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Protein

Heat shock 70 kDa protein C

Gene

hsp-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATPase activity Source: WormBase
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. endoplasmic reticulum unfolded protein response Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_34502. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein C
Gene namesi
Name:hsp-3
Synonyms:hsp70c
ORF Names:C15H9.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC15H9.6a; CE08177; WBGene00002007; hsp-3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum chaperone complex Source: WormBase
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 661644Heat shock 70 kDa protein CPRO_0000013541Add
BLAST

Proteomic databases

PaxDbiP27420.
PRIDEiP27420.

2D gel databases

World-2DPAGE0020:P27420.

Interactioni

Protein-protein interaction databases

BioGridi45812. 1 interaction.
IntActiP27420. 2 interactions.
MINTiMINT-213796.
STRINGi6239.C15H9.6.2.

Structurei

3D structure databases

ProteinModelPortaliP27420.
SMRiP27420. Positions 33-641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi658 – 6614Prevents secretion from ER

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiP27420.
KOiK09490.
OMAiESHQDGD.
PhylomeDBiP27420.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27420-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTLFLLGLI ALSAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY
60 70 80 90 100
KNGRVEIIAN DQGNRITPSY VAFSGDQGDR LIGDAAKNQL TINPENTIFD
110 120 130 140 150
AKRLIGRDYN DKTVQADIKH WPFKVIDKSN KPSVEVKVGS DNKQFTPEEV
160 170 180 190 200
SAMVLVKMKE IAESYLGKEV KNAVVTVPAY FNDAQRQATK DAGTIAGLNV
210 220 230 240 250
VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML TIDNGVFEVL
260 270 280 290 300
ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA
310 320 330 340 350
KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV
360 370 380 390 400
LEDSDLKKDD VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA
410 420 430 440 450
YGAAVQGGVI SGEEDTGEIV LLDVNPLTMG IETVGGVMTK LIGRNTVIPT
460 470 480 490 500
KKSQVFSTAA DNQPTVTIQV FEGERPMTKD NHQLGKFDLT GLPPAPRGVP
510 520 530 540 550
QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP EDIERMINDA
560 570 580 590 600
EKFAEDDKKV KDKAEARNEL ESYAYNLKNQ IEDKEKLGGK LDEDDKKTIE
610 620 630 640 650
EAVEEAISWL GSNAEASAEE LKEQKKDLES KVQPIVSKLY KDAGAGGEEA
660
PEEGSDDKDE L
Length:661
Mass (Da):73,023
Last modified:August 16, 2004 - v2
Checksum:i4DFB79714C3EC52A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91L → M in AAA28074. (PubMed:2766926)Curated
Sequence conflicti12 – 132LS → IT in AAA28074. (PubMed:2766926)Curated
Sequence conflicti17 – 171V → I in AAA28074. (PubMed:2766926)Curated
Sequence conflicti20 – 201E → K in AAA28074. (PubMed:2766926)Curated
Sequence conflicti33 – 331G → E in AAA28074. (PubMed:2766926)Curated
Sequence conflicti545 – 5451R → A in AAA28074. (PubMed:2766926)Curated
Sequence conflicti647 – 6559GEEAPEEGS → ERRPQKRDL in AAA28074. (PubMed:2766926)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26604 Genomic DNA. Translation: AAA28074.1.
FO080555 Genomic DNA. Translation: CCD64632.1.
PIRiA32475.
T15513.
RefSeqiNP_509019.1. NM_076618.5.
UniGeneiCel.17703.

Genome annotation databases

EnsemblMetazoaiC15H9.6.1; C15H9.6.1; WBGene00002007.
C15H9.6.2; C15H9.6.2; WBGene00002007.
C15H9.6.3; C15H9.6.3; WBGene00002007.
GeneIDi180880.
KEGGicel:CELE_C15H9.6.
UCSCiC15H9.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26604 Genomic DNA. Translation: AAA28074.1.
FO080555 Genomic DNA. Translation: CCD64632.1.
PIRiA32475.
T15513.
RefSeqiNP_509019.1. NM_076618.5.
UniGeneiCel.17703.

3D structure databases

ProteinModelPortaliP27420.
SMRiP27420. Positions 33-641.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45812. 1 interaction.
IntActiP27420. 2 interactions.
MINTiMINT-213796.
STRINGi6239.C15H9.6.2.

2D gel databases

World-2DPAGE0020:P27420.

Proteomic databases

PaxDbiP27420.
PRIDEiP27420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC15H9.6.1; C15H9.6.1; WBGene00002007.
C15H9.6.2; C15H9.6.2; WBGene00002007.
C15H9.6.3; C15H9.6.3; WBGene00002007.
GeneIDi180880.
KEGGicel:CELE_C15H9.6.
UCSCiC15H9.6.1. c. elegans.

Organism-specific databases

CTDi180880.
WormBaseiC15H9.6a; CE08177; WBGene00002007; hsp-3.

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiP27420.
KOiK09490.
OMAiESHQDGD.
PhylomeDBiP27420.

Enzyme and pathway databases

ReactomeiREACT_34502. ATF6-alpha activates chaperone genes.

Miscellaneous databases

NextBioi911388.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the hsp70 multigene family of Caenorhabditis elegans."
    Heschl M.F.P., Baillie D.L.
    DNA 8:233-243(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHSP7C_CAEEL
AccessioniPrimary (citable) accession number: P27420
Secondary accession number(s): Q7JNW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 16, 2004
Last modified: February 4, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.