P27363 (KITH_SUHVN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

TK

Organism

Suid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))

Taxonomic identifier

10349 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Suid herpesvirus 1

Virus host

Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.
Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Thymidine kinase		PRO_0000175082
Regions
	Nucleotide binding	10 – 17	8	ATP By similarity
Sites
	Active site	33	1	Proton acceptor Potential
	Binding site	51	1	Substrate By similarity
	Binding site	75	1	Substrate By similarity
	Binding site	118	1	Substrate By similarity
	Binding site	162	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27363 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 6833F1FD4D9ED15C	FASTA	320	35,025
	10 20 30 40 50 60 MRILRIYLDG AYDTGKSTTA RVMALGGALY VPEPMAYWRT LFDTDTVAGI YDAQTRKQNG 70 80 90 100 110 120 SLSEEDAALV TAHDQAAFAT PYLLLHTRLV PLFGPAVEGP PEMTVVFDRH PVAATVCFPL 130 140 150 160 170 180 ARFIVGDISA AAFVGLAATL PGEPPGGNLV VASLDPDEHL RRLRARARAG EHVDARLLTA 190 200 210 220 230 240 LRNVYAMLVN TSRYLSSGRR WRDDWGRAPR FDQTTRDCLA LNELCRPRDD PELQDTLFGA 250 260 270 280 290 300 YKAPELCDRR GRPLEVHAWA MDALVAKLLP LRVSTVDLGP SPRVCAAAVA AQTRGMEVTE 310 320 SAYGDHIRQC VCAFTSEMGV

References

[1]	"Loss of pseudorabies virus thymidine kinase activity due to a single base mutation and amino acid substitution." Prieto J., Hernandez A.M.M., Tabares E. J. Gen. Virol. 72:1435-1439(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X55001 Genomic DNA. Translation: CAA38747.1.
3D structure databases
ProteinModelPortal	P27363.
SMR	P27363. Positions 2-320.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001889. Herpes_TK. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_SUHVN

Accession

Primary (citable) accession number: P27363

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program