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P27405

- CAPSD_FCVF4

UniProt

P27405 - CAPSD_FCVF4

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Protein
Capsid protein
Gene
ORF2
Organism
Feline calicivirus (strain Japanese F4) (FCV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei124 – 1252Cleavage; by calicivirin By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Alternative name(s):
Coat protein
Short name:
CP
VP1
Cleaved into the following chain:
Gene namesi
ORF Names:ORF2
OrganismiFeline calicivirus (strain Japanese F4) (FCV)
Taxonomic identifieri11980 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
Virus hostiFelidae (cat family) [TaxID: 9681]
ProteomesiUP000008668: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. T=3 icosahedral viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 124124 By similarity
PRO_0000036876Add
BLAST
Chaini125 – 668544Capsid protein By similarity
PRO_0000036877Add
BLAST
Chaini?465 – 668204Protein 40k
PRO_0000341980Add
BLAST

Post-translational modificationi

Cleaved by virus calcivirin to produce mature capsid protein By similarity.
Cleaved by host caspase-2 and caspase-6 to generate protein p40 By similarity.

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins. Binds to alpha-2,6-linked sialic acid at surface of target cells. Interacts with host F11R.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP27405.
SMRiP27405. Positions 129-662.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27405-1 [UniParc]FASTAAdd to Basket

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MCSTCANVLK YYDWDPHFRL IINPNKFLPI GFCDNPLMCC YPDLLPEFGT    50
VWDCDQSPLQ IYLESILGDD EWASTHEAID PSVPPMHWDS AGKIFQPHPG 100
VLMHHLIGEV AKAWDPNLPL FRLEADDGSI TTPEQGTAVG GVIAEPSAQM 150
STAADMASGK SVDSEWEAFF SFHTSVNWST SETQGKILFK QSLGPLLNPY 200
LEHLSKLYVA WSGSIEVRFS ISGSGVFGGK LAAIVVPPGV DPVQSTSMLQ 250
YPHVLFDARQ VEPVIFTIPD LRSTLYHVMS DTDTTSLVIM VYNDLINPYA 300
NDSNSSGCIV TVETKPGPDF KFHLLKPPGS VLTHGSIPSD LIPKSSSLWI 350
GNRYWTDITD FVIRPFVFQA NRHFDFNQET AGWSTPRFRP ITITISEKNG 400
SKLGIGVATD YIIPGIPDGW PDTTIADKLI PAGDYSITTG EGNDIKTAQA 450
YDTAAVVKNT TNFRGMYICG SLQRAWGDKK ISNTAFITTA IRDGNEIKPS 500
NTIDMTKLAV YQDTHVEQEV QTSDDTLALL GYTGIGEEAI GSNRDRVVRI 550
SVLPEAGARG GNHPIFYKNS IKLGYVIRSI DVFNSQILHT SRQLSLNHYL 600
LPPDSFAVYR IIDSNGSWFD IGIDSEGFSF VGVSDIGKLE FPLSASYMGI 650
QLAKIRLASN IRSRMTKL 668
Length:668
Mass (Da):73,589
Last modified:August 1, 1992 - v1
Checksum:i85BBDCB85804E503
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90357 Genomic RNA. Translation: BAA14371.1.
PIRiB40481. VCWWFC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90357 Genomic RNA. Translation: BAA14371.1 .
PIRi B40481. VCWWFC.

3D structure databases

ProteinModelPortali P27405.
SMRi P27405. Positions 129-662.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.20. 1 hit.
InterProi IPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00915. Calici_coat. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Junctional adhesion molecule 1 is a functional receptor for feline calicivirus."
    Makino A., Shimojima M., Miyazawa T., Kato K., Tohya Y., Akashi H.
    J. Virol. 80:4482-4490(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST F11R.

Entry informationi

Entry nameiCAPSD_FCVF4
AccessioniPrimary (citable) accession number: P27405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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