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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-264-MONOMER.
CPNE115713:GHEY-519-MONOMER.
CPNE138677:GH8N-512-MONOMER.
CPNE182082:GH4N-533-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
75 kDa membrane protein
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:CPn_0503, CP_0251, CpB0523
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Chaperone protein DnaKPRO_0000078444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP27542.

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0503.

Structurei

3D structure databases

ProteinModelPortaliP27542.
SMRiP27542. Positions 8-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228135.
KOiK04043.
OMAiMSEHKKS.
OrthoDBiEOG6JMMSV.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEHKKSSKI IGIDLGTTNS CVSVMEGGQA KVITSSEGTR TTPSIVAFKG
60 70 80 90 100
NEKLVGIPAK RQAVTNPEKT LGSTKRFIGR KYSEVASEIQ TVPYTVTSGS
110 120 130 140 150
KGDAVFEVDG KQYTPEEIGA QILMKMKETA EAYLGETVTE AVITVPAYFN
160 170 180 190 200
DSQRASTKDA GRIAGLDVKR IIPEPTAAAL AYGIDKVGDK KIAVFDLGGG
210 220 230 240 250
TFDISILEIG DGVFEVLSTN GDTLLGGDDF DEVIIKWMIE EFKKQEGIDL
260 270 280 290 300
SKDNMALQRL KDAAEKAKIE LSGVSSTEIN QPFITMDAQG PKHLALTLTR
310 320 330 340 350
AQFEKLAASL IERTKSPCIK ALSDAKLSAK DIDDVLLVGG MSRMPAVQET
360 370 380 390 400
VKELFGKEPN KGVNPDEVVA IGAAIQGGVL GGEVKDVLLL DVIPLSLGIE
410 420 430 440 450
TLGGVMTTLV ERNTTIPTQK KQIFSTAADN QPAVTIVVLQ GERPMAKDNK
460 470 480 490 500
EIGRFDLTDI PPAPRGHPQI EVSFDIDANG IFHVSAKDVA SGKEQKIRIE
510 520 530 540 550
ASSGLQEDEI QRMVRDAEIN KEEDKKRREA SDAKNEADSM IFRAEKAIKD
560 570 580 590 600
YKEQIPETLV KEIEERIENV RNALKDDAPI EKIKEVTEDL SKHMQKIGES
610 620 630 640 650
MQSQSASAAA SSAANAKGGP NINTEDLKKH SFSTKPPSNN GSSEDHIEEA
660
DVEIIDNDDK
Length:660
Mass (Da):71,354
Last modified:August 1, 1992 - v1
Checksum:iE6EAF533557A3596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69227 Genomic DNA. Translation: AAA23121.1.
AE001363 Genomic DNA. Translation: AAD18643.1.
AE002161 Genomic DNA. Translation: AAF38114.1.
BA000008 Genomic DNA. Translation: BAA98709.1.
AE009440 Genomic DNA. Translation: AAP98452.1.
PIRiC86553.
S16159.
RefSeqiNP_224699.1. NC_000922.1.
WP_010883141.1. NZ_LN847257.1.

Genome annotation databases

EnsemblBacteriaiAAD18643; AAD18643; CPn_0503.
AAF38114; AAF38114; CP_0251.
AAP98452; AAP98452; CpB0523.
BAA98709; BAA98709; BAA98709.
GeneIDi894942.
KEGGicpa:CP_0251.
cpj:dnaK.
cpn:CPn0503.
cpt:CpB0523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69227 Genomic DNA. Translation: AAA23121.1.
AE001363 Genomic DNA. Translation: AAD18643.1.
AE002161 Genomic DNA. Translation: AAF38114.1.
BA000008 Genomic DNA. Translation: BAA98709.1.
AE009440 Genomic DNA. Translation: AAP98452.1.
PIRiC86553.
S16159.
RefSeqiNP_224699.1. NC_000922.1.
WP_010883141.1. NZ_LN847257.1.

3D structure databases

ProteinModelPortaliP27542.
SMRiP27542. Positions 8-532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0503.

Proteomic databases

PRIDEiP27542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18643; AAD18643; CPn_0503.
AAF38114; AAF38114; CP_0251.
AAP98452; AAP98452; CpB0523.
BAA98709; BAA98709; BAA98709.
GeneIDi894942.
KEGGicpa:CP_0251.
cpj:dnaK.
cpn:CPn0503.
cpt:CpB0523.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228135.
KOiK04043.
OMAiMSEHKKS.
OrthoDBiEOG6JMMSV.

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-264-MONOMER.
CPNE115713:GHEY-519-MONOMER.
CPNE138677:GH8N-512-MONOMER.
CPNE182082:GH4N-533-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the gene encoding the Chlamydia pneumoniae DnaK protein homolog."
    Kornak J.M., Kuo C.C., Campbell L.A.
    Infect. Immun. 59:721-725(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: TWAR.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  4. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  5. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiDNAK_CHLPN
AccessioniPrimary (citable) accession number: P27542
Secondary accession number(s): Q9JQ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: March 16, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Expressed early during infection.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.