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P27448

- MARK3_HUMAN

UniProt

P27448 - MARK3_HUMAN

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Protein
MAP/microtubule affinity-regulating kinase 3
Gene
MARK3, CTAK1, EMK2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851ATP By similarity
Active sitei178 – 1781Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 709ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiP27448.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAP/microtubule affinity-regulating kinase 3 (EC:2.7.11.1)
    Alternative name(s):
    C-TAK1
    Short name:
    cTAK1
    Cdc25C-associated protein kinase 1
    ELKL motif kinase 2
    Short name:
    EMK-2
    Protein kinase STK10
    Ser/Thr protein kinase PAR-1
    Short name:
    Par-1a
    Serine/threonine-protein kinase p78
    Gene namesi
    Name:MARK3
    Synonyms:CTAK1, EMK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:6897. MARK3.

    Subcellular locationi

    Cell membrane; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi211 – 2111T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication

    Organism-specific databases

    PharmGKBiPA30640.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 753753MAP/microtubule affinity-regulating kinase 3
    PRO_0000086304Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei42 – 421Phosphoserine1 Publication
    Modified residuei211 – 2111Phosphothreonine; by LKB11 Publication
    Modified residuei383 – 3831Phosphoserine2 Publications
    Modified residuei400 – 4001Phosphoserine1 Publication
    Modified residuei469 – 4691Phosphoserine3 Publications
    Modified residuei549 – 5491Phosphothreonine2 Publications
    Modified residuei564 – 5641Phosphothreonine; by PKC/PRKCZ By similarity
    Modified residuei598 – 5981Phosphoserine1 Publication
    Modified residuei643 – 6431Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP27448.
    PaxDbiP27448.
    PRIDEiP27448.

    PTM databases

    PhosphoSiteiP27448.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP27448.
    BgeeiP27448.
    CleanExiHS_MARK3.
    GenevestigatoriP27448.

    Organism-specific databases

    HPAiHPA024652.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ASB13Q8WXK32EBI-707595,EBI-707573
    Ppm1lQ8BHN03EBI-707595,EBI-7970002From a different organism.
    SFNP319472EBI-707595,EBI-476295
    TCEA2Q155602EBI-707595,EBI-710310
    YWHABP319464EBI-707595,EBI-359815
    YWHAGP619812EBI-707595,EBI-359832
    YWHAHQ049174EBI-707595,EBI-306940
    YWHAZP631049EBI-707595,EBI-347088

    Protein-protein interaction databases

    BioGridi110310. 33 interactions.
    DIPiDIP-34637N.
    IntActiP27448. 38 interactions.
    MINTiMINT-272697.
    STRINGi9606.ENSP00000411397.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi56 – 649
    Beta strandi66 – 7510
    Turni76 – 783
    Beta strandi81 – 888
    Helixi89 – 913
    Helixi94 – 10916
    Beta strandi118 – 1236
    Beta strandi125 – 1328
    Helixi140 – 1478
    Helixi152 – 17120
    Helixi181 – 1833
    Beta strandi184 – 1863
    Beta strandi192 – 1943
    Helixi201 – 2033
    Beta strandi204 – 2063
    Helixi208 – 2103
    Beta strandi213 – 2153
    Helixi216 – 2183
    Helixi221 – 2255
    Helixi232 – 24817
    Helixi258 – 26710
    Helixi278 – 28710
    Turni292 – 2943
    Helixi298 – 3014
    Turni305 – 3106
    Helixi329 – 3379
    Helixi342 – 3509
    Helixi356 – 3649

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QNJX-ray2.70A/B48-370[»]
    3FE3X-ray1.90A/B41-367[»]
    ProteinModelPortaliP27448.
    SMRiP27448. Positions 18-366, 657-753.

    Miscellaneous databases

    EvolutionaryTraceiP27448.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 307252Protein kinase
    Add
    BLAST
    Domaini326 – 36540UBA
    Add
    BLAST
    Domaini704 – 75350KA1
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 UBA domain.

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233025.
    HOVERGENiHBG052453.
    InParanoidiP27448.
    KOiK08798.
    TreeFamiTF315213.

    Family and domain databases

    Gene3Di3.30.310.80. 1 hit.
    InterProiIPR028375. KA1/Ssp2_C.
    IPR001772. KA1_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view]
    PfamiPF02149. KA1. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view]
    SUPFAMiSSF103243. SSF103243. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50032. KA1. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P27448-5) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ    50
    PHIGNYRLLK TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL 100
    FREVRIMKIL NHPNIVKLFE VIETEKTLYL IMEYASGGEV FDYLVAHGRM 150
    KEKEARSKFR QIVSAVQYCH QKRIVHRDLK AENLLLDADM NIKIADFGFS 200
    NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG VILYTLVSGS 250
    LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300
    IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS 350
    KMKYDEITAT YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS 400
    PHHKVQRSVF SSQKQRRYSD HAGPAIPSVV AYPKRSQTST ADSDLKEDGI 450
    SSRKSSGSAV GGKGIAPASP MLGNASNPNK ADIPERKKSS TVPSSNTASG 500
    GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS THSISSAATP 550
    DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 600
    STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN 650
    KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC 700
    VHGDGHAENL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE 750
    LKL 753
    Length:753
    Mass (Da):84,489
    Last modified:July 27, 2011 - v4
    Checksum:i0CA50C58A4A49D93
    GO
    Isoform 2 (identifier: P27448-2) [UniParc]FASTAAdd to Basket

    Also known as: CTAK75a

    The sequence of this isoform differs from the canonical sequence as follows:
         161-161: Q → QGCQAGQTIKVQVSFDLLSLMFTF
         615-638: Missing.

    Show »
    Length:752
    Mass (Da):84,015
    Checksum:i0306682A37C313D7
    GO
    Isoform 3 (identifier: P27448-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         615-638: Missing.

    Show »
    Length:729
    Mass (Da):81,499
    Checksum:i4DF13ABB00F2305D
    GO
    Isoform 4 (identifier: P27448-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         615-623: Missing.

    Show »
    Length:744
    Mass (Da):83,308
    Checksum:iEDDC40EDF509566E
    GO
    Isoform 5 (identifier: P27448-6) [UniParc]FASTAAdd to Basket

    Also known as: p58

    The sequence of this isoform differs from the canonical sequence as follows:
         371-386: Missing.
         615-638: Missing.

    Note: Contains a phosphoserine at position 384.

    Show »
    Length:713
    Mass (Da):79,936
    Checksum:i32B5C41C16F5F080
    GO
    Isoform 6 (identifier: P27448-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         161-161: Q → QGCQAGQTIKVQVSFDLLSLMFTF
         371-386: Missing.

    Note: Contains a phosphoserine at position 407.

    Show »
    Length:760
    Mass (Da):85,441
    Checksum:i4CBABE5452A1A22F
    GO
    Isoform 7 (identifier: P27448-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         179-257: Missing.
         624-638: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:659
    Mass (Da):74,151
    Checksum:iBBF32F62ABACEF9B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti429 – 4291V → A.1 Publication
    VAR_040765
    Natural varianti443 – 4431S → G.3 Publications
    Corresponds to variant rs56305318 [ dbSNP | Ensembl ].
    VAR_046763

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei161 – 1611Q → QGCQAGQTIKVQVSFDLLSL MFTF in isoform 2 and isoform 6.
    VSP_041582
    Alternative sequencei179 – 25779Missing in isoform 7.
    VSP_043197Add
    BLAST
    Alternative sequencei371 – 38616Missing in isoform 5 and isoform 6.
    VSP_004943Add
    BLAST
    Alternative sequencei615 – 63824Missing in isoform 2, isoform 3 and isoform 5.
    VSP_004944Add
    BLAST
    Alternative sequencei615 – 6239Missing in isoform 4.
    VSP_004945
    Alternative sequencei624 – 63815Missing in isoform 7.
    VSP_043198Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti125 – 1251E → Q in AAA59991. 1 Publication
    Sequence conflicti139 – 1391E → K in AAL69982. 1 Publication
    Sequence conflicti139 – 1391E → K in AAA59991. 1 Publication
    Sequence conflicti149 – 1491R → K in AAD48007. 1 Publication
    Sequence conflicti410 – 4101F → S in AAC15093. 1 Publication
    Sequence conflicti410 – 4101F → S in AAD48007. 1 Publication
    Sequence conflicti410 – 4101F → S in AAK82367. 1 Publication
    Sequence conflicti410 – 4101F → S in AAL69982. 1 Publication
    Sequence conflicti410 – 4101F → S in AAA59991. 1 Publication
    Sequence conflicti410 – 4101F → S in AAH24773. 1 Publication
    Sequence conflicti410 – 4101F → S in AAD51631. 1 Publication
    Sequence conflicti425 – 4251A → G in AAA59991. 1 Publication
    Sequence conflicti456 – 4561S → T in AAA59991. 1 Publication
    Sequence conflicti516 – 5161A → D in AAA59991. 1 Publication
    Sequence conflicti603 – 6031N → T in AAA59991. 1 Publication
    Sequence conflicti645 – 6451E → K in AAA59991. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64205 mRNA. Translation: AAC15093.1.
    AF159295 mRNA. Translation: AAD48007.1.
    AF387637 mRNA. Translation: AAK82367.1.
    AF465413 mRNA. Translation: AAL69982.1.
    M80359 mRNA. Translation: AAA59991.1.
    BX161395 mRNA. Translation: CAD61882.1.
    AL133367 Genomic DNA. No translation available.
    BC024773 mRNA. Translation: AAH24773.1.
    AF170723 mRNA. Translation: AAD51631.1.
    CCDSiCCDS41993.1. [P27448-3]
    CCDS45165.1. [P27448-5]
    CCDS45166.1. [P27448-4]
    CCDS45167.1. [P27448-8]
    CCDS55947.1. [P27448-6]
    PIRiS27966.
    RefSeqiNP_001122390.1. NM_001128918.1. [P27448-5]
    NP_001122391.1. NM_001128919.1. [P27448-4]
    NP_001122392.1. NM_001128920.1. [P27448-6]
    NP_001122393.1. NM_001128921.1. [P27448-8]
    NP_002367.4. NM_002376.5. [P27448-3]
    UniGeneiHs.35828.

