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Protein

Microtubule-associated protein 4

Gene

Map4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

GO - Molecular functioni

  • microtubule binding Source: MGI
  • poly(A) RNA binding Source: MGI

GO - Biological processi

  • cell division Source: MGI
  • establishment of spindle orientation Source: MGI
  • microtubule sliding Source: MGI
  • mitotic spindle organization Source: MGI
  • negative regulation of nonmotile primary cilium assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 4
Short name:
MAP-4
Gene namesi
Name:Map4
Synonyms:Mtap4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97178. Map4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 11251124Microtubule-associated protein 4PRO_0000072752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei60 – 601PhosphoserineBy similarity
Modified residuei99 – 991PhosphoserineBy similarity
Modified residuei254 – 2541PhosphoserineCombined sources
Modified residuei260 – 2601PhosphothreonineCombined sources
Modified residuei277 – 2771PhosphothreonineBy similarity
Modified residuei349 – 3491PhosphothreonineBy similarity
Modified residuei381 – 3811PhosphoserineCombined sources
Modified residuei447 – 4471PhosphothreonineCombined sources
Modified residuei475 – 4751PhosphoserineCombined sources
Modified residuei494 – 4941PhosphothreonineBy similarity
Modified residuei503 – 5031PhosphothreonineCombined sources
Modified residuei506 – 5061PhosphoserineCombined sources
Modified residuei511 – 5111PhosphothreonineCombined sources
Modified residuei512 – 5121PhosphoserineCombined sources
Modified residuei517 – 5171PhosphoserineCombined sources
Modified residuei519 – 5191PhosphoserineBy similarity
Modified residuei598 – 5981PhosphoserineCombined sources
Modified residuei617 – 6171PhosphoserineCombined sources
Modified residuei658 – 6581PhosphothreonineCombined sources
Modified residuei667 – 6671PhosphoserineCombined sources
Modified residuei760 – 7601PhosphoserineCombined sources
Modified residuei798 – 7981PhosphoserineBy similarity
Modified residuei901 – 9011PhosphoserineCombined sources
Modified residuei914 – 9141PhosphoserineCombined sources
Modified residuei915 – 9151PhosphothreonineBy similarity
Modified residuei973 – 9731PhosphoserineBy similarity
Modified residuei1046 – 10461PhosphoserineCombined sources
Modified residuei1118 – 11181PhosphoserineBy similarity
Modified residuei1124 – 11241PhosphoserineBy similarity
Isoform 4 (identifier: P27546-4)
Modified residuei333 – 3331PhosphoserineBy similarityCurated
Modified residuei334 – 3341Phosphoserine By similarityBy similarityCurated

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-760 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 4 is phosphorylated on Ser-333 and Ser-334 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP27546.
MaxQBiP27546.
PaxDbiP27546.
PRIDEiP27546.

PTM databases

iPTMnetiP27546.
PhosphoSiteiP27546.
SwissPalmiP27546.

Expressioni

Tissue specificityi

Testis, striated and cardiac muscle.

Gene expression databases

BgeeiP27546.
CleanExiMM_MTAP4.
ExpressionAtlasiP27546. baseline and differential.
GenevisibleiP27546. MM.

Interactioni

Subunit structurei

Interacts with SEPT2; this interaction impedes tubulin-binding. Interacts with TRAF3IP1 (PubMed:26487268).By similarity1 Publication

GO - Molecular functioni

  • microtubule binding Source: MGI

Protein-protein interaction databases

BioGridi201586. 6 interactions.
IntActiP27546. 9 interactions.
MINTiMINT-1861472.
STRINGi10090.ENSMUSP00000035055.

Structurei

3D structure databases

ProteinModelPortaliP27546.
SMRiP27546. Positions 958-1029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati896 – 92631Tau/MAP 1Add
BLAST
Repeati965 – 99531Tau/MAP 2Add
BLAST
Repeati996 – 102631Tau/MAP 3Add
BLAST
Repeati1027 – 105832Tau/MAP 4Add
BLAST

Sequence similaritiesi

Contains 4 Tau/MAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IG6M. Eukaryota.
ENOG4111J07. LUCA.
GeneTreeiENSGT00530000063491.
HOVERGENiHBG006323.
InParanoidiP27546.
KOiK10431.
OrthoDBiEOG7FFMR7.
PhylomeDBiP27546.

