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P27469

- G0S2_HUMAN

UniProt

P27469 - G0S2_HUMAN

Protein

G0/G1 switch protein 2

Gene

G0S2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular lipid metabolic process Source: Reactome
    2. extrinsic apoptotic signaling pathway Source: UniProtKB
    3. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
    4. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G0/G1 switch protein 2
    Alternative name(s):
    G0/G1 switch regulatory protein 2
    Putative lymphocyte G0/G1 switch gene
    Gene namesi
    Name:G0S2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:30229. G0S2.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. lipid particle Source: Reactome
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi35 – 351L → A: No effect on BCL2-binding; when associated with A-36. 1 Publication
    Mutagenesisi36 – 361F → A: No effect on BCL2-binding; when associated with A-35. 1 Publication
    Mutagenesisi38 – 381V → A: No effect on BCL2-binding; when associated with A-39. 1 Publication
    Mutagenesisi39 – 391V → A: No effect on BCL2-binding; when associated with A-38. 1 Publication
    Mutagenesisi43 – 431M → A: No effect on BCL2-binding; when associated with A-44. 1 Publication
    Mutagenesisi44 – 441E → A: No effect on BCL2-binding; when associated with A-43. 1 Publication
    Mutagenesisi45 – 451T → A: No effect on BCL2-binding; when associated with A-46. 1 Publication
    Mutagenesisi46 – 461V → A: No effect on BCL2-binding; when associated with A-45. 1 Publication
    Mutagenesisi50 – 501F → A: Reduced BCL2-binding; when associated with A-51. 1 Publication
    Mutagenesisi51 – 511T → A: Reduced BCL2-binding; when associated with A-50. 1 Publication
    Mutagenesisi54 – 541R → A: Reduced BCL2-binding; when associated with A-55. 1 Publication
    Mutagenesisi55 – 551R → A: Reduced BCL2-binding; when associated with A-54. 1 Publication
    Mutagenesisi57 – 571R → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-58. No effect on mitochondrial localization; when associated with A-58. 1 Publication
    Mutagenesisi58 – 581D → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-57. No effect on mitochondrial localization; when associated with A-57. 1 Publication

    Organism-specific databases

    PharmGKBiPA142671707.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 103103G0/G1 switch protein 2PRO_0000087405Add
    BLAST

    Proteomic databases

    MaxQBiP27469.
    PaxDbiP27469.
    PeptideAtlasiP27469.
    PRIDEiP27469.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver.1 Publication

    Inductioni

    Induced by TNF through the activation of the NFKB pathway.1 Publication

    Gene expression databases

    BgeeiP27469.
    CleanExiHS_G0S2.
    GenevestigatoriP27469.

    Organism-specific databases

    HPAiHPA010016.

    Interactioni

    Subunit structurei

    Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.1 Publication

    Protein-protein interaction databases

    BioGridi119073. 1 interaction.
    IntActiP27469. 1 interaction.
    STRINGi9606.ENSP00000355996.

    Structurei

    3D structure databases

    ProteinModelPortaliP27469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45933.
    HOGENOMiHOG000112682.
    HOVERGENiHBG004465.
    InParanoidiP27469.
    OMAiKELMAHK.
    OrthoDBiEOG7FBRMG.
    PhylomeDBiP27469.
    TreeFamiTF336218.

    Family and domain databases

    InterProiIPR016821. G0S2.
    [Graphical view]
    PfamiPF15103. G0-G1_switch_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P27469-1 [UniParc]FASTAAdd to Basket

    « Hide

    METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF    50
    TAARRLRDQE AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ 100
    HAS 103
    Length:103
    Mass (Da):11,321
    Last modified:August 1, 1992 - v1
    Checksum:i0FA91951D419E75C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M72885 Genomic DNA. Translation: AAA58966.1.
    M69199 Genomic DNA. Translation: AAB04044.1.
    BT007101 mRNA. Translation: AAP35765.1.
    CR542179 mRNA. Translation: CAG46976.1.
    CR542193 mRNA. Translation: CAG46990.1.
    AL031316 Genomic DNA. Translation: CAB40150.1.
    CH471100 Genomic DNA. Translation: EAW93447.1.
    BC009694 mRNA. Translation: AAH09694.1.
    CCDSiCCDS1488.1.
    PIRiB40409. A40409.
    RefSeqiNP_056529.1. NM_015714.3.
    UniGeneiHs.432132.

    Genome annotation databases

    EnsembliENST00000367029; ENSP00000355996; ENSG00000123689.
    GeneIDi50486.
    KEGGihsa:50486.
    UCSCiuc001hhi.4. human.

    Polymorphism databases

    DMDMi120624.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M72885 Genomic DNA. Translation: AAA58966.1 .
    M69199 Genomic DNA. Translation: AAB04044.1 .
    BT007101 mRNA. Translation: AAP35765.1 .
    CR542179 mRNA. Translation: CAG46976.1 .
    CR542193 mRNA. Translation: CAG46990.1 .
    AL031316 Genomic DNA. Translation: CAB40150.1 .
    CH471100 Genomic DNA. Translation: EAW93447.1 .
    BC009694 mRNA. Translation: AAH09694.1 .
    CCDSi CCDS1488.1.
    PIRi B40409. A40409.
    RefSeqi NP_056529.1. NM_015714.3.
    UniGenei Hs.432132.

    3D structure databases

    ProteinModelPortali P27469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119073. 1 interaction.
    IntActi P27469. 1 interaction.
    STRINGi 9606.ENSP00000355996.

    Polymorphism databases

    DMDMi 120624.

    Proteomic databases

    MaxQBi P27469.
    PaxDbi P27469.
    PeptideAtlasi P27469.
    PRIDEi P27469.

    Protocols and materials databases

    DNASUi 50486.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367029 ; ENSP00000355996 ; ENSG00000123689 .
    GeneIDi 50486.
    KEGGi hsa:50486.
    UCSCi uc001hhi.4. human.

    Organism-specific databases

    CTDi 50486.
    GeneCardsi GC01P209848.
    HGNCi HGNC:30229. G0S2.
    HPAi HPA010016.
    MIMi 614447. gene.
    neXtProti NX_P27469.
    PharmGKBi PA142671707.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45933.
    HOGENOMi HOG000112682.
    HOVERGENi HBG004465.
    InParanoidi P27469.
    OMAi KELMAHK.
    OrthoDBi EOG7FBRMG.
    PhylomeDBi P27469.
    TreeFami TF336218.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.

    Miscellaneous databases

    GenomeRNAii 50486.
    NextBioi 53044.
    PROi P27469.
    SOURCEi Search...

    Gene expression databases

    Bgeei P27469.
    CleanExi HS_G0S2.
    Genevestigatori P27469.

    Family and domain databases

    InterProi IPR016821. G0S2.
    [Graphical view ]
    Pfami PF15103. G0-G1_switch_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF023925. G0/G1_switch_p2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated."
      Russell L., Forsdyke D.R.
      DNA Cell Biol. 10:581-591(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. "Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2."
      Welch C., Santra M.K., El-Assaad W., Zhu X., Huber W.E., Keys R.A., Teodoro J.G., Green M.R.
      Cancer Res. 69:6782-6789(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BCL2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, MUTAGENESIS OF LEU-35; PHE-36; VAL-38; VAL-39; MET-43; GLU-44; THR-45; VAL-46; PHE-50; THR-51; ARG-54; ARG-55; ARG-57 AND ASP-58.

    Entry informationi

    Entry nameiG0S2_HUMAN
    AccessioniPrimary (citable) accession number: P27469
    Secondary accession number(s): Q6FGC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3