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Protein

Movement and silencing protein TGBp1

Gene

ORF2

Organism
Lily virus X
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).By similarity

Miscellaneous

TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-cell propagation. TGBp1 is the main movement protein that physically cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would facilitate TGBp1 function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing, Viral movement protein
Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Movement and silencing protein TGBp1
Alternative name(s):
25 kDa protein
Silencing suppressor P25
Triple gene block 1 protein
Short name:
TGBp1
Gene namesi
ORF Names:ORF2
OrganismiLily virus X
Taxonomic identifieri12194 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaePotexvirus
Virus hostiLilium formosanum [TaxID: 63788]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002225661 – 216Movement and silencing protein TGBp1Add BLAST216

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with capsid protein. Interacts with host AGO1; this interaction targets the host protein for degradation, thereby suppressing the antiviral RNA silencing (By similarity).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110(+)RNA virus helicase ATP-bindingAdd BLAST110
Domaini111 – 216(+)RNA virus helicase C-terminalAdd BLAST106

Sequence similaritiesi

Belongs to the Tymovirales TGBp1 protein family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
PfamiView protein in Pfam
PF01443. Viral_helicase1. 1 hit.
PROSITEiView protein in PROSITE
PS51657. PSRV_HELICASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P27329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFCGGTLRT RFQRTSVPNS PVTVVHTVAG SGKTTFIRNL LIDHPQLVAR
60 70 80 90 100
TYGTPDVPNL LGYGIRDRHG DAHIVDEYPA ADLRSHPSVS IVFADPLQHH
110 120 130 140 150
GEVRPAHFTC SHTHRFGKST CSLLGTLGVY CTSDKEDSVT FAGAYLAEPV
160 170 180 190 200
GTLIALGEDA ELVLDNHRVE YFTPCQALGL TFPSVTLLTD APIEDQPPVS
210
RYIALTRHTD SLLILN
Length:216
Mass (Da):23,575
Last modified:August 1, 1992 - v1
Checksum:i301ABB63308DE30B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15342 Genomic RNA. Translation: CAA33394.1.

Similar proteinsi

Entry informationi

Entry nameiTGB1_LVX
AccessioniPrimary (citable) accession number: P27329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 15, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families