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Protein

Ceramide synthase 1

Gene

Cers1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner.1 Publication

Miscellaneous

This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.

GO - Molecular functioni

  • sphingosine N-acyltransferase activity Source: HGNC

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.24. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Chemistry databases

SwissLipidsiSLP:000000115.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase 1
Short name:
CerS1
Alternative name(s):
LAG1 longevity assurance homolog 1
Longevity assurance gene 1 protein homolog 1
Protein UOG-1
Gene namesi
Name:Cers1
Synonyms:Lass1, Uog-1, Uog1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2136690. Cers1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001855082 – 350Ceramide synthase 1Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP27545.
PaxDbiP27545.
PRIDEiP27545.

PTM databases

PhosphoSitePlusiP27545.

Expressioni

Tissue specificityi

Brain-specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000087408.
ExpressionAtlasiP27545. baseline and differential.
GenevisibleiP27545. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120598.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 311TLCPROSITE-ProRule annotationAdd BLAST215

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 6Poly-Ala5

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00740000114888.
HOVERGENiHBG052309.
InParanoidiP27545.
KOiK04710.
OMAiNIPFYFF.
PhylomeDBiP27545.
TreeFamiTF314319.

Family and domain databases

InterProiView protein in InterPro
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiView protein in Pfam
PF03798. TRAM_LAG1_CLN8. 1 hit.
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiView protein in SMART
SM00724. TLC. 1 hit.
PROSITEiView protein in PROSITE
PS50922. TLC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAATPRL EAPEPMPSYA QMLQRSWASA LAAAQGCGDC GWGLARRGLA
60 70 80 90 100
EHAHLAAPEL LLAVLCALGW TALRWAATTH IFRPLAKRCR LQPRDAARLP
110 120 130 140 150
ESAWKLLFYL ACWSYCAYLL LGTSYPFFHD PPSVFYDWRS GMAVPWDIAV
160 170 180 190 200
AYLLQGSFYC HSIYATVYMD SWRKDSVVML VHHVVTLLLI ASSYAFRYHN
210 220 230 240 250
VGLLVFFLHD VSDVQLEFTK LNIYFKARGG AYHRLHGLVA NLGCLSFCFC
260 270 280 290 300
WFWFRLYWFP LKVLYATCHC SLQSVPDIPY YFFFNILLLL LMVMNIYWFL
310 320 330 340 350
YIVAFAAKVL TGQMRELEDL REYDTLEAQT AKPCKAEKPL RNGLVKDKLF
Length:350
Mass (Da):40,100
Last modified:August 1, 1992 - v1
Checksum:i8AF3D9738CF75A02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62301 mRNA. Translation: AAA37675.1.
CCDSiCCDS52570.1.
PIRiB39364.
RefSeqiNP_619588.1. NM_138647.3.
UniGeneiMm.258280.

Genome annotation databases

EnsembliENSMUST00000140239; ENSMUSP00000120598; ENSMUSG00000087408.
GeneIDi93898.
KEGGimmu:93898.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCERS1_MOUSE
AccessioniPrimary (citable) accession number: P27545
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 7, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot