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P27420

- HSP7C_CAEEL

UniProt

P27420 - HSP7C_CAEEL

Protein

Heat shock 70 kDa protein C

Gene

hsp-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATPase activity Source: WormBase
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. endoplasmic reticulum unfolded protein response Source: WormBase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_34502. ATF6-alpha activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock 70 kDa protein C
    Gene namesi
    Name:hsp-3
    Synonyms:hsp70c
    ORF Names:C15H9.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC15H9.6a; CE08177; WBGene00002007; hsp-3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum chaperone complex Source: WormBase
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 661644Heat shock 70 kDa protein CPRO_0000013541Add
    BLAST

    Proteomic databases

    PaxDbiP27420.
    PRIDEiP27420.

    2D gel databases

    World-2DPAGE0020:P27420.

    Interactioni

    Protein-protein interaction databases

    BioGridi45812. 1 interaction.
    IntActiP27420. 2 interactions.
    MINTiMINT-213796.
    STRINGi6239.C15H9.6.2.

    Structurei

    3D structure databases

    ProteinModelPortaliP27420.
    SMRiP27420. Positions 33-641.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi658 – 6614Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    GeneTreeiENSGT00750000117237.
    HOGENOMiHOG000228135.
    InParanoidiP27420.
    KOiK09490.
    OMAiDKRAVQK.
    PhylomeDBiP27420.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27420-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLFLLGLI ALSAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY    50
    KNGRVEIIAN DQGNRITPSY VAFSGDQGDR LIGDAAKNQL TINPENTIFD 100
    AKRLIGRDYN DKTVQADIKH WPFKVIDKSN KPSVEVKVGS DNKQFTPEEV 150
    SAMVLVKMKE IAESYLGKEV KNAVVTVPAY FNDAQRQATK DAGTIAGLNV 200
    VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML TIDNGVFEVL 250
    ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA 300
    KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV 350
    LEDSDLKKDD VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA 400
    YGAAVQGGVI SGEEDTGEIV LLDVNPLTMG IETVGGVMTK LIGRNTVIPT 450
    KKSQVFSTAA DNQPTVTIQV FEGERPMTKD NHQLGKFDLT GLPPAPRGVP 500
    QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP EDIERMINDA 550
    EKFAEDDKKV KDKAEARNEL ESYAYNLKNQ IEDKEKLGGK LDEDDKKTIE 600
    EAVEEAISWL GSNAEASAEE LKEQKKDLES KVQPIVSKLY KDAGAGGEEA 650
    PEEGSDDKDE L 661
    Length:661
    Mass (Da):73,023
    Last modified:August 16, 2004 - v2
    Checksum:i4DFB79714C3EC52A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91L → M in AAA28074. (PubMed:2766926)Curated
    Sequence conflicti12 – 132LS → IT in AAA28074. (PubMed:2766926)Curated
    Sequence conflicti17 – 171V → I in AAA28074. (PubMed:2766926)Curated
    Sequence conflicti20 – 201E → K in AAA28074. (PubMed:2766926)Curated
    Sequence conflicti33 – 331G → E in AAA28074. (PubMed:2766926)Curated
    Sequence conflicti545 – 5451R → A in AAA28074. (PubMed:2766926)Curated
    Sequence conflicti647 – 6559GEEAPEEGS → ERRPQKRDL in AAA28074. (PubMed:2766926)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26604 Genomic DNA. Translation: AAA28074.1.
    FO080555 Genomic DNA. Translation: CCD64632.1.
    PIRiA32475.
    T15513.
    RefSeqiNP_509019.1. NM_076618.5.
    UniGeneiCel.17703.

    Genome annotation databases

    EnsemblMetazoaiC15H9.6.1; C15H9.6.1; WBGene00002007.
    C15H9.6.2; C15H9.6.2; WBGene00002007.
    C15H9.6.3; C15H9.6.3; WBGene00002007.
    GeneIDi180880.
    KEGGicel:CELE_C15H9.6.
    UCSCiC15H9.6.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26604 Genomic DNA. Translation: AAA28074.1 .
    FO080555 Genomic DNA. Translation: CCD64632.1 .
    PIRi A32475.
    T15513.
    RefSeqi NP_509019.1. NM_076618.5.
    UniGenei Cel.17703.

    3D structure databases

    ProteinModelPortali P27420.
    SMRi P27420. Positions 33-641.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 45812. 1 interaction.
    IntActi P27420. 2 interactions.
    MINTi MINT-213796.
    STRINGi 6239.C15H9.6.2.

    2D gel databases

    World-2DPAGE 0020:P27420.

    Proteomic databases

    PaxDbi P27420.
    PRIDEi P27420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C15H9.6.1 ; C15H9.6.1 ; WBGene00002007 .
    C15H9.6.2 ; C15H9.6.2 ; WBGene00002007 .
    C15H9.6.3 ; C15H9.6.3 ; WBGene00002007 .
    GeneIDi 180880.
    KEGGi cel:CELE_C15H9.6.
    UCSCi C15H9.6.1. c. elegans.

    Organism-specific databases

    CTDi 180880.
    WormBasei C15H9.6a ; CE08177 ; WBGene00002007 ; hsp-3.

    Phylogenomic databases

    eggNOGi COG0443.
    GeneTreei ENSGT00750000117237.
    HOGENOMi HOG000228135.
    InParanoidi P27420.
    KOi K09490.
    OMAi DKRAVQK.
    PhylomeDBi P27420.

    Enzyme and pathway databases

    Reactomei REACT_34502. ATF6-alpha activates chaperone genes.

    Miscellaneous databases

    NextBioi 911388.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the hsp70 multigene family of Caenorhabditis elegans."
      Heschl M.F.P., Baillie D.L.
      DNA 8:233-243(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiHSP7C_CAEEL
    AccessioniPrimary (citable) accession number: P27420
    Secondary accession number(s): Q7JNW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3