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P27316

- L_RVFVZ

UniProt

P27316 - L_RVFVZ

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Protein
RNA-directed RNA polymerase L
Gene
L
Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. nucleoside binding Source: InterPro
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
Taxonomic identifieri11589 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]
ProteomesiUP000002477: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21492149RNA-directed RNA polymerase L
PRO_0000222023Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini975 – 1166192RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFiPIRSF000826. L_PhleboV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27316-1 [UniParc]FASTAAdd to Basket

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MDSILSKQLV DKTGFVRVPI KHFDCTMLTL ALPTFDVSKM VDRITIDFNL     50
DDIQGASEIG STLLPSMSID VEDMANFVHD FTFGHLADKT DRLLMREFPM 100
MNDGFDHLSP DMIIKTTSGV YNIVEFTNFR GDERGAFQAA MIKLAKYEVP 150
CENRSQGRTV VLYVVSAYRA WCMVYLELER TLKQREMVYR YRLALSVMDE 200
LRTLFPELSS TDEELGKTER ELPAMVSSIQ INWSVTESVF PPFSREMFDR 250
FRSSPPDSEY ITRIVSRCLI NSQEKLINSS FFAEGNDKAL RFSKNAEECS 300
LAVERALNQY RAEDNLRDLN DHKSTIQLPP WLSYHDVDGK DLCPLQGLDV 350
RGDHPMCNLW REVVTSANLE EIERMHDDAA AELEFAFGSK GQARERNRYH 400
RVHLNMGSDV LVYIAALGVN GKKHKADTLV QQMRDRSKQP FSPDHDVITY 450
LNFSLHALVT CGQQMRTCTA LSLVIRDSVG SPEDSSAILV RKGFHEIITE 500
HYKFMGSRIG HGCQMVSLIG AELSASVKQH VKPNYFVIKR LLGSGIFLLI 550
KPTSSKSHIF VSFALSALAG PLISPLPGFS SPTKMLGILL VTDFVSYKLS 600
KLTNLCKCVS LMESSFSFWA EAFGIQAGTL VGDFVPRSSD SAAMDASYMG 650
KLSLLTLLED KAATEELQTI ARYIIMEGFV SPPEIPKPHK MTSKFPKVLR 700
SELQVYLLNC LCRTIQRIAG EPFILKKKDG SISWGGMFNP FSGRPLLDMQ 750
PLISCCYNGY FKNKEEETEP SSLSGMYKKI IELEHLRPQS DAFLGYKDPE 800
LPRMHEFSVS YLKEACNHAK LVLRSLYGQN FMEQIDNQII RELSGLTLER 850
LATLKATSNF NENWYVYKDV ADKNYTRDKL LVKMSKYASE GKSLAIQKFE 900
DCMRQIESQG CMHICLFKKQ QHGGLREIYV MGAEERIVQS VVETIARSIG 950
KFFASDTLCN PPNKVKIPET HGIRARKQCK GPVWTCATSD DARKWNQGHF 1000
VTKFALMLCE FTSPKWWPLI IRGCSMFTKK RMMMNLNYLK ILDGHRELDI 1050
RDDFVMDLFK AYHGEAEVPW AFKGKTYLET TTGMMQGILH YTSSLLHTIH 1100
QEYIRSLSFK IFNLKVAPEM SKSLVCDMMQ GSDDSSMLIS FPADDEKVLT 1150
RCKVAAAICF RMKKELGVYL AIYPSEKSTA NTDFVMEYNS EFYFHTQHVR 1200
PTIRWIAACC SLPEVETLVA RQEEASNLMT SVTEGGGSFS LAAIIQQAQC 1250
TLHYMLMGMG VSELFLEYKK AVLKWNDPGL GFFLLDNPYA CGLGGFRFNL 1300
FKAITRTDLQ KLYAFFMKKV KGSAARDWAD EDVTIPETCS VSPGGALILS 1350
SSLKWGSRKK FQKLRDRLNI PENWIELINE NPEVLYRAPR TGPEILLRIA 1400
EKVHSPGVVS SLSSGNAVCK VMASAVYFLS ATIFEDTGRP EFNFLEDSKY 1450
SLLQKMAAYS GFHGFNDMEP EDILFLFPNI EELESLDSIV YNKGEIDIIP 1500
RVNIRDATQT RVTIFNEQKN LRTSPEKLVS DKWFGTQKSR IGKTTFLAEW 1550
EKLKKIVKWL EDAPEATLAH TPLNNHIQVR NFFARMESKP RTVRITGAPV 1600
KKRSGVSKIA MVIRDHFSRM GHLRGVEDLA GFTRSVSAEI LKHFLFCILQ 1650
GPYSESYKLQ LIYRVLSSVS NVEIKESDGK TKTNLIGILQ RFLDGDHVVP 1700
IIEEMGAGTV GGFIKRQQSK VVQNKVVYYG VGIWRGFMDG YQVHLEIEND 1750
IGQPPRLRNV TTNCQSSPWD LSIPIRQWAE DMGVTNNQDY SSKSSRGARY 1800
WMHSFRMQGP SKPFGCPVYI IKGDMSDVIR LRKEEVEMKV RGSTLNLYTK 1850
HHSHQDLHIL SYTASDNDLS PGIFKSISDE GVAQALQLFE REPSNCWVRC 1900
ESVAPKFISA ILEICEGKRQ IKGINRTRLS EIVRICSESS LRSKVGSMFS 1950
FVANVEEAHD VDYDALMDLM IEDAKNNAFS HVVDCIELDV SGPYEMESFH 2000
GRSTLTCTPS TILIRTYTFY LTLHQTMISV QAFQVILDEG VLLIALVNNY 2050
LRGSKANCWV RCESVAPKFI SAILEICEGK RQIKGINRTR LSEIVEFVLN 2100
LPKIKSRIYV LICRQCHGAN FPPISVRRLM LEDIASVARR LIIVASFGS 2149
Length:2,149
Mass (Da):243,591
Last modified:August 1, 1992 - v1
Checksum:i8D5739C6079A88D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56464 Genomic RNA. Translation: CAA39836.1.
PIRiS18676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56464 Genomic RNA. Translation: CAA39836.1 .
PIRi S18676.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view ]
PIRSFi PIRSF000826. L_PhleboV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Rift Valley fever phlebovirus indicates that the L RNA is negative sense and codes for a putative transcriptase-replicase."
    Mueller R., Argentini C., Bouloy M., Prehaud C., Bishop D.H.L.
    Nucleic Acids Res. 19:5433-5433(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_RVFVZ
AccessioniPrimary (citable) accession number: P27316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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