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P27447 (YES_XIPHE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase Yes
EC=2.7.10.2
Alternative name(s):
p61-Yes
Gene names
Name:yes
OrganismXiphophorus helleri (Green swordtail)
Taxonomic identifier8084 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Atherinomorpha › Cyprinodontiformes › Poeciliidae › Poeciliinae › Xiphophorus

Protein attributes

Sequence length544 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 544543Tyrosine-protein kinase Yes
PRO_0000088185

Regions

Domain92 – 15362SH3
Domain159 – 25698SH2
Domain278 – 531254Protein kinase
Nucleotide binding284 – 2929ATP By similarity

Sites

Active site3971Proton acceptor By similarity
Binding site3061ATP By similarity

Amino acid modifications

Modified residue4271Phosphotyrosine; by autocatalysis By similarity
Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
P27447 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 7D41818B3E7086EF

FASTA54461,289
        10         20         30         40         50         60 
MGCVRSKEAK GPALKYQPDN SNVVPVSAHL GHYGPEPTIM GQSPAMKTQN NSHPTALSPF 

        70         80         90        100        110        120 
GGVSSPMTPF GGASTSFTSV TVNNPFPAVI TGGVTFFVAL YDYEARTSDD LSFRKGDRFQ 

       130        140        150        160        170        180 
IINNTEGDWW EARSINTGEN GYIPSNYVAP ADSIQSEEWY FGKLSRKDTE RLLLLPGNER 

       190        200        210        220        230        240 
GTFLIRESET TKGAYSLSLR DWDETKGDNC KHYKIRKLDN GGYYITTRTQ FMSLQMLVKH 

       250        260        270        280        290        300 
YTEHVDGLCY KLTTVCPQVK PQTQGIAKDA WEIPRESLRL DVRLGQGCFG EVWMGTWNGT 

       310        320        330        340        350        360 
TKVAIKTLKP GTMSPEAFLE EAQIMKKLRH DKLVPLYAVV SEEPIYIVTE FMGKGSLLDF 

       370        380        390        400        410        420 
LKEGDGKHLK LPQLVDMASQ IADGMAFIER MNYIHRDLRA ANILVADNLV CKIADFGLAR 

       430        440        450        460        470        480 
LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELVTKG RVPYPGMVNR 

       490        500        510        520        530        540 
EVLEQVDRGY RMPCPQGCPE SLHEMMRQCW KKEPDERPTF EYIQSFLEDY FTATEPQYQP 


GDNL

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References

[1]"Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates."
Hannig G., Ottilie S., Schartl M.
Oncogene 6:361-369(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Rio Lancetilla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X54970 mRNA. Translation: CAA38714.1.
PIRI51593.

3D structure databases

ProteinModelPortalP27447.
SMRP27447. Positions 94-544.
ModBaseSearch...

Proteomic databases

PRIDEP27447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG008761.

Enzyme and pathway databases

BRENDA2.7.10.2. 6732.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
SSF50044. SH3. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYES_XIPHE
AccessionPrimary (citable) accession number: P27447
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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