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Protein

G0/G1 switch protein 2

Gene

G0S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.1 Publication

GO - Biological processi

  1. cellular lipid metabolic process Source: Reactome
  2. extrinsic apoptotic signaling pathway Source: UniProtKB
  3. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
G0/G1 switch protein 2
Alternative name(s):
G0/G1 switch regulatory protein 2
Putative lymphocyte G0/G1 switch gene
Gene namesi
Name:G0S2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30229. G0S2.

Subcellular locationi

  1. Mitochondrion 1 Publication

GO - Cellular componenti

  1. lipid particle Source: Reactome
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi35 – 351L → A: No effect on BCL2-binding; when associated with A-36. 1 Publication
Mutagenesisi36 – 361F → A: No effect on BCL2-binding; when associated with A-35. 1 Publication
Mutagenesisi38 – 381V → A: No effect on BCL2-binding; when associated with A-39. 1 Publication
Mutagenesisi39 – 391V → A: No effect on BCL2-binding; when associated with A-38. 1 Publication
Mutagenesisi43 – 431M → A: No effect on BCL2-binding; when associated with A-44. 1 Publication
Mutagenesisi44 – 441E → A: No effect on BCL2-binding; when associated with A-43. 1 Publication
Mutagenesisi45 – 451T → A: No effect on BCL2-binding; when associated with A-46. 1 Publication
Mutagenesisi46 – 461V → A: No effect on BCL2-binding; when associated with A-45. 1 Publication
Mutagenesisi50 – 501F → A: Reduced BCL2-binding; when associated with A-51. 1 Publication
Mutagenesisi51 – 511T → A: Reduced BCL2-binding; when associated with A-50. 1 Publication
Mutagenesisi54 – 541R → A: Reduced BCL2-binding; when associated with A-55. 1 Publication
Mutagenesisi55 – 551R → A: Reduced BCL2-binding; when associated with A-54. 1 Publication
Mutagenesisi57 – 571R → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-58. No effect on mitochondrial localization; when associated with A-58. 1 Publication
Mutagenesisi58 – 581D → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-57. No effect on mitochondrial localization; when associated with A-57. 1 Publication

Organism-specific databases

PharmGKBiPA142671707.

Polymorphism and mutation databases

BioMutaiG0S2.
DMDMi120624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103G0/G1 switch protein 2PRO_0000087405Add
BLAST

Proteomic databases

MaxQBiP27469.
PaxDbiP27469.
PeptideAtlasiP27469.
PRIDEiP27469.

Expressioni

Tissue specificityi

Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver.1 Publication

Inductioni

Induced by TNF through the activation of the NFKB pathway.1 Publication

Gene expression databases

BgeeiP27469.
CleanExiHS_G0S2.
GenevestigatoriP27469.

Organism-specific databases

HPAiHPA010016.

Interactioni

Subunit structurei

Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.1 Publication

Protein-protein interaction databases

BioGridi119073. 1 interaction.
IntActiP27469. 1 interaction.
STRINGi9606.ENSP00000355996.

Structurei

3D structure databases

ProteinModelPortaliP27469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45933.
GeneTreeiENSGT00390000005294.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiP27469.
OMAiKELMAHK.
OrthoDBiEOG7FBRMG.
PhylomeDBiP27469.
TreeFamiTF336218.

Family and domain databases

InterProiIPR016821. G0S2.
[Graphical view]
PfamiPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

P27469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF
60 70 80 90 100
TAARRLRDQE AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ

HAS
Length:103
Mass (Da):11,321
Last modified:August 1, 1992 - v1
Checksum:i0FA91951D419E75C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72885 Genomic DNA. Translation: AAA58966.1.
M69199 Genomic DNA. Translation: AAB04044.1.
BT007101 mRNA. Translation: AAP35765.1.
CR542179 mRNA. Translation: CAG46976.1.
CR542193 mRNA. Translation: CAG46990.1.
AL031316 Genomic DNA. Translation: CAB40150.1.
CH471100 Genomic DNA. Translation: EAW93447.1.
BC009694 mRNA. Translation: AAH09694.1.
CCDSiCCDS1488.1.
PIRiB40409. A40409.
RefSeqiNP_056529.1. NM_015714.3.
UniGeneiHs.432132.

Genome annotation databases

EnsembliENST00000367029; ENSP00000355996; ENSG00000123689.
GeneIDi50486.
KEGGihsa:50486.
UCSCiuc001hhi.4. human.

Polymorphism and mutation databases

BioMutaiG0S2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72885 Genomic DNA. Translation: AAA58966.1.
M69199 Genomic DNA. Translation: AAB04044.1.
BT007101 mRNA. Translation: AAP35765.1.
CR542179 mRNA. Translation: CAG46976.1.
CR542193 mRNA. Translation: CAG46990.1.
AL031316 Genomic DNA. Translation: CAB40150.1.
CH471100 Genomic DNA. Translation: EAW93447.1.
BC009694 mRNA. Translation: AAH09694.1.
CCDSiCCDS1488.1.
PIRiB40409. A40409.
RefSeqiNP_056529.1. NM_015714.3.
UniGeneiHs.432132.

3D structure databases

ProteinModelPortaliP27469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119073. 1 interaction.
IntActiP27469. 1 interaction.
STRINGi9606.ENSP00000355996.

Polymorphism and mutation databases

BioMutaiG0S2.
DMDMi120624.

Proteomic databases

MaxQBiP27469.
PaxDbiP27469.
PeptideAtlasiP27469.
PRIDEiP27469.

Protocols and materials databases

DNASUi50486.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367029; ENSP00000355996; ENSG00000123689.
GeneIDi50486.
KEGGihsa:50486.
UCSCiuc001hhi.4. human.

Organism-specific databases

CTDi50486.
GeneCardsiGC01P209848.
HGNCiHGNC:30229. G0S2.
HPAiHPA010016.
MIMi614447. gene.
neXtProtiNX_P27469.
PharmGKBiPA142671707.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45933.
GeneTreeiENSGT00390000005294.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiP27469.
OMAiKELMAHK.
OrthoDBiEOG7FBRMG.
PhylomeDBiP27469.
TreeFamiTF336218.

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.

Miscellaneous databases

GenomeRNAii50486.
NextBioi53044.
PROiP27469.
SOURCEiSearch...

Gene expression databases

BgeeiP27469.
CleanExiHS_G0S2.
GenevestigatoriP27469.

Family and domain databases

InterProiIPR016821. G0S2.
[Graphical view]
PfamiPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated."
    Russell L., Forsdyke D.R.
    DNA Cell Biol. 10:581-591(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. "Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2."
    Welch C., Santra M.K., El-Assaad W., Zhu X., Huber W.E., Keys R.A., Teodoro J.G., Green M.R.
    Cancer Res. 69:6782-6789(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BCL2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, MUTAGENESIS OF LEU-35; PHE-36; VAL-38; VAL-39; MET-43; GLU-44; THR-45; VAL-46; PHE-50; THR-51; ARG-54; ARG-55; ARG-57 AND ASP-58.

Entry informationi

Entry nameiG0S2_HUMAN
AccessioniPrimary (citable) accession number: P27469
Secondary accession number(s): Q6FGC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 29, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.