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P27420 (HSP7C_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock 70 kDa protein C
Gene names
Name:hsp-3
Synonyms:hsp70c
ORF Names:C15H9.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen.

Sequence similarities

Belongs to the heat shock protein 70 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 661644Heat shock 70 kDa protein C
PRO_0000013541

Regions

Motif658 – 6614Prevents secretion from ER

Experimental info

Sequence conflict91L → M in AAA28074. Ref.1
Sequence conflict12 – 132LS → IT in AAA28074. Ref.1
Sequence conflict171V → I in AAA28074. Ref.1
Sequence conflict201E → K in AAA28074. Ref.1
Sequence conflict331G → E in AAA28074. Ref.1
Sequence conflict5451R → A in AAA28074. Ref.1
Sequence conflict647 – 6559GEEAPEEGS → ERRPQKRDL in AAA28074. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P27420 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: 4DFB79714C3EC52A

FASTA66173,023
        10         20         30         40         50         60 
MKTLFLLGLI ALSAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY KNGRVEIIAN 

        70         80         90        100        110        120 
DQGNRITPSY VAFSGDQGDR LIGDAAKNQL TINPENTIFD AKRLIGRDYN DKTVQADIKH 

       130        140        150        160        170        180 
WPFKVIDKSN KPSVEVKVGS DNKQFTPEEV SAMVLVKMKE IAESYLGKEV KNAVVTVPAY 

       190        200        210        220        230        240 
FNDAQRQATK DAGTIAGLNV VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML 

       250        260        270        280        290        300 
TIDNGVFEVL ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA 

       310        320        330        340        350        360 
KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV LEDSDLKKDD 

       370        380        390        400        410        420 
VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA YGAAVQGGVI SGEEDTGEIV 

       430        440        450        460        470        480 
LLDVNPLTMG IETVGGVMTK LIGRNTVIPT KKSQVFSTAA DNQPTVTIQV FEGERPMTKD 

       490        500        510        520        530        540 
NHQLGKFDLT GLPPAPRGVP QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP 

       550        560        570        580        590        600 
EDIERMINDA EKFAEDDKKV KDKAEARNEL ESYAYNLKNQ IEDKEKLGGK LDEDDKKTIE 

       610        620        630        640        650        660 
EAVEEAISWL GSNAEASAEE LKEQKKDLES KVQPIVSKLY KDAGAGGEEA PEEGSDDKDE 


L 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the hsp70 multigene family of Caenorhabditis elegans."
Heschl M.F.P., Baillie D.L.
DNA 8:233-243(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M26604 Genomic DNA. Translation: AAA28074.1.
FO080555 Genomic DNA. Translation: CCD64632.1.
PIRA32475.
T15513.
RefSeqNP_509019.1. NM_076618.5.
UniGeneCel.17703.

3D structure databases

ProteinModelPortalP27420.
SMRP27420. Positions 33-641.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid45812. 1 interaction.
IntActP27420. 2 interactions.
MINTMINT-213796.
STRING6239.C15H9.6.2.

2D gel databases

World-2DPAGE0020:P27420.

Proteomic databases

PaxDbP27420.
PRIDEP27420.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC15H9.6.1; C15H9.6.1; WBGene00002007.
C15H9.6.2; C15H9.6.2; WBGene00002007.
C15H9.6.3; C15H9.6.3; WBGene00002007.
GeneID180880.
KEGGcel:CELE_C15H9.6.
UCSCC15H9.6.1. c. elegans.

Organism-specific databases

CTD180880.
WormBaseC15H9.6a; CE08177; WBGene00002007; hsp-3.

Phylogenomic databases

eggNOGCOG0443.
GeneTreeENSGT00750000117237.
HOGENOMHOG000228135.
InParanoidP27420.
KOK09490.
OMADKRAVQK.
PhylomeDBP27420.

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio911388.

Entry information

Entry nameHSP7C_CAEEL
AccessionPrimary (citable) accession number: P27420
Secondary accession number(s): Q7JNW0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase