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P27448

- MARK3_HUMAN

UniProt

P27448 - MARK3_HUMAN

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Protein
MAP/microtubule affinity-regulating kinase 3
Gene
MARK3, CTAK1, EMK2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851ATP By similarity
Active sitei178 – 1781Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 709ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP27448.

Names & Taxonomyi

Protein namesi
Recommended name:
MAP/microtubule affinity-regulating kinase 3 (EC:2.7.11.1)
Alternative name(s):
C-TAK1
Short name:
cTAK1
Cdc25C-associated protein kinase 1
ELKL motif kinase 2
Short name:
EMK-2
Protein kinase STK10
Ser/Thr protein kinase PAR-1
Short name:
Par-1a
Serine/threonine-protein kinase p78
Gene namesi
Name:MARK3
Synonyms:CTAK1, EMK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:6897. MARK3.

Subcellular locationi

Cell membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi211 – 2111T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication

Organism-specific databases

PharmGKBiPA30640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753MAP/microtubule affinity-regulating kinase 3
PRO_0000086304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Phosphoserine1 Publication
Modified residuei211 – 2111Phosphothreonine; by LKB11 Publication
Modified residuei383 – 3831Phosphoserine2 Publications
Modified residuei400 – 4001Phosphoserine1 Publication
Modified residuei469 – 4691Phosphoserine3 Publications
Modified residuei549 – 5491Phosphothreonine2 Publications
Modified residuei564 – 5641Phosphothreonine; by PKC/PRKCZ By similarity
Modified residuei598 – 5981Phosphoserine1 Publication
Modified residuei643 – 6431Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP27448.
PaxDbiP27448.
PRIDEiP27448.

PTM databases

PhosphoSiteiP27448.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiP27448.
BgeeiP27448.
CleanExiHS_MARK3.
GenevestigatoriP27448.

Organism-specific databases

HPAiHPA024652.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASB13Q8WXK32EBI-707595,EBI-707573
Ppm1lQ8BHN03EBI-707595,EBI-7970002From a different organism.
SFNP319472EBI-707595,EBI-476295
TCEA2Q155602EBI-707595,EBI-710310
YWHABP319464EBI-707595,EBI-359815
YWHAGP619812EBI-707595,EBI-359832
YWHAHQ049174EBI-707595,EBI-306940
YWHAZP631049EBI-707595,EBI-347088

Protein-protein interaction databases

BioGridi110310. 33 interactions.
DIPiDIP-34637N.
IntActiP27448. 38 interactions.
MINTiMINT-272697.
STRINGi9606.ENSP00000411397.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi56 – 649
Beta strandi66 – 7510
Turni76 – 783
Beta strandi81 – 888
Helixi89 – 913
Helixi94 – 10916
Beta strandi118 – 1236
Beta strandi125 – 1328
Helixi140 – 1478
Helixi152 – 17120
Helixi181 – 1833
Beta strandi184 – 1863
Beta strandi192 – 1943
Helixi201 – 2033
Beta strandi204 – 2063
Helixi208 – 2103
Beta strandi213 – 2153
Helixi216 – 2183
Helixi221 – 2255
Helixi232 – 24817
Helixi258 – 26710
Helixi278 – 28710
Turni292 – 2943
Helixi298 – 3014
Turni305 – 3106
Helixi329 – 3379
Helixi342 – 3509
Helixi356 – 3649

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QNJX-ray2.70A/B48-370[»]
3FE3X-ray1.90A/B41-367[»]
ProteinModelPortaliP27448.
SMRiP27448. Positions 18-366, 657-753.

Miscellaneous databases

EvolutionaryTraceiP27448.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 307252Protein kinase
Add
BLAST
Domaini326 – 36540UBA
Add
BLAST
Domaini704 – 75350KA1
Add
BLAST

Sequence similaritiesi

Contains 1 UBA domain.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233025.
HOVERGENiHBG052453.
InParanoidiP27448.
KOiK08798.
TreeFamiTF315213.