Family and domain databases

InterProiIPR027324. MAP2/MAP4/Tau.
IPR027323. MAP4.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 2 hits.
PTHR11501:SF16. PTHR11501:SF16. 2 hits.
PfamiPF00418. Tubulin-binding. 4 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 4 hits.
PS51491. TAU_MAP_2. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P27546-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADLSLVDAL TEPPPEIEGE IKRDFMAALE AEPYDDIVGE TVEKTEFIPL
60 70 80 90 100
LDGDEKTGNS ESKKKPCLDT SQVEGIPSSK PTLLANGDHG MEGNNTAGSP
110 120 130 140 150
TDFLEERVDY PDYQSSQNWP EDASFCFQPQ QVLDTDQAEP FNEHRDDGLA
160 170 180 190 200
DLLFVSSGPT NASAFTERDN PSEDSYGMLP CDSFASTAVV SQEWSVGAPN
210 220 230 240 250
SPCSESCVSP EVTIETLQPA TELSKAAEVE SVKEQLPAKA LETMAEQTTD
260 270 280 290 300
VVHSPSTDTT PGPDTEAALA KDIEEITKPD VILANVTQPS TESDMFLAQD
310 320 330 340 350
MELLTGTEAA HANNIILPTE PDESSTKDVA PPMEEEIVPG NDTTSPKETE
360 370 380 390 400
TTLPIKMDLA PPEDVLLTKE TELAPAKGMV SLSEIEEALA KNDESSAEIP
410 420 430 440 450
VAQETVVSET EVVLATEVVL PSDPITTLTK DVTLPLEAER PLVTDMTPSL
460 470 480 490 500
ETEMTLGKET APPTETNLGM AKDMSPLPES EVTLGKDVVI LPETKVAEFN
510 520 530 540 550
NVTPLSEEEV TSVKDMSPSA ETEAPLAKNA DLHSGTELIV DNSMAPASDL
560 570 580 590 600
ALPLETKVAT VPIKDKGTVQ TEEKPREDSQ LASMQHKGQS TVPPCTASPE
610 620 630 640 650
PVKAAEQMST LPIDAPSPLE NLEQKETPGS QPSEPCSGVS RQEEAKAAVG
660 670 680 690 700
VTGNDITTPP NKEPPPSPEK KAKPLATTQP AKTSTSKAKT QPTSLPKQPA
710 720 730 740 750
PTTSGGLNKK PMSLASGSVP AAPHKRPAAA TATARPSTLP ARDVKPKPIT
760 770 780 790 800
EAKVAEKRTS PSKPSSAPAL KPGPKTTPTV SKATSPSTLV STGPSSRSPA
810 820 830 840 850
TTLPKRPTSI KTEGKPADVK RMTAKSASAD LSRSKTTSAS SVKRNTTPTG
860 870 880 890 900
AAPPAGMTST RVKPMSAPSR SSGALSVDKK PTSTKPSSSA PRVSRLATTV
910 920 930 940 950
SAPDLKSVRS KVGSTENIKH QPGGGRAKVE KKTEAATTAG KPEPNAVTKA
960 970 980 990 1000
AGSIASAQKP PAGKVQIVSK KVSYSHIQSK CGSKDNIKHV PGGGNVQIQN
1010 1020 1030 1040 1050
KKVDISKVSS KCGSKANIKH KPGGGDVKIE SQKLNFKEKA QAKVGSLDNV
1060 1070 1080 1090 1100
GHLPAGGAVK TEGGGSEALP CPGPPAGEEP VIPEAAPDAG APTSASGLSG
1110 1120
HTTLSGGGDQ REPQTLDSQI QETSI
Length:1,125
Mass (Da):117,429
Last modified:June 12, 2007 - v3
Checksum:iE948B7F1F5B903E9
GO
Isoform 2 (identifier: P27546-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1124-1125: SI → N

Show »
Length:1,124
Mass (Da):117,343
Checksum:i2947F1F5B903E9EC
GO
Isoform 3 (identifier: P27546-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     927-964: Missing.
     1124-1125: SI → N

Show »
Length:1,086
Mass (Da):113,656
Checksum:i476A250416BBACFD
GO
Isoform 4 (identifier: P27546-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MADLSLVDALTEPPPEIEGEIKRDFM → MSLPEKQPAALT
     30-259: EAEPYDDIVG...DVVHSPSTDT → AAEDEQLSKG...YSVTQSPQAA
     263-419: PDTEAALAKD...TEVVLATEVV → KEKNGLVSSC...KYPELPAREE
     424-531: PITTLTKDVT...TEAPLAKNAD → LLPPTSSPMP...KKELGIAGLY
     535-625: GTELIVDNSM...PSPLENLEQK → KLEQIPEGSH...TQSIPSLLLE
     629-637: GSQPSEPCS → RD
     927-964: Missing.
     965-995: Missing.
     1124-1125: SI → N