    Genome annotation databases

    EnsembliENST00000216288; ENSP00000216288; ENSG00000075413. [P27448-6]
    ENST00000303622; ENSP00000303698; ENSG00000075413. [P27448-3]
    ENST00000416682; ENSP00000408092; ENSG00000075413. [P27448-2]
    ENST00000429436; ENSP00000411397; ENSG00000075413. [P27448-5]
    ENST00000440884; ENSP00000402104; ENSG00000075413. [P27448-8]
    ENST00000553942; ENSP00000450772; ENSG00000075413. [P27448-4]
    GeneIDi4140.
    KEGGihsa:4140.
    UCSCiuc001ymw.4. human. [P27448-3]
    uc001ymx.4. human. [P27448-4]
    uc001ymy.4. human. [P27448-8]
    uc001ymz.4. human. [P27448-5]
    uc001yna.4. human. [P27448-6]
    uc010awp.3. human. [P27448-2]
    uc010tyb.2. human. [P27448-7]

    Polymorphism databases

    DMDMi341941142.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64205 mRNA. Translation: AAC15093.1 .
    AF159295 mRNA. Translation: AAD48007.1 .
    AF387637 mRNA. Translation: AAK82367.1 .
    AF465413 mRNA. Translation: AAL69982.1 .
    M80359 mRNA. Translation: AAA59991.1 .
    BX161395 mRNA. Translation: CAD61882.1 .
    AL133367 Genomic DNA. No translation available.
    BC024773 mRNA. Translation: AAH24773.1 .
    AF170723 mRNA. Translation: AAD51631.1 .
    CCDSi CCDS41993.1. [P27448-3 ]
    CCDS45165.1. [P27448-5 ]
    CCDS45166.1. [P27448-4 ]
    CCDS45167.1. [P27448-8 ]
    CCDS55947.1. [P27448-6 ]
    PIRi S27966.
    RefSeqi NP_001122390.1. NM_001128918.1. [P27448-5 ]
    NP_001122391.1. NM_001128919.1. [P27448-4 ]
    NP_001122392.1. NM_001128920.1. [P27448-6 ]
    NP_001122393.1. NM_001128921.1. [P27448-8 ]
    NP_002367.4. NM_002376.5. [P27448-3 ]
    UniGenei Hs.35828.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QNJ X-ray 2.70 A/B 48-370 [» ]
    3FE3 X-ray 1.90 A/B 41-367 [» ]
    ProteinModelPortali P27448.
    SMRi P27448. Positions 18-366, 657-753.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 110310. 33 interactions.
    DIPi DIP-34637N.
    IntActi P27448. 38 interactions.
    MINTi MINT-272697.
    STRINGi 9606.ENSP00000411397.

    Chemistry

    ChEMBLi CHEMBL5600.
    GuidetoPHARMACOLOGYi 2099.

    PTM databases

    PhosphoSitei P27448.

    Polymorphism databases

    DMDMi 341941142.

    Proteomic databases

    MaxQBi P27448.
    PaxDbi P27448.
    PRIDEi P27448.

    Protocols and materials databases

    DNASUi 4140.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216288 ; ENSP00000216288 ; ENSG00000075413 . [P27448-6 ]
    ENST00000303622 ; ENSP00000303698 ; ENSG00000075413 . [P27448-3 ]
    ENST00000416682 ; ENSP00000408092 ; ENSG00000075413 . [P27448-2 ]
    ENST00000429436 ; ENSP00000411397 ; ENSG00000075413 . [P27448-5 ]
    ENST00000440884 ; ENSP00000402104 ; ENSG00000075413 . [P27448-8 ]
    ENST00000553942 ; ENSP00000450772 ; ENSG00000075413 . [P27448-4 ]
    GeneIDi 4140.
    KEGGi hsa:4140.
    UCSCi uc001ymw.4. human. [P27448-3 ]
    uc001ymx.4. human. [P27448-4 ]
    uc001ymy.4. human. [P27448-8 ]
    uc001ymz.4. human. [P27448-5 ]
    uc001yna.4. human. [P27448-6 ]
    uc010awp.3. human. [P27448-2 ]
    uc010tyb.2. human. [P27448-7 ]

    Organism-specific databases

    CTDi 4140.
    GeneCardsi GC14P103851.
    HGNCi HGNC:6897. MARK3.
    HPAi HPA024652.
    MIMi 602678. gene.
    neXtProti NX_P27448.
    PharmGKBi PA30640.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233025.
    HOVERGENi HBG052453.
    InParanoidi P27448.
    KOi K08798.
    TreeFami TF315213.

    Enzyme and pathway databases

    SignaLinki P27448.

    Miscellaneous databases

    ChiTaRSi MARK3. human.
    EvolutionaryTracei P27448.
    GeneWikii MARK3.
    GenomeRNAii 4140.
    NextBioi 16260.
    PROi P27448.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P27448.
    Bgeei P27448.
    CleanExi HS_MARK3.
    Genevestigatori P27448.

    Family and domain databases

    Gene3Di 3.30.310.80. 1 hit.
    InterProi IPR028375. KA1/Ssp2_C.
    IPR001772. KA1_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view ]
    Pfami PF02149. KA1. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103243. SSF103243. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50032. KA1. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding."
      Peng C.Y., Graves P.R., Ogg S., Thoma R.S., Byrnes M.J. III, Wu Z., Stephenson M.T., Piwnica-Worms H.
      Cell Growth Differ. 9:197-208(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT GLY-443.
      Tissue: Cervix carcinoma.
    2. "Human serine/threonine protein kinase cTAK1/Kp78/Mark3: Identification of a novel splice variant and a larger 5'UTR."
      Waggoner S.N., Stephen R., Farrar W.L., Howard O.M.Z.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLY-443.
      Tissue: Monocyte.
    3. "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling."
      Sun T.-Q., Lu B., Feng J.-J., Reinhard C., Jan Y.N., Fantl W.J., Williams L.T.
      Nat. Cell Biol. 3:628-636(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    4. "Characterization of an alternatively spliced form of MARK3 from human brain."
      Drewes G.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. Maheshwari K.K., Som S., Parsa I.
      Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
      Tissue: Pancreas.
    6. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Neuroblastoma.
    7. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Cervix.
    9. "Homo sapiens mRNA partial sequence for a protein kinase, STK10, similar to p78/C-TAK1."
      Reynolds C.H., Patel U.A., Anderton B.H.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-752 (ISOFORM 6).
      Tissue: Urinary bladder.
    10. "Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity."
      Hurov J.B., Watkins J.L., Piwnica-Worms H.
      Curr. Biol. 14:736-741(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-564.
    11. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."
      Lizcano J.M., Goeransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Maekelae T.P., Hardie D.G., Alessi D.R.
      EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, PHOSPHORYLATION AT THR-211, MUTAGENESIS OF THR-211.
    12. "New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases."
      Dequiedt F., Martin M., Von Blume J., Vertommen D., Lecomte E., Mari N., Heinen M.F., Bachmann M., Twizere J.C., Huang M.C., Rider M.H., Piwnica-Worms H., Seufferlein T., Kettmann R.
      Mol. Cell. Biol. 26:7086-7102(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-549, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-400; SER-469; THR-549; SER-598 AND SER-643, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384 (ISOFORM 5), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407 (ISOFORM 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-383; SER-469 AND SER-643, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    19. "Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids."
      Moravcevic K., Mendrola J.M., Schmitz K.R., Wang Y.H., Slochower D., Janmey P.A., Lemmon M.A.
      Cell 143:966-977(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-429 AND GLY-443.

    Entry informationi

    Entry nameiMARK3_HUMAN
    AccessioniPrimary (citable) accession number: P27448
    Secondary accession number(s): O60219
    , Q86TT8, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: July 27, 2011
    Last modified: July 9, 2014
    This is version 150 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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