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P27420

- HSP7C_CAEEL

UniProt

P27420 - HSP7C_CAEEL

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Protein
Heat shock 70 kDa protein C
Gene
hsp-3, hsp70c, C15H9.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: WormBase

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. endoplasmic reticulum unfolded protein response Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_34502. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein C
Gene namesi
Name:hsp-3
Synonyms:hsp70c
ORF Names:C15H9.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC15H9.6a; CE08177; WBGene00002007; hsp-3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum chaperone complex Source: WormBase
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 661644Heat shock 70 kDa protein C
PRO_0000013541Add
BLAST

Proteomic databases

PaxDbiP27420.
PRIDEiP27420.

2D gel databases

World-2DPAGE0020:P27420.

Interactioni

Protein-protein interaction databases

BioGridi45812. 1 interaction.
IntActiP27420. 2 interactions.
MINTiMINT-213796.
STRINGi6239.C15H9.6.2.

Structurei

3D structure databases

ProteinModelPortaliP27420.
SMRiP27420. Positions 33-641.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi658 – 6614Prevents secretion from ER

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
GeneTreeiENSGT00750000117237.
HOGENOMiHOG000228135.
InParanoidiP27420.
KOiK09490.
OMAiDKRAVQK.
PhylomeDBiP27420.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27420-1 [UniParc]FASTAAdd to Basket

« Hide

MKTLFLLGLI ALSAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY    50
KNGRVEIIAN DQGNRITPSY VAFSGDQGDR LIGDAAKNQL TINPENTIFD 100
AKRLIGRDYN DKTVQADIKH WPFKVIDKSN KPSVEVKVGS DNKQFTPEEV 150
SAMVLVKMKE IAESYLGKEV KNAVVTVPAY FNDAQRQATK DAGTIAGLNV 200
VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML TIDNGVFEVL 250
ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA 300
KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV 350
LEDSDLKKDD VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA 400
YGAAVQGGVI SGEEDTGEIV LLDVNPLTMG IETVGGVMTK LIGRNTVIPT 450
KKSQVFSTAA DNQPTVTIQV FEGERPMTKD NHQLGKFDLT GLPPAPRGVP 500
QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP EDIERMINDA 550
EKFAEDDKKV KDKAEARNEL ESYAYNLKNQ IEDKEKLGGK LDEDDKKTIE 600
EAVEEAISWL GSNAEASAEE LKEQKKDLES KVQPIVSKLY KDAGAGGEEA 650
PEEGSDDKDE L 661
Length:661
Mass (Da):73,023
Last modified:August 16, 2004 - v2
Checksum:i4DFB79714C3EC52A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91L → M in AAA28074. 1 Publication
Sequence conflicti12 – 132LS → IT in AAA28074. 1 Publication
Sequence conflicti17 – 171V → I in AAA28074. 1 Publication
Sequence conflicti20 – 201E → K in AAA28074. 1 Publication
Sequence conflicti33 – 331G → E in AAA28074. 1 Publication
Sequence conflicti545 – 5451R → A in AAA28074. 1 Publication
Sequence conflicti647 – 6559GEEAPEEGS → ERRPQKRDL in AAA28074. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26604 Genomic DNA. Translation: AAA28074.1.
FO080555 Genomic DNA. Translation: CCD64632.1.
PIRiA32475.
T15513.
RefSeqiNP_509019.1. NM_076618.5.
UniGeneiCel.17703.

Genome annotation databases

EnsemblMetazoaiC15H9.6.1; C15H9.6.1; WBGene00002007.
C15H9.6.2; C15H9.6.2; WBGene00002007.
C15H9.6.3; C15H9.6.3; WBGene00002007.
GeneIDi180880.
KEGGicel:CELE_C15H9.6.
UCSCiC15H9.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26604 Genomic DNA. Translation: AAA28074.1 .
FO080555 Genomic DNA. Translation: CCD64632.1 .
PIRi A32475.
T15513.
RefSeqi NP_509019.1. NM_076618.5.
UniGenei Cel.17703.

3D structure databases

ProteinModelPortali P27420.
SMRi P27420. Positions 33-641.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 45812. 1 interaction.
IntActi P27420. 2 interactions.
MINTi MINT-213796.
STRINGi 6239.C15H9.6.2.

2D gel databases

World-2DPAGE 0020:P27420.

Proteomic databases

PaxDbi P27420.
PRIDEi P27420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C15H9.6.1 ; C15H9.6.1 ; WBGene00002007 .
C15H9.6.2 ; C15H9.6.2 ; WBGene00002007 .
C15H9.6.3 ; C15H9.6.3 ; WBGene00002007 .
GeneIDi 180880.
KEGGi cel:CELE_C15H9.6.
UCSCi C15H9.6.1. c. elegans.

Organism-specific databases

CTDi 180880.
WormBasei C15H9.6a ; CE08177 ; WBGene00002007 ; hsp-3.

Phylogenomic databases

eggNOGi COG0443.
GeneTreei ENSGT00750000117237.
HOGENOMi HOG000228135.
InParanoidi P27420.
KOi K09490.
OMAi DKRAVQK.
PhylomeDBi P27420.

Enzyme and pathway databases

Reactomei REACT_34502. ATF6-alpha activates chaperone genes.

Miscellaneous databases

NextBioi 911388.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the hsp70 multigene family of Caenorhabditis elegans."
    Heschl M.F.P., Baillie D.L.
    DNA 8:233-243(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHSP7C_CAEEL
AccessioniPrimary (citable) accession number: P27420
Secondary accession number(s): Q7JNW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi