P27453 (CAPSD_AEDEV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Capsid protein VP1/VP2

Alternative name(s):
Coat protein VP1/VP2

Gene names

Name:

VP

Organism

Aedes densonucleosis virus (strain GKV 002 002) (Aedes densovirus) [Complete proteome]

Taxonomic identifier

10808 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Densovirinae › Brevidensovirus

Virus host

Aedes [TaxID: 7158]

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of size variants of the capsid proteins, which differ in the N-terminushe capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis By similarity.

Subcellular location

Virion Potential.

Ontologies

Keywords
Biological process	Clathrin-mediated endocytosis of virus by host Host-virus interaction Initiation of viral infection Viral attachment to host cell Viral penetration into host cytoplasm Viral penetration via permeabilization of host organellar membrane Virus endocytosis by host
Cellular component	Virion
Coding sequence diversity	Alternative initiation
Molecular function	Capsid protein T=1 icosahedral capsid protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Select]

Isoform VP1 (identifier: P27453-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform VP2 (identifier: P27453-2)

The sequence of this isoform is not available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Capsid protein VP1/VP2		PRO_0000039445

Sequences

	Sequence		Length	Mass (Da)
	Isoform VP1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 9DB7681D0E0813D0	FASTA	358	40,508
	10 20 30 40 50 60 MADSTSMDHD GEQRGTKRKR DAGAGGSGAG IGKGTSNYVK EGYGPNMSEM VPRNIMNKGN 70 80 90 100 110 120 HTVYHVVKQQ KYLDFNYVSN QNPYIIPYQT AGFWASMWDQ TDIGSNNTIN IMKALNNVSV 130 140 150 160 170 180 GVTWIKGEIT FEVYAVTRQR LLTGTTNQTT WDFETSQNMF IADADREPEN FNLATAAATG 190 200 210 220 230 240 PLAQQTTQTL LFNANNDRYT KYELPQRNQY TREYDFQQLT NNYMWKPTDI SAAANFRRLI 250 260 270 280 290 300 PMAEGVYTTT AATTKMAELT EQKSVYAGSG KTTEASLFRN RTSYPRMHMA QPQVPDETGY 310 320 330 340 350 MKFRYQVRMS TKLHLVFHLY PDYSTSTNIE YMGRQVLELP EVTATGGVVT CMPYEIKT
	Isoform VP2 (Sequence not available).		–	–

References

[1]	"Nucleotide sequence and genomic organization of Aedes densonucleosis virus." Afanasiev B.N., Galyov E.E., Buchatsky L.P., Kozlov Y.V. Virology 185:323-336(1991) [PubMed: 1833875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M37899 Genomic DNA. No translation available.
PIR	VCPVAD. D40784.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CAPSD_AEDEV

Accession

Primary (citable) accession number: P27453

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	May 31, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program