ID   143C_HUMAN     STANDARD;      PRT;   245 AA.
AC   P27348;
DT   01-AUG-1992 (REL. 23, CREATED)
DT   01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   14-3-3 PROTEIN T-CELL.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=T-CELL;
RM   91198149
RA   NIELSEN P.J.;
RL   BIOCHIM. BIOPHYS. ACTA 1088:425-428(1991).
CC   -!- FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE
CC       PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND
CC       STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL
CC       REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH
CC       KINASES.
CC   -!- SUBUNIT: HOMODIMER.
CC   -!- SUBCELLULAR LOCATION: CYTOSOLIC.
CC   -!- TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND
CC       ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO
CC       PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES.
CC   -!- SIMILARITY: BELONGS TO THE 14-3-3 FAMILY OF PROTEINS.
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DR   EMBL; X56468; HS1433.
DR   PIR; S15076; S15076.
DR   PROSITE; PS00796; 1433_1.
DR   PROSITE; PS00797; 1433_2.
KW   BRAIN; NEURONE; PHOSPHORYLATION; MULTIGENE FAMILY.
FT   MOD_RES      63     63       PHOSPHORYLATION (POTENTIAL).
FT   DOMAIN      168    245       POTENTIAL BINDING REGION TO REGULATORY
FT                                DOMAIN OF THE HYDROXLASE.
SQ   SEQUENCE   245 AA;  27764 MW;  283195 CN;
     MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR
     VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK
     MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE
     ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA
     EGAEN
//