P27372 (NDHL_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit L
EC=1.6.5.-

Alternative name(s):
Inorganic carbon transport protein
NAD(P)H dehydrogenase I subunit L
NDH-1 subunit L
NDH-L

Gene names

Name:	ndhL
Synonyms:	ictA
Ordered Locus Names:	ssr1386

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	80 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration. Ref.1
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP-Rule MF_01355
Subunit structure	NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions. Ref.3
Subcellular location	Cellular thylakoid membrane; Multi-pass membrane protein Probable Ref.4.
Sequence similarities	Belongs to the complex I NdhL subunit family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Inferred from electronic annotation. Source: HAMAP quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 80	80	NAD(P)H-quinone oxidoreductase subunit L HAMAP-Rule MF_01355		PRO_0000084150
Regions
	Transmembrane	14 – 34	21	Helical; Potential
	Transmembrane	51 – 71	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P27372 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 311AD10FA3B6136D	FASTA	80	9,252
	10 20 30 40 50 60 MEDLLGLLLS ETGLLAIIYL GLSLAYLLVF PALLYWYLQK RWYVASSVER LVMYFLVFLF 70 80 FPGLLVLSPV LNLRPRRQAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and inactivation of a gene essential to inorganic carbon transport of Synechocystis PCC6803." Ogawa T. Plant Physiol. 96:280-284(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN INORGANIC CARBON TRANSPORT.
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.
[3]	"Identification of NdhL and Ssl1690 (NdhO) in NDH-1L and NDH-1M complexes of Synechocystis sp. PCC 6803." Battchikova N., Zhang P., Rudd S., Ogawa T., Aro E.-M. J. Biol. Chem. 280:2587-2595(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 42-50, SUBUNIT.
[4]	"Identification and characterization of the ictA/ndhL gene product essential to inorganic carbon transport of Synechocystis PCC6803." Ogawa T. Plant Physiol. 99:1604-1608(1992) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION AS A MEMBER OF THE NAD(P)H-QUINONE OXIDOREDUCTASE COMPLEX, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73833 Genomic DNA. Translation: AAA27290.1. BA000022 Genomic DNA. Translation: BAA18123.1.
PIR	JQ1959.
RefSeq	NP_441443.1. NC_000911.1. YP_005651501.1. NC_017277.1. YP_007451325.1. NC_020286.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P27372. 7 interactions.
STRING	1148.ssr1386.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA18123; BAA18123; BAA18123.
GeneID	12254151. 14616983. 954803.
KEGG	syn:ssr1386. syy:SYNGTS_1548.
PATRIC	23840291. VBISynSp132158_1705.
Phylogenomic databases
eggNOG	NOG268505.
HOGENOM	HOG000022604.
KO	K05583.
OMA	LLFYWMN.
ProtClustDB	CLSK893123.
Family and domain databases
HAMAP	MF_01355. NDH1_NDH1L.
InterPro	IPR019654. NADH-quinone_OxRdatse_su_L. [Graphical view]
Pfam	PF10716. NdhL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDHL_SYNY3

Accession

Primary (citable) accession number: P27372

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program