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Protein

V-type proton ATPase 16 kDa proteolipid subunit

Gene

ATP6V0C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei139Essential for proton translocationBy similarity1

GO - Molecular functioni

  • proton-transporting ATPase activity, rotational mechanism Source: ProtInc
  • proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • insulin receptor signaling pathway Source: Reactome
  • ion transmembrane transport Source: Reactome
  • lysosomal lumen acidification Source: GO_Central
  • neutrophil degranulation Source: Reactome
  • positive regulation of Wnt signaling pathway Source: UniProtKB
  • proton transmembrane transport Source: ProtInc
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • transferrin transport Source: Reactome
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-34368
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-6798695 Neutrophil degranulation
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 16 kDa proteolipid subunit
Short name:
V-ATPase 16 kDa proteolipid subunit
Alternative name(s):
Vacuolar proton pump 16 kDa proteolipid subunit
Gene namesi
Name:ATP6V0C
Synonyms:ATP6C, ATP6L, ATPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000185883.11
HGNCiHGNC:855 ATP6V0C
MIMi108745 gene
neXtProtiNX_P27449

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10LumenalSequence analysis10
Transmembranei11 – 33HelicalSequence analysisAdd BLAST23
Topological domaini34 – 55CytoplasmicSequence analysisAdd BLAST22
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 92LumenalSequence analysisAdd BLAST16
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 131CytoplasmicSequence analysisAdd BLAST17
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 155LumenalSequence analysis3

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

DisGeNETi527
OpenTargetsiENSG00000185883
PharmGKBiPA25149

Polymorphism and mutation databases

BioMutaiATP6V0C
DMDMi137479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717431 – 155V-type proton ATPase 16 kDa proteolipid subunitAdd BLAST155

Post-translational modificationi

Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiP27449
MaxQBiP27449
PaxDbiP27449
PeptideAtlasiP27449
PRIDEiP27449
TopDownProteomicsiP27449

PTM databases

iPTMnetiP27449
PhosphoSitePlusiP27449

Expressioni

Gene expression databases

BgeeiENSG00000185883
CleanExiHS_ATP6V0C
ExpressionAtlasiP27449 baseline and differential
GenevisibleiP27449 HS

Organism-specific databases

HPAiHPA065100

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with LASS2. Interacts with HTLV-1 accessory protein p12I. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107010, 31 interactors
IntActiP27449, 25 interactors
MINTiP27449
STRINGi9606.ENSP00000329757

Structurei

3D structure databases

ProteinModelPortaliP27449
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0232 Eukaryota
COG0636 LUCA
GeneTreeiENSGT00550000074873
HOGENOMiHOG000056520
HOVERGENiHBG002712
InParanoidiP27449
KOiK02155
OMAiDMFARGI
OrthoDBiEOG091G0U1Y
PhylomeDBiP27449
TreeFamiTF300025

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR011555 ATPase_proteolipid_su_C_euk
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 2 hits
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 2 hits
TIGRFAMsiTIGR01100 V_ATP_synt_C, 1 hit

Sequencei

Sequence statusi: Complete.

P27449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESKSGPEY ASFFAVMGAS AAMVFSALGA AYGTAKSGTG IAAMSVMRPE
60 70 80 90 100
QIMKSIIPVV MAGIIAIYGL VVAVLIANSL NDDISLYKSF LQLGAGLSVG
110 120 130 140 150
LSGLAAGFAI GIVGDAGVRG TAQQPRLFVG MILILIFAEV LGLYGLIVAL

ILSTK
Length:155
Mass (Da):15,736
Last modified:August 1, 1992 - v1
Checksum:i91141854A0492A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62762 mRNA Translation: AAA60039.1
CR541930 mRNA Translation: CAG46728.1
CR541951 mRNA Translation: CAG46749.1
BT007155 mRNA Translation: AAP35819.1
BC004537 mRNA Translation: AAH04537.1
BC007389 mRNA Translation: AAH07389.1
BC007759 mRNA Translation: AAH07759.1
BC009290 mRNA Translation: AAH09290.1
CCDSiCCDS10470.1
PIRiA39367
RefSeqiNP_001185498.1, NM_001198569.1
NP_001685.1, NM_001694.3
UniGeneiHs.389107

Genome annotation databases

EnsembliENST00000330398; ENSP00000329757; ENSG00000185883
GeneIDi527
KEGGihsa:527
UCSCiuc002cqn.4 human

Entry informationi

Entry nameiVATL_HUMAN
AccessioniPrimary (citable) accession number: P27449
Secondary accession number(s): Q6FH26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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