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P27470

- GTF2_STRDO

UniProt

P27470 - GTF2_STRDO

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Protein

Glucosyltransferase-I

Gene
N/A
Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activityi

Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

GO - Molecular functioni

  1. dextransucrase activity Source: UniProtKB-EC
  2. glucosyltransferase activity Source: InterPro

GO - Biological processi

  1. glucan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGH70. Glycoside Hydrolase Family 70.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosyltransferase-I (EC:2.4.1.5)
Short name:
GTF-I
Alternative name(s):
Dextransucrase
Sucrose 6-glucosyltransferase
OrganismiStreptococcus downei (Streptococcus sobrinus)
Taxonomic identifieri1317 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 Reviewed predictionAdd
BLAST
Chaini39 – 15921554Glucosyltransferase-IPRO_0000021384Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP27470.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati151 – 17020Cell wall-binding 1Add
BLAST
Repeati172 – 19120Cell wall-binding 2Add
BLAST
Repeati1083 – 110220Cell wall-binding 3Add
BLAST
Repeati1103 – 112220Cell wall-binding 4Add
BLAST
Repeati1167 – 118620Cell wall-binding 5Add
BLAST
Repeati1211 – 123121Cell wall-binding 6Add
BLAST
Repeati1232 – 125120Cell wall-binding 7Add
BLAST
Repeati1276 – 129621Cell wall-binding 8Add
BLAST
Repeati1297 – 131620Cell wall-binding 9Add
BLAST
Repeati1411 – 143020Cell wall-binding 10Add
BLAST
Repeati1455 – 147420Cell wall-binding 11Add
BLAST
Repeati1523 – 154220Cell wall-binding 12Add
BLAST
Repeati1567 – 158620Cell wall-binding 13Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 1044845Catalytic; approximateAdd
BLAST
Regioni1093 – 1592500Glucan-binding; approximateAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di3.20.20.80. 4 hits.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view]
PfamiPF01473. CW_binding_1. 5 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 4 hits.
TIGRFAMsiTIGR04035. glucan_65_rpt. 5 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEiPS51170. CW. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27470-1 [UniParc]FASTAAdd to Basket

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MEKNVRFKMH KVKKRWVTLS VASATMLASA LGASVASADT DTASDDSNQT     50
VVTGDQTTNN QATDQTSIAA TATSEQSAST DAATDQASAA EQTQGTTAST 100
DTAAQTTTNA NEAKWVPTEN ENQGFTDEML AEAKNVATAE SDSIPSDLAK 150
MSNVKQVDGK YYYYDQDGNV KKNFAVSVGD KIYYFDETGA YKDTSKVDAD 200
KSSSAVSQNA TIFAANNRAY STSAKNFEAV DNYLTADSWY RPKSILKDGK 250
TWTESGKDDF RPLLMAWWPD TETKRNYVNY MNKVVGIDKT YTAETSQADL 300
TAAAELVQAR IEQKITSENN TKWLREAISA FVKTQPQWNG ESEKPYDDHL 350
QNGALLFDNQ TDLTPDTQSN YRLLNRTPTN QTGSLDSRFT YNPNDPLGGY 400
DFLLANDVDN SNPVVQAEQL NWLHYLLNFG SIYANDADAN FDSIRVDAED 450
NVDADQLQIS SDYLKAAYGI DKNNKNANNH VSIVEAWSDN DTPYLHDDGD 500
NLMNMDNKFR LSMLWSLAKP TDVRSGLNPL IHNSLVDREV DDREVETVPS 550
YSFARAHDSE VQDIIRDIIK AEINPNSFGY SFTQEEIDQA FKIYNEDLKK 600
SDKKYTHYNV PLSYTLLLTN KGSIPRVYYG DMFTDDGQYM ANKTVNYDAI 650
ESLLKARMKY VAGGQAMQNY QIGNGEILTS VRYGKGALKQ SDKGDATTRT 700
SGVGVVMGNQ PNFSLDGKVV ALNMGAAHAN QEYRALMVST KDGVATYATD 750
ADASKAGLVK RTDENGYLYF LNDDLKGVAN PQVSGFLQVW VPVGAADDQD 800
IRVAASDTAS TDGKSLHQDA AMDSRVMFEG FSNFQSFATK EEEYTNVVIA 850
NNVDKFVSWG ITDFEMAPQY VSSTDGQFQD SVIQNGYAFT DRYDLGMSKA 900
NKYGTADQLV KAIKALHAKG LKVMADWVPD QMYTFPKQEV VTVTRTDKFG 950
KPIAGSQINH SLYVTDTKSS GDDYQAKYGG AFLDELKEKY PELFTKKQMS 1000
TGQAIDPSVK IKQWSAKYFN GSNILGRGAD YVLSDQVSNK YFNVASDTLF 1050
LPSSLLGKVV ESGIRYDGKG YIYNSSATGD QVKASFITEA GNLYYFGKDG 1100
YMVTGAQTIN GANYFFLENG TALRNTIYTD AQGNSHYYAN DGKRYENENG 1150
YQQFGNDWRY FKDGNMAVGL TTVDGNVQYF DKDGVQAKDK IIVTRDGKVR 1200
YFDQHNGNAV TNTFIADKTG HWYYLGKDGV AVTGAQTVGK QKLYFEANGQ 1250
QVKGDFVTSD EGKLYFYDVD SGDMWTDTFI EDKAGNWFYL GKDGAAVTGA 1300
QTIRGQKLYF KANGQQVKGD IVKGTDGKIR YYDAKSGEQV FNKTVKAADG 1350
KTYVIGNDGV AVDPSVVKGQ TFKDASGALR FYNLKGQLVT GSGWYETANH 1400
DWVYIQSGKA LTGEQTINGQ HLYFKKDGHQ VKGQLVTGTD GKVRYYDANS 1450
GDQAFNKSVT VNGKTYYFGN DGTAQTAGNP KGQTFKDGSD IRFYSMEGQL 1500
VTGSGWYSNA QGQWLYVKNG KVLTGLQTVG SQRVYFDENG IQAKGKAVRT 1550
SDGKIRYFDE NSGSMITNQW KEVNGRYYYF GNDGARIYRG WN 1592
Length:1,592
Mass (Da):176,168
Last modified:August 1, 1992 - v1
Checksum:iBC0A66D079351ECF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90213 Genomic DNA. Translation: BAA14241.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90213 Genomic DNA. Translation: BAA14241.1 .

3D structure databases

ProteinModelPortali P27470.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH70. Glycoside Hydrolase Family 70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 4 hits.
InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view ]
Pfami PF01473. CW_binding_1. 5 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 4 hits.
TIGRFAMsi TIGR04035. glucan_65_rpt. 5 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEi PS51170. CW. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Peptide sequences for sucrose splitting and glucan binding within Streptococcus sobrinus glucosyltransferase (water-insoluble glucan synthetase)."
    Abo H., Matsumura T., Kodama T., Ohta H., Fukui K., Kato K., Kagawa H.
    J. Bacteriol. 173:989-996(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 6715 / Serotype G.

Entry informationi

Entry nameiGTF2_STRDO
AccessioniPrimary (citable) accession number: P27470
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 16, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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