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P27469 (G0S2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G0/G1 switch protein 2
Alternative name(s):
G0/G1 switch regulatory protein 2
Putative lymphocyte G0/G1 switch gene
Gene names
Name:G0S2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length103 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. Ref.7

Subunit structure

Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex. Ref.7

Subcellular location

Mitochondrion Ref.7.

Tissue specificity

Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver. Ref.7

Induction

Induced by TNF through the activation of the NFKB pathway. Ref.7

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 103103G0/G1 switch protein 2
PRO_0000087405

Experimental info

Mutagenesis351L → A: No effect on BCL2-binding; when associated with A-36. Ref.7
Mutagenesis361F → A: No effect on BCL2-binding; when associated with A-35. Ref.7
Mutagenesis381V → A: No effect on BCL2-binding; when associated with A-39. Ref.7
Mutagenesis391V → A: No effect on BCL2-binding; when associated with A-38. Ref.7
Mutagenesis431M → A: No effect on BCL2-binding; when associated with A-44. Ref.7
Mutagenesis441E → A: No effect on BCL2-binding; when associated with A-43. Ref.7
Mutagenesis451T → A: No effect on BCL2-binding; when associated with A-46. Ref.7
Mutagenesis461V → A: No effect on BCL2-binding; when associated with A-45. Ref.7
Mutagenesis501F → A: Reduced BCL2-binding; when associated with A-51. Ref.7
Mutagenesis511T → A: Reduced BCL2-binding; when associated with A-50. Ref.7
Mutagenesis541R → A: Reduced BCL2-binding; when associated with A-55. Ref.7
Mutagenesis551R → A: Reduced BCL2-binding; when associated with A-54. Ref.7
Mutagenesis571R → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-58. No effect on mitochondrial localization; when associated with A-58. Ref.7
Mutagenesis581D → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-57. No effect on mitochondrial localization; when associated with A-57. Ref.7

Sequences

Sequence LengthMass (Da)Tools
P27469 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 0FA91951D419E75C

FASTA10311,321
        10         20         30         40         50         60 
METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF TAARRLRDQE 

        70         80         90        100 
AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ HAS 

« Hide

References

« Hide 'large scale' references
[1]"A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated."
Russell L., Forsdyke D.R.
DNA Cell Biol. 10:581-591(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[7]"Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2."
Welch C., Santra M.K., El-Assaad W., Zhu X., Huber W.E., Keys R.A., Teodoro J.G., Green M.R.
Cancer Res. 69:6782-6789(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH BCL2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, MUTAGENESIS OF LEU-35; PHE-36; VAL-38; VAL-39; MET-43; GLU-44; THR-45; VAL-46; PHE-50; THR-51; ARG-54; ARG-55; ARG-57 AND ASP-58.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M72885 Genomic DNA. Translation: AAA58966.1.
M69199 Genomic DNA. Translation: AAB04044.1.
BT007101 mRNA. Translation: AAP35765.1.
CR542179 mRNA. Translation: CAG46976.1.
CR542193 mRNA. Translation: CAG46990.1.
AL031316 Genomic DNA. Translation: CAB40150.1.
CH471100 Genomic DNA. Translation: EAW93447.1.
BC009694 mRNA. Translation: AAH09694.1.
CCDSCCDS1488.1.
PIRA40409. B40409.
RefSeqNP_056529.1. NM_015714.3.
UniGeneHs.432132.

3D structure databases

ProteinModelPortalP27469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119073. 1 interaction.
IntActP27469. 1 interaction.
STRING9606.ENSP00000355996.

Polymorphism databases

DMDM120624.

Proteomic databases

MaxQBP27469.
PaxDbP27469.
PeptideAtlasP27469.
PRIDEP27469.

Protocols and materials databases

DNASU50486.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367029; ENSP00000355996; ENSG00000123689.
GeneID50486.
KEGGhsa:50486.
UCSCuc001hhi.4. human.

Organism-specific databases

CTD50486.
GeneCardsGC01P209848.
HGNCHGNC:30229. G0S2.
HPAHPA010016.
MIM614447. gene.
neXtProtNX_P27469.
PharmGKBPA142671707.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45933.
HOGENOMHOG000112682.
HOVERGENHBG004465.
InParanoidP27469.
OMAKELMAHK.
OrthoDBEOG7FBRMG.
PhylomeDBP27469.
TreeFamTF336218.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

BgeeP27469.
CleanExHS_G0S2.
GenevestigatorP27469.

Family and domain databases

InterProIPR016821. G0S2.
[Graphical view]
PfamPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFPIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi50486.
NextBio53044.
PROP27469.
SOURCESearch...

Entry information

Entry nameG0S2_HUMAN
AccessionPrimary (citable) accession number: P27469
Secondary accession number(s): Q6FGC8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM