P27423 (VP7_ROTPK) Reviewed, UniProtKB/Swiss-Prot
Last modified October 16, 2013. Version 63. History...
Names and origin
|Sequence length||326 AA.|
|Sequence processing||The displayed sequence is further processed into a mature form.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Major outer capsid protein, which forms the smooth surface of the virus. Responsible for the calcium-dependent uncoating of the virus during cell entry. The rotavirus outer capsid probably assembles from calcium-dependent VP7 trimers By similarity.
Homotrimer; in the presence of calcium By similarity.
Virion By similarity. Host endoplasmic reticulum lumen Potential. Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.
N-glycosylated By similarity.
Intramolecular disulfide bonds By similarity.
Belongs to the rotavirus VP7 family.
|Cellular component||Host endoplasmic reticulum|
|Coding sequence diversity||Alternative initiation|
|Molecular function||Capsid protein|
Outer capsid protein
T=13 icosahedral capsid protein
|Gene Ontology (GO)|
|Cellular_component||T=13 icosahedral viral capsid|
Inferred from electronic annotation. Source: UniProtKB-KWhost cell endoplasmic reticulum lumen
Inferred from electronic annotation. Source: UniProtKB-SubCellviral outer capsid
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
|This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]|
|Isoform 1 (identifier: P27423-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
|Isoform 2 (identifier: P27423-2) |
The sequence of this isoform differs from the canonical sequence as follows:
|Note: Produced by alternative initiation at Met-30 of isoform 1. No experimental confirmation available.|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Signal peptide||1 – 50||50||Potential|
|Chain||51 – 326||276||Outer capsid glycoprotein VP7||PRO_0000149618|
Amino acid modifications
|Glycosylation||69||1||N-linked (GlcNAc...); by host Potential|
|Glycosylation||211||1||N-linked (GlcNAc...); by host Potential|
|Alternative sequence||1 – 29||29||Missing in isoform 2.||VSP_038639|
|X58439 mRNA. Translation: CAA41345.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR001963. VP7. |
|Pfam||PF00434. VP7. 1 hit. |
|ProDom||PD000191. VP7. 1 hit. |
[Graphical view] [Entries sharing at least one domain]
|Accession||Primary (citable) accession number: P27423|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families