Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P27362

- PGK_PLAF7

UniProt

P27362 - PGK_PLAF7

Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Binding sitei122 – 1221SubstrateBy similarity
    Binding sitei170 – 1701SubstrateBy similarity
    Binding sitei215 – 2151ATP
    Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
    Binding sitei343 – 3431ATP
    Binding sitei374 – 3741ATP

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi372 – 3754ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: GeneDB_Pfalciparum

    GO - Biological processi

    1. glycolytic process Source: GeneDB_Pfalciparum

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGK
    ORF Names:PFI1105w
    OrganismiPlasmodium falciparum (isolate 3D7)
    Taxonomic identifieri36329 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
    ProteomesiUP000001450: Chromosome 9

    Organism-specific databases

    EuPathDBiPlasmoDB:PF3D7_0922500.

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Phosphoglycerate kinasePRO_0000145859Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi1208777. 3 interactions.
    IntActiP27362. 3 interactions.
    MINTiMINT-1572586.
    STRINGi5833.PFI1105w-1.

    Structurei

    Secondary structure

    1
    416
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 43
    Helixi8 – 103
    Beta strandi18 – 225
    Beta strandi33 – 353
    Helixi38 – 414
    Helixi44 – 5310
    Beta strandi56 – 616
    Helixi73 – 753
    Helixi78 – 8811
    Beta strandi93 – 964
    Beta strandi98 – 1003
    Helixi101 – 1099
    Beta strandi114 – 1185
    Helixi121 – 1233
    Turni125 – 1284
    Beta strandi129 – 1324
    Beta strandi138 – 1403
    Helixi143 – 15412
    Beta strandi158 – 1625
    Helixi165 – 1673
    Helixi173 – 1764
    Beta strandi183 – 1853
    Helixi187 – 20014
    Beta strandi205 – 2128
    Helixi217 – 2193
    Helixi220 – 2278
    Beta strandi231 – 2366
    Helixi239 – 24810
    Turni259 – 2613
    Helixi262 – 27413
    Beta strandi278 – 2803
    Beta strandi283 – 29210
    Beta strandi297 – 3048
    Beta strandi311 – 3155
    Helixi317 – 32812
    Beta strandi331 – 3377
    Helixi345 – 3473
    Helixi349 – 36416
    Beta strandi367 – 3704
    Helixi373 – 3819
    Helixi385 – 3873
    Beta strandi388 – 3914
    Helixi396 – 4027
    Helixi408 – 4114

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LGImodel-A4-416[»]
    1LTKX-ray3.00A/B/C2-416[»]
    3OZ7X-ray2.70A/B2-415[»]
    3OZAX-ray3.00A/B/C2-416[»]
    ProteinModelPortaliP27362.
    SMRiP27362. Positions 2-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP27362.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni63 – 664Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiFPVDYVT.
    PhylomeDBiP27362.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGNKLSISD LKDIKNKKVL VRVDFNVPIE NGIIKDTNRI TATLPTINHL    50
    KKEGASKIIL ISHCGRPDGL RNEKYTLKPV AETLKGLLGE EVLFLNDCVG 100
    KEVEDKINAA KENSVILLEN LRFHIEEEGK GVDANGNKVK ANKEDVEKFQ 150
    NDLTKLADVF INDAFGTAHR AHSSMVGVKL NVKASGFLMK KELEYFSKAL 200
    ENPQRPLLAI LGGAKVSDKI QLIKNLLDKV DRMIIGGGMA YTFKKVLNNM 250
    KIGTSLFDEA GSKIVGEIME KAKAKNVQIF LPVDFKIADN FDNNANTKFV 300
    TDEEGIPDNW MGLDAGPKSI ENYKDVILTS KTVIWNGPQG VFEMPNFAKG 350
    SIECLNLVVE VTKKGAITIV GGGDTASLVE QQNKKNEISH VSTGGGASLE 400
    LLEGKELPGV LALSNK 416
    Length:416
    Mass (Da):45,427
    Last modified:August 1, 1992 - v1
    Checksum:i91105E552AE944CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59249 Genomic DNA. Translation: AAA29727.1.
    AL844508 Genomic DNA. Translation: CAD51907.1.
    PIRiJU0475.
    RefSeqiXP_001352096.1. XM_001352060.1.

    Genome annotation databases

    EnsemblProtistsiPFI1105w:mRNA; PFI1105w:pep; PFI1105w.
    GeneIDi813501.
    KEGGipfa:PFI1105w.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59249 Genomic DNA. Translation: AAA29727.1 .
    AL844508 Genomic DNA. Translation: CAD51907.1 .
    PIRi JU0475.
    RefSeqi XP_001352096.1. XM_001352060.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LGI model - A 4-416 [» ]
    1LTK X-ray 3.00 A/B/C 2-416 [» ]
    3OZ7 X-ray 2.70 A/B 2-415 [» ]
    3OZA X-ray 3.00 A/B/C 2-416 [» ]
    ProteinModelPortali P27362.
    SMRi P27362. Positions 2-415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1208777. 3 interactions.
    IntActi P27362. 3 interactions.
    MINTi MINT-1572586.
    STRINGi 5833.PFI1105w-1.

    Chemistry

    DrugBanki DB00131. Adenosine monophosphate.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PFI1105w:mRNA ; PFI1105w:pep ; PFI1105w .
    GeneIDi 813501.
    KEGGi pfa:PFI1105w.

    Organism-specific databases

    EuPathDBi PlasmoDB:PF3D7_0922500.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi FPVDYVT.
    PhylomeDBi P27362.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Miscellaneous databases

    EvolutionaryTracei P27362.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glycolytic pathway of the human malaria parasite Plasmodium falciparum: primary sequence analysis of the gene encoding 3-phosphoglycerate kinase and chromosomal mapping studies."
      Hicks K.E., Read M., Holloway S.P., Sims P.F.G., Hyde J.E.
      Gene 100:123-129(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7.
    3. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
      Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
      , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
      Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7.
    4. "Biochemical characterization and crystallization of recombinant 3-phosphoglycerate kinase of Plasmodium falciparum."
      Pal B., Pybus B., Muccio D.D., Chattopadhyay D.
      Biochim. Biophys. Acta 1699:277-280(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 2-416 IN COMPLEX WITH AMP.

    Entry informationi

    Entry nameiPGK_PLAF7
    AccessioniPrimary (citable) accession number: P27362
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3