Reviewed, UniProtKB/Swiss-Prot P27459 (PRLA_ACHLY)

Names and origin

Protein names	Recommended name:     Alpha-lytic protease     EC=3.4.21.12 Alternative name(s):     Alpha-lytic endopeptidase
Organism	Achromobacter lyticus
Taxonomic identifier	224 [NCBI]
Taxonomic lineage	Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Achromobacter

Protein attributes

Sequence length	25 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Preferential cleavage: Ala-|-Xaa, Val-|-Xaa in bacterial cell walls, elastin and other proteins.
Sequence similarities	Belongs to the peptidase S1 family.

Ontologies

Keywords
Molecular function	Hydrolase Protease Serine protease
PTM	Zymogen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›25	›25	Alpha-lytic protease		PRO_0000093855
Experimental info
	Sequence uncertainty	17	1
	Non-terminal residue	25	1

Sequences

	Sequence		Length	Mass (Da)
	P27459-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 33F56B45BF81573E	FASTA	25	2,572
	10 20 ANIVGGIEYS INNASICSVG FSVTR

References

[1]	"Molecular cloning and nucleotide sequence of the beta-lytic protease gene from Achromobacter lyticus." Li S.L., Norioka S., Sakiyama F. J. Bacteriol. 172:6506-6511(1990) [PubMed: 2228973] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: M497-1.

Cross-references

3D structure databases
HSSP	HSSP built from PDB template 1QQ4 based on UniProtKB P00778.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.4.21.12. 19051.
Family and domain databases
InterPro	IPR018114. Peptidase_S1/S6_AS. [Graphical view]
PROSITE	PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRLA_ACHLY

Accession

Primary (citable) accession number: P27459

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	March 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)