Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
  2. Phosphoglycerate kinase (PGK)
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. Pyruvate kinase (PF3D7_0626800)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei170SubstrateBy similarity1
Binding sitei215ATP1
Binding sitei312ATP; via carbonyl oxygenBy similarity1
Binding sitei343ATP1
Binding sitei374ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi372 – 375ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.2.3. 4889.
ReactomeiR-PFA-70171. Glycolysis.
R-PFA-70263. Gluconeogenesis.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
ORF Names:PFI1105w
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0922500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458591 – 416Phosphoglycerate kinaseAdd BLAST416

Proteomic databases

PRIDEiP27362.

PTM databases

SwissPalmiP27362.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi1208777. 3 interactors.
IntActiP27362. 3 interactors.
MINTiMINT-1572586.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Helixi8 – 10Combined sources3
Beta strandi18 – 22Combined sources5
Beta strandi33 – 35Combined sources3
Helixi38 – 41Combined sources4
Helixi44 – 53Combined sources10
Beta strandi56 – 61Combined sources6
Helixi73 – 75Combined sources3
Helixi78 – 88Combined sources11
Beta strandi93 – 96Combined sources4
Beta strandi98 – 100Combined sources3
Helixi101 – 109Combined sources9
Beta strandi114 – 118Combined sources5
Helixi121 – 123Combined sources3
Turni125 – 128Combined sources4
Beta strandi129 – 132Combined sources4
Beta strandi138 – 140Combined sources3
Helixi143 – 154Combined sources12
Beta strandi158 – 162Combined sources5
Helixi165 – 167Combined sources3
Helixi173 – 176Combined sources4
Beta strandi183 – 185Combined sources3
Helixi187 – 200Combined sources14
Beta strandi205 – 212Combined sources8
Helixi217 – 219Combined sources3
Helixi220 – 227Combined sources8
Beta strandi231 – 236Combined sources6
Helixi239 – 248Combined sources10
Turni259 – 261Combined sources3
Helixi262 – 274Combined sources13
Beta strandi278 – 280Combined sources3
Beta strandi283 – 292Combined sources10
Beta strandi297 – 304Combined sources8
Beta strandi311 – 315Combined sources5
Helixi317 – 328Combined sources12
Beta strandi331 – 337Combined sources7
Helixi345 – 347Combined sources3
Helixi349 – 364Combined sources16
Beta strandi367 – 370Combined sources4
Helixi373 – 381Combined sources9
Helixi385 – 387Combined sources3
Beta strandi388 – 391Combined sources4
Helixi396 – 402Combined sources7
Helixi408 – 411Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LGImodel-A4-416[»]
1LTKX-ray3.00A/B/C2-416[»]
3OZ7X-ray2.70A/B2-415[»]
3OZAX-ray3.00A/B/C2-416[»]
ProteinModelPortaliP27362.
SMRiP27362.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27362.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni63 – 66Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000227107.
InParanoidiP27362.
KOiK00927.
OMAiTEYHANT.
PhylomeDBiP27362.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGNKLSISD LKDIKNKKVL VRVDFNVPIE NGIIKDTNRI TATLPTINHL
60 70 80 90 100
KKEGASKIIL ISHCGRPDGL RNEKYTLKPV AETLKGLLGE EVLFLNDCVG
110 120 130 140 150
KEVEDKINAA KENSVILLEN LRFHIEEEGK GVDANGNKVK ANKEDVEKFQ
160 170 180 190 200
NDLTKLADVF INDAFGTAHR AHSSMVGVKL NVKASGFLMK KELEYFSKAL
210 220 230 240 250
ENPQRPLLAI LGGAKVSDKI QLIKNLLDKV DRMIIGGGMA YTFKKVLNNM
260 270 280 290 300
KIGTSLFDEA GSKIVGEIME KAKAKNVQIF LPVDFKIADN FDNNANTKFV
310 320 330 340 350
TDEEGIPDNW MGLDAGPKSI ENYKDVILTS KTVIWNGPQG VFEMPNFAKG
360 370 380 390 400
SIECLNLVVE VTKKGAITIV GGGDTASLVE QQNKKNEISH VSTGGGASLE
410
LLEGKELPGV LALSNK
Length:416
Mass (Da):45,427
Last modified:August 1, 1992 - v1
Checksum:i91105E552AE944CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59249 Genomic DNA. Translation: AAA29727.1.
AL844508 Genomic DNA. Translation: CAD51907.1.
PIRiJU0475.
RefSeqiXP_001352096.1. XM_001352060.1.

Genome annotation databases

EnsemblProtistsiCAD51907; CAD51907; PF3D7_0922500.
GeneDBiPF3D7_0922500.1:pep.
GeneIDi813501.
KEGGipfa:PFI1105w.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59249 Genomic DNA. Translation: AAA29727.1.
AL844508 Genomic DNA. Translation: CAD51907.1.
PIRiJU0475.
RefSeqiXP_001352096.1. XM_001352060.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LGImodel-A4-416[»]
1LTKX-ray3.00A/B/C2-416[»]
3OZ7X-ray2.70A/B2-415[»]
3OZAX-ray3.00A/B/C2-416[»]
ProteinModelPortaliP27362.
SMRiP27362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1208777. 3 interactors.
IntActiP27362. 3 interactors.
MINTiMINT-1572586.

PTM databases

SwissPalmiP27362.

Proteomic databases

PRIDEiP27362.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAD51907; CAD51907; PF3D7_0922500.
GeneDBiPF3D7_0922500.1:pep.
GeneIDi813501.
KEGGipfa:PFI1105w.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0922500.

Phylogenomic databases

HOGENOMiHOG000227107.
InParanoidiP27362.
KOiK00927.
OMAiTEYHANT.
PhylomeDBiP27362.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BRENDAi2.7.2.3. 4889.
ReactomeiR-PFA-70171. Glycolysis.
R-PFA-70263. Gluconeogenesis.

Miscellaneous databases

EvolutionaryTraceiP27362.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_PLAF7
AccessioniPrimary (citable) accession number: P27362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.