Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase Yes

Gene

yes

Organism
Xiphophorus helleri (Green swordtail)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei306ATPPROSITE-ProRule annotation1
Active sitei397Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi284 – 292ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6732.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Yes (EC:2.7.10.2)
Alternative name(s):
p61-Yes
Gene namesi
Name:yes
OrganismiXiphophorus helleri (Green swordtail)
Taxonomic identifieri8084 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaeXiphophorus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000881852 – 544Tyrosine-protein kinase YesAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei427Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PRIDEiP27447.

Structurei

3D structure databases

ProteinModelPortaliP27447.
SMRiP27447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 153SH3PROSITE-ProRule annotationAdd BLAST62
Domaini159 – 256SH2PROSITE-ProRule annotationAdd BLAST98
Domaini278 – 531Protein kinasePROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR035025. Yes1.
PANTHERiPTHR24418:SF315. PTHR24418:SF315. 1 hit.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVRSKEAK GPALKYQPDN SNVVPVSAHL GHYGPEPTIM GQSPAMKTQN
60 70 80 90 100
NSHPTALSPF GGVSSPMTPF GGASTSFTSV TVNNPFPAVI TGGVTFFVAL
110 120 130 140 150
YDYEARTSDD LSFRKGDRFQ IINNTEGDWW EARSINTGEN GYIPSNYVAP
160 170 180 190 200
ADSIQSEEWY FGKLSRKDTE RLLLLPGNER GTFLIRESET TKGAYSLSLR
210 220 230 240 250
DWDETKGDNC KHYKIRKLDN GGYYITTRTQ FMSLQMLVKH YTEHVDGLCY
260 270 280 290 300
KLTTVCPQVK PQTQGIAKDA WEIPRESLRL DVRLGQGCFG EVWMGTWNGT
310 320 330 340 350
TKVAIKTLKP GTMSPEAFLE EAQIMKKLRH DKLVPLYAVV SEEPIYIVTE
360 370 380 390 400
FMGKGSLLDF LKEGDGKHLK LPQLVDMASQ IADGMAFIER MNYIHRDLRA
410 420 430 440 450
ANILVADNLV CKIADFGLAR LIEDNEYTAR QGAKFPIKWT APEAALYGRF
460 470 480 490 500
TIKSDVWSFG ILLTELVTKG RVPYPGMVNR EVLEQVDRGY RMPCPQGCPE
510 520 530 540
SLHEMMRQCW KKEPDERPTF EYIQSFLEDY FTATEPQYQP GDNL
Length:544
Mass (Da):61,289
Last modified:January 23, 2007 - v3
Checksum:i7D41818B3E7086EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54970 mRNA. Translation: CAA38714.1.
PIRiI51593.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiYES_XIPHE
AccessioniPrimary (citable) accession number: P27447
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families