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Protein

14-3-3 protein theta

Gene

YWHAQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein domain specific binding Source: InterPro
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
SignaLinkiP27348
SIGNORiP27348

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein theta
Alternative name(s):
14-3-3 protein T-cell
14-3-3 protein tau
Protein HS1
Gene namesi
Name:YWHAQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000134308.13
HGNCiHGNC:12854 YWHAQ
MIMi609009 gene
neXtProtiNX_P27348

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10971
OpenTargetsiENSG00000134308
PharmGKBiPA37443

Chemistry databases

ChEMBLiCHEMBL3710408

Polymorphism and mutation databases

DMDMi112690

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000586361 – 24514-3-3 protein thetaAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei3N6-acetyllysineCombined sources1
Modified residuei49N6-acetyllysine; alternateCombined sources1
Cross-linki49Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei68N6-acetyllysineCombined sources1
Modified residuei82Nitrated tyrosineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei104Nitrated tyrosineBy similarity1
Modified residuei115N6-acetyllysineCombined sources1
Modified residuei232PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Ser-232 is probably phosphorylated by CK1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Nitration, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP27348
MaxQBiP27348
PaxDbiP27348
PeptideAtlasiP27348
PRIDEiP27348
TopDownProteomicsiP27348

2D gel databases

OGPiP27348
REPRODUCTION-2DPAGEIPI00018146

PTM databases

iPTMnetiP27348
PhosphoSitePlusiP27348
SwissPalmiP27348

Miscellaneous databases

PMAP-CutDBP27348

Expressioni

Tissue specificityi

Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.1 Publication

Gene expression databases

BgeeiENSG00000134308
CleanExiHS_YWHAQ
ExpressionAtlasiP27348 baseline and differential
GenevisibleiP27348 HS

Organism-specific databases

HPAiCAB010286
HPA007925

Interactioni

Subunit structurei

Homodimer. Interacts with CDK16 (By similarity). Interacts with RGS7 (phosphorylated form) (PubMed:10862767). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with RIPOR2 isoform 2 (PubMed:25588844). Interacts with INAVA; the interaction increases upon PRR (pattern recognition receptor) stimulation and is required for cellular signaling pathway activation and cytokine secretion (PubMed:28436939).By similarity11 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei56Interaction with phosphoserine on interacting protein1
Sitei127Interaction with phosphoserine on interacting protein1

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein domain specific binding Source: InterPro
  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116168, 462 interactors
CORUMiP27348
DIPiDIP-27584N
ELMiP27348
IntActiP27348, 114 interactors
MINTiP27348
STRINGi9606.ENSP00000238081

Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 15Combined sources13
Helixi19 – 30Combined sources12
Helixi38 – 67Combined sources30
Helixi74 – 103Combined sources30
Turni104 – 108Combined sources5
Helixi112 – 132Combined sources21
Helixi136 – 159Combined sources24
Helixi165 – 180Combined sources16
Helixi185 – 201Combined sources17
Helixi202 – 205Combined sources4
Turni208 – 210Combined sources3
Helixi211 – 229Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BTPX-ray2.80A/B1-234[»]
5IQPX-ray2.60A/B1-245[»]
ProteinModelPortaliP27348
SMRiP27348
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27348

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
GeneTreeiENSGT00760000119116
HOGENOMiHOG000240379
HOVERGENiHBG050423
InParanoidiP27348
KOiK16197
OMAiPLCNEER
OrthoDBiEOG091G0VKY
PhylomeDBiP27348
TreeFamiTF102002

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

Sequencei

Sequence statusi: Complete.

P27348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN
60 70 80 90 100
VVGGRRSAWR VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL
110 120 130 140 150
LDKYLIANAT NPESKVFYLK MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ
160 170 180 190 200
EAFDISKKEM QPTHPIRLGL ALNFSVFYYE ILNNPELACT LAKTAFDEAI
210 220 230 240
AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA EGAEN
Length:245
Mass (Da):27,764
Last modified:August 1, 1992 - v1
Checksum:i175534325E9E37C4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136D → N in AAV38817 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56468 mRNA Translation: CAA39840.1
X57347 mRNA Translation: CAA40622.1
BT020014 mRNA Translation: AAV38817.1
CH471053 Genomic DNA Translation: EAX00977.1
CH471053 Genomic DNA Translation: EAX00979.1
BC050601 mRNA Translation: AAH50601.1
BC056867 mRNA Translation: AAH56867.1
BC093019 mRNA Translation: AAH93019.1
AF070556 mRNA Translation: AAC28640.1
CCDSiCCDS1666.1
PIRiS15076
RefSeqiNP_006817.1, NM_006826.3
UniGeneiHs.74405

Genome annotation databases

EnsembliENST00000238081; ENSP00000238081; ENSG00000134308
ENST00000381844; ENSP00000371267; ENSG00000134308
GeneIDi10971
KEGGihsa:10971
UCSCiuc002qzx.5 human

Similar proteinsi

Entry informationi

Entry namei1433T_HUMAN
AccessioniPrimary (citable) accession number: P27348
Secondary accession number(s): D6W4Z5
, Q567U5, Q5TZU8, Q9UP48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 199 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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