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P27480

- LOXA_PHAVU

UniProt

P27480 - LOXA_PHAVU

Protein

Linoleate 9S-lipoxygenase 1

Gene

LOXA

Organism
Phaseolus vulgaris (Kidney bean) (French bean)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.

    Catalytic activityi

    Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
    Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.
    Linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.

    Cofactori

    Binds 1 iron ion per subunit. Iron is tightly bound By similarity.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi522 – 5221Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi527 – 5271Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi713 – 7131Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi717 – 7171Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi862 – 8621Iron; via carboxylate; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. linoleate 13S-lipoxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. oxylipin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKP27480.
    UniPathwayiUPA00382.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Linoleate 9S-lipoxygenase 1 (EC:1.13.11.58)
    Alternative name(s):
    Lipoxygenase 1 (EC:1.13.11.12)
    Gene namesi
    Name:LOXA
    Synonyms:LOX1
    OrganismiPhaseolus vulgaris (Kidney bean) (French bean)
    Taxonomic identifieri3885 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaePhaseolus

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Linoleate 9S-lipoxygenase 1PRO_0000220715Add
    BLAST

    Proteomic databases

    ProMEXiP27480.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP27480.
    SMRiP27480. Positions 8-862.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 171128PLATPROSITE-ProRule annotationAdd
    BLAST
    Domaini174 – 862689LipoxygenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lipoxygenase family.Curated
    Contains 1 lipoxygenase domain.PROSITE-ProRule annotation
    Contains 1 PLAT domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    4.10.372.10. 1 hit.
    InterProiIPR008976. Lipase_LipOase.
    IPR000907. LipOase.
    IPR013819. LipOase_C.
    IPR020834. LipOase_CS.
    IPR020833. LipOase_Fe_BS.
    IPR001246. LipOase_pln.
    IPR027433. Lipoxygenase_domain_3.
    IPR001024. PLAT/LH2_dom.
    [Graphical view]
    PANTHERiPTHR11771. PTHR11771. 1 hit.
    PfamiPF00305. Lipoxygenase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view]
    PRINTSiPR00087. LIPOXYGENASE.
    PR00468. PLTLPOXGNASE.
    SMARTiSM00308. LH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48484. SSF48484. 1 hit.
    SSF49723. SSF49723. 1 hit.
    PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
    PS00081. LIPOXYGENASE_2. 1 hit.
    PS51393. LIPOXYGENASE_3. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGILNRGHK IKGTVVLMTK NVFDFNEFVS TTRGGIVGAA GGLFGAATDI    50
    VGGIVDGATA IFSRNIAIQL ISATKTDGLG NGKVGKQTFL EKHLPSLPNL 100
    GDRQDAFNVY FEWDENFGIP EAFYIKNFMQ SEFFLVSLTL EDIPNHGTIH 150
    FVCNSWVYNA KSYKRDRIFF ANKTYLPNET PASLVKYRKE ELENLRGDGT 200
    GERKEYDRIY DYAVYNDLGN PDKNKNLART TLGGSSDFPY PRRGRTGRKS 250
    TRKDPKCEIP TSDTYIPRDE NFGHLKSGDF LTYAIKSLTQ NVLPTFQKAF 300
    GFNNEFDTFE DVRGLFEGGL YLPTDVISKI SPIPVLKEIL RTDGEQVLKF 350
    PPPHVIRVTK SAWMTDEEFG REMLAGVNPC LIQRLQEFPP KSKLDVTVYG 400
    DQTSTMTKEH LEINLGGLTV EEALHGNRLF ILDHHDAFIP YLERINDLPT 450
    AKCYATRTIL FLKDDNTLKP LAIELSLPNP GGKGANSRVI LPADGGAEST 500
    IWLLAKAYVV VNDSCYHQLM SHWLNTHAVM EPFVIATNRH LSVLHPIYKL 550
    LLPHYRDTMN INALARQSLI NAGGVIERSF LPGEFAVEMS SAVYKSWVFT 600
    DQALPADLIK RGMAVEDPSS PYGLRLVVED YPYAVDGLEI WDTIQTWVKD 650
    YVSLYYPTND AVKKDTELQA WWKEAVEKGH GDLKDKPWWP KLNTPQDLIH 700
    TCSIIIWIAS ALHAAVNFGQ YPYGGFILNR PTITRRLLPE PGTKEYGELT 750
    SNYQKAYLRT ITGKVEAIVD LSVIEILSRH ASDEVYLGQR DNPNWTNNIK 800
    ALQAFKRFGQ KLKEIEEKIM GRNKDSSLRN RNGPVKMPYT VLLPTCEDEG 850
    LTFRGIPNSI SI 862
    Length:862
    Mass (Da):97,155
    Last modified:August 1, 1992 - v1
    Checksum:i24D56D1CEE3C191E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63525 Genomic DNA. Translation: CAA45088.1.
    PIRiS22153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63525 Genomic DNA. Translation: CAA45088.1 .
    PIRi S22153.

    3D structure databases

    ProteinModelPortali P27480.
    SMRi P27480. Positions 8-862.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    ProMEXi P27480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00382 .
    SABIO-RK P27480.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    4.10.372.10. 1 hit.
    InterProi IPR008976. Lipase_LipOase.
    IPR000907. LipOase.
    IPR013819. LipOase_C.
    IPR020834. LipOase_CS.
    IPR020833. LipOase_Fe_BS.
    IPR001246. LipOase_pln.
    IPR027433. Lipoxygenase_domain_3.
    IPR001024. PLAT/LH2_dom.
    [Graphical view ]
    PANTHERi PTHR11771. PTHR11771. 1 hit.
    Pfami PF00305. Lipoxygenase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view ]
    PRINTSi PR00087. LIPOXYGENASE.
    PR00468. PLTLPOXGNASE.
    SMARTi SM00308. LH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48484. SSF48484. 1 hit.
    SSF49723. SSF49723. 1 hit.
    PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
    PS00081. LIPOXYGENASE_2. 1 hit.
    PS51393. LIPOXYGENASE_3. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complex spatial and temporal expression of lipoxygenase genes during Phaseolus vulgaris (L.) development."
      Eiben H.G., Slusarenko A.J.
      Plant J. 5:123-135(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Red Mexican.
      Tissue: Leaf.

    Entry informationi

    Entry nameiLOXA_PHAVU
    AccessioniPrimary (citable) accession number: P27480
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3