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P27362

- PGK_PLAF7

UniProt

P27362 - PGK_PLAF7

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Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei170 – 1701SubstrateBy similarity
Binding sitei215 – 2151ATP
Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
Binding sitei343 – 3431ATP
Binding sitei374 – 3741ATP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3754ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: GeneDB_Pfalciparum

GO - Biological processi

  1. glycolytic process Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
ORF Names:PFI1105w
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 9

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0922500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Phosphoglycerate kinasePRO_0000145859Add
BLAST

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi1208777. 3 interactions.
IntActiP27362. 3 interactions.
MINTiMINT-1572586.
STRINGi5833.PFI1105w-1.

Structurei

Secondary structure

1
416
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43
Helixi8 – 103
Beta strandi18 – 225
Beta strandi33 – 353
Helixi38 – 414
Helixi44 – 5310
Beta strandi56 – 616
Helixi73 – 753
Helixi78 – 8811
Beta strandi93 – 964
Beta strandi98 – 1003
Helixi101 – 1099
Beta strandi114 – 1185
Helixi121 – 1233
Turni125 – 1284
Beta strandi129 – 1324
Beta strandi138 – 1403
Helixi143 – 15412
Beta strandi158 – 1625
Helixi165 – 1673
Helixi173 – 1764
Beta strandi183 – 1853
Helixi187 – 20014
Beta strandi205 – 2128
Helixi217 – 2193
Helixi220 – 2278
Beta strandi231 – 2366
Helixi239 – 24810
Turni259 – 2613
Helixi262 – 27413
Beta strandi278 – 2803
Beta strandi283 – 29210
Beta strandi297 – 3048
Beta strandi311 – 3155
Helixi317 – 32812
Beta strandi331 – 3377
Helixi345 – 3473
Helixi349 – 36416
Beta strandi367 – 3704
Helixi373 – 3819
Helixi385 – 3873
Beta strandi388 – 3914
Helixi396 – 4027
Helixi408 – 4114

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LGImodel-A4-416[»]
1LTKX-ray3.00A/B/C2-416[»]
3OZ7X-ray2.70A/B2-415[»]
3OZAX-ray3.00A/B/C2-416[»]
ProteinModelPortaliP27362.
SMRiP27362. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27362.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
InParanoidiP27362.
KOiK00927.
OMAiFPVDYVT.
PhylomeDBiP27362.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27362-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGNKLSISD LKDIKNKKVL VRVDFNVPIE NGIIKDTNRI TATLPTINHL
60 70 80 90 100
KKEGASKIIL ISHCGRPDGL RNEKYTLKPV AETLKGLLGE EVLFLNDCVG
110 120 130 140 150
KEVEDKINAA KENSVILLEN LRFHIEEEGK GVDANGNKVK ANKEDVEKFQ
160 170 180 190 200
NDLTKLADVF INDAFGTAHR AHSSMVGVKL NVKASGFLMK KELEYFSKAL
210 220 230 240 250
ENPQRPLLAI LGGAKVSDKI QLIKNLLDKV DRMIIGGGMA YTFKKVLNNM
260 270 280 290 300
KIGTSLFDEA GSKIVGEIME KAKAKNVQIF LPVDFKIADN FDNNANTKFV
310 320 330 340 350
TDEEGIPDNW MGLDAGPKSI ENYKDVILTS KTVIWNGPQG VFEMPNFAKG
360 370 380 390 400
SIECLNLVVE VTKKGAITIV GGGDTASLVE QQNKKNEISH VSTGGGASLE
410
LLEGKELPGV LALSNK
Length:416
Mass (Da):45,427
Last modified:August 1, 1992 - v1
Checksum:i91105E552AE944CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59249 Genomic DNA. Translation: AAA29727.1.
AL844508 Genomic DNA. Translation: CAD51907.1.
PIRiJU0475.
RefSeqiXP_001352096.1. XM_001352060.1.

Genome annotation databases

EnsemblProtistsiPFI1105w:mRNA; PFI1105w:pep; PFI1105w.
GeneIDi813501.
KEGGipfa:PFI1105w.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59249 Genomic DNA. Translation: AAA29727.1 .
AL844508 Genomic DNA. Translation: CAD51907.1 .
PIRi JU0475.
RefSeqi XP_001352096.1. XM_001352060.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LGI model - A 4-416 [» ]
1LTK X-ray 3.00 A/B/C 2-416 [» ]
3OZ7 X-ray 2.70 A/B 2-415 [» ]
3OZA X-ray 3.00 A/B/C 2-416 [» ]
ProteinModelPortali P27362.
SMRi P27362. Positions 2-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1208777. 3 interactions.
IntActi P27362. 3 interactions.
MINTi MINT-1572586.
STRINGi 5833.PFI1105w-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PFI1105w:mRNA ; PFI1105w:pep ; PFI1105w .
GeneIDi 813501.
KEGGi pfa:PFI1105w.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_0922500.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
InParanoidi P27362.
KOi K00927.
OMAi FPVDYVT.
PhylomeDBi P27362.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Miscellaneous databases

EvolutionaryTracei P27362.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Glycolytic pathway of the human malaria parasite Plasmodium falciparum: primary sequence analysis of the gene encoding 3-phosphoglycerate kinase and chromosomal mapping studies."
    Hicks K.E., Read M., Holloway S.P., Sims P.F.G., Hyde J.E.
    Gene 100:123-129(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  3. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  4. "Biochemical characterization and crystallization of recombinant 3-phosphoglycerate kinase of Plasmodium falciparum."
    Pal B., Pybus B., Muccio D.D., Chattopadhyay D.
    Biochim. Biophys. Acta 1699:277-280(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 2-416 IN COMPLEX WITH AMP.

Entry informationi

Entry nameiPGK_PLAF7
AccessioniPrimary (citable) accession number: P27362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3