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P27469

- G0S2_HUMAN

UniProt

P27469 - G0S2_HUMAN

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Protein
G0/G1 switch protein 2
Gene
G0S2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cellular lipid metabolic process Source: Reactome
  2. extrinsic apoptotic signaling pathway Source: UniProtKB
  3. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
G0/G1 switch protein 2
Alternative name(s):
G0/G1 switch regulatory protein 2
Putative lymphocyte G0/G1 switch gene
Gene namesi
Name:G0S2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30229. G0S2.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. lipid particle Source: Reactome
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi35 – 351L → A: No effect on BCL2-binding; when associated with A-36. 1 Publication
Mutagenesisi36 – 361F → A: No effect on BCL2-binding; when associated with A-35. 1 Publication
Mutagenesisi38 – 381V → A: No effect on BCL2-binding; when associated with A-39. 1 Publication
Mutagenesisi39 – 391V → A: No effect on BCL2-binding; when associated with A-38. 1 Publication
Mutagenesisi43 – 431M → A: No effect on BCL2-binding; when associated with A-44. 1 Publication
Mutagenesisi44 – 441E → A: No effect on BCL2-binding; when associated with A-43. 1 Publication
Mutagenesisi45 – 451T → A: No effect on BCL2-binding; when associated with A-46. 1 Publication
Mutagenesisi46 – 461V → A: No effect on BCL2-binding; when associated with A-45. 1 Publication
Mutagenesisi50 – 501F → A: Reduced BCL2-binding; when associated with A-51. 1 Publication
Mutagenesisi51 – 511T → A: Reduced BCL2-binding; when associated with A-50. 1 Publication
Mutagenesisi54 – 541R → A: Reduced BCL2-binding; when associated with A-55. 1 Publication
Mutagenesisi55 – 551R → A: Reduced BCL2-binding; when associated with A-54. 1 Publication
Mutagenesisi57 – 571R → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-58. No effect on mitochondrial localization; when associated with A-58. 1 Publication
Mutagenesisi58 – 581D → A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-57. No effect on mitochondrial localization; when associated with A-57. 1 Publication

Organism-specific databases

PharmGKBiPA142671707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103G0/G1 switch protein 2
PRO_0000087405Add
BLAST

Proteomic databases

MaxQBiP27469.
PaxDbiP27469.
PeptideAtlasiP27469.
PRIDEiP27469.

Expressioni

Tissue specificityi

Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver.1 Publication

Inductioni

Induced by TNF through the activation of the NFKB pathway.1 Publication

Gene expression databases

BgeeiP27469.
CleanExiHS_G0S2.
GenevestigatoriP27469.

Organism-specific databases

HPAiHPA010016.

Interactioni

Subunit structurei

Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.1 Publication

Protein-protein interaction databases

BioGridi119073. 1 interaction.
IntActiP27469. 1 interaction.
STRINGi9606.ENSP00000355996.

Structurei

3D structure databases

ProteinModelPortaliP27469.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45933.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiP27469.
OMAiKELMAHK.
OrthoDBiEOG7FBRMG.
PhylomeDBiP27469.
TreeFamiTF336218.

Family and domain databases

InterProiIPR016821. G0S2.
[Graphical view]
PfamiPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

P27469-1 [UniParc]FASTAAdd to Basket

« Hide

METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF    50
TAARRLRDQE AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ 100
HAS 103
Length:103
Mass (Da):11,321
Last modified:August 1, 1992 - v1
Checksum:i0FA91951D419E75C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M72885 Genomic DNA. Translation: AAA58966.1.
M69199 Genomic DNA. Translation: AAB04044.1.
BT007101 mRNA. Translation: AAP35765.1.
CR542179 mRNA. Translation: CAG46976.1.
CR542193 mRNA. Translation: CAG46990.1.
AL031316 Genomic DNA. Translation: CAB40150.1.
CH471100 Genomic DNA. Translation: EAW93447.1.
BC009694 mRNA. Translation: AAH09694.1.
CCDSiCCDS1488.1.
PIRiB40409. A40409.
RefSeqiNP_056529.1. NM_015714.3.
UniGeneiHs.432132.

Genome annotation databases

EnsembliENST00000367029; ENSP00000355996; ENSG00000123689.
GeneIDi50486.
KEGGihsa:50486.
UCSCiuc001hhi.4. human.

Polymorphism databases

DMDMi120624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M72885 Genomic DNA. Translation: AAA58966.1 .
M69199 Genomic DNA. Translation: AAB04044.1 .
BT007101 mRNA. Translation: AAP35765.1 .
CR542179 mRNA. Translation: CAG46976.1 .
CR542193 mRNA. Translation: CAG46990.1 .
AL031316 Genomic DNA. Translation: CAB40150.1 .
CH471100 Genomic DNA. Translation: EAW93447.1 .
BC009694 mRNA. Translation: AAH09694.1 .
CCDSi CCDS1488.1.
PIRi B40409. A40409.
RefSeqi NP_056529.1. NM_015714.3.
UniGenei Hs.432132.

3D structure databases

ProteinModelPortali P27469.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119073. 1 interaction.
IntActi P27469. 1 interaction.
STRINGi 9606.ENSP00000355996.

Polymorphism databases

DMDMi 120624.

Proteomic databases

MaxQBi P27469.
PaxDbi P27469.
PeptideAtlasi P27469.
PRIDEi P27469.

Protocols and materials databases

DNASUi 50486.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367029 ; ENSP00000355996 ; ENSG00000123689 .
GeneIDi 50486.
KEGGi hsa:50486.
UCSCi uc001hhi.4. human.

Organism-specific databases

CTDi 50486.
GeneCardsi GC01P209848.
HGNCi HGNC:30229. G0S2.
HPAi HPA010016.
MIMi 614447. gene.
neXtProti NX_P27469.
PharmGKBi PA142671707.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45933.
HOGENOMi HOG000112682.
HOVERGENi HBG004465.
InParanoidi P27469.
OMAi KELMAHK.
OrthoDBi EOG7FBRMG.
PhylomeDBi P27469.
TreeFami TF336218.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.

Miscellaneous databases

GenomeRNAii 50486.
NextBioi 53044.
PROi P27469.
SOURCEi Search...

Gene expression databases

Bgeei P27469.
CleanExi HS_G0S2.
Genevestigatori P27469.

Family and domain databases

InterProi IPR016821. G0S2.
[Graphical view ]
Pfami PF15103. G0-G1_switch_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated."
    Russell L., Forsdyke D.R.
    DNA Cell Biol. 10:581-591(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. "Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2."
    Welch C., Santra M.K., El-Assaad W., Zhu X., Huber W.E., Keys R.A., Teodoro J.G., Green M.R.
    Cancer Res. 69:6782-6789(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BCL2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, MUTAGENESIS OF LEU-35; PHE-36; VAL-38; VAL-39; MET-43; GLU-44; THR-45; VAL-46; PHE-50; THR-51; ARG-54; ARG-55; ARG-57 AND ASP-58.

Entry informationi

Entry nameiG0S2_HUMAN
AccessioniPrimary (citable) accession number: P27469
Secondary accession number(s): Q6FGC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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