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Protein

Retinal dehydrogenase 1

Gene

ALDH1A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).By similarity

Catalytic activityi

Retinal + NAD+ + H2O = retinoate + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei178 – 1781Transition state stabilizerBy similarity
Active sitei277 – 2771Proton acceptorPROSITE-ProRule annotation
Active sitei311 – 3111NucleophilePROSITE-ProRule annotation
Binding sitei464 – 4641NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi254 – 2596NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.36. 1306.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal dehydrogenase 1 (EC:1.2.1.36)
Short name:
RALDH 1
Short name:
RalDH1
Alternative name(s):
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A1
Aldehyde dehydrogenase, cytosolic
Gene namesi
Name:ALDH1A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Retinal dehydrogenase 1PRO_0000056421Add
BLAST

Proteomic databases

PRIDEiP27463.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP27463.
SMRiP27463. Positions 17-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP27463.
KOiK07249.
PhylomeDBiP27463.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQGSPSNP APVLPALPEP LKDLKIKYTK IFINNEWHDS VSGKKFEVFN
60 70 80 90 100
PANEEKICEV AEGDKADIDK AVKAARKAFE LGSPWRTMDA SERGRLLNKL
110 120 130 140 150
ADLVERDRLT LATMEAIDGG KLFSTAYLMD LGACIKTIRY CAGWADKIHG
160 170 180 190 200
RTVPMDGNFF TFTRHEPVGV CGQIIPWNFP LVMFIWKIAP ALCCGNTVVV
210 220 230 240 250
KPAEQTPLSA LYMGSLIKEA GFPPGVVNIV PGFGPTAGAA ISHHMDIDKV
260 270 280 290 300
SFTGSTEVGK LIKEAAGKTN LKRVTLELGG KSPNIIFADA DLDEAAEFAH
310 320 330 340 350
IGLFYHQGQC CIAGSRIFVE EPIYDEFVRR SIERAKKYTL GDPLLPGVQQ
360 370 380 390 400
GPQIDKEQFQ KILDLIESGK KEGAKLECGG GPWGNKGYFI QPTVFSNVTD
410 420 430 440 450
DMRIAKEEIF GPVQQIMKFK TIDEVIKRAN NTTYGLAAAV FTKDIDKALT
460 470 480 490 500
FASALQAGTV WVNCYSAFSA QCPFGGFKMS GNGRELGEYG LQEYTEVKTV

TIKIPQKNS
Length:509
Mass (Da):55,809
Last modified:August 1, 1992 - v1
Checksum:i7771181FA2F05DA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58869 mRNA. Translation: CAA41679.1.
PIRiS14629.
RefSeqiNP_989908.1. NM_204577.4.
UniGeneiGga.4119.

Genome annotation databases

GeneIDi395264.
KEGGigga:395264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58869 mRNA. Translation: CAA41679.1.
PIRiS14629.
RefSeqiNP_989908.1. NM_204577.4.
UniGeneiGga.4119.

3D structure databases

ProteinModelPortaliP27463.
SMRiP27463. Positions 17-509.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP27463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395264.
KEGGigga:395264.

Organism-specific databases

CTDi216.

Phylogenomic databases

HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP27463.
KOiK07249.
PhylomeDBiP27463.

Enzyme and pathway databases

UniPathwayiUPA00912.
BRENDAi1.2.1.36. 1306.

Miscellaneous databases

NextBioi20815353.
PROiP27463.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High levels of aldehyde dehydrogenase transcripts in the undifferentiated chick retina."
    Godbout R.
    Exp. Eye Res. 54:297-305(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic retina.

Entry informationi

Entry nameiAL1A1_CHICK
AccessioniPrimary (citable) accession number: P27463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 17, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.