P27469 (G0S2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G0/G1 switch protein 2

Alternative name(s):
G0/G1 switch regulatory protein 2
Putative lymphocyte G0/G1 switch gene

Gene names

Name:

G0S2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. Ref.7
Subunit structure	Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex. Ref.7
Subcellular location	Mitochondrion Ref.7.
Tissue specificity	Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver. Ref.7
Induction	Induced by TNF through the activation of the NFKB pathway. Ref.7

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from direct assay Ref.7. Source: UniProtKB cellular lipid metabolic process Traceable author statement. Source: Reactome positive regulation of apoptotic process Inferred from direct assay Ref.7. Source: UniProtKB small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	lipid particle Traceable author statement. Source: Reactome mitochondrion Inferred from direct assay Ref.7. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	G0/G1 switch protein 2		PRO_0000087405
Experimental info
	Mutagenesis	35	1	L → A: No effect on BCL2-binding; when associated with A-36. Ref.7
	Mutagenesis	36	1	F → A: No effect on BCL2-binding; when associated with A-35. Ref.7
	Mutagenesis	38	1	V → A: No effect on BCL2-binding; when associated with A-39. Ref.7
	Mutagenesis	39	1	V → A: No effect on BCL2-binding; when associated with A-38. Ref.7
	Mutagenesis	43	1	M → A: No effect on BCL2-binding; when associated with A-44. Ref.7
	Mutagenesis	44	1	E → A: No effect on BCL2-binding; when associated with A-43. Ref.7
	Mutagenesis	45	1	T → A: No effect on BCL2-binding; when associated with A-46. Ref.7
	Mutagenesis	46	1	V → A: No effect on BCL2-binding; when associated with A-45. Ref.7
	Mutagenesis	50	1	F → A: Reduced BCL2-binding; when associated with A-51. Ref.7
	Mutagenesis	51	1	T → A: Reduced BCL2-binding; when associated with A-50. Ref.7
	Mutagenesis	54	1	R → A: Reduced BCL2-binding; when associated with A-55. Ref.7
	Mutagenesis	55	1	R → A: Reduced BCL2-binding; when associated with A-54. Ref.7
	Mutagenesis	57	1	R → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-58. No effect on mitochondrial localization; when associated with A-58. Ref.7
	Mutagenesis	58	1	D → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-57. No effect on mitochondrial localization; when associated with A-57. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P27469 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 0FA91951D419E75C	FASTA	103	11,321
	10 20 30 40 50 60 METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF TAARRLRDQE 70 80 90 100 AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ HAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated." Russell L., Forsdyke D.R. DNA Cell Biol. 10:581-591(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[7]	"Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2." Welch C., Santra M.K., El-Assaad W., Zhu X., Huber W.E., Keys R.A., Teodoro J.G., Green M.R. Cancer Res. 69:6782-6789(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH BCL2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, MUTAGENESIS OF LEU-35; PHE-36; VAL-38; VAL-39; MET-43; GLU-44; THR-45; VAL-46; PHE-50; THR-51; ARG-54; ARG-55; ARG-57 AND ASP-58.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M72885 Genomic DNA. Translation: AAA58966.1. M69199 Genomic DNA. Translation: AAB04044.1. BT007101 mRNA. Translation: AAP35765.1. CR542179 mRNA. Translation: CAG46976.1. CR542193 mRNA. Translation: CAG46990.1. AL031316 Genomic DNA. Translation: CAB40150.1. CH471100 Genomic DNA. Translation: EAW93447.1. BC009694 mRNA. Translation: AAH09694.1.
IPI	IPI00018915.
PIR	A40409. B40409.
RefSeq	NP_056529.1. NM_015714.3.
UniGene	Hs.432132.
3D structure databases
ProteinModelPortal	P27469.
ModBase	Search...
Protein-protein interaction databases
IntAct	P27469. 1 interaction.
STRING	9606.ENSP00000355996.
Polymorphism databases
DMDM	120624.
Proteomic databases
PaxDb	P27469.
PeptideAtlas	P27469.
PRIDE	P27469.
Protocols and materials databases
DNASU	50486.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367029; ENSP00000355996; ENSG00000123689.
GeneID	50486.
KEGG	hsa:50486.
UCSC	uc001hhi.4. human.
Organism-specific databases
CTD	50486.
GeneCards	GC01P209848.
HGNC	HGNC:30229. G0S2.
HPA	HPA010016.
MIM	614447. gene.
neXtProt	NX_P27469.
PharmGKB	PA142671707.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45933.
HOGENOM	HOG000112682.
HOVERGEN	HBG004465.
InParanoid	P27469.
OMA	KELMAHK.
OrthoDB	EOG42NJ24.
PhylomeDB	P27469.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
Bgee	P27469.
CleanEx	HS_G0S2.
Genevestigator	P27469.
GermOnline	ENSG00000123689. Homo sapiens.
Family and domain databases
InterPro	IPR016821. G0/G1_switch_2_put. [Graphical view]
PIRSF	PIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	50486.
NextBio	53044.
SOURCE	Search...

Entry information

Entry name

G0S2_HUMAN

Accession

Primary (citable) accession number: P27469
Secondary accession number(s): Q6FGC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.