P27510 (APAH_ENTAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:

apaH

Organism

Enterobacter aerogenes (Aerobacter aerogenes)

Taxonomic identifier

548 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Enterobacter

Protein attributes

Sequence length	259 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 259	›259	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_0000197994
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P27510 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 8755312AAC7AF7CD	FASTA	259	29,115
	10 20 30 40 50 60 EFDPRRDTLW LTGDLVARGP GSLEVLRYVK SLGDTVRLVL GNHDLHLLAV FAGISRNKPK 70 80 90 100 110 120 DRLKPLLEAP DADELLNWLR RQPLLQVDEE KKLVMAHAGI TPQWDLETAQ QCARDVEAVL 130 140 150 160 170 180 SSDSYPFFLD AMYGDMPNHW SNELSGLARL RFISNAFTRM RYCFPNGQLD MYSKEAPEDA 190 200 210 220 230 240 PAPLKPWFAI PGPVSNAYSI AFGHWASLEG RGTPEGIYAL DTGCCWGGEL TCLRWEDKQY 250 FTQPSNRQKS LDEGEAVAS

References

[1]

"Cloning and nucleotide sequence of a negative regulator gene for Klebsiella aerogenes arylsulfatase synthesis and identification of the gene as folA." Azakami H., Sugino H., Murooka Y. J. Bacteriol. 174:2344-2351(1992) [PubMed: 1551851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: W70.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10358 Genomic DNA. Translation: BAA01188.1.
3D structure databases
ProteinModelPortal	P27510.
SMR	P27510. Positions 1-245.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_ENTAE

Accession

Primary (citable) accession number: P27510

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	September 21, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program