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P27404

- CAPSD_FCVC6

UniProt

P27404 - CAPSD_FCVC6

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Protein
Capsid protein
Gene
ORF2
Organism
Feline calicivirus (strain CFI/68 FIV) (FCV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei124 – 1252Cleavage; by calicivirin By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Alternative name(s):
Coat protein
Short name:
CP
VP1
Cleaved into the following chain:
Gene namesi
ORF Names:ORF2
OrganismiFeline calicivirus (strain CFI/68 FIV) (FCV)
Taxonomic identifieri11979 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
Virus hostiFelidae (cat family) [TaxID: 9681]
ProteomesiUP000008667: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. T=3 icosahedral viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 124124 By similarity
PRO_0000036874Add
BLAST
Chaini125 – 668544Capsid protein By similarity
PRO_0000036875Add
BLAST
Chaini?465 – 668204Protein 40k
PRO_0000341979Add
BLAST

Post-translational modificationi

Cleaved by virus calcivirin to produce mature capsid protein By similarity.
Cleaved by host caspase-2 and caspase-6 to generate protein p40 By similarity.

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins. Binds to alpha-2,6-linked sialic acid at surface of target cells. Interacts with host F11R By similarity.

Structurei

3D structure databases

ProteinModelPortaliP27404.
SMRiP27404. Positions 129-662.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27404-1 [UniParc]FASTAAdd to Basket

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MCSTCANVLK YYDWDPHIKL VINPNKFLHV GFCDNPLMCC YPELLPEFGT    50
MWDCDQSPLQ VYLESILGDD EWSSTHEAID PVVPPMHWDE AGKIFQPHPG 100
VLMHHLICKV AEGWDPNLPL FRLEADDGSI TTPEQGTMVG GVIAEPNAQM 150
STAADMATGK SVDSEWEAFF SFHTSVNWST SETQGKILFK QSLGPLLNPY 200
LTHLAKLYVA WSGSVDVRFS ISGSGVFGGK LAAIVVPPGI DPVQSTSMLQ 250
YPHVLFDARQ VEPVIFSIPD LRSTLYHLMS DTDTTSLVIM VYNDLINPYA 300
NDSNSSGCIV TVETKPGPDF KFHLLKPPGS MLTHGSIPSD LIPKSSSLWI 350
GNRFWSDITD FVIRPFVFQA NRHFDFNQET AGWSTPRFRP ITITISVKES 400
AKLGIGVATD YIVPGIPDGW PDTTIPGELV PVGDYAITNG TNNDITTAAQ 450
YDAATEIRNN TNFRGMYICG SLQRAWGDKK ISNTAFITTG TVDGAKLIPS 500
NTIDQTKIAV FQDTHANKHV QTSDDTLALL GYTGIGEEAI GADRDRVVRI 550
SVLPERGARG GNHPIFHKNS IKLGYVIRSI DVFNSQILHT SRQLSLNHYL 600
LSPDSFAVYR IIDSNGSWFD IGIDNDGFSF VGVSSIGKLE FPLTASYMGI 650
QLAKIRLASN IRSVMTKL 668
Length:668
Mass (Da):73,550
Last modified:August 1, 1992 - v1
Checksum:i9E52312108D4D441
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32819 Genomic RNA. Translation: AAA42925.1.
U13992 Genomic RNA. Translation: AAC13993.1.
PIRiA40507. VCWWFF.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32819 Genomic RNA. Translation: AAA42925.1 .
U13992 Genomic RNA. Translation: AAC13993.1 .
PIRi A40507. VCWWFF.

3D structure databases

ProteinModelPortali P27404.
SMRi P27404. Positions 129-662.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.20. 1 hit.
InterProi IPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00915. Calici_coat. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and expression of the capsid protein gene of feline calicivirus."
    Neill J.D., Reardon I.M., Heinrikson R.L.
    J. Virol. 65:5440-5447(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiCAPSD_FCVC6
AccessioniPrimary (citable) accession number: P27404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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