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Protein

Aryl hydrocarbon receptor nuclear translocator

Gene

ARNT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

GO - Molecular functioni

  • aryl hydrocarbon receptor activity Source: Ensembl
  • aryl hydrocarbon receptor binding Source: BHF-UCL
  • enhancer binding Source: MGI
  • protein heterodimerization activity Source: BHF-UCL
  • transcription coactivator activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • transcription factor binding Source: BHF-UCL

GO - Biological processi

  • cell differentiation Source: Ensembl
  • embryonic placenta development Source: Ensembl
  • mRNA transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of erythrocyte differentiation Source: BHF-UCL
  • positive regulation of glycolytic process Source: BHF-UCL
  • positive regulation of hormone biosynthetic process Source: BHF-UCL
  • positive regulation of protein sumoylation Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of vascular endothelial growth factor production Source: BHF-UCL
  • positive regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
  • regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
  • response to hypoxia Source: BHF-UCL
  • transcription, DNA-templated Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143437-MONOMER.
ReactomeiR-HSA-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
SignaLinkiP27540.
SIGNORiP27540.

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator
Short name:
ARNT protein
Alternative name(s):
Class E basic helix-loop-helix protein 2
Short name:
bHLHe2
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta
Short name:
HIF-1-beta
Short name:
HIF1-beta
Gene namesi
Name:ARNT
Synonyms:BHLHE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:700. ARNT.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • nucleoplasm Source: Reactome
  • nucleus Source: BHF-UCL
  • RNA polymerase II transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi91R → A: Diminishes DNA interaction. 1 Publication1
Mutagenesisi93N → A: Diminishes DNA interaction. 1 Publication1
Mutagenesisi94H → A: Severely diminishes DNA interaction. 1 Publication1
Mutagenesisi98E → A: Severely diminishes DNA interaction. 1 Publication1
Mutagenesisi99R → A: Diminishes DNA interaction. 1 Publication1
Mutagenesisi101R → A: Severely diminishes DNA interaction. 1 Publication1
Mutagenesisi102R → A: Severely diminishes DNA interaction. 1 Publication1

Organism-specific databases

DisGeNETi405.
OpenTargetsiENSG00000143437.
PharmGKBiPA24994.

Chemistry databases

ChEMBLiCHEMBL5618.

Polymorphism and mutation databases

BioMutaiARNT.
DMDMi114163.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001271182 – 789Aryl hydrocarbon receptor nuclear translocatorAdd BLAST788

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei77PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP27540.
MaxQBiP27540.
PaxDbiP27540.
PeptideAtlasiP27540.
PRIDEiP27540.

PTM databases

iPTMnetiP27540.
PhosphoSitePlusiP27540.

Expressioni

Gene expression databases

BgeeiENSG00000143437.
CleanExiHS_ARNT.
ExpressionAtlasiP27540. baseline and differential.
GenevisibleiP27540. HS.

Organism-specific databases

HPAiCAB004318.
HPA001759.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7. Heterodimer with HIF1A.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AHRP358695EBI-80809,EBI-80780
HIF1AQ166659EBI-80809,EBI-447269
NCOA7Q8NI082EBI-80809,EBI-80799
NCOR2Q9Y6182EBI-80809,EBI-80830

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106898. 48 interactors.
DIPiDIP-30886N.
IntActiP27540. 28 interactors.
MINTiMINT-1196758.
STRINGi9606.ENSP00000351407.

Structurei

Secondary structure

1789
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi356 – 358Combined sources3
Beta strandi362 – 367Combined sources6
Beta strandi371 – 376Combined sources6
Helixi380 – 384Combined sources5
Helixi388 – 390Combined sources3
Turni391 – 393Combined sources3
Helixi396 – 399Combined sources4
Turni402 – 404Combined sources3
Helixi405 – 415Combined sources11
Turni416 – 420Combined sources5
Beta strandi423 – 430Combined sources8
Beta strandi436 – 446Combined sources11
Turni449 – 451Combined sources3
Beta strandi456 – 463Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D7Gmodel-C87-145[»]
1X0ONMR-A356-470[»]
2A24NMR-B358-465[»]
2ARNmodel-A335-462[»]
2B02X-ray1.50A354-470[»]
2HV1NMR-A/B356-470[»]
2K7SNMR-A356-470[»]
3F1NX-ray1.48B356-470[»]
3F1OX-ray1.60B356-470[»]
3F1PX-ray1.17B356-470[»]
3H7WX-ray1.65B356-470[»]
3H82X-ray1.50B356-470[»]
4EQ1X-ray1.60A/B357-464[»]
4GHIX-ray1.50B356-470[»]
4GS9X-ray1.72B356-470[»]
4H6JX-ray1.52B357-470[»]
4LPZX-ray3.15A/B356-470[»]
4PKYX-ray3.20A/D356-470[»]
4XT2X-ray1.70B/D356-470[»]
5T0TX-ray2.20B356-467[»]
5TBMX-ray1.85B356-467[»]
ProteinModelPortaliP27540.
SMRiP27540.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27540.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 142bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini161 – 235PAS 1PROSITE-ProRule annotationAdd BLAST75
Domaini349 – 419PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini424 – 467PACAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 102Poly-Arg4
Compositional biasi503 – 507Poly-Gln5
Compositional biasi710 – 769Gln-richAdd BLAST60
Compositional biasi738 – 741Poly-Ser4

