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P27423

- VP7_ROTPK

UniProt

P27423 - VP7_ROTPK

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Protein
Outer capsid glycoprotein VP7
Gene
N/A
Organism
Rotavirus A (strain Pig/Russia/K/1987) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Major outer capsid protein, which forms the smooth surface of the virus. Responsible for the calcium-dependent uncoating of the virus during cell entry. The rotavirus outer capsid probably assembles from calcium-dependent VP7 trimers By similarity.

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid glycoprotein VP7
OrganismiRotavirus A (strain Pig/Russia/K/1987) (RV-A)
Taxonomic identifieri10918 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

Virion By similarity. Host endoplasmic reticulum lumen Reviewed prediction
Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.

GO - Cellular componenti

  1. T=13 icosahedral viral capsid Source: UniProtKB-KW
  2. host cell endoplasmic reticulum lumen Source: UniProtKB-SubCell
  3. viral outer capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host endoplasmic reticulum, Outer capsid protein, T=13 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050 Reviewed prediction
Add
BLAST
Chaini51 – 326276Outer capsid glycoprotein VP7
PRO_0000149618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi211 – 2111N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.
Intramolecular disulfide bonds By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer; in the presence of calcium By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP7 family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001963. VP7.
[Graphical view]
PfamiPF00434. VP7. 1 hit.
[Graphical view]
ProDomiPD000191. VP7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: P27423-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYGIEYTTVL FYLISFILVS YILKTITKIM DYLIYRITFI IVVLSMLSNA    50
QNYGINLPIT GSMDIAYANS TQNDNFLSST LCLYYPTEAS TQISDNEWKD 100
TLSQLFLTKG WPTGSVYFNE YSNVLEFSID PKLYCDYNIV LIRFTSGEEL 150
DISELADLIL NEWLCNPMDI TLYYYQQTGE ANKWISMGSS CTVKVCPLNT 200
QTLGIGCQTT NATTFETVAD REKLAIVDVV DGVNHKLDVT STTCTIRNCN 250
KLGPRENVAI IQVGGSNILD ITADPTTSPQ TERMMRVNWK KWWQVFYTVV 300
DYINQIVQVM SKRSRSLDSS SFYYRV 326
Length:326
Mass (Da):37,192
Last modified:August 1, 1992 - v1
Checksum:i87D0B9CF3DB860EA
GO
Isoform 2 (identifier: P27423-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: Produced by alternative initiation at Met-30 of isoform 1. No experimental confirmation available.

Show »
Length:297
Mass (Da):33,762
Checksum:i9AAB5B9ACB5E9B95
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform 2.
VSP_038639Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58439 mRNA. Translation: CAA41345.1.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58439 mRNA. Translation: CAA41345.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001963. VP7.
[Graphical view ]
Pfami PF00434. VP7. 1 hit.
[Graphical view ]
ProDomi PD000191. VP7. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVP7_ROTPK
AccessioniPrimary (citable) accession number: P27423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 16, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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