specificityi

    Found only in peripheral nervous system Schwann cells.

    Gene expression databases

    CleanExiMM_MPZ.
    GenevestigatoriP27573.

    Interactioni

    Subunit structurei

    Homodimer and homotetramer.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kcnma1Q084604EBI-1634589,EBI-1633915

    Protein-protein interaction databases

    IntActiP27573. 1 interaction.
    STRINGi10090.ENSMUSP00000106966.

    Structurei

    3D structure databases

    ProteinModelPortaliP27573.
    SMRiP27573. Positions 30-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 153124ExtracellularBy similarityAdd
    BLAST
    Topological domaini180 – 24869CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei154 – 17926HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 143114Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the myelin P0 protein family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47065.
    HOGENOMiHOG000232144.
    HOVERGENiHBG096384.
    InParanoidiQ542C9.
    KOiK06770.
    PhylomeDBiP27573.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR019566. Myelin-PO_C.
    IPR000920. Myelin_P0.
    IPR019738. Myelin_P0_CS.
    [Graphical view]
    PfamiPF10570. Myelin-PO_C. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR00213. MYELINP0.
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00568. MYELIN_P0. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27573-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPGAPSSSP SPILAALLFS SLVLSPALAI VVYTDREIYG AVGSQVTLHC    50
    SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGAFKERIQ 100
    WVGDPRWKDG SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV 150
    PTRYGVVLGA VIGGILGVVL LLLLLFYLIR YCWLRRQAAL QRRLSAMEKG 200
    RFHKSSKDSS KRGRQTPVLY AMLDHSRSTK AASEKKSKGL GESRKDKK 248
    Length:248
    Mass (Da):27,622
    Last modified:August 1, 1992 - v1
    Checksum:i936D66684300CAC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62860
    , M62857, M62858, M62859 Genomic DNA. Translation: AAA39867.1.
    AK089180 mRNA. Translation: BAC40781.1.
    AK157960 mRNA. Translation: BAE34285.1.
    CH466520 Genomic DNA. Translation: EDL39129.1.
    CH466520 Genomic DNA. Translation: EDL39131.1.
    BC139139 mRNA. Translation: AAI39140.1.
    BC141226 mRNA. Translation: AAI41227.1.
    CCDSiCCDS15479.1.
    PIRiA54662.
    RefSeqiNP_032649.2. NM_008623.4.
    UniGeneiMm.9986.

    Genome annotation databases

    GeneIDi17528.
    KEGGimmu:17528.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62860
    , M62857 , M62858 , M62859 Genomic DNA. Translation: AAA39867.1 .
    AK089180 mRNA. Translation: BAC40781.1 .
    AK157960 mRNA. Translation: BAE34285.1 .
    CH466520 Genomic DNA. Translation: EDL39129.1 .
    CH466520 Genomic DNA. Translation: EDL39131.1 .
    BC139139 mRNA. Translation: AAI39140.1 .
    BC141226 mRNA. Translation: AAI41227.1 .
    CCDSi CCDS15479.1.
    PIRi A54662.
    RefSeqi NP_032649.2. NM_008623.4.
    UniGenei Mm.9986.

    3D structure databases

    ProteinModelPortali P27573.
    SMRi P27573. Positions 30-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P27573. 1 interaction.
    STRINGi 10090.ENSMUSP00000106966.

    PTM databases

    PhosphoSitei P27573.

    Proteomic databases

    PRIDEi P27573.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 17528.
    KEGGi mmu:17528.

    Organism-specific databases

    CTDi 4359.
    MGIi MGI:103177. Mpz.

    Phylogenomic databases

    eggNOGi NOG47065.
    HOGENOMi HOG000232144.
    HOVERGENi HBG096384.
    InParanoidi Q542C9.
    KOi K06770.
    PhylomeDBi P27573.

    Miscellaneous databases

    NextBioi 292144.
    PROi P27573.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MPZ.
    Genevestigatori P27573.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR019566. Myelin-PO_C.
    IPR000920. Myelin_P0.
    IPR019738. Myelin_P0_CS.
    [Graphical view ]
    Pfami PF10570. Myelin-PO_C. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR00213. MYELINP0.
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00568. MYELIN_P0. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence, genomic organization, and chromosomal localization of the mouse peripheral myelin protein zero gene: identification of polymorphic alleles."
      You K.H., Hsieh C.L., Hayes C., Stahl N., Francke U., Popko B.
      Genomics 9:751-757(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Inner ear.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Myelin P0 glycoprotein: identification of the site phosphorylated in vitro and in vivo by endogenous protein kinases."
      Hilmi S., Fournier M., Valeins H., Gandar J.C., Bonnet J.
      J. Neurochem. 64:902-907(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-226; SER-228; SER-233; SER-237 AND SER-243.

    Entry informationi

    Entry nameiMYP0_MOUSE
    AccessioniPrimary (citable) accession number: P27573
    Secondary accession number(s): Q542C9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3