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P27363

- KITH_SUHVN

UniProt

P27363 - KITH_SUHVN

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Protein

Thymidine kinase

Gene
TK
Organism
Suid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor Reviewed prediction
Binding sitei51 – 511Substrate By similarity
Binding sitei75 – 751Substrate By similarity
Binding sitei118 – 1181Substrate By similarity
Binding sitei162 – 1621ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiSuid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))
Taxonomic identifieri10349 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Thymidine kinasePRO_0000175082Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP27363.
SMRiP27363. Positions 2-320.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P27363-1 [UniParc]FASTAAdd to Basket

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MRILRIYLDG AYDTGKSTTA RVMALGGALY VPEPMAYWRT LFDTDTVAGI    50
YDAQTRKQNG SLSEEDAALV TAHDQAAFAT PYLLLHTRLV PLFGPAVEGP 100
PEMTVVFDRH PVAATVCFPL ARFIVGDISA AAFVGLAATL PGEPPGGNLV 150
VASLDPDEHL RRLRARARAG EHVDARLLTA LRNVYAMLVN TSRYLSSGRR 200
WRDDWGRAPR FDQTTRDCLA LNELCRPRDD PELQDTLFGA YKAPELCDRR 250
GRPLEVHAWA MDALVAKLLP LRVSTVDLGP SPRVCAAAVA AQTRGMEVTE 300
SAYGDHIRQC VCAFTSEMGV 320
Length:320
Mass (Da):35,025
Last modified:August 1, 1992 - v1
Checksum:i6833F1FD4D9ED15C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55001 Genomic DNA. Translation: CAA38747.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55001 Genomic DNA. Translation: CAA38747.1 .

3D structure databases

ProteinModelPortali P27363.
SMRi P27363. Positions 2-320.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Loss of pseudorabies virus thymidine kinase activity due to a single base mutation and amino acid substitution."
    Prieto J., Hernandez A.M.M., Tabares E.
    J. Gen. Virol. 72:1435-1439(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_SUHVN
AccessioniPrimary (citable) accession number: P27363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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