Show »
Length:902
Mass (Da):94,517
Checksum:i031215FB486E6845
GO

Sequence cautioni

The sequence AAH42645.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE27434.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251K → E in AAH55364 (PubMed:15489334).Curated
Sequence conflicti252 – 2521V → A in AAH55364 (PubMed:15489334).Curated
Sequence conflicti394 – 3952ES → VR in AAA16372 (PubMed:1718985).Curated
Sequence conflicti416 – 4161T → I in AAH55332 (PubMed:15489334).Curated
Sequence conflicti955 – 9551A → V in AAH55364 (PubMed:15489334).Curated
Sequence conflicti982 – 9821G → V in AAA16372 (PubMed:1718985).Curated
Sequence conflicti993 – 9931G → C in AAA16372 (PubMed:1718985).Curated
Sequence conflicti1053 – 10531L → F in AAA16372 (PubMed:1718985).Curated
Sequence conflicti1060 – 10601K → KV in AAH44654 (PubMed:15489334).Curated
Sequence conflicti1060 – 10601K → KV in AAH55364 (PubMed:15489334).Curated
Sequence conflicti1089 – 10891A → R in AAA16372 (PubMed:1718985).Curated
Isoform 4 (identifier: P27546-4)
Sequence conflicti435 – 4351K → E in BAE23650 (PubMed:16141072).By similarityCurated
Sequence conflicti435 – 4351K → E in BAE22377 (PubMed:16141072).By similarityCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2626MADLS…KRDFM → MSLPEKQPAALT in isoform 4. 2 PublicationsVSP_026089Add
BLAST
Alternative sequencei30 – 259230EAEPY…PSTDT → AAEDEQLSKGNPPECGMDSR KEIGQDGFEWQRTEGKLNEI GLNVSMDGQLKDRLVKNSSF LEQNKLGFFEGKLDKELSIE KPNKAYQETSGHLESGYVIS GTCQPSEGNLVHQKAAEFHP GLTEGKDKAATVQGKVAGKS GLEIKSQPDLNFPGAADTLT QHGEEQETSAWNANFYSVTQ SPQAA in isoform 4. 2 PublicationsVSP_026090Add
BLAST
Alternative sequencei263 – 419157PDTEA…ATEVV → KEKNGLVSSCSVTGVMSDNS GQLNNKSPLLVAITHPDPTS EHLPTTSPPITMVEFTQENL NAGQDKELEKLRSSEEGPML DQVPQQKKAIRRALSECYHL SVPPAVNLVDKYPELPAREE in isoform 4. 2 PublicationsVSP_026091Add
BLAST
Alternative sequencei424 – 531108PITTL…AKNAD → LLPPTSSPMPSPMPRKLGVP AMRRSMTVAEDQSASCRLSA GELASLSASQVPTALTFEEP VAKEREEQIHFSNDSNSSGK KELGIAGLY in isoform 4. 2 PublicationsVSP_026092Add
BLAST
Alternative sequencei535 – 62591GTELI…NLEQK → KLEQIPEGSHKGKGQKNTGE TRVDSCPFICLGGEKQLMAL AGKKEIEVTATQSIPSLLLE in isoform 4. 2 PublicationsVSP_026093Add
BLAST
Alternative sequencei629 – 6379GSQPSEPCS → RD in isoform 4. 2 PublicationsVSP_026094
Alternative sequencei927 – 96438Missing in isoform 3 and isoform 4. 2 PublicationsVSP_026095Add
BLAST
Alternative sequencei965 – 99531Missing in isoform 4. 2 PublicationsVSP_026096Add
BLAST
Alternative sequencei1124 – 11252SI → N in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_026097

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72414 mRNA. Translation: AAA16372.1.
AK134996 mRNA. Translation: BAE22377.1.
AK138416 mRNA. Translation: BAE23650.1.
AK146790 mRNA. Translation: BAE27434.1. Different initiation.
BC042645 mRNA. Translation: AAH42645.1. Different initiation.
BC044654 mRNA. Translation: AAH44654.1.
BC050893 mRNA. Translation: AAH50893.1.
BC055332 mRNA. Translation: AAH55332.1.
BC055364 mRNA. Translation: AAH55364.1.
CCDSiCCDS57704.1. [P27546-1]
CCDS81083.1. [P27546-4]
PIRiB41206.
RefSeqiNP_001192259.1. NM_001205330.1. [P27546-1]
NP_001192261.1. NM_001205332.1. [P27546-3]
NP_001298092.1. NM_001311163.1.
NP_001298093.1. NM_001311164.1.
NP_032659.2. NM_008633.4.
UniGeneiMm.217318.
Mm.443428.
Mm.484451.

