P27454 (VNCS_AEDEV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-capsid protein NS-1

Alternative name(s):
NCVP1
Non-structural protein NS1

Gene names

Name:

NS1

Organism

Aedes densonucleosis virus (strain GKV 002 002) (Aedes densovirus) [Complete proteome]

Taxonomic identifier

10808 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Densovirinae › Brevidensovirus

Virus host

Aedes [TaxID: 7158]

Protein attributes

Sequence length	849 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems necessary for viral DNA replication, plays an important role in the regulation of capsid gene expression. It is covalently bound to the 5'-termini of viral DNA, and can influence DNA packaging. NS1 is also believed to possess the topoisomerase I type nicking activity, and cytotoxic activity.
Sequence similarities	Belongs to the parvoviruses non-capsid protein family. Contains 1 SF3 helicase domain.

Ontologies

Keywords
Biological process	DNA replication
Ligand	ATP-binding Nucleotide-binding
PTM	Covalent protein-DNA linkage
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 849	849	Non-capsid protein NS-1		PRO_0000222478
Regions
	Domain	594 – 749	156	SF3 helicase
	Nucleotide binding	624 – 631	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P27454 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: D4FA0980B08E152E	FASTA	849	97,543
	10 20 30 40 50 60 MEYGLISKFY MDHWRWKIRE KHKVENNLLS TYKYILNFHY HMVHPYIRST KGGPNRVMNS 70 80 90 100 110 120 VCVEHSPCEH GNLFCECIYC WEHDGQCRGR KLDLGASTGI ERRLANDNQQ PGLSDLYCTE 130 140 150 160 170 180 TIHLATAIPE RRTIDRENYV KDFAGQTVGD LYPQLQGSTG ASEPIDFAFP TVGSGSWEIL 190 200 210 220 230 240 VRESHKHFEP NYTEEAYQSH IRSVRRRLFP EETMDNNGSQ ASTTEMLRDA VQRCGFEGPP 250 260 270 280 290 300 NSPSENNRDG IDGTCISTVD IQSNCIVNAH CPKQGTSNQT NKRKKSTDTT ESSGSKKNKS 310 320 330 340 350 360 SNYQQNLQEQ GSTSISDTID IVDGELDGST GSNRETAYYT FVLHKNNVKE DWRYIATTRA 370 380 390 400 410 420 KQAPSFITFD HGDHIHILFS SSNTGGNSTR VRTRITKFLS ATSAGSAEAT ITFSKVKFLR 430 440 450 460 470 480 NYILYCIRYG IETVNIYGNK IQQQLTEAMD TFKILFENRD PNDVILEAGC KLYHEEKKDN 490 500 510 520 530 540 KQKRCGQRKQ QNLTDIILEK IKEKKITTAQ QWENQIEPEF KIQLMKEFGL NVDSYVTRIV 550 560 570 580 590 600 RIERTRIQQL IKAKTLTEIM LEILNDEYIK HFTPGEDNSK TAKCIEWIEY LFKENNINII 610 620 630 640 650 660 HFLAWNEIIK TKRYKKINGM VLEGITNAGK SLILDNLLAM VKPEEIPRER DNSGFHLDQV 670 680 690 700 710 720 PGAGSILFEE PMITPVNVGT WKLLLEGKTI KTDVKNKDKE PIERTPTWIT TATPITNNID 730 740 750 760 770 780 MNETSQILQR IKLYILKKSI QHRDDKYTIN AQIQNKLISR PPTLIEPIHM AIVFIKNFTK 790 800 810 820 830 840 IYNLIAEEDK AHTVNEKAIQ INNEVKEEAE SWQTALQWTM TENNEEQNEN ETQALEDQVL ELAKEQATT

References

[1]	"Nucleotide sequence and genomic organization of Aedes densonucleosis virus." Afanasiev B.N., Galyov E.E., Buchatsky L.P., Kozlov Y.V. Virology 185:323-336(1991) [PubMed: 1833875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M37899 Genomic DNA. No translation available.
PIR	UYPVAD. A40784.
3D structure databases
ProteinModelPortal	P27454.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR014015. Helicase_SF3_DNA-vir. IPR001257. Parvovirus_NS1_helicase. [Graphical view]
Pfam	PF01057. Parvo_NS1. 1 hit. [Graphical view]
PROSITE	PS51206. SF3_HELICASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VNCS_AEDEV

Accession

Primary (citable) accession number: P27454

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	September 21, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program