Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol-binding protein 4

Gene

RBP4

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateCombined sources1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP
Gene namesi
Name:RBP4
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001796819 – 201Retinol-binding protein 4Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 178Combined sources1 Publication
Disulfide bondi88 ↔ 192Combined sources1 Publication
Disulfide bondi138 ↔ 147Combined sources1 Publication
Modified residuei139Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

PaxDbiP27485.
PeptideAtlasiP27485.
PRIDEiP27485.

Expressioni

Developmental stagei

Produced between days 10 and 15 of pregnancy and at day 15 found in both the peri-implantation conceptus (trophectoderm and yolk sac) and the endometrial surface and glandular epithelium. Found in allantoic fluid at day 30 of gestation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011168.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 26Combined sources3
Helixi35 – 38Combined sources4
Beta strandi40 – 48Combined sources9
Beta strandi51 – 53Combined sources3
Beta strandi55 – 65Combined sources11
Beta strandi71 – 80Combined sources10
Beta strandi86 – 97Combined sources12
Beta strandi103 – 112Combined sources10
Beta strandi118 – 127Combined sources10
Beta strandi129 – 141Combined sources13
Beta strandi145 – 158Combined sources14
Helixi164 – 176Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQBX-ray1.65A19-201[»]
ProteinModelPortaliP27485.
SMRiP27485.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27485.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
HOGENOMiHOG000293156.
HOVERGENiHBG004493.
InParanoidiP27485.
KOiK18271.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
[Graphical view]
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWVWALVLL AALGSAQAER DCRVSSFRVK ENFDKARFSG TWYAMAKKDP
60 70 80 90 100
EGLFLQDNIV AEFSVDENGH MSATAKGRVR LLNNWDVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQKGND DHWIIDTDYD TYAVQYSCRL QNLDGTCADS
160 170 180 190 200
YSFVFARDPH GFSPEVQKIV RQRQEELCLA RQYRIITHNG YCDGKSERNI

L
Length:201
Mass (Da):23,067
Last modified:July 15, 1998 - v2
Checksum:iA20E39D3C9471DC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134V → A in AAA31113 (PubMed:1723146).Curated1
Sequence conflicti185I → L in AAA31113 (PubMed:1723146).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68860 mRNA. Translation: AAA31113.1.
PIRiA39486.
RefSeqiNP_999222.1. NM_214057.1.
UniGeneiSsc.15695.

Genome annotation databases

GeneIDi397124.
KEGGissc:397124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68860 mRNA. Translation: AAA31113.1.
PIRiA39486.
RefSeqiNP_999222.1. NM_214057.1.
UniGeneiSsc.15695.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQBX-ray1.65A19-201[»]
ProteinModelPortaliP27485.
SMRiP27485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011168.

Proteomic databases

PaxDbiP27485.
PeptideAtlasiP27485.
PRIDEiP27485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397124.
KEGGissc:397124.

Organism-specific databases

CTDi5950.

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
HOGENOMiHOG000293156.
HOVERGENiHBG004493.
InParanoidiP27485.
KOiK18271.

Miscellaneous databases

EvolutionaryTraceiP27485.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
[Graphical view]
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRET4_PIG
AccessioniPrimary (citable) accession number: P27485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.