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Protein

Cytoskeleton protein RodZ

Gene

rodZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 49H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • regulation of cell shape Source: EcoCyc

Keywordsi

Molecular functionDNA-binding
Biological processCell shape

Enzyme and pathway databases

BioCyciEcoCyc:EG10015-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoskeleton protein RodZ
Gene namesi
Name:rodZ
Synonyms:yfgA
Ordered Locus Names:b2516, JW2500
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10015 yfgA

Subcellular locationi

  • Cell inner membrane 1 Publication; Single-pass type II membrane protein 1 Publication
  • Note: Forms helical filaments along the long axis of the cell.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 111CytoplasmicSequence analysisAdd BLAST111
Transmembranei112 – 132Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini133 – 337PeriplasmicSequence analysisAdd BLAST205

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Affects the lengths of both the long and short axes of the cell, but especially the long axis. Cells become shorter and fatter and form round or oval shapes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001497611 – 337Cytoskeleton protein RodZAdd BLAST337

Proteomic databases

EPDiP27434
PaxDbiP27434
PRIDEiP27434

Interactioni

Protein-protein interaction databases

BioGridi4261301, 535 interactors
DIPiDIP-12034N
IntActiP27434, 12 interactors
MINTiP27434
STRINGi316385.ECDH10B_2682

Structurei

3D structure databases

ProteinModelPortaliP27434
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 71HTH cro/C1-typeAdd BLAST53

Domaini

The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein-protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm.

Sequence similaritiesi

Belongs to the RodZ family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105HSZ Bacteria
COG1426 LUCA
HOGENOMiHOG000276142
InParanoidiP27434
KOiK15539
OMAiADCWTQV

Family and domain databases

CDDicd00093 HTH_XRE, 1 hit
HAMAPiMF_02017 RodZ, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR025194 DUF4115
IPR010982 Lambda_DNA-bd_dom_sf
IPR023690 RodZ
PfamiView protein in Pfam
PF13464 DUF4115, 1 hit
SMARTiView protein in SMART
SM00530 HTH_XRE, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS50943 HTH_CROC1, 1 hit

Sequencei

Sequence statusi: Complete.

P27434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTEATHDQN EALTTGARLR NAREQLGLSQ QAVAERLCLK VSTVRDIEED
60 70 80 90 100
KAPADLASTF LRGYIRSYAR LVHIPEEELL PGLEKQAPLR AAKVAPMQSF
110 120 130 140 150
SLGKRRKKRD GWLMTFTWLV LFVVIGLSGA WWWQDRKAQQ EEITTMADQS
160 170 180 190 200
SAELSSNSEQ GQSVPLNTST TTDPATTSTP PASVDTTATN TQTPAVTAPA
210 220 230 240 250
PAVDPQQNAV VSPSQANVDT AATPAPTAAT TPDGAAPLPT DQAGVTTPVA
260 270 280 290 300
DPNALVMNFT ADCWLEVTDA TGKKLFSGMQ RKDGNLNLTG QAPYKLKIGA
310 320 330
PAAVQIQYQG KPVDLSRFIR TNQVARLTLN AEQSPAQ
Length:337
Mass (Da):36,192
Last modified:June 1, 1994 - v2
Checksum:i67F90B10319F61C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27G → E in BAA04685 (PubMed:7764507).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75569.1
AP009048 Genomic DNA Translation: BAA16403.1
U02965 Genomic DNA Translation: AAA21360.1
U83188 Genomic DNA Translation: AAB40289.1
X64451 Genomic DNA Translation: CAA45782.1
D21149 Genomic DNA Translation: BAA04685.1
PIRiC65028
RefSeqiNP_417011.1, NC_000913.3
WP_001090866.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75569; AAC75569; b2516
BAA16403; BAA16403; BAA16403
GeneIDi946992
KEGGiecj:JW2500
eco:b2516
PATRICifig|1411691.4.peg.4220

Similar proteinsi

Entry informationi

Entry nameiRODZ_ECOLI
AccessioniPrimary (citable) accession number: P27434
Secondary accession number(s): P76987, P77137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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