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P27470

- GTF2_STRDO

UniProt

P27470 - GTF2_STRDO

Protein

Glucosyltransferase-I

Gene
N/A
Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

    Catalytic activityi

    Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

    GO - Molecular functioni

    1. dextransucrase activity Source: UniProtKB-EC
    2. glucosyltransferase activity Source: InterPro

    GO - Biological processi

    1. glucan biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGH70. Glycoside Hydrolase Family 70.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucosyltransferase-I (EC:2.4.1.5)
    Short name:
    GTF-I
    Alternative name(s):
    Dextransucrase
    Sucrose 6-glucosyltransferase
    OrganismiStreptococcus downei (Streptococcus sobrinus)
    Taxonomic identifieri1317 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Dental caries

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 15921554Glucosyltransferase-IPRO_0000021384Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP27470.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati151 – 17020Cell wall-binding 1Add
    BLAST
    Repeati172 – 19120Cell wall-binding 2Add
    BLAST
    Repeati1083 – 110220Cell wall-binding 3Add
    BLAST
    Repeati1103 – 112220Cell wall-binding 4Add
    BLAST
    Repeati1167 – 118620Cell wall-binding 5Add
    BLAST
    Repeati1211 – 123121Cell wall-binding 6Add
    BLAST
    Repeati1232 – 125120Cell wall-binding 7Add
    BLAST
    Repeati1276 – 129621Cell wall-binding 8Add
    BLAST
    Repeati1297 – 131620Cell wall-binding 9Add
    BLAST
    Repeati1411 – 143020Cell wall-binding 10Add
    BLAST
    Repeati1455 – 147420Cell wall-binding 11Add
    BLAST
    Repeati1523 – 154220Cell wall-binding 12Add
    BLAST
    Repeati1567 – 158620Cell wall-binding 13Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni200 – 1044845Catalytic; approximateAdd
    BLAST
    Regioni1093 – 1592500Glucan-binding; approximateAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 70 family.Curated
    Contains 13 cell wall-binding repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di3.20.20.80. 4 hits.
    InterProiIPR018337. Cell_wall/Cho-bd_repeat.
    IPR027636. Glucan-bd_rpt.
    IPR003318. Glyco_hydro70cat.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR022263. KxYKxGKxW.
    [Graphical view]
    PfamiPF01473. CW_binding_1. 5 hits.
    PF02324. Glyco_hydro_70. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 4 hits.
    TIGRFAMsiTIGR04035. glucan_65_rpt. 5 hits.
    TIGR03715. KxYKxGKxW. 1 hit.
    PROSITEiPS51170. CW. 13 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27470-1 [UniParc]FASTAAdd to Basket

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    MEKNVRFKMH KVKKRWVTLS VASATMLASA LGASVASADT DTASDDSNQT     50
    VVTGDQTTNN QATDQTSIAA TATSEQSAST DAATDQASAA EQTQGTTAST 100
    DTAAQTTTNA NEAKWVPTEN ENQGFTDEML AEAKNVATAE SDSIPSDLAK 150
    MSNVKQVDGK YYYYDQDGNV KKNFAVSVGD KIYYFDETGA YKDTSKVDAD 200
    KSSSAVSQNA TIFAANNRAY STSAKNFEAV DNYLTADSWY RPKSILKDGK 250
    TWTESGKDDF RPLLMAWWPD TETKRNYVNY MNKVVGIDKT YTAETSQADL 300
    TAAAELVQAR IEQKITSENN TKWLREAISA FVKTQPQWNG ESEKPYDDHL 350
    QNGALLFDNQ TDLTPDTQSN YRLLNRTPTN QTGSLDSRFT YNPNDPLGGY 400
    DFLLANDVDN SNPVVQAEQL NWLHYLLNFG SIYANDADAN FDSIRVDAED 450
    NVDADQLQIS SDYLKAAYGI DKNNKNANNH VSIVEAWSDN DTPYLHDDGD 500
    NLMNMDNKFR LSMLWSLAKP TDVRSGLNPL IHNSLVDREV DDREVETVPS 550
    YSFARAHDSE VQDIIRDIIK AEINPNSFGY SFTQEEIDQA FKIYNEDLKK 600
    SDKKYTHYNV PLSYTLLLTN KGSIPRVYYG DMFTDDGQYM ANKTVNYDAI 650
    ESLLKARMKY VAGGQAMQNY QIGNGEILTS VRYGKGALKQ SDKGDATTRT 700
    SGVGVVMGNQ PNFSLDGKVV ALNMGAAHAN QEYRALMVST KDGVATYATD 750
    ADASKAGLVK RTDENGYLYF LNDDLKGVAN PQVSGFLQVW VPVGAADDQD 800
    IRVAASDTAS TDGKSLHQDA AMDSRVMFEG FSNFQSFATK EEEYTNVVIA 850
    NNVDKFVSWG ITDFEMAPQY VSSTDGQFQD SVIQNGYAFT DRYDLGMSKA 900
    NKYGTADQLV KAIKALHAKG LKVMADWVPD QMYTFPKQEV VTVTRTDKFG 950
    KPIAGSQINH SLYVTDTKSS GDDYQAKYGG AFLDELKEKY PELFTKKQMS 1000
    TGQAIDPSVK IKQWSAKYFN GSNILGRGAD YVLSDQVSNK YFNVASDTLF 1050
    LPSSLLGKVV ESGIRYDGKG YIYNSSATGD QVKASFITEA GNLYYFGKDG 1100
    YMVTGAQTIN GANYFFLENG TALRNTIYTD AQGNSHYYAN DGKRYENENG 1150
    YQQFGNDWRY FKDGNMAVGL TTVDGNVQYF DKDGVQAKDK IIVTRDGKVR 1200
    YFDQHNGNAV TNTFIADKTG HWYYLGKDGV AVTGAQTVGK QKLYFEANGQ 1250
    QVKGDFVTSD EGKLYFYDVD SGDMWTDTFI EDKAGNWFYL GKDGAAVTGA 1300
    QTIRGQKLYF KANGQQVKGD IVKGTDGKIR YYDAKSGEQV FNKTVKAADG 1350
    KTYVIGNDGV AVDPSVVKGQ TFKDASGALR FYNLKGQLVT GSGWYETANH 1400
    DWVYIQSGKA LTGEQTINGQ HLYFKKDGHQ VKGQLVTGTD GKVRYYDANS 1450
    GDQAFNKSVT VNGKTYYFGN DGTAQTAGNP KGQTFKDGSD IRFYSMEGQL 1500
    VTGSGWYSNA QGQWLYVKNG KVLTGLQTVG SQRVYFDENG IQAKGKAVRT 1550
    SDGKIRYFDE NSGSMITNQW KEVNGRYYYF GNDGARIYRG WN 1592
    Length:1,592
    Mass (Da):176,168
    Last modified:August 1, 1992 - v1
    Checksum:iBC0A66D079351ECF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90213 Genomic DNA. Translation: BAA14241.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90213 Genomic DNA. Translation: BAA14241.1 .

    3D structure databases

    ProteinModelPortali P27470.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH70. Glycoside Hydrolase Family 70.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 4 hits.
    InterProi IPR018337. Cell_wall/Cho-bd_repeat.
    IPR027636. Glucan-bd_rpt.
    IPR003318. Glyco_hydro70cat.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR022263. KxYKxGKxW.
    [Graphical view ]
    Pfami PF01473. CW_binding_1. 5 hits.
    PF02324. Glyco_hydro_70. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 4 hits.
    TIGRFAMsi TIGR04035. glucan_65_rpt. 5 hits.
    TIGR03715. KxYKxGKxW. 1 hit.
    PROSITEi PS51170. CW. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Peptide sequences for sucrose splitting and glucan binding within Streptococcus sobrinus glucosyltransferase (water-insoluble glucan synthetase)."
      Abo H., Matsumura T., Kodama T., Ohta H., Fukui K., Kato K., Kagawa H.
      J. Bacteriol. 173:989-996(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 6715 / Serotype G.

    Entry informationi

    Entry nameiGTF2_STRDO
    AccessioniPrimary (citable) accession number: P27470
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans.

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3