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Protein

Linoleate 9S-lipoxygenase

Gene
N/A
Organism
Phaseolus vulgaris (Kidney bean) (French bean)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.

Catalytic activityi

Linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi: oxylipin biosynthesis

This protein is involved in the pathway oxylipin biosynthesis, which is part of Lipid metabolism.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway oxylipin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi407Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi412Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi598Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi602Iron; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382

Names & Taxonomyi

Protein namesi
Recommended name:
Linoleate 9S-lipoxygenase (EC:1.13.11.58)
Alternative name(s):
Lipoxygenase (EC:1.13.11.12)
OrganismiPhaseolus vulgaris (Kidney bean) (French bean)
Taxonomic identifieri3885 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaePhaseolus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000220716‹1 – ›741Linoleate 9S-lipoxygenaseAdd BLAST›741

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP27481
SMRiP27481
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 53PLATPROSITE-ProRule annotationAdd BLAST›53
Domaini56 – 741LipoxygenasePROSITE-ProRule annotationAdd BLAST686

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Family and domain databases

Gene3Di4.10.372.10, 1 hit
InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001246 LipOase_plant
IPR027433 Lipoxygenase_dom_3
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00468 PLTLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Fragment.

P27481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IPGAFYIKNF MQVEFYLKSL TLEDIPNHGT IHFICNSWIY NSKVYKSDRI
60 70 80 90 100
FFANNTYLPS ETPAPLLKYR EEELKNVRGD GSGERKEWDR VYDYDVYNDL
110 120 130 140 150
GNPDKGAALA RPVLGGSTLP YPRRGRTGRP KTKKDPNSEK PSDFVYLPRD
160 170 180 190 200
EAFGHLKSSD FLAYGLKSVS QDVLPVLTDA FDGNLLSLEF DNFAEVHKLY
210 220 230 240 250
EGGVTLPTNF LSKYAPIPIV KEIFRSDGEQ FLKYPPPKVM QVNKSAWMTD
260 270 280 290 300
EEFARETIAG VNPNVIKSLE EFPPRSKLDT QSFGDHTSII TKEHLEINLG
310 320 330 340 350
GLTVEQAIQS KKLFILDHHD YLIPYLRRIN ASATKTYATR TIFFLKSDGT
360 370 380 390 400
LAPLAIELSK PHPQGDEHGP VSEVYVPAYE GVEAYIWLLA KAYVVVNDSC
410 420 430 440 450
YHQLVSHWLN THAVVEPFVL ATNRQLSVVH PVYKLLFPHY RDTMNINSLA
460 470 480 490 500
RKSLVNADGI IEKTFLWGRY ALELSAVIYK DWSLHDQALP NDLVKRGVAV
510 520 530 540 550
KDPSAPHGVK LVIEDYPYAS DGLEIWDAIK SWVVEYVAFY YKSDEVLQQD
560 570 580 590 600
SELQAWWKEL VQVGHGDLKD KPWWPKMQSR ENLVEVSTTL IWIASALHAA
610 620 630 640 650
VNFGQYPYGG LILNRPTISR RFMPEKGSAE YAALAKNPEK EFLKTITGKK
660 670 680 690 700
ETLIDLTVIE ILSRHASDEI YLGERDGGDH WTSDAGPLEA FKRFGKKLAE
710 720 730 740
IEKKLVQKNN DETLRNRTGP AKMPYTLLYP SSEEGLTFRG I
Length:741
Mass (Da):84,197
Last modified:August 1, 1992 - v1
Checksum:i2F2CDD5979606AC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei7411

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63521 mRNA Translation: CAA45086.1
PIRiS18906

Similar proteinsi

Entry informationi

Entry nameiLOXB_PHAVU
AccessioniPrimary (citable) accession number: P27481
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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