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P27406

- CAPSD_FCVF9

UniProt

P27406 - CAPSD_FCVF9

Protein

Capsid protein

Gene

CPP76

Organism
Feline calicivirus (strain F9) (FCV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei124 – 1252Cleavage; by calicivirinBy similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsid protein
    Alternative name(s):
    Coat protein
    Short name:
    CP
    VP1
    Cleaved into the following chain:
    Gene namesi
    Name:CPP76
    ORF Names:ORF2
    OrganismiFeline calicivirus (strain F9) (FCV)
    Taxonomic identifieri11981 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
    Virus hostiFelidae (cat family) [TaxID: 9681]
    ProteomesiUP000008762: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. T=3 icosahedral viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 1241241 PublicationPRO_0000036878Add
    BLAST
    Chaini125 – 671547Capsid proteinPRO_0000036879Add
    BLAST
    Chaini?465 – 671207Protein 40kPRO_0000341981Add
    BLAST

    Post-translational modificationi

    Cleaved by virus calcivirin to produce mature capsid protein.
    Cleaved by host caspase-2 and caspase-6 to generate protein p40.

    Interactioni

    Subunit structurei

    Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins. Binds to alpha-2,6-linked sialic acid at surface of target cells. Interacts with host F11R.2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliP27406.
    SMRiP27406. Positions 129-665.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.60.120.20. 1 hit.
    InterProiIPR004005. Calicivirus_coat.
    IPR029053. Viral_coat.
    [Graphical view]
    PfamiPF00915. Calici_coat. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27406-1 [UniParc]FASTAAdd to Basket

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    MCSTCANVLK YYDWDPHFKL VINPNNFLSV GFCSNPLMCC YPELLPEFGT    50
    VWDCDRSPLE IYLESILGDD EWASTFDAVD PVVPPMHWGA AGKIFQPHPG 100
    VLMHHLIGKV AAGWDPDLPL IRLEADDGSI TAPEQGTMVG GVIAEPSAQM 150
    STAADMATGK SVDSEWEAFF SFHTSVNWST SETQGKILFK QSLGPLLNPY 200
    LEHLAKLYVA WSGSIEVRFS ISGSGVFGGK LAAIVVPPGV DPVQSTSMLQ 250
    YPHVLFDARQ VEPVIFCLPD LRSTLYHLMS DTDTTSLVIM VYNDLINPYA 300
    NDANSSGCIV TVETKPGPDF KFHLLKPPGS MLTHGSIPSD LIPKTSSLWI 350
    GNRYWSDITD FVIRPFVFQA NRHFDFNQET AGWSTPRFRP ISVTITEQNG 400
    AKLGIGVATD YIVPGIPDGW PDTTIPGELI PAGDYAITNG TGNDITTATG 450
    YDTADIIKNN TNFRGMYICG SLQRAWGDKK ISNTAFITTA TLDGDNNNKI 500
    NPCNTIDQSK IVVFQDNHVG KKAQTSDDTL ALLGYTGIGE QAIGSDRDRV 550
    VRISTLPETG ARGGNHPIFY KNSIKLGYVI RSIDVFNSQI LHTSRQLSLN 600
    HYLLPPDSFA VYRIIDSNGS WFDIGIDSDG FSFVGVSGFG KLEFPLSASY 650
    MGIQLAKIRL ASNIRSPMTK L 671
    Length:671
    Mass (Da):73,441
    Last modified:August 1, 1992 - v1
    Checksum:i33BEE86D8370D5E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86379 Genomic RNA. Translation: AAA79327.1.
    Z11536 Genomic RNA. Translation: CAA77636.1.
    PIRiB43382. VCWWF9.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86379 Genomic RNA. Translation: AAA79327.1 .
    Z11536 Genomic RNA. Translation: CAA77636.1 .
    PIRi B43382. VCWWF9.

    3D structure databases

    ProteinModelPortali P27406.
    SMRi P27406. Positions 129-665.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.20. 1 hit.
    InterProi IPR004005. Calicivirus_coat.
    IPR029053. Viral_coat.
    [Graphical view ]
    Pfami PF00915. Calici_coat. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete nucleotide sequence of a feline calicivirus."
      Carter M.J., Milton I.D., Meanger J., Bennett M., Gaskell R.M., Turner P.C.
      Virology 190:443-448(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Cloning and sequence determination of the feline calicivirus strain F9."
      Meanger J., Carter M.J., Gaskell R.M., Turner P.C.
      Biochem. Soc. Trans. 20:26S-26S(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Identification and sequence determination of the capsid protein gene of feline calicivirus."
      Carter M.J., Milton I.D., Turner P.C., Meanger J., Bennett M., Gaskell R.M.
      Arch. Virol. 122:223-235(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 125-131, PROTEOLYTIC PROCESSING.
    4. "Caspase-mediated cleavage of the feline calicivirus capsid protein."
      Al-Molawi N., Beardmore V.A., Carter M.J., Kass G.E., Roberts L.O.
      J. Gen. Virol. 84:1237-1244(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE BY HOST CASPASE.
    5. "Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes."
      Stuart A.D., Brown T.D.
      J. Virol. 80:7500-7509(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VIRAL ENTRY.
    6. "Identification of regions and residues in feline junctional adhesion molecule required for feline calicivirus binding and infection."
      Ossiboff R.J., Parker J.S.L.
      J. Virol. 81:13608-13621(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOST F11R.
    7. "Alpha2,6-linked sialic acid acts as a receptor for Feline calicivirus."
      Stuart A.D., Brown T.D.
      J. Gen. Virol. 88:177-186(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ALPHA2,6-LINKED SIALIC ACID.

    Entry informationi

    Entry nameiCAPSD_FCVF9
    AccessioniPrimary (citable) accession number: P27406
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3