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P27363 (KITH_SUHVN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismSuid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))
Taxonomic identifier10349 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Thymidine kinase
PRO_0000175082

Regions

Nucleotide binding10 – 178ATP By similarity

Sites

Active site331Proton acceptor Potential
Binding site511Substrate By similarity
Binding site751Substrate By similarity
Binding site1181Substrate By similarity
Binding site1621ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P27363 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 6833F1FD4D9ED15C

FASTA32035,025
        10         20         30         40         50         60 
MRILRIYLDG AYDTGKSTTA RVMALGGALY VPEPMAYWRT LFDTDTVAGI YDAQTRKQNG 

        70         80         90        100        110        120 
SLSEEDAALV TAHDQAAFAT PYLLLHTRLV PLFGPAVEGP PEMTVVFDRH PVAATVCFPL 

       130        140        150        160        170        180 
ARFIVGDISA AAFVGLAATL PGEPPGGNLV VASLDPDEHL RRLRARARAG EHVDARLLTA 

       190        200        210        220        230        240 
LRNVYAMLVN TSRYLSSGRR WRDDWGRAPR FDQTTRDCLA LNELCRPRDD PELQDTLFGA 

       250        260        270        280        290        300 
YKAPELCDRR GRPLEVHAWA MDALVAKLLP LRVSTVDLGP SPRVCAAAVA AQTRGMEVTE 

       310        320 
SAYGDHIRQC VCAFTSEMGV 

« Hide

References

[1]"Loss of pseudorabies virus thymidine kinase activity due to a single base mutation and amino acid substitution."
Prieto J., Hernandez A.M.M., Tabares E.
J. Gen. Virol. 72:1435-1439(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55001 Genomic DNA. Translation: CAA38747.1.

3D structure databases

ProteinModelPortalP27363.
SMRP27363. Positions 2-320.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_SUHVN
AccessionPrimary (citable) accession number: P27363
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families