P27420 (HSP7C_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock 70 kDa protein C

Gene names

Name:	hsp-3
Synonyms:	hsp70c
ORF Names:	C15H9.6

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	661 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.
Subcellular location	Endoplasmic reticulum lumen.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Endoplasmic reticulum
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein secretion Inferred from sequence or structural similarity PubMed 2225768. Source: WormBase response to chemical stimulus Inferred from sequence or structural similarity PubMed 2225768. Source: WormBase response to stress Inferred from sequence or structural similarity PubMed 2225768. Source: WormBase
Cellular_component	endoplasmic reticulum chaperone complex Inferred from sequence or structural similarity PubMed 2225768. Source: WormBase endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from sequence or structural similarity PubMed 2225768. Source: WormBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 661	644	Heat shock 70 kDa protein C		PRO_0000013541
Regions
	Motif	658 – 661	4	Prevents secretion from ER
Experimental info
	Sequence conflict	9	1	L → M in AAA28074. Ref.1
	Sequence conflict	12 – 13	2	LS → IT in AAA28074. Ref.1
	Sequence conflict	17	1	V → I in AAA28074. Ref.1
	Sequence conflict	20	1	E → K in AAA28074. Ref.1
	Sequence conflict	33	1	G → E in AAA28074. Ref.1
	Sequence conflict	545	1	R → A in AAA28074. Ref.1
	Sequence conflict	647 – 655	9	GEEAPEEGS → ERRPQKRDL in AAA28074. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P27420 [UniParc]. Last modified August 16, 2004. Version 2. Checksum: 4DFB79714C3EC52A	FASTA	661	73,023
	10 20 30 40 50 60 MKTLFLLGLI ALSAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY KNGRVEIIAN 70 80 90 100 110 120 DQGNRITPSY VAFSGDQGDR LIGDAAKNQL TINPENTIFD AKRLIGRDYN DKTVQADIKH 130 140 150 160 170 180 WPFKVIDKSN KPSVEVKVGS DNKQFTPEEV SAMVLVKMKE IAESYLGKEV KNAVVTVPAY 190 200 210 220 230 240 FNDAQRQATK DAGTIAGLNV VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML 250 260 270 280 290 300 TIDNGVFEVL ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA 310 320 330 340 350 360 KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV LEDSDLKKDD 370 380 390 400 410 420 VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA YGAAVQGGVI SGEEDTGEIV 430 440 450 460 470 480 LLDVNPLTMG IETVGGVMTK LIGRNTVIPT KKSQVFSTAA DNQPTVTIQV FEGERPMTKD 490 500 510 520 530 540 NHQLGKFDLT GLPPAPRGVP QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP 550 560 570 580 590 600 EDIERMINDA EKFAEDDKKV KDKAEARNEL ESYAYNLKNQ IEDKEKLGGK LDEDDKKTIE 610 620 630 640 650 660 EAVEEAISWL GSNAEASAEE LKEQKKDLES KVQPIVSKLY KDAGAGGEEA PEEGSDDKDE L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the hsp70 multigene family of Caenorhabditis elegans." Heschl M.F.P., Baillie D.L. DNA 8:233-243(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M26604 Genomic DNA. Translation: AAA28074.1. FO080555 Genomic DNA. Translation: CCD64632.1.
PIR	A32475. T15513.
RefSeq	NP_509019.1. NM_076618.5.
3D structure databases
ProteinModelPortal	P27420.
SMR	P27420. Positions 33-641.
ModBase	Search...
Protein-protein interaction databases
IntAct	P27420. 2 interactions.
MINT	MINT-213796.
STRING	6239.C15H9.6.2.
2D gel databases
World-2DPAGE	0020:P27420.
Proteomic databases
PaxDb	P27420.
PRIDE	P27420.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C15H9.6.1; C15H9.6.1; C15H9.6. C15H9.6.2; C15H9.6.2; C15H9.6. C15H9.6.3; C15H9.6.3; C15H9.6.
GeneID	180880.
KEGG	cel:CELE_C15H9.6.
UCSC	C15H9.6.1. c. elegans.
Organism-specific databases
CTD	180880.
WormBase	C15H9.6; CE08177; WBGene00002007; hsp-3.
Phylogenomic databases
eggNOG	COG0443.
GeneTree	ENSGT00550000074467.
HOGENOM	HOG000228135.
InParanoid	P27420.
KO	K09490.
OMA	DKRAVQK.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	911388.

Entry information

Entry name

HSP7C_CAEEL

Accession

Primary (citable) accession number: P27420
Secondary accession number(s): Q7JNW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project