Reviewed,
UniProtKB/Swiss-Prot P27422 (DYR7_ECOLX)
Last modified
June 16, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydrofolate reductase type 7 EC=1.5.1.3 Alternative name(s): Dihydrofolate reductase type VII | ||
| Gene names |
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| Encoded on | Plasmid pLMO27 Ref.1 Plasmid IncP-beta R751 Ref.2 Plasmid pDGO100 Ref.3 | ||
| Organism | Escherichia coli | ||
| Taxonomic identifier | 562 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 157 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH. |
| Pathway | Cofactor biosynthesis; tetrahydrofolate biosynthesis; tetrahydrofolate from dihydrofolate: step 1/1. |
| Subunit structure | Homodimer By similarity. |
| Miscellaneous | The reaction catalyzed by this enzyme represents an essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP. |
| Sequence similarities | Belongs to the dihydrofolate reductase family. Contains 1 DHFR (dihydrofolate reductase) domain. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "Characterization of transposon Tn5086, carrying the site-specifically inserted gene dhfrVII mediating trimethoprim resistance." Sundstroem L., Swedberg G., Skoeld O. J. Bacteriol. 175:1796-1805(1993) [PubMed: 8383666] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Transposon: Tn5086. |
| [2] | "Transposon Tn5090 of plasmid R751, which carries an integron, is related to Tn7, Mu, and the retroelements." Raadstroem P., Skoeld O., Swedberg G., Flensburg J., Roy P.H., Sundstroem L. J. Bacteriol. 176:3257-3268(1994) [PubMed: 8195081] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Transposon: Tn5090. |
| [3] | "Plasmid pDGO100 contains a second integron with the trimethoprim resistance gene dfrA7 as the inserted cassette." Burnside J.M., Groot Obbink D.J. Plasmid 35:67-70(1996) [PubMed: 8693029] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: VA292. |
Cross-references
Sequence databases | |
|---|---|
| X58425 Genomic DNA. Translation: CAA41326.1. U31119 Genomic DNA. Translation: AAB18756.1. | |
| PIR | A47087. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DRA based on UniProtKB P00379. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.3. 246. |
Family and domain databases | |
| InterPro | IPR012259. DHFR. IPR001796. DHFR_reg. IPR017925. Dihydrofolate_reductase_CS. [Graphical view] |
| PANTHER | PTHR11549:SF1. DHFR. 1 hit. |
| Pfam | PF00186. DHFR_1. 1 hit. [Graphical view] |
| PRINTS | PR00070. DHFR. |
| PROSITE | PS00075. DHFR_1. 1 hit. PS51330. DHFR_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DYR7_ECOLX | ||||||||
| Accession | Primary (citable) accession number: P27422 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


