Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P27449

- VATL_HUMAN

UniProt

P27449 - VATL_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

V-type proton ATPase 16 kDa proteolipid subunit

Gene

ATP6V0C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei139 – 1391Essential for proton translocationBy similarity

GO - Molecular functioni

  1. proton-transporting ATPase activity, rotational mechanism Source: ProtInc
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB
  3. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. cellular iron ion homeostasis Source: Reactome
  3. insulin receptor signaling pathway Source: Reactome
  4. interaction with host Source: Reactome
  5. phagosome maturation Source: Reactome
  6. positive regulation of Wnt signaling pathway Source: UniProt
  7. proton transport Source: ProtInc
  8. transferrin transport Source: Reactome
  9. transmembrane transport Source: Reactome
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-34368.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 16 kDa proteolipid subunit
Short name:
V-ATPase 16 kDa proteolipid subunit
Alternative name(s):
Vacuolar proton pump 16 kDa proteolipid subunit
Gene namesi
Name:ATP6V0C
Synonyms:ATP6C, ATP6L, ATPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:855. ATP6V0C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010LumenalSequence Analysis
Transmembranei11 – 3323HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 5522CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Topological domaini77 – 9216LumenalSequence AnalysisAdd
BLAST
Transmembranei93 – 11422HelicalSequence AnalysisAdd
BLAST
Topological domaini115 – 13117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Topological domaini153 – 1553LumenalSequence Analysis

GO - Cellular componenti

  1. endosome membrane Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
  3. focal adhesion Source: UniProtKB
  4. integral component of membrane Source: ProtInc
  5. lysosomal membrane Source: UniProtKB
  6. phagocytic vesicle membrane Source: Reactome
  7. proton-transporting V-type ATPase, V0 domain Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155V-type proton ATPase 16 kDa proteolipid subunitPRO_0000071743Add
BLAST

Post-translational modificationi

Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP27449.
PaxDbiP27449.
PRIDEiP27449.

PTM databases

PhosphoSiteiP27449.

Expressioni

Gene expression databases

BgeeiP27449.
CleanExiHS_ATP6V0C.
ExpressionAtlasiP27449. baseline.
GenevestigatoriP27449.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with LASS2. Interacts with HTLV-1 accessory protein p12I. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-721179,EBI-1057080
E5P0CK452EBI-721179,EBI-7015490From a different organism.

Protein-protein interaction databases

BioGridi107010. 5 interactions.
IntActiP27449. 6 interactions.
MINTiMINT-1414327.
STRINGi9606.ENSP00000329757.

Structurei

3D structure databases

ProteinModelPortaliP27449.
SMRiP27449. Positions 14-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0636.
GeneTreeiENSGT00550000074873.
HOGENOMiHOG000056520.
HOVERGENiHBG002712.
InParanoidiP27449.
KOiK02155.
OMAiMATELCP.
OrthoDBiEOG7FV3RW.
PhylomeDBiP27449.
TreeFamiTF300025.

Family and domain databases

HAMAPiMF_01396. ATP_synth_c_bact.
InterProiIPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.

Sequencei

Sequence statusi: Complete.

P27449-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESKSGPEY ASFFAVMGAS AAMVFSALGA AYGTAKSGTG IAAMSVMRPE
60 70 80 90 100
QIMKSIIPVV MAGIIAIYGL VVAVLIANSL NDDISLYKSF LQLGAGLSVG
110 120 130 140 150
LSGLAAGFAI GIVGDAGVRG TAQQPRLFVG MILILIFAEV LGLYGLIVAL

ILSTK
Length:155
Mass (Da):15,736
Last modified:August 1, 1992 - v1
Checksum:i91141854A0492A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62762 mRNA. Translation: AAA60039.1.
CR541930 mRNA. Translation: CAG46728.1.
CR541951 mRNA. Translation: CAG46749.1.
BT007155 mRNA. Translation: AAP35819.1.
BC004537 mRNA. Translation: AAH04537.1.
BC007389 mRNA. Translation: AAH07389.1.
BC007759 mRNA. Translation: AAH07759.1.
BC009290 mRNA. Translation: AAH09290.1.
CCDSiCCDS10470.1.
PIRiA39367.
RefSeqiNP_001185498.1. NM_001198569.1.
NP_001685.1. NM_001694.3.
UniGeneiHs.389107.