Genome annotation databases

EnsembliENSMUST00000035055; ENSMUSP00000035055; ENSMUSG00000032479. [P27546-1]
ENSMUST00000165876; ENSMUSP00000132662; ENSMUSG00000032479. [P27546-2]
GeneIDi17758.
KEGGimmu:17758.
UCSCiuc009rsz.3. mouse. [P27546-2]
uc009rta.3. mouse. [P27546-1]
uc009rtb.3. mouse. [P27546-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72414 mRNA. Translation: AAA16372.1.
AK134996 mRNA. Translation: BAE22377.1.
AK138416 mRNA. Translation: BAE23650.1.
AK146790 mRNA. Translation: BAE27434.1. Different initiation.
BC042645 mRNA. Translation: AAH42645.1. Different initiation.
BC044654 mRNA. Translation: AAH44654.1.
BC050893 mRNA. Translation: AAH50893.1.
BC055332 mRNA. Translation: AAH55332.1.
BC055364 mRNA. Translation: AAH55364.1.
CCDSiCCDS57704.1. [P27546-1]
CCDS81083.1. [P27546-4]
PIRiB41206.
RefSeqiNP_001192259.1. NM_001205330.1. [P27546-1]
NP_001192261.1. NM_001205332.1. [P27546-3]
NP_001298092.1. NM_001311163.1.
NP_001298093.1. NM_001311164.1.
NP_032659.2. NM_008633.4.
UniGeneiMm.217318.
Mm.443428.
Mm.484451.

3D structure databases

ProteinModelPortaliP27546.
SMRiP27546. Positions 958-1029.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201586. 6 interactions.
IntActiP27546. 9 interactions.
MINTiMINT-1861472.
STRINGi10090.ENSMUSP00000035055.

PTM databases

iPTMnetiP27546.
PhosphoSiteiP27546.
SwissPalmiP27546.

Proteomic databases

EPDiP27546.
MaxQBiP27546.
PaxDbiP27546.
PRIDEiP27546.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035055; ENSMUSP00000035055; ENSMUSG00000032479. [P27546-1]
ENSMUST00000165876; ENSMUSP00000132662; ENSMUSG00000032479. [P27546-2]
GeneIDi17758.
KEGGimmu:17758.
UCSCiuc009rsz.3. mouse. [P27546-2]
uc009rta.3. mouse. [P27546-1]
uc009rtb.3. mouse. [P27546-3]

Organism-specific databases

CTDi4134.
MGIiMGI:97178. Map4.

Phylogenomic databases

eggNOGiENOG410IG6M. Eukaryota.
ENOG4111J07. LUCA.
GeneTreeiENSGT00530000063491.
HOVERGENiHBG006323.
InParanoidiP27546.
KOiK10431.
OrthoDBiEOG7FFMR7.
PhylomeDBiP27546.

Miscellaneous databases

PROiP27546.
SOURCEiSearch...

Gene expression databases

BgeeiP27546.
CleanExiMM_MTAP4.
ExpressionAtlasiP27546. baseline and differential.
GenevisibleiP27546. MM.

Family and domain databases

InterProiIPR027324. MAP2/MAP4/Tau.
IPR027323. MAP4.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 2 hits.
PTHR11501:SF16. PTHR11501:SF16. 2 hits.
PfamiPF00418. Tubulin-binding. 4 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 4 hits.
PS51491. TAU_MAP_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences."
    West R.R., Tenbarge K.M., Olmsted J.B.
    J. Biol. Chem. 266:21886-21896(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: C57BL/6J.
    Tissue: Heart, Hypothalamus and Olfactory bulb.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Strain: C3H/He and C57BL/6.
    Tissue: Brain, Eye and Osteoblast.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475 AND SER-617, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475; THR-503; SER-506; SER-517 AND SER-1046, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475 AND SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475 AND SER-667, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254; THR-260; SER-381; THR-447; SER-475; THR-503; SER-506; THR-511; SER-512; SER-517; SER-598; SER-617; THR-658; SER-667; SER-760; SER-901; SER-914 AND SER-1046, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  10. Cited for: INTERACTION WITH TRAF3IP1.

Entry informationi

Entry nameiMAP4_MOUSE
AccessioniPrimary (citable) accession number: P27546
Secondary accession number(s): Q05BJ2
, Q3UIS2, Q3UUH5, Q3UY36, Q7TPC6, Q7TPD4, Q80YQ5, Q8CFP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: June 12, 2007
Last modified: June 8, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.