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P27505

- PQQC_KLEPN

UniProt

P27505 - PQQC_KLEPN

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Protein

Pyrroloquinoline-quinone synthase

Gene

pqqC

Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.1 Publication

Catalytic activityi

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O.

Pathwayi

GO - Molecular functioni

  1. pyrroloquinoline-quinone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrroloquinoline quinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PQQ biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15352.
BRENDAi1.3.3.11. 2814.
UniPathwayiUPA00539.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroloquinoline-quinone synthase (EC:1.3.3.11)
Alternative name(s):
Coenzyme PQQ synthesis protein C
Pyrroloquinoline quinone biosynthesis protein C
Gene namesi
Name:pqqC
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Pyrroloquinoline-quinone synthasePRO_0000219979Add
BLAST

2D gel databases

UCD-2DPAGEP27505.

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1
251
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 1810
Helixi19 – 224
Helixi24 – 263
Helixi28 – 347
Helixi40 – 6627
Helixi71 – 8515
Beta strandi87 – 904
Helixi93 – 10311
Helixi108 – 1125
Helixi119 – 13416
Helixi137 – 1426
Helixi143 – 1497
Turni162 – 1643
Helixi170 – 18112
Helixi189 – 1979
Helixi201 – 22929
Turni235 – 2395

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OTVX-ray2.10A/B1-251[»]
1OTWX-ray2.30A/B1-251[»]
ProteinModelPortaliP27505.
SMRiP27505. Positions 1-251.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27505.

Family & Domainsi

Sequence similaritiesi

Belongs to the PqqC family.Curated

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.

Sequencei

Sequence statusi: Complete.

P27505 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLITDTLSPQ AFEEALRAKG AFYHIHHPYH IAMHNGDATR KQIQGWVANR
60 70 80 90 100
FYYQTTIPLK DAAIMANCPD AQTRRKWVQR ILDHDGSHGE DGGIEAWLRL
110 120 130 140 150
GEAVGLSRDD LLSERHVLPG VRFAVDAYLN FARRACWQEA ACSSLTELFA
160 170 180 190 200
PQIHQSRLDS WPQHYPWIKE EGYFYFRSRL SQANRDVEHG LALAKAYCDS
210 220 230 240 250
AEKQNRMLEI LQFKLDILWS MLDAMTMAYA LQRPPYHTVT DKAAWHTTRL

V
Length:251
Mass (Da):28,986
Last modified:August 1, 1992 - v1
Checksum:iB48A494FA63B6598
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58778 Genomic DNA. Translation: CAA41581.1.
PIRiS20455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58778 Genomic DNA. Translation: CAA41581.1 .
PIRi S20455.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OTV X-ray 2.10 A/B 1-251 [» ]
1OTW X-ray 2.30 A/B 1-251 [» ]
ProteinModelPortali P27505.
SMRi P27505. Positions 1-251.
ModBasei Search...
MobiDBi Search...

2D gel databases

UCD-2DPAGE P27505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00539 .
BioCyci MetaCyc:MONOMER-15352.
BRENDAi 1.3.3.11. 2814.

Miscellaneous databases

EvolutionaryTracei P27505.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
HAMAPi MF_00654. PQQ_syn_PqqC.
InterProi IPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view ]
Pfami PF03070. TENA_THI-4. 1 hit.
[Graphical view ]
SUPFAMi SSF48613. SSF48613. 1 hit.
TIGRFAMsi TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and structure of the Klebsiella pneumoniae pqq operon."
    Meulenberg J.J.M., Sellink E., Riegman N.H., Postma P.W.
    Mol. Gen. Genet. 232:284-294(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15380 / DSM 2026 / NCTC 418 / NCIMB 418.
  2. "Synthesis of pyrroloquinoline quinone in vivo and in vitro and detection of an intermediate in the biosynthetic pathway."
    Velterop J.S., Sellink E., Meulenberg J.J., David S., Bulder I., Postma P.W.
    J. Bacteriol. 177:5088-5098(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: ATCC 15380 / DSM 2026 / NCTC 418 / NCIMB 418.
  3. "Quinone biogenesis: structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone."
    Magnusson O.T., Toyama H., Saeki M., Rojas A., Reed J.C., Liddington R.C., Klinman J.P., Schwarzenbacher R.
    Proc. Natl. Acad. Sci. U.S.A. 101:7913-7918(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiPQQC_KLEPN
AccessioniPrimary (citable) accession number: P27505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3