Reviewed,
UniProtKB/Swiss-Prot P27470 (GTF2_STRDO)
Last modified
June 16, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glucosyltransferase-I Short name=GTF-I EC=2.4.1.5 Alternative name(s): Dextransucrase Sucrose 6-glucosyltransferase |
| Organism | Streptococcus downei (Streptococcus sobrinus) |
| Taxonomic identifier | 1317 [NCBI] |
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus |
Protein attributes
| Sequence length | 1592 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris. |
| Catalytic activity | Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1). |
| Subcellular location | |
| Miscellaneous | GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans. |
| Sequence similarities | Belongs to the glycosyl hydrolase 70 family. Contains 13 cell wall-binding repeats. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Disease | Dental caries |
| Domain | Repeat Signal |
| Molecular function | Glycosyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | glucan biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | cation binding Inferred from electronic annotation. Source: InterPro dextransucrase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 38 | 38 | Potential | ||||||
| Chain | 39 – 1592 | 1554 | Glucosyltransferase-I | PRO_0000021384 | |||||
Regions | |||||||||
| Repeat | 151 – 170 | 20 | Cell wall-binding 1 | ||||||
| Repeat | 172 – 191 | 20 | Cell wall-binding 2 | ||||||
| Repeat | 1083 – 1102 | 20 | Cell wall-binding 3 | ||||||
| Repeat | 1103 – 1122 | 20 | Cell wall-binding 4 | ||||||
| Repeat | 1167 – 1186 | 20 | Cell wall-binding 5 | ||||||
| Repeat | 1211 – 1231 | 21 | Cell wall-binding 6 | ||||||
| Repeat | 1232 – 1251 | 20 | Cell wall-binding 7 | ||||||
| Repeat | 1276 – 1296 | 21 | Cell wall-binding 8 | ||||||
| Repeat | 1297 – 1316 | 20 | Cell wall-binding 9 | ||||||
| Repeat | 1411 – 1430 | 20 | Cell wall-binding 10 | ||||||
| Repeat | 1455 – 1474 | 20 | Cell wall-binding 11 | ||||||
| Repeat | 1523 – 1542 | 20 | Cell wall-binding 12 | ||||||
| Repeat | 1567 – 1586 | 20 | Cell wall-binding 13 | ||||||
| Region | 200 – 1044 | 845 | Catalytic; approximate | ||||||
| Region | 1093 – 1592 | 500 | Glucan-binding; approximate | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Peptide sequences for sucrose splitting and glucan binding within Streptococcus sobrinus glucosyltransferase (water-insoluble glucan synthetase)." Abo H., Matsumura T., Kodama T., Ohta H., Fukui K., Kato K., Kagawa H. J. Bacteriol. 173:989-996(1991) [PubMed: 1704006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 6715 / Serotype G. |
Cross-references
Sequence databases | |
|---|---|
| D90213 Genomic DNA. Translation: BAA14241.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GVM based on UniProtKB P06653. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GH70. Glycoside Hydrolase Family 70. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.5. 290403. |
Family and domain databases | |
| InterPro | IPR018337. Cell_wall/Cho-bd_repeat. IPR002479. Cell_wall_bd_put. IPR003318. Glyco_hydro70cat. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view] |
| Gene3D | G3DSA:3.20.20.80. Glyco_hydro_cat. 2 hits. |
| Pfam | PF01473. CW_binding_1. 3 hits. PF02324. Glyco_hydro_70. 1 hit. [Graphical view] |
| PROSITE | PS51170. CW. 13 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GTF2_STRDO | ||||||||
| Accession | Primary (citable) accession number: P27470 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |
