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Protein

MAP/microtubule affinity-regulating kinase 3

Gene

MARK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85ATPPROSITE-ProRule annotation1
Active sitei178Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 70ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS01177-MONOMER.
ReactomeiR-HSA-5673000. RAF activation.
R-HSA-5674135. MAP2K and MAPK activation.
R-HSA-5675221. Negative regulation of MAPK pathway.
R-HSA-6802946. Signaling by moderate kinase activity BRAF mutants.
R-HSA-6802948. Signaling by high-kinase activity BRAF mutants.
R-HSA-6802949. Signaling by RAS mutants.
R-HSA-6802952. Signaling by BRAF and RAF fusions.
R-HSA-6802955. Paradoxical activation of RAF signaling by kinase inactive BRAF.
SignaLinkiP27448.
SIGNORiP27448.

Names & Taxonomyi

Protein namesi
Recommended name:
MAP/microtubule affinity-regulating kinase 3 (EC:2.7.11.1)
Alternative name(s):
C-TAK1
Short name:
cTAK1
Cdc25C-associated protein kinase 1
ELKL motif kinase 2
Short name:
EMK-2
Protein kinase STK10
Ser/Thr protein kinase PAR-1
Short name:
Par-1a
Serine/threonine-protein kinase p78
Gene namesi
Name:MARK3
Synonyms:CTAK1, EMK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:6897. MARK3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi211T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication1

Organism-specific databases

DisGeNETi4140.
PharmGKBiPA30640.

Chemistry databases

ChEMBLiCHEMBL5600.
GuidetoPHARMACOLOGYi2099.

Polymorphism and mutation databases

BioMutaiMARK3.
DMDMi341941142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863041 – 753MAP/microtubule affinity-regulating kinase 3Add BLAST753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei211Phosphothreonine; by LKB11 Publication1
Modified residuei368PhosphoserineBy similarity1
Modified residuei374PhosphoserineBy similarity1
Modified residuei376PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei543PhosphoserineBy similarity1
Modified residuei549PhosphothreonineCombined sources1
Modified residuei564Phosphothreonine; by PKC/PRKCZBy similarity1
Modified residuei583PhosphoserineCombined sources1
Modified residuei598PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Isoform 5 (identifier: P27448-6)
Modified residuei384PhosphoserineCombined sources1
Isoform 6 (identifier: P27448-7)
Modified residuei407PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP27448.
PaxDbiP27448.
PeptideAtlasiP27448.
PRIDEiP27448.

PTM databases

iPTMnetiP27448.
PhosphoSitePlusiP27448.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000075413.
CleanExiHS_MARK3.
ExpressionAtlasiP27448. baseline and differential.
GenevisibleiP27448. HS.

Organism-specific databases

HPAiHPA024652.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASB13Q8WXK32EBI-707595,EBI-707573
Ppm1lQ8BHN03EBI-707595,EBI-7970002From a different organism.
SFNP319472EBI-707595,EBI-476295
TCEA2Q155602EBI-707595,EBI-710310
YWHABP319464EBI-707595,EBI-359815
YWHAGP619812EBI-707595,EBI-359832
YWHAHQ049174EBI-707595,EBI-306940
YWHAZP6310410EBI-707595,EBI-347088

Protein-protein interaction databases

BioGridi110310. 59 interactors.
DIPiDIP-34637N.
IntActiP27448. 53 interactors.
MINTiMINT-272697.
STRINGi9606.ENSP00000411397.

Chemistry databases

BindingDBiP27448.

Structurei

Secondary structure

1753
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi56 – 64Combined sources9
Beta strandi66 – 75Combined sources10
Turni76 – 78Combined sources3
Beta strandi81 – 88Combined sources8
Helixi89 – 91Combined sources3
Helixi94 – 109Combined sources16
Beta strandi118 – 123Combined sources6
Beta strandi125 – 132Combined sources8
Helixi140 – 147Combined sources8
Helixi152 – 171Combined sources20
Helixi181 – 183Combined sources3
Beta strandi184 – 186Combined sources3
Beta strandi192 – 194Combined sources3
Helixi201 – 203Combined sources3
Beta strandi204 – 206Combined sources3
Helixi208 – 210Combined sources3
Beta strandi213 – 215Combined sources3
Helixi216 – 218Combined sources3
Helixi221 – 225Combined sources5
Helixi232 – 248Combined sources17
Helixi258 – 267Combined sources10
Helixi278 – 287Combined sources10
Turni292 – 294Combined sources3
Helixi298 – 301Combined sources4
Turni305 – 310Combined sources6
Helixi329 – 337Combined sources9
Helixi342 – 350Combined sources9
Helixi356 – 364Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QNJX-ray2.70A/B48-370[»]
3FE3X-ray1.90A/B41-367[»]
ProteinModelPortaliP27448.
SMRiP27448.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27448.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 307Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini326 – 365UBAPROSITE-ProRule annotationAdd BLAST40
Domaini704 – 753KA1PROSITE-ProRule annotationAdd BLAST50

Sequence similaritiesi

Contains 1 KA1 (kinase-associated) domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
HOGENOMiHOG000233025.
HOVERGENiHBG052453.
InParanoidiP27448.
KOiK08798.
TreeFamiTF315213.

Family and domain databases

Gene3Di3.30.310.80. 1 hit.
InterProiIPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom.
IPR033624. MARK/par1.
IPR033628. MARK3.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PANTHERiPTHR24346. PTHR24346. 1 hit.
PTHR24346:SF1. PTHR24346:SF1. 1 hit.
PfamiPF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P27448-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ
60 70 80 90 100
PHIGNYRLLK TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL
110 120 130 140 150
FREVRIMKIL NHPNIVKLFE VIETEKTLYL IMEYASGGEV FDYLVAHGRM
160 170 180 190 200
KEKEARSKFR QIVSAVQYCH QKRIVHRDLK AENLLLDADM NIKIADFGFS
210 220 230 240 250
NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG VILYTLVSGS
260 270 280 290 300
LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ
310 320 330 340 350
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS
360 370 380 390 400
KMKYDEITAT YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS
410 420 430 440 450
PHHKVQRSVF SSQKQRRYSD HAGPAIPSVV AYPKRSQTST ADSDLKEDGI
460 470 480 490 500
SSRKSSGSAV GGKGIAPASP MLGNASNPNK ADIPERKKSS TVPSSNTASG
510 520 530 540 550
GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS THSISSAATP
560 570 580 590 600
DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG
610 620 630 640 650
STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN
660 670 680 690 700
KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC
710 720 730 740 750
VHGDGHAENL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE

LKL
Length:753
Mass (Da):84,489
Last modified:July 27, 2011 - v4
Checksum:i0CA50C58A4A49D93
GO
Isoform 2 (identifier: P27448-2) [UniParc]FASTAAdd to basket
Also known as: CTAK75a

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: Q → QGCQAGQTIKVQVSFDLLSLMFTF
     615-638: Missing.

Show »
Length:752
Mass (Da):84,015
Checksum:i0306682A37C313D7
GO
Isoform 3 (identifier: P27448-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-638: Missing.

Show »
Length:729
Mass (Da):81,499
Checksum:i4DF13ABB00F2305D
GO
Isoform 4 (identifier: P27448-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-623: Missing.

Show »
Length:744
Mass (Da):83,308
Checksum:iEDDC40EDF509566E
GO
Isoform 5 (identifier: P27448-6) [UniParc]FASTAAdd to basket
Also known as: p58

The sequence of this isoform differs from the canonical sequence as follows:
     371-386: Missing.
     615-638: Missing.

Show »
Length:713
Mass (Da):79,936
Checksum:i32B5C41C16F5F080
GO
Isoform 6 (identifier: P27448-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: Q → QGCQAGQTIKVQVSFDLLSLMFTF
     371-386: Missing.

Show »
Length:760
Mass (Da):85,441
Checksum:i4CBABE5452A1A22F
GO
Isoform 7 (identifier: P27448-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-257: Missing.
     624-638: Missing.

Note: No experimental confirmation available.
Show »
Length:659
Mass (Da):74,151
Checksum:iBBF32F62ABACEF9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125E → Q in AAA59991 (Ref. 5) Curated1
Sequence conflicti139E → K in AAL69982 (Ref. 4) Curated1
Sequence conflicti139E → K in AAA59991 (Ref. 5) Curated1
Sequence conflicti149R → K in AAD48007 (Ref. 2) Curated1
Sequence conflicti410F → S in AAC15093 (PubMed:9543386).Curated1
Sequence conflicti410F → S in AAD48007 (Ref. 2) Curated1
Sequence conflicti410F → S in AAK82367 (PubMed:11433294).Curated1
Sequence conflicti410F → S in AAL69982 (Ref. 4) Curated1
Sequence conflicti410F → S in AAA59991 (Ref. 5) Curated1
Sequence conflicti410F → S in AAH24773 (PubMed:12508121).Curated1
Sequence conflicti410F → S in AAD51631 (PubMed:15489334).Curated1
Sequence conflicti425A → G in AAA59991 (Ref. 5) Curated1
Sequence conflicti456S → T in AAA59991 (Ref. 5) Curated1
Sequence conflicti516A → D in AAA59991 (Ref. 5) Curated1
Sequence conflicti603N → T in AAA59991 (Ref. 5) Curated1
Sequence conflicti645E → K in AAA59991 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040765429V → A.1 Publication1
Natural variantiVAR_046763443S → G.3 PublicationsCorresponds to variant rs56305318dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041582161Q → QGCQAGQTIKVQVSFDLLSL MFTF in isoform 2 and isoform 6. 2 Publications1
Alternative sequenceiVSP_043197179 – 257Missing in isoform 7. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_004943371 – 386Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_004944615 – 638Missing in isoform 2, isoform 3 and isoform 5. 4 PublicationsAdd BLAST24
Alternative sequenceiVSP_004945615 – 623Missing in isoform 4. 1 Publication9
Alternative sequenceiVSP_043198624 – 638Missing in isoform 7. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64205 mRNA. Translation: AAC15093.1.
AF159295 mRNA. Translation: AAD48007.1.
AF387637 mRNA. Translation: AAK82367.1.
AF465413 mRNA. Translation: AAL69982.1.
M80359 mRNA. Translation: AAA59991.1.
BX161395 mRNA. Translation: CAD61882.1.
AL133367 Genomic DNA. No translation available.
BC024773 mRNA. Translation: AAH24773.1.
AF170723 mRNA. Translation: AAD51631.1.
CCDSiCCDS41993.1. [P27448-3]
CCDS45165.1. [P27448-5]
CCDS45166.1. [P27448-4]
CCDS45167.1. [P27448-8]
CCDS55947.1. [P27448-6]
PIRiS27966.
RefSeqiNP_001122390.2. NM_001128918.2.
NP_001122391.2. NM_001128919.2.
NP_001122392.2. NM_001128920.2.
NP_001122393.2. NM_001128921.2.
NP_002367.5. NM_002376.6.
UniGeneiHs.35828.

