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Protein

Glutathione reductase, chloroplastic/mitochondrial

Gene

GR

Organism
Pisum sativum (Garden pea)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Maintains high levels of reduced glutathione in the chloroplast.

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei277NADPBy similarity1
Binding sitei283NADPBy similarity1
Active sitei515Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi112 – 121FADBy similarity10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase, chloroplastic/mitochondrial (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Alternative name(s):
GOR1
Gene namesi
Name:GR
Synonyms:GOR1
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Mitochondrion, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 60Chloroplast and mitochondrionSequence analysisAdd BLAST60
ChainiPRO_000003028161 – 552Glutathione reductase, chloroplastic/mitochondrialAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi121 ↔ 126Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP27456
SMRiP27456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006324 Glut-diS_reduct
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 3 hits
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01424 gluta_reduc_2, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQAMATPLS LSCCSPTLTR STLFFTKTFP FSRSFSTPLP LSTKTLISLS
60 70 80 90 100
PPHRTFAVRA ESQNGADPAR QYDFDLFTIG AGSGGVRASR FASNFGASSA
110 120 130 140 150
VCELPFSTIS SDTTGGVGGT CVIRGCVPKK LLVYASKFSH EFEESNGFGW
160 170 180 190 200
RYDSEPKHDW SSLIANKNAE LQRLTGIYKN TLKNAGVKLI EGRGKIVDAH
210 220 230 240 250
TVDVDGKLYS AKHILVSVGG RPFIPDIPGK EYAIDSDAAL DLPSKPQKIA
260 270 280 290 300
IVGGGYIALE FAGIFNGLKS EVHVFIRQKK VLRGFDEEIR DFVAENMALR
310 320 330 340 350
GIEFHTEESP VAITKAADGS LSLKTNKGTE EGFSHIMFAT GRSPNTKDLG
360 370 380 390 400
LESVGVKVAK DGSIEVDEYS QTSVPSIWAI GDATNRVNLT PVALMEGVAL
410 420 430 440 450
AKTLFQNEPT KPDYRAIPSA VFSQPPIGGV GLTEEQAAEQ YGDIDVFTAN
460 470 480 490 500
FRPMKATLSG LPDRVFMKLI VSAETNVVLG LHMCGEDAAE IAQGFAVGIK
510 520 530 540 550
AGLTKADFDA TVGIHPTAAE EFVTMRTPTR KVRKNQASQG KSDSKAKAVA

GS
Length:552
Mass (Da):59,108
Last modified:August 1, 1992 - v1
Checksum:i690D1058AE4168BC
GO

Sequence cautioni

The sequence CAA42921 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60373 mRNA Translation: CAA42921.1 Different initiation.
X90996 Genomic DNA Translation: CAA62482.1
PIRiS18973

Similar proteinsi

Entry informationi

Entry nameiGSHRP_PEA
AccessioniPrimary (citable) accession number: P27456
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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