Family and domain databases

Gene3Di3.30.310.80. 1 hit.
InterProiIPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA/transl_elong_EF1B_N_euk.
[Graphical view]
PfamiPF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P27448-5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ    50
PHIGNYRLLK TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL 100
FREVRIMKIL NHPNIVKLFE VIETEKTLYL IMEYASGGEV FDYLVAHGRM 150
KEKEARSKFR QIVSAVQYCH QKRIVHRDLK AENLLLDADM NIKIADFGFS 200
NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG VILYTLVSGS 250
LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS 350
KMKYDEITAT YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS 400
PHHKVQRSVF SSQKQRRYSD HAGPAIPSVV AYPKRSQTST ADSDLKEDGI 450
SSRKSSGSAV GGKGIAPASP MLGNASNPNK ADIPERKKSS TVPSSNTASG 500
GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS THSISSAATP 550
DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 600
STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN 650
KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC 700
VHGDGHAENL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE 750
LKL 753
Length:753
Mass (Da):84,489
Last modified:July 27, 2011 - v4
Checksum:i0CA50C58A4A49D93
GO
Isoform 2 (identifier: P27448-2) [UniParc]FASTAAdd to Basket

Also known as: CTAK75a

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: Q → QGCQAGQTIKVQVSFDLLSLMFTF
     615-638: Missing.

Show »
Length:752
Mass (Da):84,015
Checksum:i0306682A37C313D7
GO
Isoform 3 (identifier: P27448-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-638: Missing.

Show »
Length:729
Mass (Da):81,499
Checksum:i4DF13ABB00F2305D
GO
Isoform 4 (identifier: P27448-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-623: Missing.

Show »
Length:744
Mass (Da):83,308
Checksum:iEDDC40EDF509566E
GO
Isoform 5 (identifier: P27448-6) [UniParc]FASTAAdd to Basket

Also known as: p58

The sequence of this isoform differs from the canonical sequence as follows:
     371-386: Missing.
     615-638: Missing.

Note: Contains a phosphoserine at position 384.

Show »
Length:713
Mass (Da):79,936
Checksum:i32B5C41C16F5F080
GO
Isoform 6 (identifier: P27448-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: Q → QGCQAGQTIKVQVSFDLLSLMFTF
     371-386: Missing.

Note: Contains a phosphoserine at position 407.

Show »
Length:760
Mass (Da):85,441
Checksum:i4CBABE5452A1A22F
GO
Isoform 7 (identifier: P27448-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-257: Missing.
     624-638: Missing.

Note: No experimental confirmation available.

Show »
Length:659
Mass (Da):74,151
Checksum:iBBF32F62ABACEF9B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti429 – 4291V → A.1 Publication
VAR_040765
Natural varianti443 – 4431S → G.3 Publications
Corresponds to variant rs56305318 [ dbSNP | Ensembl ].
VAR_046763

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 1611Q → QGCQAGQTIKVQVSFDLLSL MFTF in isoform 2 and isoform 6.
VSP_041582
Alternative sequencei179 – 25779Missing in isoform 7.
VSP_043197Add
BLAST
Alternative sequencei371 – 38616Missing in isoform 5 and isoform 6.
VSP_004943Add
BLAST
Alternative sequencei615 – 63824Missing in isoform 2, isoform 3 and isoform 5.
VSP_004944Add
BLAST
Alternative sequencei615 – 6239Missing in isoform 4.
VSP_004945
Alternative sequencei624 – 63815Missing in isoform 7.
VSP_043198Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251E → Q in AAA59991. 1 Publication
Sequence conflicti139 – 1391E → K in AAL69982. 1 Publication
Sequence conflicti139 – 1391E → K in AAA59991. 1 Publication
Sequence conflicti149 – 1491R → K in AAD48007. 1 Publication
Sequence conflicti410 – 4101F → S in AAC15093. 1 Publication
Sequence conflicti410 – 4101F → S in AAD48007. 1 Publication
Sequence conflicti410 – 4101F → S in AAK82367. 1 Publication
Sequence conflicti410 – 4101F → S in AAL69982. 1 Publication
Sequence conflicti410 – 4101F → S in AAA59991. 1 Publication
Sequence conflicti410 – 4101F → S in AAH24773. 1 Publication
Sequence conflicti410 – 4101F → S in AAD51631. 1 Publication
Sequence conflicti425 – 4251A → G in AAA59991. 1 Publication
Sequence conflicti456 – 4561S → T in AAA59991. 1 Publication
Sequence conflicti516 – 5161A → D in AAA59991. 1 Publication
Sequence conflicti603 – 6031N → T in AAA59991. 1 Publication
Sequence conflicti645 – 6451E → K in AAA59991. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64205 mRNA. Translation: AAC15093.1.
AF159295 mRNA. Translation: AAD48007.1.
AF387637 mRNA. Translation: AAK82367.1.
AF465413 mRNA. Translation: AAL69982.1.
M80359 mRNA. Translation: AAA59991.1.
BX161395 mRNA. Translation: CAD61882.1.
AL133367 Genomic DNA. No translation available.
BC024773 mRNA. Translation: AAH24773.1.
AF170723 mRNA. Translation: AAD51631.1.
CCDSiCCDS41993.1. [P27448-3]
CCDS45165.1. [P27448-5]
CCDS45166.1. [P27448-4]
CCDS45167.1. [P27448-8]
CCDS55947.1. [P27448-6]
PIRiS27966.
RefSeqiNP_001122390.1. NM_001128918.1. [P27448-5]
NP_001122391.1. NM_001128919.1. [P27448-4]
NP_001122392.1. NM_001128920.1. [P27448-6]
NP_001122393.1. NM_001128921.1. [P27448-8]
NP_002367.4. NM_002376.5. [P27448-3]
UniGeneiHs.35828.

