ID   143T_HUMAN     STANDARD;      PRT;   245 AA.
AC   P27348;
DT   01-AUG-1992 (REL. 23, CREATED)
DT   01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   14-3-3 PROTEIN THETA (14-3-3 PROTEIN T-CELL) (HS1 PROTEIN).
OS   HOMO SAPIENS (HUMAN), AND BOS TAURUS (BOVINE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   SPECIES=HUMAN; TISSUE=T-CELL;
RM   91198149
RA   NIELSEN P.J.;
RL   BIOCHIM. BIOPHYS. ACTA 1088:425-428(1991).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   SPECIES=HUMAN; TISSUE=KERATINOCYTES;
RM   93294871
RA   LEFFERS H., MADSEN P., RASMUSSEN H.H., HONORE B., ANDERSEN A.H.,
RA   WALBUM E., VANDEKERCKHOVE J., CELIS J.E.;
RL   J. MOL. BIOL. 231:982-998(1993).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   SPECIES=BOVINE;
RM   93211953
RA   FU H., COBURN J., COLLIER R.J.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 90:2320-2324(1993).
CC   -!- FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE
CC       PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND
CC       STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL
CC       REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH
CC       KINASES.
CC   -!- SUBUNIT: HOMODIMER.
CC   -!- SUBCELLULAR LOCATION: CYTOPLASMIC.
CC   -!- TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND
CC       ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO
CC       PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES.
CC   -!- SIMILARITY: BELONGS TO THE 14-3-3 FAMILY OF PROTEINS.
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DR   EMBL; X56468; HS1433.
DR   EMBL; X57347; HSHS1RNA.
DR   EMBL; L07955; BTFAS.
DR   PIR; S15076; S15076.
DR   PIR; S29342; S29342.
DR   PROSITE; PS00796; 1433_1.
DR   PROSITE; PS00797; 1433_2.
KW   BRAIN; NEURONE; PHOSPHORYLATION; MULTIGENE FAMILY.
FT   MOD_RES      63     63       PHOSPHORYLATION (POTENTIAL).
FT   DOMAIN      168    245       BINDING REGION TO THE REGULATORY DOMAIN
FT                                OF HYDROXYLASES (POTENTIAL).
SQ   SEQUENCE   245 AA;  27764 MW;  283195 CN;
     MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR
     VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK
     MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE
     ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA
     EGAEN
//