Genome annotation databases

EnsembliENST00000330398; ENSP00000329757; ENSG00000185883.
ENST00000618152; ENSP00000481778; ENSG00000185883.
GeneIDi527.
KEGGihsa:527.
UCSCiuc002cqn.3. human.

Polymorphism databases

DMDMi137479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62762 mRNA. Translation: AAA60039.1 .
CR541930 mRNA. Translation: CAG46728.1 .
CR541951 mRNA. Translation: CAG46749.1 .
BT007155 mRNA. Translation: AAP35819.1 .
BC004537 mRNA. Translation: AAH04537.1 .
BC007389 mRNA. Translation: AAH07389.1 .
BC007759 mRNA. Translation: AAH07759.1 .
BC009290 mRNA. Translation: AAH09290.1 .
CCDSi CCDS10470.1.
PIRi A39367.
RefSeqi NP_001185498.1. NM_001198569.1.
NP_001685.1. NM_001694.3.
UniGenei Hs.389107.

3D structure databases

ProteinModelPortali P27449.
SMRi P27449. Positions 14-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107010. 5 interactions.
IntActi P27449. 6 interactions.
MINTi MINT-1414327.
STRINGi 9606.ENSP00000329757.

PTM databases

PhosphoSitei P27449.

Polymorphism databases

DMDMi 137479.

Proteomic databases

MaxQBi P27449.
PaxDbi P27449.
PRIDEi P27449.

Protocols and materials databases

DNASUi 527.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330398 ; ENSP00000329757 ; ENSG00000185883 .
ENST00000618152 ; ENSP00000481778 ; ENSG00000185883 .
GeneIDi 527.
KEGGi hsa:527.
UCSCi uc002cqn.3. human.

Organism-specific databases

CTDi 527.
GeneCardsi GC16P002563.
HGNCi HGNC:855. ATP6V0C.
MIMi 108745. gene.
neXtProti NX_P27449.
PharmGKBi PA25149.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0636.
GeneTreei ENSGT00550000074873.
HOGENOMi HOG000056520.
HOVERGENi HBG002712.
InParanoidi P27449.
KOi K02155.
OMAi MATELCP.
OrthoDBi EOG7FV3RW.
PhylomeDBi P27449.
TreeFami TF300025.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER66-34368.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

GeneWikii ATP6V0C.
GenomeRNAii 527.
NextBioi 2187.
PROi P27449.
SOURCEi Search...

Gene expression databases

Bgeei P27449.
CleanExi HS_ATP6V0C.
ExpressionAtlasi P27449. baseline.
Genevestigatori P27449.

Family and domain databases

HAMAPi MF_01396. ATP_synth_c_bact.
InterProi IPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view ]
Pfami PF00137. ATP-synt_C. 2 hits.
[Graphical view ]
PRINTSi PR00122. VACATPASE.
SUPFAMi SSF81333. SSF81333. 2 hits.
TIGRFAMsi TIGR01100. V_ATP_synt_C. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CpG island in the region of an autosomal dominant polycystic kidney disease locus defines the 5' end of a gene encoding a putative proton channel."
    Gillespie G.A.J., Somlo S., Germino G.G., Weinstat-Saslow D., Reeders S.T.
    Proc. Natl. Acad. Sci. U.S.A. 88:4289-4293(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Muscle and Skin.
  5. "Vacuolar type H(+)-ATPase genes: presence of four genes including pseudogenes for the 16-kDa proteolipid subunit in the human genome."
    Hasebe M., Hanada H., Moriyama Y., Maeda M., Futai M.
    Biochem. Biophys. Res. Commun. 183:856-863(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-155.
  6. "Mapping of the intermolecular association of human T cell leukaemia/lymphotropic virus type I p12I and the vacuolar H+-ATPase 16 kDa subunit protein."
    Koralnik I.J., Mulloy J.C., Andresson T., Fullen J., Franchini G.
    J. Gen. Virol. 76:1909-1916(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
  7. "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."
    Pan H., Qin W.-X., Huo K.-K., Wan D.-F., Yu Y., Xu Z.-G., Hu Q.-D., Gu K.T., Zhou X.-M., Jiang H.-Q., Zhang P.-P., Huang Y., Li Y.-Y., Gu J.-R.
    Genomics 77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LASS2.
  8. "A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation."
    Liu Q.Y., Lei J.X., Sikorska M., Liu R.
    Mol. Neurodegener. 3:4-4(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF182, UBIQUITINATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVATL_HUMAN
AccessioniPrimary (citable) accession number: P27449
Secondary accession number(s): Q6FH26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3