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Protein

Retinal dehydrogenase 1

Gene

ALDH1A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity).By similarity

Catalytic activityi

Retinal + NAD+ + H2O = retinoate + NADH.By similarity

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei178Transition state stabilizerBy similarity1
Active sitei277Proton acceptorPROSITE-ProRule annotation1
Active sitei311NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 178NADBy similarity4
Nucleotide bindingi201 – 204NADBy similarity4
Nucleotide bindingi234 – 235NADBy similarity2
Nucleotide bindingi254 – 255NADBy similarity2
Nucleotide bindingi277 – 279NADBy similarity3
Nucleotide bindingi357 – 361NADBy similarity5
Nucleotide bindingi408 – 410NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.36. 1306.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal dehydrogenase 1Curated (EC:1.2.1.-By similarity, EC:1.2.1.36By similarity)
Short name:
RALDH 1Curated
Short name:
RalDH1Curated
Alternative name(s):
Aldehyde dehydrogenase, cytosolic1 Publication
Gene namesi
Name:ALDH1A1By similarity
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasmcytosol By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564211 – 509Retinal dehydrogenase 1Add BLAST509

Proteomic databases

PRIDEiP27463.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP27463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP27463.
KOiK07249.
PhylomeDBiP27463.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQGSPSNP APVLPALPEP LKDLKIKYTK IFINNEWHDS VSGKKFEVFN
60 70 80 90 100
PANEEKICEV AEGDKADIDK AVKAARKAFE LGSPWRTMDA SERGRLLNKL
110 120 130 140 150
ADLVERDRLT LATMEAIDGG KLFSTAYLMD LGACIKTIRY CAGWADKIHG
160 170 180 190 200
RTVPMDGNFF TFTRHEPVGV CGQIIPWNFP LVMFIWKIAP ALCCGNTVVV
210 220 230 240 250
KPAEQTPLSA LYMGSLIKEA GFPPGVVNIV PGFGPTAGAA ISHHMDIDKV
260 270 280 290 300
SFTGSTEVGK LIKEAAGKTN LKRVTLELGG KSPNIIFADA DLDEAAEFAH
310 320 330 340 350
IGLFYHQGQC CIAGSRIFVE EPIYDEFVRR SIERAKKYTL GDPLLPGVQQ
360 370 380 390 400
GPQIDKEQFQ KILDLIESGK KEGAKLECGG GPWGNKGYFI QPTVFSNVTD
410 420 430 440 450
DMRIAKEEIF GPVQQIMKFK TIDEVIKRAN NTTYGLAAAV FTKDIDKALT
460 470 480 490 500
FASALQAGTV WVNCYSAFSA QCPFGGFKMS GNGRELGEYG LQEYTEVKTV

TIKIPQKNS
Length:509
Mass (Da):55,809
Last modified:August 1, 1992 - v1
Checksum:i7771181FA2F05DA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58869 mRNA. Translation: CAA41679.1.
PIRiS14629.
RefSeqiNP_989908.1. NM_204577.4.
UniGeneiGga.4119.

Genome annotation databases

GeneIDi395264.
KEGGigga:395264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58869 mRNA. Translation: CAA41679.1.
PIRiS14629.
RefSeqiNP_989908.1. NM_204577.4.
UniGeneiGga.4119.

3D structure databases

ProteinModelPortaliP27463.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP27463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395264.
KEGGigga:395264.

Organism-specific databases

CTDi216.

Phylogenomic databases

HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP27463.
KOiK07249.
PhylomeDBiP27463.

Enzyme and pathway databases

UniPathwayiUPA00912.
BRENDAi1.2.1.36. 1306.

Miscellaneous databases

PROiP27463.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1A1_CHICK
AccessioniPrimary (citable) accession number: P27463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.