Genome annotation databases

EnsembliENST00000216288; ENSP00000216288; ENSG00000075413. [P27448-6]
ENST00000303622; ENSP00000303698; ENSG00000075413. [P27448-3]
ENST00000416682; ENSP00000408092; ENSG00000075413. [P27448-2]
ENST00000429436; ENSP00000411397; ENSG00000075413. [P27448-5]
ENST00000440884; ENSP00000402104; ENSG00000075413. [P27448-8]
ENST00000553942; ENSP00000450772; ENSG00000075413. [P27448-4]
GeneIDi4140.
KEGGihsa:4140.
UCSCiuc001ymw.4. human. [P27448-3]
uc001ymx.4. human. [P27448-4]
uc001ymy.4. human. [P27448-8]
uc001ymz.4. human. [P27448-5]
uc001yna.4. human. [P27448-6]
uc010awp.3. human. [P27448-2]
uc010tyb.2. human. [P27448-7]

Polymorphism databases

DMDMi341941142.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64205 mRNA. Translation: AAC15093.1 .
AF159295 mRNA. Translation: AAD48007.1 .
AF387637 mRNA. Translation: AAK82367.1 .
AF465413 mRNA. Translation: AAL69982.1 .
M80359 mRNA. Translation: AAA59991.1 .
BX161395 mRNA. Translation: CAD61882.1 .
AL133367 Genomic DNA. No translation available.
BC024773 mRNA. Translation: AAH24773.1 .
AF170723 mRNA. Translation: AAD51631.1 .
CCDSi CCDS41993.1. [P27448-3 ]
CCDS45165.1. [P27448-5 ]
CCDS45166.1. [P27448-4 ]
CCDS45167.1. [P27448-8 ]
CCDS55947.1. [P27448-6 ]
PIRi S27966.
RefSeqi NP_001122390.1. NM_001128918.1. [P27448-5 ]
NP_001122391.1. NM_001128919.1. [P27448-4 ]
NP_001122392.1. NM_001128920.1. [P27448-6 ]
NP_001122393.1. NM_001128921.1. [P27448-8 ]
NP_002367.4. NM_002376.5. [P27448-3 ]
UniGenei Hs.35828.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2QNJ X-ray 2.70 A/B 48-370 [» ]
3FE3 X-ray 1.90 A/B 41-367 [» ]
ProteinModelPortali P27448.
SMRi P27448. Positions 18-366, 657-753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110310. 33 interactions.
DIPi DIP-34637N.
IntActi P27448. 38 interactions.
MINTi MINT-272697.
STRINGi 9606.ENSP00000411397.

Chemistry

ChEMBLi CHEMBL5600.
GuidetoPHARMACOLOGYi 2099.

PTM databases

PhosphoSitei P27448.

Polymorphism databases

DMDMi 341941142.

Proteomic databases

MaxQBi P27448.
PaxDbi P27448.
PRIDEi P27448.

Protocols and materials databases

DNASUi 4140.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216288 ; ENSP00000216288 ; ENSG00000075413 . [P27448-6 ]
ENST00000303622 ; ENSP00000303698 ; ENSG00000075413 . [P27448-3 ]
ENST00000416682 ; ENSP00000408092 ; ENSG00000075413 . [P27448-2 ]
ENST00000429436 ; ENSP00000411397 ; ENSG00000075413 . [P27448-5 ]
ENST00000440884 ; ENSP00000402104 ; ENSG00000075413 . [P27448-8 ]
ENST00000553942 ; ENSP00000450772 ; ENSG00000075413 . [P27448-4 ]
GeneIDi 4140.
KEGGi hsa:4140.
UCSCi uc001ymw.4. human. [P27448-3 ]
uc001ymx.4. human. [P27448-4 ]
uc001ymy.4. human. [P27448-8 ]
uc001ymz.4. human. [P27448-5 ]
uc001yna.4. human. [P27448-6 ]
uc010awp.3. human. [P27448-2 ]
uc010tyb.2. human. [P27448-7 ]

Organism-specific databases

CTDi 4140.
GeneCardsi GC14P103851.
HGNCi HGNC:6897. MARK3.
HPAi HPA024652.
MIMi 602678. gene.
neXtProti NX_P27448.
PharmGKBi PA30640.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233025.
HOVERGENi HBG052453.
InParanoidi P27448.
KOi K08798.
TreeFami TF315213.

Enzyme and pathway databases

SignaLinki P27448.

Miscellaneous databases

ChiTaRSi MARK3. human.
EvolutionaryTracei P27448.
GeneWikii MARK3.
GenomeRNAii 4140.
NextBioi 16260.
PROi P27448.
SOURCEi Search...

Gene expression databases

ArrayExpressi P27448.
Bgeei P27448.
CleanExi HS_MARK3.
Genevestigatori P27448.

Family and domain databases

Gene3Di 3.30.310.80. 1 hit.
InterProi IPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA/transl_elong_EF1B_N_euk.
[Graphical view ]
Pfami PF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view ]
SUPFAMi SSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding."
    Peng C.Y., Graves P.R., Ogg S., Thoma R.S., Byrnes M.J. III, Wu Z., Stephenson M.T., Piwnica-Worms H.
    Cell Growth Differ. 9:197-208(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT GLY-443.
    Tissue: Cervix carcinoma.
  2. "Human serine/threonine protein kinase cTAK1/Kp78/Mark3: Identification of a novel splice variant and a larger 5'UTR."
    Waggoner S.N., Stephen R., Farrar W.L., Howard O.M.Z.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLY-443.
    Tissue: Monocyte.
  3. "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling."
    Sun T.-Q., Lu B., Feng J.-J., Reinhard C., Jan Y.N., Fantl W.J., Williams L.T.
    Nat. Cell Biol. 3:628-636(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  4. "Characterization of an alternatively spliced form of MARK3 from human brain."
    Drewes G.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. Maheshwari K.K., Som S., Parsa I.
    Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Tissue: Pancreas.
  6. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Neuroblastoma.
  7. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cervix.
  9. "Homo sapiens mRNA partial sequence for a protein kinase, STK10, similar to p78/C-TAK1."
    Reynolds C.H., Patel U.A., Anderton B.H.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-752 (ISOFORM 6).
    Tissue: Urinary bladder.
  10. "Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity."
    Hurov J.B., Watkins J.L., Piwnica-Worms H.
    Curr. Biol. 14:736-741(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-564.
  11. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."
    Lizcano J.M., Goeransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Maekelae T.P., Hardie D.G., Alessi D.R.
    EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, PHOSPHORYLATION AT THR-211, MUTAGENESIS OF THR-211.
  12. "New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases."
    Dequiedt F., Martin M., Von Blume J., Vertommen D., Lecomte E., Mari N., Heinen M.F., Bachmann M., Twizere J.C., Huang M.C., Rider M.H., Piwnica-Worms H., Seufferlein T., Kettmann R.
    Mol. Cell. Biol. 26:7086-7102(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-549, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-400; SER-469; THR-549; SER-598 AND SER-643, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384 (ISOFORM 5), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407 (ISOFORM 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-383; SER-469 AND SER-643, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  19. "Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids."
    Moravcevic K., Mendrola J.M., Schmitz K.R., Wang Y.H., Slochower D., Janmey P.A., Lemmon M.A.
    Cell 143:966-977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-429 AND GLY-443.

Entry informationi

Entry nameiMARK3_HUMAN
AccessioniPrimary (citable) accession number: P27448
Secondary accession number(s): O60219
, Q86TT8, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 150 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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