Reviewed, UniProtKB/Swiss-Prot P27463 (AL1A1_CHICK)

Names and origin

Protein names

Recommended name:
    Retinal dehydrogenase 1
      Short name=RALDH 1
      Short name=RalDH1
    EC=1.2.1.36
Alternative name(s):
    Aldehyde dehydrogenase family 1 member A1
    Aldehyde dehydrogenase, cytosolic
    ALHDII
    ALDH-E1

Gene names

Name:

ALDH1A1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid By similarity.
Catalytic activity	Retinal + NAD+ + H2O = retinoate + NADH.
Pathway	Cofactor metabolism; retinol metabolism.
Subunit structure	Homotetramer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	retinal dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Retinal dehydrogenase 1		PRO_0000056421
Regions
	Nucleotide binding	254 – 259	6	NAD By similarity
Sites
	Active site	277	1	Proton acceptor By similarity
	Active site	311	1	Nucleophile By similarity
	Site	178	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27463-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 7771181FA2F05DA9	FASTA	509	55,809
	10 20 30 40 50 60 MKKQGSPSNP APVLPALPEP LKDLKIKYTK IFINNEWHDS VSGKKFEVFN PANEEKICEV 70 80 90 100 110 120 AEGDKADIDK AVKAARKAFE LGSPWRTMDA SERGRLLNKL ADLVERDRLT LATMEAIDGG 130 140 150 160 170 180 KLFSTAYLMD LGACIKTIRY CAGWADKIHG RTVPMDGNFF TFTRHEPVGV CGQIIPWNFP 190 200 210 220 230 240 LVMFIWKIAP ALCCGNTVVV KPAEQTPLSA LYMGSLIKEA GFPPGVVNIV PGFGPTAGAA 250 260 270 280 290 300 ISHHMDIDKV SFTGSTEVGK LIKEAAGKTN LKRVTLELGG KSPNIIFADA DLDEAAEFAH 310 320 330 340 350 360 IGLFYHQGQC CIAGSRIFVE EPIYDEFVRR SIERAKKYTL GDPLLPGVQQ GPQIDKEQFQ 370 380 390 400 410 420 KILDLIESGK KEGAKLECGG GPWGNKGYFI QPTVFSNVTD DMRIAKEEIF GPVQQIMKFK 430 440 450 460 470 480 TIDEVIKRAN NTTYGLAAAV FTKDIDKALT FASALQAGTV WVNCYSAFSA QCPFGGFKMS 490 500 GNGRELGEYG LQEYTEVKTV TIKIPQKNS

References

[1]	"High levels of aldehyde dehydrogenase transcripts in the undifferentiated chick retina." Godbout R. Exp. Eye Res. 54:297-305(1992) [PubMed: 1559558] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryonic retina.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X58869 mRNA. Translation: CAA41679.1.
IPI	IPI00578794.
PIR	S14629.
RefSeq	NP_989908.1.
UniGene	Gga.4119
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000015147. Gallus gallus. [Contig view]
GeneID	395264.
KEGG	gga:395264.
Phylogenomic databases
HOVERGEN	P27463.
Enzyme and pathway databases
BRENDA	1.2.1.36. 4.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL1A1_CHICK

Accession

Primary (citable) accession number: P27463

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)