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Protein

NAD(P)H-quinone oxidoreductase subunit L

Gene

ndhL

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity). Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.By similarity1 Publication

Catalytic activityi

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, NADP, Plastoquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H-quinone oxidoreductase subunit L (EC:1.6.5.-)
Alternative name(s):
Inorganic carbon transport protein
NAD(P)H dehydrogenase I subunit L
NDH-1 subunit L
NDH-L
Gene namesi
Name:ndhL
Synonyms:ictA
Ordered Locus Names:ssr1386
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

  • Cellular thylakoid membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8080NAD(P)H-quinone oxidoreductase subunit LPRO_0000084150Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.1 Publication

Protein-protein interaction databases

IntActiP27372. 7 interactions.
STRINGi1148.SYNGTS_1548.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NdhL subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268505.
HOGENOMiHOG000022604.
KOiK05583.
OMAiLLFYWMN.
OrthoDBiEOG6Q2SSH.

Family and domain databases

HAMAPiMF_01355. NDH1_NDH1L.
InterProiIPR019654. NADH-quinone_OxRdatse_su_L.
[Graphical view]
PfamiPF10716. NdhL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDLLGLLLS ETGLLAIIYL GLSLAYLLVF PALLYWYLQK RWYVASSVER
60 70 80
LVMYFLVFLF FPGLLVLSPV LNLRPRRQAA
Length:80
Mass (Da):9,252
Last modified:August 1, 1992 - v1
Checksum:i311AD10FA3B6136D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73833 Genomic DNA. Translation: AAA27290.1.
BA000022 Genomic DNA. Translation: BAA18123.1.
PIRiJQ1959.
RefSeqiYP_005651501.1. NC_017277.1.
YP_007451325.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18123; BAA18123; BAA18123.
KEGGisyn:ssr1386.
PATRICi23840291. VBISynSp132158_1705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73833 Genomic DNA. Translation: AAA27290.1.
BA000022 Genomic DNA. Translation: BAA18123.1.
PIRiJQ1959.
RefSeqiYP_005651501.1. NC_017277.1.
YP_007451325.1. NC_020286.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP27372. 7 interactions.
STRINGi1148.SYNGTS_1548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18123; BAA18123; BAA18123.
KEGGisyn:ssr1386.
PATRICi23840291. VBISynSp132158_1705.

Phylogenomic databases

eggNOGiNOG268505.
HOGENOMiHOG000022604.
KOiK05583.
OMAiLLFYWMN.
OrthoDBiEOG6Q2SSH.

Family and domain databases

HAMAPiMF_01355. NDH1_NDH1L.
InterProiIPR019654. NADH-quinone_OxRdatse_su_L.
[Graphical view]
PfamiPF10716. NdhL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and inactivation of a gene essential to inorganic carbon transport of Synechocystis PCC6803."
    Ogawa T.
    Plant Physiol. 96:280-284(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN INORGANIC CARBON TRANSPORT.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "Identification of NdhL and Ssl1690 (NdhO) in NDH-1L and NDH-1M complexes of Synechocystis sp. PCC 6803."
    Battchikova N., Zhang P., Rudd S., Ogawa T., Aro E.-M.
    J. Biol. Chem. 280:2587-2595(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 42-50, SUBUNIT.
  4. "Identification and characterization of the ictA/ndhL gene product essential to inorganic carbon transport of Synechocystis PCC6803."
    Ogawa T.
    Plant Physiol. 99:1604-1608(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION AS A MEMBER OF THE NAD(P)H-QUINONE OXIDOREDUCTASE COMPLEX, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNDHL_SYNY3
AccessioniPrimary (citable) accession number: P27372
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.