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P27406

- CAPSD_FCVF9

UniProt

P27406 - CAPSD_FCVF9

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Protein

Capsid protein

Gene

CPP76

Organism
Feline calicivirus (strain F9) (FCV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei124 – 1252Cleavage; by calicivirinBy similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Alternative name(s):
Coat protein
Short name:
CP
VP1
Cleaved into the following chain:
Gene namesi
Name:CPP76
ORF Names:ORF2
OrganismiFeline calicivirus (strain F9) (FCV)
Taxonomic identifieri11981 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
Virus hostiFelidae (cat family) [TaxID: 9681]
ProteomesiUP000008762: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. T=3 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1241241 PublicationPRO_0000036878Add
BLAST
Chaini125 – 671547Capsid proteinPRO_0000036879Add
BLAST
Chaini?465 – 671207Protein 40kPRO_0000341981Add
BLAST

Post-translational modificationi

Cleaved by virus calcivirin to produce mature capsid protein.
Cleaved by host caspase-2 and caspase-6 to generate protein p40.

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins. Binds to alpha-2,6-linked sialic acid at surface of target cells. Interacts with host F11R.2 Publications

Structurei

3D structure databases

ProteinModelPortaliP27406.
SMRiP27406. Positions 129-665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27406 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSTCANVLK YYDWDPHFKL VINPNNFLSV GFCSNPLMCC YPELLPEFGT
60 70 80 90 100
VWDCDRSPLE IYLESILGDD EWASTFDAVD PVVPPMHWGA AGKIFQPHPG
110 120 130 140 150
VLMHHLIGKV AAGWDPDLPL IRLEADDGSI TAPEQGTMVG GVIAEPSAQM
160 170 180 190 200
STAADMATGK SVDSEWEAFF SFHTSVNWST SETQGKILFK QSLGPLLNPY
210 220 230 240 250
LEHLAKLYVA WSGSIEVRFS ISGSGVFGGK LAAIVVPPGV DPVQSTSMLQ
260 270 280 290 300
YPHVLFDARQ VEPVIFCLPD LRSTLYHLMS DTDTTSLVIM VYNDLINPYA
310 320 330 340 350
NDANSSGCIV TVETKPGPDF KFHLLKPPGS MLTHGSIPSD LIPKTSSLWI
360 370 380 390 400
GNRYWSDITD FVIRPFVFQA NRHFDFNQET AGWSTPRFRP ISVTITEQNG
410 420 430 440 450
AKLGIGVATD YIVPGIPDGW PDTTIPGELI PAGDYAITNG TGNDITTATG
460 470 480 490 500
YDTADIIKNN TNFRGMYICG SLQRAWGDKK ISNTAFITTA TLDGDNNNKI
510 520 530 540 550
NPCNTIDQSK IVVFQDNHVG KKAQTSDDTL ALLGYTGIGE QAIGSDRDRV
560 570 580 590 600
VRISTLPETG ARGGNHPIFY KNSIKLGYVI RSIDVFNSQI LHTSRQLSLN
610 620 630 640 650
HYLLPPDSFA VYRIIDSNGS WFDIGIDSDG FSFVGVSGFG KLEFPLSASY
660 670
MGIQLAKIRL ASNIRSPMTK L
Length:671
Mass (Da):73,441
Last modified:August 1, 1992 - v1
Checksum:i33BEE86D8370D5E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86379 Genomic RNA. Translation: AAA79327.1.
Z11536 Genomic RNA. Translation: CAA77636.1.
PIRiB43382. VCWWF9.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86379 Genomic RNA. Translation: AAA79327.1 .
Z11536 Genomic RNA. Translation: CAA77636.1 .
PIRi B43382. VCWWF9.

3D structure databases

ProteinModelPortali P27406.
SMRi P27406. Positions 129-665.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.20. 1 hit.
InterProi IPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00915. Calici_coat. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of a feline calicivirus."
    Carter M.J., Milton I.D., Meanger J., Bennett M., Gaskell R.M., Turner P.C.
    Virology 190:443-448(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Cloning and sequence determination of the feline calicivirus strain F9."
    Meanger J., Carter M.J., Gaskell R.M., Turner P.C.
    Biochem. Soc. Trans. 20:26S-26S(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Identification and sequence determination of the capsid protein gene of feline calicivirus."
    Carter M.J., Milton I.D., Turner P.C., Meanger J., Bennett M., Gaskell R.M.
    Arch. Virol. 122:223-235(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 125-131, PROTEOLYTIC PROCESSING.
  4. "Caspase-mediated cleavage of the feline calicivirus capsid protein."
    Al-Molawi N., Beardmore V.A., Carter M.J., Kass G.E., Roberts L.O.
    J. Gen. Virol. 84:1237-1244(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY HOST CASPASE.
  5. "Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes."
    Stuart A.D., Brown T.D.
    J. Virol. 80:7500-7509(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VIRAL ENTRY.
  6. "Identification of regions and residues in feline junctional adhesion molecule required for feline calicivirus binding and infection."
    Ossiboff R.J., Parker J.S.L.
    J. Virol. 81:13608-13621(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST F11R.
  7. "Alpha2,6-linked sialic acid acts as a receptor for Feline calicivirus."
    Stuart A.D., Brown T.D.
    J. Gen. Virol. 88:177-186(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALPHA2,6-LINKED SIALIC ACID.

Entry informationi

Entry nameiCAPSD_FCVF9
AccessioniPrimary (citable) accession number: P27406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3