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5T. Eukaryota.
ENOG410XVHF. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000234380.
HOVERGENiHBG000164.
InParanoidiP27540.
KOiK09097.
OMAiIVEFCHP.
OrthoDBiEOG091G03AI.
PhylomeDBiP27540.
TreeFamiTF319983.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 4 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P27540-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD
60 70 80 90 100
DDGEGNSKFL RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR
110 120 130 140 150
RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST
160 170 180 190 200
DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP
210 220 230 240 250
QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ
260 270 280 290 300
SSMRMCMGSR RSFICRMRCG SSSVDPVSVN RLSFVRNRCR NGLGSVKDGE
310 320 330 340 350
PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN
360 370 380 390 400
CTDMSNVCQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC
410 420 430 440 450
HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR SKNQEWLWMR TSSFTFQNPY
460 470 480 490 500
SDEIEYIICT NTNVKNSSQE PRPTLSNTIQ RPQLGPTANL PLEMGSGQLA
510 520 530 540 550
PRQQQQQTEL DMVPGRDGLA SYNHSQVVQP VTTTGPEHSK PLEKSDGLFA
560 570 580 590 600
QDRDPRFSEI YHNINADQSK GISSSTVPAT QQLFSQGNTF PPTPRPAENF
610 620 630 640 650
RNSGLAPPVT IVQPSASAGQ MLAQISRHSN PTQGATPTWT PTTRSGFSAQ
660 670 680 690 700
QVATQATAKT RTSQFGVGSF QTPSSFSSMS LPGAPTASPG AAAYPSLTNR
710 720 730 740 750
GSNFAPETGQ TAGQFQTRTA EGVGVWPQWQ GQQPHHRSSS SEQHVQQPPA
760 770 780
QQPGQPEVFQ EMLSMLGDQS NSYNNEEFPD LTMFPPFSE
Length:789
Mass (Da):86,636
Last modified:August 1, 1992 - v1
Checksum:i2E278F8E62BFBF6D
GO
Isoform 2 (identifier: P27540-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     77-91: Missing.

Show »
Length:774
Mass (Da):84,948
Checksum:i0653070528296044
GO
Isoform 3 (identifier: P27540-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     319-323: Missing.

Note: No experimental confirmation available.
Show »
Length:775
Mass (Da):85,296
Checksum:i74839AACC350CB6B
GO
Isoform 4 (identifier: P27540-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     601-602: Missing.

Show »
Length:787
Mass (Da):86,366
Checksum:i956940ABFFF1E71A
GO

Sequence cautioni

The sequence BAD93114 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD38953 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti627R → H in BAG36518 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024280430R → Q.Corresponds to variant rs2229175dbSNPEnsembl.1
Natural variantiVAR_049537435E → K.Corresponds to variant rs2229176dbSNPEnsembl.1
Natural variantiVAR_014819511D → N.Corresponds to variant rs1805133dbSNPEnsembl.1
Natural variantiVAR_018906517D → E.1 PublicationCorresponds to variant rs10305741dbSNPEnsembl.1
Natural variantiVAR_020189706P → L.Corresponds to variant rs2275237dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0365321 – 9Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_00209277 – 91Missing in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_036533319 – 323Missing in isoform 3. 1 Publication5
Alternative sequenceiVSP_055030601 – 602Missing in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69238 mRNA. Translation: AAA51777.1.
Y18859
, AJ251863, AJ404851, AJ404852, AJ404853, AJ404854 Genomic DNA. Translation: CAC21446.1.
AK290177 mRNA. Translation: BAF82866.1.
AK293027 mRNA. Translation: BAF85716.1.
AK313780 mRNA. Translation: BAG36518.1.
AB209877 mRNA. Translation: BAD93114.1. Different initiation.
AL834279 mRNA. Translation: CAD38953.1. Different initiation.
AY430083 Genomic DNA. Translation: AAQ96598.1.
AL355860 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53510.1.
CH471121 Genomic DNA. Translation: EAW53513.1.
CCDSiCCDS65641.1. [P27540-3]
CCDS65642.1. [P27540-4]
CCDS970.1. [P27540-1]
CCDS971.1. [P27540-2]
PIRiI59550.
RefSeqiNP_001184254.1. NM_001197325.1.
NP_001272964.1. NM_001286035.1. [P27540-3]
NP_001272965.1. NM_001286036.1. [P27540-4]
NP_001659.1. NM_001668.3. [P27540-1]
NP_848514.1. NM_178427.2. [P27540-2]
XP_016856778.1. XM_017001289.1. [P27540-3]
UniGeneiHs.632446.

Genome annotation databases

EnsembliENST00000354396; ENSP00000346372; ENSG00000143437. [P27540-4]
ENST00000358595; ENSP00000351407; ENSG00000143437. [P27540-1]
ENST00000505755; ENSP00000427571; ENSG00000143437. [P27540-2]
ENST00000515192; ENSP00000423851; ENSG00000143437. [P27540-3]
GeneIDi405.
KEGGihsa:405.
UCSCiuc001evr.2. human. [P27540-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69238 mRNA. Translation: AAA51777.1.
Y18859
, AJ251863, AJ404851, AJ404852, AJ404853, AJ404854 Genomic DNA. Translation: CAC21446.1.
AK290177 mRNA. Translation: BAF82866.1.
AK293027 mRNA. Translation: BAF85716.1.
AK313780 mRNA. Translation: BAG36518.1.
AB209877 mRNA. Translation: BAD93114.1. Different initiation.
AL834279 mRNA. Translation: CAD38953.1. Different initiation.
AY430083 Genomic DNA. Translation: AAQ96598.1.
AL355860 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53510.1.
CH471121 Genomic DNA. Translation: EAW53513.1.
CCDSiCCDS65641.1. [P27540-3]
CCDS65642.1. [P27540-4]
CCDS970.1. [P27540-1]
CCDS971.1. [P27540-2]
PIRiI59550.
RefSeqiNP_001184254.1. NM_001197325.1.
NP_001272964.1. NM_001286035.1. [P27540-3]
NP_001272965.1. NM_001286036.1. [P27540-4]
NP_001659.1. NM_001668.3. [P27540-1]
NP_848514.1. NM_178427.2. [P27540-2]
XP_016856778.1. XM_017001289.1. [P27540-3]
UniGeneiHs.632446.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D7Gmodel-C87-145[»]
1X0ONMR-A356-470[»]
2A24NMR-B358-465[»]
2ARNmodel-A335-462[»]
2B02X-ray1.50A354-470[»]
2HV1NMR-A/B356-470[»]
2K7SNMR-A356-470[»]
3F1NX-ray1.48B356-470[»]
3F1OX-ray1.60B356-470[»]
3F1PX-ray1.17B356-470[»]
3H7WX-ray1.65B356-470[»]
3H82X-ray1.50B356-470[»]
4EQ1X-ray1.60A/B357-464[»]
4GHIX-ray1.50B356-470[»]
4GS9X-ray1.72B356-470[»]
4H6JX-ray1.52B357-470[»]
4LPZX-ray3.15A/B356-470[»]
4PKYX-ray3.20A/D356-470[»]
4XT2X-ray1.70B/D356-470[»]
5T0TX-ray2.20B356-467[»]
5TBMX-ray1.85B356-467[»]
ProteinModelPortaliP27540.
SMRiP27540.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106898. 48 interactors.
DIPiDIP-30886N.
IntActiP27540. 28 interactors.
MINTiMINT-1196758.
STRINGi9606.ENSP00000351407.

Chemistry databases

ChEMBLiCHEMBL5618.

PTM databases

iPTMnetiP27540.
PhosphoSitePlusiP27540.

Polymorphism and mutation databases

BioMutaiARNT.
DMDMi114163.

Proteomic databases

EPDiP27540.
MaxQBiP27540.
PaxDbiP27540.
PeptideAtlasiP27540.
PRIDEiP27540.

Protocols and materials databases

DNASUi405.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354396; ENSP00000346372; ENSG00000143437. [P27540-4]
ENST00000358595; ENSP00000351407; ENSG00000143437. [P27540-1]
ENST00000505755; ENSP00000427571; ENSG00000143437. [P27540-2]
ENST00000515192; ENSP00000423851; ENSG00000143437. [P27540-3]
GeneIDi405.
KEGGihsa:405.
UCSCiuc001evr.2. human. [P27540-1]

Organism-specific databases

CTDi405.
DisGeNETi405.
GeneCardsiARNT.
HGNCiHGNC:700. ARNT.
HPAiCAB004318.
HPA001759.
MIMi126110. gene.
neXtProtiNX_P27540.
OpenTargetsiENSG00000143437.
PharmGKBiPA24994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ5T. Eukaryota.
ENOG410XVHF. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000234380.
HOVERGENiHBG000164.
InParanoidiP27540.
KOiK09097.
OMAiIVEFCHP.
OrthoDBiEOG091G03AI.
PhylomeDBiP27540.
TreeFamiTF319983.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143437-MONOMER.
ReactomeiR-HSA-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
SignaLinkiP27540.
SIGNORiP27540.

Miscellaneous databases

ChiTaRSiARNT. human.
EvolutionaryTraceiP27540.
GeneWikiiAryl_hydrocarbon_receptor_nuclear_translocator.
GenomeRNAii405.
PROiP27540.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143437.
CleanExiHS_ARNT.
ExpressionAtlasiP27540. baseline and differential.
GenevisibleiP27540. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 4 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARNT_HUMAN
AccessioniPrimary (citable) accession number: P27540
Secondary accession number(s): B2R9H1
, C4AMA1, F8WAP6, Q59ED4, Q5QP39, Q8NDC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 30, 2016
This is version 185 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.