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Protein

Pyrroloquinoline-quinone synthase

Gene

pqqC

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.1 Publication

Catalytic activityi

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O.

Pathwayi: pyrroloquinoline quinone biosynthesis

This protein is involved in the pathway pyrroloquinoline quinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway pyrroloquinoline quinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PQQ biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15352.
BRENDAi1.3.3.11. 2814.
UniPathwayiUPA00539.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroloquinoline-quinone synthase (EC:1.3.3.11)
Alternative name(s):
Coenzyme PQQ synthesis protein C
Pyrroloquinoline quinone biosynthesis protein C
Gene namesi
Name:pqqC
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002199791 – 251Pyrroloquinoline-quinone synthaseAdd BLAST251

2D gel databases

UCD-2DPAGEP27505.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi272620.KPN_01811.

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 18Combined sources10
Helixi19 – 22Combined sources4
Helixi24 – 26Combined sources3
Helixi28 – 34Combined sources7
Helixi40 – 66Combined sources27
Helixi71 – 85Combined sources15
Beta strandi87 – 90Combined sources4
Helixi93 – 103Combined sources11
Helixi108 – 112Combined sources5
Helixi119 – 134Combined sources16
Helixi137 – 142Combined sources6
Helixi143 – 149Combined sources7
Turni162 – 164Combined sources3
Helixi170 – 181Combined sources12
Helixi189 – 197Combined sources9
Helixi201 – 229Combined sources29
Turni235 – 239Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OTVX-ray2.10A/B1-251[»]
1OTWX-ray2.30A/B1-251[»]
ProteinModelPortaliP27505.
SMRiP27505.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27505.

Family & Domainsi

Sequence similaritiesi

Belongs to the PqqC family.Curated

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.

Sequencei

Sequence statusi: Complete.

P27505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLITDTLSPQ AFEEALRAKG AFYHIHHPYH IAMHNGDATR KQIQGWVANR
60 70 80 90 100
FYYQTTIPLK DAAIMANCPD AQTRRKWVQR ILDHDGSHGE DGGIEAWLRL
110 120 130 140 150
GEAVGLSRDD LLSERHVLPG VRFAVDAYLN FARRACWQEA ACSSLTELFA
160 170 180 190 200
PQIHQSRLDS WPQHYPWIKE EGYFYFRSRL SQANRDVEHG LALAKAYCDS
210 220 230 240 250
AEKQNRMLEI LQFKLDILWS MLDAMTMAYA LQRPPYHTVT DKAAWHTTRL

V
Length:251
Mass (Da):28,986
Last modified:August 1, 1992 - v1
Checksum:iB48A494FA63B6598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58778 Genomic DNA. Translation: CAA41581.1.
PIRiS20455.
RefSeqiWP_004225008.1. NZ_JYBC01000008.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58778 Genomic DNA. Translation: CAA41581.1.
PIRiS20455.
RefSeqiWP_004225008.1. NZ_JYBC01000008.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OTVX-ray2.10A/B1-251[»]
1OTWX-ray2.30A/B1-251[»]
ProteinModelPortaliP27505.
SMRiP27505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_01811.

2D gel databases

UCD-2DPAGEP27505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00539.
BioCyciMetaCyc:MONOMER-15352.
BRENDAi1.3.3.11. 2814.

Miscellaneous databases

EvolutionaryTraceiP27505.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPQQC_KLEPN
AccessioniPrimary (citable) accession number: P27505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.