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Protein

G0/G1 switch protein 2

Gene

G0S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.1 Publication

GO - Biological processi

  • extrinsic apoptotic signaling pathway Source: UniProtKB
  • positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  • regulation of lipid metabolic process Source: Reactome

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-1989781. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
G0/G1 switch protein 2
Alternative name(s):
G0/G1 switch regulatory protein 2
Putative lymphocyte G0/G1 switch gene
Gene namesi
Name:G0S2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000123689.5.
HGNCiHGNC:30229. G0S2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi35L → A: No effect on BCL2-binding; when associated with A-36. 1 Publication1
Mutagenesisi36F → A: No effect on BCL2-binding; when associated with A-35. 1 Publication1
Mutagenesisi38V → A: No effect on BCL2-binding; when associated with A-39. 1 Publication1
Mutagenesisi39V → A: No effect on BCL2-binding; when associated with A-38. 1 Publication1
Mutagenesisi43M → A: No effect on BCL2-binding; when associated with A-44. 1 Publication1
Mutagenesisi44E → A: No effect on BCL2-binding; when associated with A-43. 1 Publication1
Mutagenesisi45T → A: No effect on BCL2-binding; when associated with A-46. 1 Publication1
Mutagenesisi46V → A: No effect on BCL2-binding; when associated with A-45. 1 Publication1
Mutagenesisi50F → A: Reduced BCL2-binding; when associated with A-51. 1 Publication1
Mutagenesisi51T → A: Reduced BCL2-binding; when associated with A-50. 1 Publication1
Mutagenesisi54R → A: Reduced BCL2-binding; when associated with A-55. 1 Publication1
Mutagenesisi55R → A: Reduced BCL2-binding; when associated with A-54. 1 Publication1
Mutagenesisi57R → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-58. No effect on mitochondrial localization; when associated with A-58. 1 Publication1
Mutagenesisi58D → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-57. No effect on mitochondrial localization; when associated with A-57. 1 Publication1

Organism-specific databases

DisGeNETi50486.
OpenTargetsiENSG00000123689.
PharmGKBiPA142671707.

Polymorphism and mutation databases

BioMutaiG0S2.
DMDMi120624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874051 – 103G0/G1 switch protein 2Add BLAST103

Proteomic databases

PaxDbiP27469.
PeptideAtlasiP27469.
PRIDEiP27469.

PTM databases

PhosphoSitePlusiP27469.

Expressioni

Tissue specificityi

Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver.1 Publication

Inductioni

Induced by TNF through the activation of the NFKB pathway.1 Publication

Gene expression databases

BgeeiENSG00000123689.
CleanExiHS_G0S2.
GenevisibleiP27469. HS.

Interactioni

Subunit structurei

Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.1 Publication

Protein-protein interaction databases

BioGridi119073. 15 interactors.
IntActiP27469. 2 interactors.
STRINGi9606.ENSP00000355996.

Structurei

3D structure databases

ProteinModelPortaliP27469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J22N. Eukaryota.
ENOG410YZQR. LUCA.
GeneTreeiENSGT00390000005294.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiP27469.
OMAiKPNRKMV.
OrthoDBiEOG091G14MV.
PhylomeDBiP27469.
TreeFamiTF336218.

Family and domain databases

InterProiView protein in InterPro
IPR016821. G0S2.
PfamiView protein in Pfam
PF15103. G0-G1_switch_2. 1 hit.
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

P27469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF
60 70 80 90 100
TAARRLRDQE AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ

HAS
Length:103
Mass (Da):11,321
Last modified:August 1, 1992 - v1
Checksum:i0FA91951D419E75C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72885 Genomic DNA. Translation: AAA58966.1.
M69199 Genomic DNA. Translation: AAB04044.1.
BT007101 mRNA. Translation: AAP35765.1.
CR542179 mRNA. Translation: CAG46976.1.
CR542193 mRNA. Translation: CAG46990.1.
AL031316 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93447.1.
BC009694 mRNA. Translation: AAH09694.1.
CCDSiCCDS1488.1.
PIRiB40409. A40409.
RefSeqiNP_056529.1. NM_015714.3.
UniGeneiHs.432132.

Genome annotation databases

EnsembliENST00000367029; ENSP00000355996; ENSG00000123689.
GeneIDi50486.
KEGGihsa:50486.
UCSCiuc001hhi.5. human.

Similar proteinsi

Entry informationi

Entry nameiG0S2_HUMAN
AccessioniPrimary (citable) accession number: P27469
Secondary accession number(s): Q6FGC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot