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P27480

- LOXA_PHAVU

UniProt

P27480 - LOXA_PHAVU

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Protein

Linoleate 9S-lipoxygenase 1

Gene
LOXA, LOX1
Organism
Phaseolus vulgaris (Kidney bean) (French bean)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.
Linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.

Cofactori

Binds 1 iron ion per subunit. Iron is tightly bound By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi522 – 5221Iron; catalytic By similarity
Metal bindingi527 – 5271Iron; catalytic By similarity
Metal bindingi713 – 7131Iron; catalytic By similarity
Metal bindingi717 – 7171Iron; catalytic By similarity
Metal bindingi862 – 8621Iron; via carboxylate; catalytic By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. oxylipin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP27480.
UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Linoleate 9S-lipoxygenase 1 (EC:1.13.11.58)
Alternative name(s):
Lipoxygenase 1 (EC:1.13.11.12)
Gene namesi
Name:LOXA
Synonyms:LOX1
OrganismiPhaseolus vulgaris (Kidney bean) (French bean)
Taxonomic identifieri3885 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaePhaseolus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Linoleate 9S-lipoxygenase 1PRO_0000220715Add
BLAST

Proteomic databases

ProMEXiP27480.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP27480.
SMRiP27480. Positions 8-862.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 171128PLATAdd
BLAST
Domaini174 – 862689LipoxygenaseAdd
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.
Contains 1 PLAT domain.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27480-1 [UniParc]FASTAAdd to Basket

« Hide

MFGILNRGHK IKGTVVLMTK NVFDFNEFVS TTRGGIVGAA GGLFGAATDI    50
VGGIVDGATA IFSRNIAIQL ISATKTDGLG NGKVGKQTFL EKHLPSLPNL 100
GDRQDAFNVY FEWDENFGIP EAFYIKNFMQ SEFFLVSLTL EDIPNHGTIH 150
FVCNSWVYNA KSYKRDRIFF ANKTYLPNET PASLVKYRKE ELENLRGDGT 200
GERKEYDRIY DYAVYNDLGN PDKNKNLART TLGGSSDFPY PRRGRTGRKS 250
TRKDPKCEIP TSDTYIPRDE NFGHLKSGDF LTYAIKSLTQ NVLPTFQKAF 300
GFNNEFDTFE DVRGLFEGGL YLPTDVISKI SPIPVLKEIL RTDGEQVLKF 350
PPPHVIRVTK SAWMTDEEFG REMLAGVNPC LIQRLQEFPP KSKLDVTVYG 400
DQTSTMTKEH LEINLGGLTV EEALHGNRLF ILDHHDAFIP YLERINDLPT 450
AKCYATRTIL FLKDDNTLKP LAIELSLPNP GGKGANSRVI LPADGGAEST 500
IWLLAKAYVV VNDSCYHQLM SHWLNTHAVM EPFVIATNRH LSVLHPIYKL 550
LLPHYRDTMN INALARQSLI NAGGVIERSF LPGEFAVEMS SAVYKSWVFT 600
DQALPADLIK RGMAVEDPSS PYGLRLVVED YPYAVDGLEI WDTIQTWVKD 650
YVSLYYPTND AVKKDTELQA WWKEAVEKGH GDLKDKPWWP KLNTPQDLIH 700
TCSIIIWIAS ALHAAVNFGQ YPYGGFILNR PTITRRLLPE PGTKEYGELT 750
SNYQKAYLRT ITGKVEAIVD LSVIEILSRH ASDEVYLGQR DNPNWTNNIK 800
ALQAFKRFGQ KLKEIEEKIM GRNKDSSLRN RNGPVKMPYT VLLPTCEDEG 850
LTFRGIPNSI SI 862
Length:862
Mass (Da):97,155
Last modified:August 1, 1992 - v1
Checksum:i24D56D1CEE3C191E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63525 Genomic DNA. Translation: CAA45088.1.
PIRiS22153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63525 Genomic DNA. Translation: CAA45088.1 .
PIRi S22153.

3D structure databases

ProteinModelPortali P27480.
SMRi P27480. Positions 8-862.
ModBasei Search...
MobiDBi Search...

Proteomic databases

ProMEXi P27480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00382 .
SABIO-RK P27480.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complex spatial and temporal expression of lipoxygenase genes during Phaseolus vulgaris (L.) development."
    Eiben H.G., Slusarenko A.J.
    Plant J. 5:123-135(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Red Mexican.
    Tissue: Leaf.

Entry informationi

Entry nameiLOXA_PHAVU
AccessioniPrimary (citable) accession number: P27480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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