Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P27423 (VP7_ROTPK) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer capsid glycoprotein VP7
OrganismRotavirus A (strain Pig/Russia/K/1987) (RV-A)
Taxonomic identifier10918 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Major outer capsid protein, which forms the smooth surface of the virus. Responsible for the calcium-dependent uncoating of the virus during cell entry. The rotavirus outer capsid probably assembles from calcium-dependent VP7 trimers By similarity.

Subunit structure

Homotrimer; in the presence of calcium By similarity.

Subcellular location

Virion By similarity. Host endoplasmic reticulum lumen Potential. Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.

Post-translational modification

N-glycosylated By similarity.

Intramolecular disulfide bonds By similarity.

Sequence similarities

Belongs to the rotavirus VP7 family.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform 1 (identifier: P27423-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P27423-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
Note: Produced by alternative initiation at Met-30 of isoform 1. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5050 Potential
Chain51 – 326276Outer capsid glycoprotein VP7
PRO_0000149618

Amino acid modifications

Glycosylation691N-linked (GlcNAc...); by host Potential
Glycosylation2111N-linked (GlcNAc...); by host Potential

Natural variations

Alternative sequence1 – 2929Missing in isoform 2.
VSP_038639

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 87D0B9CF3DB860EA

FASTA32637,192
        10         20         30         40         50         60 
MYGIEYTTVL FYLISFILVS YILKTITKIM DYLIYRITFI IVVLSMLSNA QNYGINLPIT 

        70         80         90        100        110        120 
GSMDIAYANS TQNDNFLSST LCLYYPTEAS TQISDNEWKD TLSQLFLTKG WPTGSVYFNE 

       130        140        150        160        170        180 
YSNVLEFSID PKLYCDYNIV LIRFTSGEEL DISELADLIL NEWLCNPMDI TLYYYQQTGE 

       190        200        210        220        230        240 
ANKWISMGSS CTVKVCPLNT QTLGIGCQTT NATTFETVAD REKLAIVDVV DGVNHKLDVT 

       250        260        270        280        290        300 
STTCTIRNCN KLGPRENVAI IQVGGSNILD ITADPTTSPQ TERMMRVNWK KWWQVFYTVV 

       310        320 
DYINQIVQVM SKRSRSLDSS SFYYRV 

« Hide

Isoform 2 [UniParc].

Checksum: 9AAB5B9ACB5E9B95
Show »

FASTA29733,762

References

[1]"Nucleotide sequence of the cDNA for porcine rotavirus VP7 gene (strain K)."
Akopian T.A., Lunin V.G., Kruglyak V.A., Ruchadze G.G., Bakhutashvili V.I., Naroditsky B.S., Tikhonenko T.I.
Virus Genes 6:393-396(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58439 mRNA. Translation: CAA41345.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001963. VP7.
[Graphical view]
PfamPF00434. VP7. 1 hit.
[Graphical view]
ProDomPD000191. VP7. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameVP7_ROTPK
AccessionPrimary (citable) accession number: P27423
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 16, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families