P27486 (1A1C_DIACA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-aminocyclopropane-1-carboxylate synthase
Short name=ACC synthase
EC=4.4.1.14

Alternative name(s):
S-adenosyl-L-methionine methylthioadenosine-lyase

Gene names

Name:	ACS2
Synonyms:	CARACC

Organism

Dianthus caryophyllus (Carnation) (Clove pink)

Taxonomic identifier

3570 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Caryophyllaceae › Dianthus

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants.
Catalytic activity	S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.
Cofactor	Pyridoxal phosphate.
Pathway	Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 1/2.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Ethylene biosynthesis Fruit ripening
Ligand	Pyridoxal phosphate S-adenosyl-L-methionine
Molecular function	Lyase
Gene Ontology (GO)
Biological process	ethylene biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW ripening Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	1-aminocyclopropane-1-carboxylate synthase		PRO_0000123911
Regions
	Compositional bias	453 – 470	18	Poly-Thr
Amino acid modifications
	Modified residue	277	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27486 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: C31BA10732E940AE	FASTA	517	58,057
	10 20 30 40 50 60 MGSYKGVYDR EILSKIATND GHGENLEYFD GWKAYDRDPY HSTKNSNGVI QMGLAENQLC 70 80 90 100 110 120 FDLVTEWLLK NPQASICTNE GVNKFMDIAI FQDYHGLPEF RSAVAKFMGK ARDEKVIFNP 130 140 150 160 170 180 DRIVMSGGAS ASETLLFCLA NPGDAFLIPS PYYPAFNRDL RWRTGVNLIP FTCSSSNNFK 190 200 210 220 230 240 ITKEALQSAY EDALKKNIKV KGIIVTNPSN PLGTVLDKDT LKMLLTFVNA KNIHLVCDEI 250 260 270 280 290 300 YATTVFNSPS FISVAEVIKD MPHVNQDLVH ILYSLSKDMG MPGFRVGIIY SYNDRVVSTA 310 320 330 340 350 360 RRMSSFGLVS SQTQFMIAAL LSDDDFVRRF LVESRDRLFR RHQHFTSELA KIGIGCLQGN 370 380 390 400 410 420 AALFVWMDLR HLLDEATVER ELKLWRVIIN EVKINVSPGS SFLCSEPGWF RVCFANMDNA 430 440 450 460 470 480 TLDVALNRIR SFVTRGRVDN STMTTTSARA AATTTTTTTT TTTTTTTTTT IKKKRGQMEL 490 500 510 RLSFNNRRFE DGLMSPHSIL LSPHSPMPQS PLVKART

References

[1]	"Molecular cloning of an 1-aminocyclopropane-1-carboxylate synthase from senescing carnation flower petals." Park K.Y., Drory A., Woodson W.R. Plant Mol. Biol. 18:377-386(1992) [PubMed: 1731995] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Petal.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M66619 mRNA. Translation: AAA33275.1.
PIR	S19252.
3D structure databases
ProteinModelPortal	P27486.
SMR	P27486. Positions 12-433.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

1A1C_DIACA

Accession

Primary (citable) accession number: P27486

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	May 31, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program