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P27404 (CAPSD_FCVC6) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Capsid protein
Alternative name(s):
Coat protein
Short name=CP
VP1

Cleaved into the following chain:

  1. Protein 40k
Gene names
ORF Names:ORF2
OrganismFeline calicivirus (strain CFI/68 FIV) (FCV) [Complete proteome]
Taxonomic identifier11979 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length668 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.

Subunit structure

Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins. Binds to alpha-2,6-linked sialic acid at surface of target cells. Interacts with host F11R By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Post-translational modification

Cleaved by virus calcivirin to produce mature capsid protein By similarity.

Cleaved by host caspase-2 and caspase-6 to generate protein p40 By similarity.

Sequence similarities

Belongs to the caliciviridae capsid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 124124 By similarity
PRO_0000036874
Chain125 – 668544Capsid protein By similarity
PRO_0000036875
Chain?465 – 668204Protein 40k
PRO_0000341979

Sites

Site124 – 1252Cleavage; by calicivirin By similarity

Sequences

Sequence LengthMass (Da)Tools
P27404 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 9E52312108D4D441

FASTA66873,550
        10         20         30         40         50         60 
MCSTCANVLK YYDWDPHIKL VINPNKFLHV GFCDNPLMCC YPELLPEFGT MWDCDQSPLQ 

        70         80         90        100        110        120 
VYLESILGDD EWSSTHEAID PVVPPMHWDE AGKIFQPHPG VLMHHLICKV AEGWDPNLPL 

       130        140        150        160        170        180 
FRLEADDGSI TTPEQGTMVG GVIAEPNAQM STAADMATGK SVDSEWEAFF SFHTSVNWST 

       190        200        210        220        230        240 
SETQGKILFK QSLGPLLNPY LTHLAKLYVA WSGSVDVRFS ISGSGVFGGK LAAIVVPPGI 

       250        260        270        280        290        300 
DPVQSTSMLQ YPHVLFDARQ VEPVIFSIPD LRSTLYHLMS DTDTTSLVIM VYNDLINPYA 

       310        320        330        340        350        360 
NDSNSSGCIV TVETKPGPDF KFHLLKPPGS MLTHGSIPSD LIPKSSSLWI GNRFWSDITD 

       370        380        390        400        410        420 
FVIRPFVFQA NRHFDFNQET AGWSTPRFRP ITITISVKES AKLGIGVATD YIVPGIPDGW 

       430        440        450        460        470        480 
PDTTIPGELV PVGDYAITNG TNNDITTAAQ YDAATEIRNN TNFRGMYICG SLQRAWGDKK 

       490        500        510        520        530        540 
ISNTAFITTG TVDGAKLIPS NTIDQTKIAV FQDTHANKHV QTSDDTLALL GYTGIGEEAI 

       550        560        570        580        590        600 
GADRDRVVRI SVLPERGARG GNHPIFHKNS IKLGYVIRSI DVFNSQILHT SRQLSLNHYL 

       610        620        630        640        650        660 
LSPDSFAVYR IIDSNGSWFD IGIDNDGFSF VGVSSIGKLE FPLTASYMGI QLAKIRLASN 


IRSVMTKL 

« Hide

References

[1]"Nucleotide sequence and expression of the capsid protein gene of feline calicivirus."
Neill J.D., Reardon I.M., Heinrikson R.L.
J. Virol. 65:5440-5447(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32819 Genomic RNA. Translation: AAA42925.1.
U13992 Genomic RNA. Translation: AAC13993.1.
PIRVCWWFF. A40507.

3D structure databases

ProteinModelPortalP27404.
SMRP27404. Positions 129-662.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004005. Calicivirus_coat.
[Graphical view]
PfamPF00915. Calici_coat. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPSD_FCVC6
AccessionPrimary (citable) accession number: P27404
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families