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Protein

Myelin protein P0

Gene

Mpz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.

GO - Biological processi

  • cell-cell junction maintenance Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein P0
Alternative name(s):
Myelin peripheral protein
Short name:
MPP
Myelin protein zero
Gene namesi
Name:Mpz
Synonyms:P0
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103177. Mpz.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 153ExtracellularBy similarityAdd BLAST124
Transmembranei154 – 179HelicalBy similarityAdd BLAST26
Topological domaini180 – 248CytoplasmicBy similarityAdd BLAST69

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000001930130 – 248Myelin protein P0Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 127PROSITE-ProRule annotation
Glycosylationi122N-linked (GlcNAc...) (complex)Sequence analysis1
Modified residuei210Phosphoserine; by PKCBy similarity1
Modified residuei226Phosphoserine1 Publication1
Modified residuei228Phosphoserine1 Publication1
Modified residuei233Phosphoserine; by PKCBy similarity1
Modified residuei237Phosphoserine1 Publication1
Modified residuei243Phosphoserine1 Publication1

Post-translational modificationi

N-glycosylated; contains sulfate-substituted glycan.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP27573.
PaxDbiP27573.
PRIDEiP27573.

PTM databases

iPTMnetiP27573.
PhosphoSitePlusiP27573.

Expressioni

Tissue specificityi

Found only in peripheral nervous system Schwann cells.

Gene expression databases

CleanExiMM_MPZ.

Interactioni

Subunit structurei

Homodimer and homotetramer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084604EBI-1634589,EBI-1633915

Protein-protein interaction databases

BioGridi201482. 1 interactor.
DIPiDIP-51664N.
IntActiP27573. 1 interactor.
STRINGi10090.ENSMUSP00000066701.

Structurei

3D structure databases

ProteinModelPortaliP27573.
SMRiP27573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 143Ig-like V-typeAdd BLAST114

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG4. Eukaryota.
ENOG4111R0Y. LUCA.
HOGENOMiHOG000232144.
HOVERGENiHBG096384.
InParanoidiP27573.
KOiK06770.
PhylomeDBiP27573.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR019566. Myelin-PO_C.
IPR000920. Myelin_P0-rel.
IPR019738. Myelin_P0_CS.
IPR029869. P0.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF7. PTHR13869:SF7. 1 hit.
PfamiPF10570. Myelin-PO_C. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00568. MYELIN_P0. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGAPSSSP SPILAALLFS SLVLSPALAI VVYTDREIYG AVGSQVTLHC
60 70 80 90 100
SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGAFKERIQ
110 120 130 140 150
WVGDPRWKDG SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV
160 170 180 190 200
PTRYGVVLGA VIGGILGVVL LLLLLFYLIR YCWLRRQAAL QRRLSAMEKG
210 220 230 240
RFHKSSKDSS KRGRQTPVLY AMLDHSRSTK AASEKKSKGL GESRKDKK
Length:248
Mass (Da):27,622
Last modified:August 1, 1992 - v1
Checksum:i936D66684300CAC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62860
, M62857, M62858, M62859 Genomic DNA. Translation: AAA39867.1.
AK089180 mRNA. Translation: BAC40781.1.
AK157960 mRNA. Translation: BAE34285.1.
CH466520 Genomic DNA. Translation: EDL39129.1.
CH466520 Genomic DNA. Translation: EDL39131.1.
BC139139 mRNA. Translation: AAI39140.1.
BC141226 mRNA. Translation: AAI41227.1.
CCDSiCCDS15479.1.
PIRiA54662.
RefSeqiNP_001302428.1. NM_001315499.1.
NP_001302429.1. NM_001315500.1.
NP_032649.2. NM_008623.5.
UniGeneiMm.9986.

Genome annotation databases

GeneIDi17528.
KEGGimmu:17528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62860
, M62857, M62858, M62859 Genomic DNA. Translation: AAA39867.1.
AK089180 mRNA. Translation: BAC40781.1.
AK157960 mRNA. Translation: BAE34285.1.
CH466520 Genomic DNA. Translation: EDL39129.1.
CH466520 Genomic DNA. Translation: EDL39131.1.
BC139139 mRNA. Translation: AAI39140.1.
BC141226 mRNA. Translation: AAI41227.1.
CCDSiCCDS15479.1.
PIRiA54662.
RefSeqiNP_001302428.1. NM_001315499.1.
NP_001302429.1. NM_001315500.1.
NP_032649.2. NM_008623.5.
UniGeneiMm.9986.

3D structure databases

ProteinModelPortaliP27573.
SMRiP27573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201482. 1 interactor.
DIPiDIP-51664N.
IntActiP27573. 1 interactor.
STRINGi10090.ENSMUSP00000066701.

PTM databases

iPTMnetiP27573.
PhosphoSitePlusiP27573.

Proteomic databases

MaxQBiP27573.
PaxDbiP27573.
PRIDEiP27573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17528.
KEGGimmu:17528.

Organism-specific databases

CTDi4359.
MGIiMGI:103177. Mpz.

Phylogenomic databases

eggNOGiENOG410IJG4. Eukaryota.
ENOG4111R0Y. LUCA.
HOGENOMiHOG000232144.
HOVERGENiHBG096384.
InParanoidiP27573.
KOiK06770.
PhylomeDBiP27573.

Miscellaneous databases

PROiP27573.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MPZ.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR019566. Myelin-PO_C.
IPR000920. Myelin_P0-rel.
IPR019738. Myelin_P0_CS.
IPR029869. P0.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF7. PTHR13869:SF7. 1 hit.
PfamiPF10570. Myelin-PO_C. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00568. MYELIN_P0. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYP0_MOUSE
AccessioniPrimary (citable) accession number: P27573
Secondary accession number(s): Q542C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.