ID   143T_HUMAN     STANDARD;      PRT;   245 AA.
AC   P27348;
DT   01-AUG-1992 (REL. 23, CREATED)
DT   01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE)
DT   01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE)
DE   14-3-3 PROTEIN TAU (14-3-3 PROTEIN THETA) (14-3-3 PROTEIN T-CELL)
DE   (HS1 PROTEIN).
GN   YWHAQ.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=T-CELL;
RX   MEDLINE; 91198149.
RA   NIELSEN P.J.;
RT   "Primary structure of a human protein kinase regulator protein.";
RL   BIOCHIM. BIOPHYS. ACTA 1088:425-428(1991).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=KERATINOCYTES;
RX   MEDLINE; 93294871.
RA   LEFFERS H., MADSEN P., RASMUSSEN H.H., HONORE B., ANDERSEN A.H.,
RA   WALBUM E., VANDEKERCKHOVE J., CELIS J.E.;
RT   "Molecular cloning and expression of the transformation sensitive
RT   epithelial marker stratifin. A member of a protein family that has
RT   been involved in the protein kinase C signalling pathway.";
RL   J. MOL. BIOL. 231:982-998(1993).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
RX   MEDLINE; 95327195.
RA   XIAO B., SMERDON S.J., JONES D.H., DODSON G.G., SONEJI Y.,
RA   AITKEN A., GAMBLIN S.J.;
RT   "Structure of a 14-3-3 protein and implications for coordination of
RT   multiple signalling pathways.";
RL   NATURE 376:188-191(1995).
CC   -!- FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE
CC       PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND
CC       STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL
CC       REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH
CC       KINASES.
CC   -!- SUBUNIT: HOMODIMER.
CC   -!- SUBCELLULAR LOCATION: CYTOPLASMIC.
CC   -!- TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND
CC       ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO
CC       PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES.
CC   -!- SIMILARITY: BELONGS TO THE 14-3-3 FAMILY.
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DR   EMBL; X56468; G23222; -.
DR   EMBL; X57347; G32464; -.
DR   PIR; S15076; S15076.
DR   PIR; S29342; S29342.
DR   PIR; S34754; S34754.
DR   PROSITE; PS00796; 1433_1; 1.
DR   PROSITE; PS00797; 1433_2; 1.
DR   PFAM; PF00244; 14-3-3; 1.
KW   BRAIN; NEURONE; PHOSPHORYLATION; MULTIGENE FAMILY.
SQ   SEQUENCE   245 AA;  27764 MW;  EBED446B CRC32;
     MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR
     VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK
     MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE
     ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA
     EGAEN
//