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P27363

- KITH_SUHVN

UniProt

P27363 - KITH_SUHVN

Protein

Thymidine kinase

Gene

TK

Organism
Suid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton acceptorSequence Analysis
    Binding sitei51 – 511SubstrateBy similarity
    Binding sitei75 – 751SubstrateBy similarity
    Binding sitei118 – 1181SubstrateBy similarity
    Binding sitei162 – 1621ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 178ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiSuid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))
    Taxonomic identifieri10349 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiSus scrofa (Pig) [TaxID: 9823]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Thymidine kinasePRO_0000175082Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP27363.
    SMRiP27363. Positions 2-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P27363-1 [UniParc]FASTAAdd to Basket

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    MRILRIYLDG AYDTGKSTTA RVMALGGALY VPEPMAYWRT LFDTDTVAGI    50
    YDAQTRKQNG SLSEEDAALV TAHDQAAFAT PYLLLHTRLV PLFGPAVEGP 100
    PEMTVVFDRH PVAATVCFPL ARFIVGDISA AAFVGLAATL PGEPPGGNLV 150
    VASLDPDEHL RRLRARARAG EHVDARLLTA LRNVYAMLVN TSRYLSSGRR 200
    WRDDWGRAPR FDQTTRDCLA LNELCRPRDD PELQDTLFGA YKAPELCDRR 250
    GRPLEVHAWA MDALVAKLLP LRVSTVDLGP SPRVCAAAVA AQTRGMEVTE 300
    SAYGDHIRQC VCAFTSEMGV 320
    Length:320
    Mass (Da):35,025
    Last modified:August 1, 1992 - v1
    Checksum:i6833F1FD4D9ED15C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55001 Genomic DNA. Translation: CAA38747.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55001 Genomic DNA. Translation: CAA38747.1 .

    3D structure databases

    ProteinModelPortali P27363.
    SMRi P27363. Positions 2-320.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Loss of pseudorabies virus thymidine kinase activity due to a single base mutation and amino acid substitution."
      Prieto J., Hernandez A.M.M., Tabares E.
      J. Gen. Virol. 72:1435-1439(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_SUHVN
    AccessioniPrimary (citable) accession number: P27363
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3