Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P27406 (CAPSD_FCVF9) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Capsid protein
Alternative name(s):
Coat protein
Short name=CP
VP1

Cleaved into the following chain:

  1. Protein 40k
Gene names
Name:CPP76
ORF Names:ORF2
OrganismFeline calicivirus (strain F9) (FCV) [Complete proteome]
Taxonomic identifier11981 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.

Subunit structure

Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins. Binds to alpha-2,6-linked sialic acid at surface of target cells. Interacts with host F11R. Ref.6 Ref.7

Subcellular location

Virion. Host cytoplasm.

Post-translational modification

Cleaved by virus calcivirin to produce mature capsid protein.

Cleaved by host caspase-2 and caspase-6 to generate protein p40.

Sequence similarities

Belongs to the caliciviridae capsid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 124124
PRO_0000036878
Chain125 – 671547Capsid protein
PRO_0000036879
Chain?465 – 671207Protein 40k
PRO_0000341981

Sites

Site124 – 1252Cleavage; by calicivirin By similarity

Sequences

Sequence LengthMass (Da)Tools
P27406 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 33BEE86D8370D5E5

FASTA67173,441
        10         20         30         40         50         60 
MCSTCANVLK YYDWDPHFKL VINPNNFLSV GFCSNPLMCC YPELLPEFGT VWDCDRSPLE 

        70         80         90        100        110        120 
IYLESILGDD EWASTFDAVD PVVPPMHWGA AGKIFQPHPG VLMHHLIGKV AAGWDPDLPL 

       130        140        150        160        170        180 
IRLEADDGSI TAPEQGTMVG GVIAEPSAQM STAADMATGK SVDSEWEAFF SFHTSVNWST 

       190        200        210        220        230        240 
SETQGKILFK QSLGPLLNPY LEHLAKLYVA WSGSIEVRFS ISGSGVFGGK LAAIVVPPGV 

       250        260        270        280        290        300 
DPVQSTSMLQ YPHVLFDARQ VEPVIFCLPD LRSTLYHLMS DTDTTSLVIM VYNDLINPYA 

       310        320        330        340        350        360 
NDANSSGCIV TVETKPGPDF KFHLLKPPGS MLTHGSIPSD LIPKTSSLWI GNRYWSDITD 

       370        380        390        400        410        420 
FVIRPFVFQA NRHFDFNQET AGWSTPRFRP ISVTITEQNG AKLGIGVATD YIVPGIPDGW 

       430        440        450        460        470        480 
PDTTIPGELI PAGDYAITNG TGNDITTATG YDTADIIKNN TNFRGMYICG SLQRAWGDKK 

       490        500        510        520        530        540 
ISNTAFITTA TLDGDNNNKI NPCNTIDQSK IVVFQDNHVG KKAQTSDDTL ALLGYTGIGE 

       550        560        570        580        590        600 
QAIGSDRDRV VRISTLPETG ARGGNHPIFY KNSIKLGYVI RSIDVFNSQI LHTSRQLSLN 

       610        620        630        640        650        660 
HYLLPPDSFA VYRIIDSNGS WFDIGIDSDG FSFVGVSGFG KLEFPLSASY MGIQLAKIRL 

       670 
ASNIRSPMTK L 

« Hide

References

[1]"The complete nucleotide sequence of a feline calicivirus."
Carter M.J., Milton I.D., Meanger J., Bennett M., Gaskell R.M., Turner P.C.
Virology 190:443-448(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Cloning and sequence determination of the feline calicivirus strain F9."
Meanger J., Carter M.J., Gaskell R.M., Turner P.C.
Biochem. Soc. Trans. 20:26S-26S(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Identification and sequence determination of the capsid protein gene of feline calicivirus."
Carter M.J., Milton I.D., Turner P.C., Meanger J., Bennett M., Gaskell R.M.
Arch. Virol. 122:223-235(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 125-131, PROTEOLYTIC PROCESSING.
[4]"Caspase-mediated cleavage of the feline calicivirus capsid protein."
Al-Molawi N., Beardmore V.A., Carter M.J., Kass G.E., Roberts L.O.
J. Gen. Virol. 84:1237-1244(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE BY HOST CASPASE.
[5]"Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes."
Stuart A.D., Brown T.D.
J. Virol. 80:7500-7509(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VIRAL ENTRY.
[6]"Identification of regions and residues in feline junctional adhesion molecule required for feline calicivirus binding and infection."
Ossiboff R.J., Parker J.S.L.
J. Virol. 81:13608-13621(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HOST F11R.
[7]"Alpha2,6-linked sialic acid acts as a receptor for Feline calicivirus."
Stuart A.D., Brown T.D.
J. Gen. Virol. 88:177-186(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ALPHA2,6-LINKED SIALIC ACID.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M86379 Genomic RNA. Translation: AAA79327.1.
Z11536 Genomic RNA. Translation: CAA77636.1.
PIRVCWWF9. B43382.

3D structure databases

ProteinModelPortalP27406.
SMRP27406. Positions 129-665.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.20. 1 hit.
InterProIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamPF00915. Calici_coat. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPSD_FCVF9
AccessionPrimary (citable) accession number: P27406
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families