Genome annotation databases

EnsembliENST00000303622; ENSP00000303698; ENSG00000075413.
ENST00000553942; ENSP00000450772; ENSG00000075413.
GeneIDi4140.
KEGGihsa:4140.
UCSCiuc001ymw.5. human. [P27448-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64205 mRNA. Translation: AAC15093.1.
AF159295 mRNA. Translation: AAD48007.1.
AF387637 mRNA. Translation: AAK82367.1.
AF465413 mRNA. Translation: AAL69982.1.
M80359 mRNA. Translation: AAA59991.1.
BX161395 mRNA. Translation: CAD61882.1.
AL133367 Genomic DNA. No translation available.
BC024773 mRNA. Translation: AAH24773.1.
AF170723 mRNA. Translation: AAD51631.1.
CCDSiCCDS41993.1. [P27448-3]
CCDS45165.1. [P27448-5]
CCDS45166.1. [P27448-4]
CCDS45167.1. [P27448-8]
CCDS55947.1. [P27448-6]
PIRiS27966.
RefSeqiNP_001122390.2. NM_001128918.2.
NP_001122391.2. NM_001128919.2.
NP_001122392.2. NM_001128920.2.
NP_001122393.2. NM_001128921.2.
NP_002367.5. NM_002376.6.
UniGeneiHs.35828.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QNJX-ray2.70A/B48-370[»]
3FE3X-ray1.90A/B41-367[»]
ProteinModelPortaliP27448.
SMRiP27448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110310. 59 interactors.
DIPiDIP-34637N.
IntActiP27448. 53 interactors.
MINTiMINT-272697.
STRINGi9606.ENSP00000411397.

Chemistry databases

BindingDBiP27448.
ChEMBLiCHEMBL5600.
GuidetoPHARMACOLOGYi2099.

PTM databases

iPTMnetiP27448.
PhosphoSitePlusiP27448.

Polymorphism and mutation databases

BioMutaiMARK3.
DMDMi341941142.

Proteomic databases

EPDiP27448.
PaxDbiP27448.
PeptideAtlasiP27448.
PRIDEiP27448.

Protocols and materials databases

DNASUi4140.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303622; ENSP00000303698; ENSG00000075413.
ENST00000553942; ENSP00000450772; ENSG00000075413.
GeneIDi4140.
KEGGihsa:4140.
UCSCiuc001ymw.5. human. [P27448-5]

Organism-specific databases

CTDi4140.
DisGeNETi4140.
GeneCardsiMARK3.
HGNCiHGNC:6897. MARK3.
HPAiHPA024652.
MIMi602678. gene.
neXtProtiNX_P27448.
PharmGKBiPA30640.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
HOGENOMiHOG000233025.
HOVERGENiHBG052453.
InParanoidiP27448.
KOiK08798.
TreeFamiTF315213.

Enzyme and pathway databases

BioCyciZFISH:HS01177-MONOMER.
ReactomeiR-HSA-5673000. RAF activation.
R-HSA-5674135. MAP2K and MAPK activation.
R-HSA-5675221. Negative regulation of MAPK pathway.
R-HSA-6802946. Signaling by moderate kinase activity BRAF mutants.
R-HSA-6802948. Signaling by high-kinase activity BRAF mutants.
R-HSA-6802949. Signaling by RAS mutants.
R-HSA-6802952. Signaling by BRAF and RAF fusions.
R-HSA-6802955. Paradoxical activation of RAF signaling by kinase inactive BRAF.
SignaLinkiP27448.
SIGNORiP27448.

Miscellaneous databases

ChiTaRSiMARK3. human.
EvolutionaryTraceiP27448.
GeneWikiiMARK3.
GenomeRNAii4140.
PROiP27448.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075413.
CleanExiHS_MARK3.
ExpressionAtlasiP27448. baseline and differential.
GenevisibleiP27448. HS.

Family and domain databases

Gene3Di3.30.310.80. 1 hit.
InterProiIPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom.
IPR033624. MARK/par1.
IPR033628. MARK3.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PANTHERiPTHR24346. PTHR24346. 1 hit.
PTHR24346:SF1. PTHR24346:SF1. 1 hit.
PfamiPF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMARK3_HUMAN
AccessioniPrimary (citable) accession number: P27448
Secondary accession number(s): O60219
, Q86TT8, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 174 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.