V-type proton ATPase 16 kDa proteolipid subunit

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Reviewed, UniProtKB/Swiss-Prot P27449 (VATL_HUMAN)

Last modified December 15, 2009. Version 98. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    V-type proton ATPase 16 kDa proteolipid subunit
      Short name=V-ATPase 16 kDa proteolipid subunit
Alternative name(s):
    Vacuolar proton pump 16 kDa proteolipid subunit

Gene names

Name:	ATP6V0C
Synonyms:	ATP6C, ATP6L, ATPL

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit structure	V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with LASS2. Interacts with HTLV-1 accessory protein p12I. Ref.6 Ref.7
Subcellular location	Vacuole membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the V-ATPase proteolipid subunit family.

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Ontologies

Keywords
Biological process	Host-virus interaction Hydrogen ion transport Ion transport Transport
Cellular component	Membrane Vacuole
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Ref.1 Traceable author statement. Source: ProtInc proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: InterPro proton-transporting V-type ATPase, V0 domain Inferred from electronic annotation. Source: InterPro vacuole Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transporting ATP synthase activity, rotational mechanism Ref.1 Traceable author statement. Source: UniProtKB protein binding Ref.7 Inferred from physical interaction. Source: IntAct proton-transporting ATPase activity, rotational mechanism Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
LASS2	Q96G23	1	EBI-721179,EBI-1057080

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 155

155

V-type proton ATPase 16 kDa proteolipid subunit

PRO_0000071743

Regions

Topological domain

1 – 10

Lumenal Potential

Transmembrane

11 – 33

Potential

Topological domain

34 – 55

Cytoplasmic Potential

Transmembrane

56 – 76

Potential

Topological domain

77 – 92

Lumenal Potential

Transmembrane

93 – 114

Potential

Topological domain

115 – 126

Cytoplasmic Potential

Transmembrane

127 – 152

Potential

Topological domain

153 – 155

Lumenal Potential

Sites

Site

139

Essential for proton translocation By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P27449-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 91141854A0492A5B
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FASTA

155

15,736

        10         20         30         40         50         60 
MSESKSGPEY ASFFAVMGAS AAMVFSALGA AYGTAKSGTG IAAMSVMRPE QIMKSIIPVV 

        70         80         90        100        110        120 
MAGIIAIYGL VVAVLIANSL NDDISLYKSF LQLGAGLSVG LSGLAAGFAI GIVGDAGVRG 

       130        140        150 
TAQQPRLFVG MILILIFAEV LGLYGLIVAL ILSTK

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CpG island in the region of an autosomal dominant polycystic kidney disease locus defines the 5' end of a gene encoding a putative proton channel." Gillespie G.A.J., Somlo S., Germino G.G., Weinstat-Saslow D., Reeders S.T. Proc. Natl. Acad. Sci. U.S.A. 88:4289-4293(1991) [PubMed: 1709739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Muscle and Skin.
[5]	"Vacuolar type H(+)-ATPase genes: presence of four genes including pseudogenes for the 16-kDa proteolipid subunit in the human genome." Hasebe M., Hanada H., Moriyama Y., Maeda M., Futai M. Biochem. Biophys. Res. Commun. 183:856-863(1992) [PubMed: 1532310] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-155.
[6]	"Mapping of the intermolecular association of human T cell leukaemia/lymphotropic virus type I p12I and the vacuolar H+-ATPase 16 kDa subunit protein." Koralnik I.J., Mulloy J.C., Andresson T., Fullen J., Franchini G. J. Gen. Virol. 76:1909-1916(1995) [PubMed: 7636472] [Abstract] Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
[7]	"Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1." Pan H., Qin W.-X., Huo K.-K., Wan D.-F., Yu Y., Xu Z.-G., Hu Q.-D., Gu K.T., Zhou X.-M., Jiang H.-Q., Zhang P.-P., Huang Y., Li Y.-Y., Gu J.-R. Genomics 77:58-64(2001) [PubMed: 11543633] [Abstract] Cited for: INTERACTION WITH LASS2.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	M62762 mRNA. Translation: AAA60039.1. CR541930 mRNA. Translation: CAG46728.1. CR541951 mRNA. Translation: CAG46749.1. BT007155 mRNA. Translation: AAP35819.1. BC004537 mRNA. Translation: AAH04537.1. BC007389 mRNA. Translation: AAH07389.1. BC007759 mRNA. Translation: AAH07759.1. BC009290 mRNA. Translation: AAH09290.1.
IPI	IPI00018855.
PIR	A39367.
RefSeq	NP_001685.1.
UniGene	Hs.389107
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P27449. 2 interactions.
STRING	P27449.
Proteomic databases
PRIDE	P27449.
Genome annotation databases
Ensembl	ENST00000330398; ENSP00000329757; ENSG00000185883; Homo sapiens. [Genome view]
GeneID	527.
KEGG	hsa:527.
UCSC	uc002cqn.1. human.
Organism-specific databases
CTD	527.
GeneCards	GC16P002503.
H-InvDB	HIX0012726. HIX0039609.
HGNC	HGNC:855. ATP6V0C.
MIM	108745. gene.
PharmGKB	PA25149.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG325773.
HOVERGEN	P27449.
InParanoid	P27449.
OMA	GPEYASF.
OrthoDB	EOG9QNQG5.
Enzyme and pathway databases
BRENDA	3.6.3.14. 247.
Gene expression databases
ArrayExpress	P27449.
Bgee	P27449.
CleanEx	HS_ATP6V0C.
Genevestigator	P27449.
GermOnline	ENSG00000185883. Homo sapiens.
Family and domain databases
InterPro	IPR000454. ATPase_F0-cplx_csu. IPR002379. ATPase_F0/V0-cplx_csu. IPR000245. ATPase_V0-cplx_csu. IPR011555. ATPase_V0-cplx_csu_euk. [Graphical view]
Pfam	PF00137. ATP-synt_C. 2 hits. [Graphical view]
PRINTS	PR00122. VACATPASE.
ProtoNet	Search...
Other Resources
NextBio	2187.
SOURCE	Search...

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Entry information

Entry name

VATL_HUMAN

Accession

Primary (citable) accession number: P27449
Secondary accession number(s): Q6FH26

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	December 15, 2009
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents