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P27480

- LOXA_PHAVU

UniProt

P27480 - LOXA_PHAVU

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Protein

Linoleate 9S-lipoxygenase 1

Gene

LOXA

Organism
Phaseolus vulgaris (Kidney bean) (French bean)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.
Linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi522 – 5221Iron; catalyticPROSITE-ProRule annotation
Metal bindingi527 – 5271Iron; catalyticPROSITE-ProRule annotation
Metal bindingi713 – 7131Iron; catalyticPROSITE-ProRule annotation
Metal bindingi717 – 7171Iron; catalyticPROSITE-ProRule annotation
Metal bindingi862 – 8621Iron; via carboxylate; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. oxylipin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP27480.
UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Linoleate 9S-lipoxygenase 1 (EC:1.13.11.58)
Alternative name(s):
Lipoxygenase 1 (EC:1.13.11.12)
Gene namesi
Name:LOXA
Synonyms:LOX1
OrganismiPhaseolus vulgaris (Kidney bean) (French bean)
Taxonomic identifieri3885 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaePhaseolus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Linoleate 9S-lipoxygenase 1PRO_0000220715Add
BLAST

Proteomic databases

ProMEXiP27480.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP27480.
SMRiP27480. Positions 8-862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 171128PLATPROSITE-ProRule annotationAdd
BLAST
Domaini174 – 862689LipoxygenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated
Contains 1 lipoxygenase domain.PROSITE-ProRule annotation
Contains 1 PLAT domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27480-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFGILNRGHK IKGTVVLMTK NVFDFNEFVS TTRGGIVGAA GGLFGAATDI
60 70 80 90 100
VGGIVDGATA IFSRNIAIQL ISATKTDGLG NGKVGKQTFL EKHLPSLPNL
110 120 130 140 150
GDRQDAFNVY FEWDENFGIP EAFYIKNFMQ SEFFLVSLTL EDIPNHGTIH
160 170 180 190 200
FVCNSWVYNA KSYKRDRIFF ANKTYLPNET PASLVKYRKE ELENLRGDGT
210 220 230 240 250
GERKEYDRIY DYAVYNDLGN PDKNKNLART TLGGSSDFPY PRRGRTGRKS
260 270 280 290 300
TRKDPKCEIP TSDTYIPRDE NFGHLKSGDF LTYAIKSLTQ NVLPTFQKAF
310 320 330 340 350
GFNNEFDTFE DVRGLFEGGL YLPTDVISKI SPIPVLKEIL RTDGEQVLKF
360 370 380 390 400
PPPHVIRVTK SAWMTDEEFG REMLAGVNPC LIQRLQEFPP KSKLDVTVYG
410 420 430 440 450
DQTSTMTKEH LEINLGGLTV EEALHGNRLF ILDHHDAFIP YLERINDLPT
460 470 480 490 500
AKCYATRTIL FLKDDNTLKP LAIELSLPNP GGKGANSRVI LPADGGAEST
510 520 530 540 550
IWLLAKAYVV VNDSCYHQLM SHWLNTHAVM EPFVIATNRH LSVLHPIYKL
560 570 580 590 600
LLPHYRDTMN INALARQSLI NAGGVIERSF LPGEFAVEMS SAVYKSWVFT
610 620 630 640 650
DQALPADLIK RGMAVEDPSS PYGLRLVVED YPYAVDGLEI WDTIQTWVKD
660 670 680 690 700
YVSLYYPTND AVKKDTELQA WWKEAVEKGH GDLKDKPWWP KLNTPQDLIH
710 720 730 740 750
TCSIIIWIAS ALHAAVNFGQ YPYGGFILNR PTITRRLLPE PGTKEYGELT
760 770 780 790 800
SNYQKAYLRT ITGKVEAIVD LSVIEILSRH ASDEVYLGQR DNPNWTNNIK
810 820 830 840 850
ALQAFKRFGQ KLKEIEEKIM GRNKDSSLRN RNGPVKMPYT VLLPTCEDEG
860
LTFRGIPNSI SI
Length:862
Mass (Da):97,155
Last modified:August 1, 1992 - v1
Checksum:i24D56D1CEE3C191E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63525 Genomic DNA. Translation: CAA45088.1.
PIRiS22153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63525 Genomic DNA. Translation: CAA45088.1 .
PIRi S22153.

3D structure databases

ProteinModelPortali P27480.
SMRi P27480. Positions 8-862.
ModBasei Search...
MobiDBi Search...

Proteomic databases

ProMEXi P27480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00382 .
SABIO-RK P27480.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complex spatial and temporal expression of lipoxygenase genes during Phaseolus vulgaris (L.) development."
    Eiben H.G., Slusarenko A.J.
    Plant J. 5:123-135(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Red Mexican.
    Tissue: Leaf.

Entry informationi

Entry nameiLOXA_PHAVU
AccessioniPrimary (citable) accession number: P27480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3