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Protein

Calmodulin-like protein 3

Gene

CALML3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 3
Alternative name(s):
CaM-like protein
Short name:
CLP
Calmodulin-related protein NB-1
Gene namesi
Name:CALML3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:1452. CALML3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi810.
OpenTargetsiENSG00000178363.
PharmGKBiPA26044.

Polymorphism and mutation databases

BioMutaiCALML3.
DMDMi115502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735471 – 149Calmodulin-like protein 3Add BLAST149

Proteomic databases

EPDiP27482.
MaxQBiP27482.
PaxDbiP27482.
PeptideAtlasiP27482.
PRIDEiP27482.
TopDownProteomicsiP27482.

PTM databases

iPTMnetiP27482.
PhosphoSitePlusiP27482.

Expressioni

Tissue specificityi

Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000178363.
CleanExiHS_CALML3.
GenevisibleiP27482. HS.

Organism-specific databases

HPAiCAB010070.
HPA044999.

Interactioni

Subunit structurei

Interacts with MYO10, the interaction is calcium-dependent and essential for MYO10 function in filopodial extension.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C11orf65Q8NCR33EBI-747537,EBI-744790
KIAA1683A0JP073EBI-747537,EBI-10171456
KIAA1683Q9H0B34EBI-747537,EBI-745878
MYO10Q9HD673EBI-747537,EBI-307061
TERF2IPQ9NYB02EBI-747537,EBI-750109

Protein-protein interaction databases

BioGridi107261. 58 interactors.
IntActiP27482. 18 interactors.
MINTiMINT-1440064.
STRINGi9606.ENSP00000315299.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 20Combined sources14
Beta strandi25 – 28Combined sources4
Helixi30 – 39Combined sources10
Helixi46 – 54Combined sources9
Beta strandi61 – 65Combined sources5
Helixi66 – 93Combined sources28
Beta strandi98 – 101Combined sources4
Helixi103 – 112Combined sources10
Helixi119 – 129Combined sources11
Beta strandi133 – 138Combined sources6
Helixi139 – 147Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GGZX-ray1.50A2-149[»]
ProteinModelPortaliP27482.
SMRiP27482.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27482.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP27482.
KOiK02183.
OMAiCITTQEL.
OrthoDBiEOG091G0V73.
PhylomeDBiP27482.
TreeFamiTF300912.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQV TEFKEAFSLF DKDGDGCITT RELGTVMRSL GQNPTEAELR
60 70 80 90 100
DMMSEIDRDG NGTVDFPEFL GMMARKMKDT DNEEEIREAF RVFDKDGNGF
110 120 130 140
VSAAELRHVM TRLGEKLSDE EVDEMIRAAD TDGDGQVNYE EFVRVLVSK
Length:149
Mass (Da):16,891
Last modified:January 23, 2007 - v2
Checksum:i1AB883E8ED4D263D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58026 mRNA. Translation: AAA36356.1.
X13461 Genomic DNA. Translation: CAA31809.1.
AL732437 Genomic DNA. Translation: CAI11029.1.
AK313934 mRNA. Translation: BAG36653.1.
CH471072 Genomic DNA. Translation: EAW86443.1.
BC031889 mRNA. Translation: AAH31889.1.
CCDSiCCDS7069.1.
PIRiA38278. MCHUNB.
RefSeqiNP_005176.1. NM_005185.3.
UniGeneiHs.239600.

Genome annotation databases

EnsembliENST00000315238; ENSP00000315299; ENSG00000178363.
GeneIDi810.
KEGGihsa:810.
UCSCiuc001iie.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58026 mRNA. Translation: AAA36356.1.
X13461 Genomic DNA. Translation: CAA31809.1.
AL732437 Genomic DNA. Translation: CAI11029.1.
AK313934 mRNA. Translation: BAG36653.1.
CH471072 Genomic DNA. Translation: EAW86443.1.
BC031889 mRNA. Translation: AAH31889.1.
CCDSiCCDS7069.1.
PIRiA38278. MCHUNB.
RefSeqiNP_005176.1. NM_005185.3.
UniGeneiHs.239600.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GGZX-ray1.50A2-149[»]
ProteinModelPortaliP27482.
SMRiP27482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107261. 58 interactors.
IntActiP27482. 18 interactors.
MINTiMINT-1440064.
STRINGi9606.ENSP00000315299.

PTM databases

iPTMnetiP27482.
PhosphoSitePlusiP27482.

Polymorphism and mutation databases

BioMutaiCALML3.
DMDMi115502.

Proteomic databases

EPDiP27482.
MaxQBiP27482.
PaxDbiP27482.
PeptideAtlasiP27482.
PRIDEiP27482.
TopDownProteomicsiP27482.

Protocols and materials databases

DNASUi810.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315238; ENSP00000315299; ENSG00000178363.
GeneIDi810.
KEGGihsa:810.
UCSCiuc001iie.2. human.

Organism-specific databases

CTDi810.
DisGeNETi810.
GeneCardsiCALML3.
HGNCiHGNC:1452. CALML3.
HPAiCAB010070.
HPA044999.
MIMi114184. gene.
neXtProtiNX_P27482.
OpenTargetsiENSG00000178363.
PharmGKBiPA26044.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP27482.
KOiK02183.
OMAiCITTQEL.
OrthoDBiEOG091G0V73.
PhylomeDBiP27482.
TreeFamiTF300912.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178363-MONOMER.

Miscellaneous databases

ChiTaRSiCALML3. human.
EvolutionaryTraceiP27482.
GeneWikiiCALML3.
GenomeRNAii810.
PROiP27482.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178363.
CleanExiHS_CALML3.
GenevisibleiP27482. HS.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALL3_HUMAN
AccessioniPrimary (citable) accession number: P27482
Secondary accession number(s): B2R9V6, Q5SQI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds four calcium ions.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.