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P27316

- L_RVFVZ

UniProt

P27316 - L_RVFVZ

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleoside binding Source: InterPro
    2. nucleotide binding Source: UniProtKB-KW
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
    Taxonomic identifieri11589 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiAedes [TaxID: 7158]
    Bos taurus (Bovine) [TaxID: 9913]
    Bos taurus x Bison bison (beefalo) [TaxID: 297284]
    Camelus bactrianus (Bactrian camel) [TaxID: 9837]
    Capra hircus (Goat) [TaxID: 9925]
    Homo sapiens (Human) [TaxID: 9606]
    Ovis aries (Sheep) [TaxID: 9940]
    Phlebotomus papatasi (Sandfly) [TaxID: 29031]
    ProteomesiUP000002477: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21492149RNA-directed RNA polymerase LPRO_0000222023Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini975 – 1166192RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phlebovirus RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR022531. DUF3770.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR014385. RNA-dir_pol_phlebovirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    PF12603. DUF3770. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000826. L_PhleboV. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27316-1 [UniParc]FASTAAdd to Basket

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    MDSILSKQLV DKTGFVRVPI KHFDCTMLTL ALPTFDVSKM VDRITIDFNL     50
    DDIQGASEIG STLLPSMSID VEDMANFVHD FTFGHLADKT DRLLMREFPM 100
    MNDGFDHLSP DMIIKTTSGV YNIVEFTNFR GDERGAFQAA MIKLAKYEVP 150
    CENRSQGRTV VLYVVSAYRA WCMVYLELER TLKQREMVYR YRLALSVMDE 200
    LRTLFPELSS TDEELGKTER ELPAMVSSIQ INWSVTESVF PPFSREMFDR 250
    FRSSPPDSEY ITRIVSRCLI NSQEKLINSS FFAEGNDKAL RFSKNAEECS 300
    LAVERALNQY RAEDNLRDLN DHKSTIQLPP WLSYHDVDGK DLCPLQGLDV 350
    RGDHPMCNLW REVVTSANLE EIERMHDDAA AELEFAFGSK GQARERNRYH 400
    RVHLNMGSDV LVYIAALGVN GKKHKADTLV QQMRDRSKQP FSPDHDVITY 450
    LNFSLHALVT CGQQMRTCTA LSLVIRDSVG SPEDSSAILV RKGFHEIITE 500
    HYKFMGSRIG HGCQMVSLIG AELSASVKQH VKPNYFVIKR LLGSGIFLLI 550
    KPTSSKSHIF VSFALSALAG PLISPLPGFS SPTKMLGILL VTDFVSYKLS 600
    KLTNLCKCVS LMESSFSFWA EAFGIQAGTL VGDFVPRSSD SAAMDASYMG 650
    KLSLLTLLED KAATEELQTI ARYIIMEGFV SPPEIPKPHK MTSKFPKVLR 700
    SELQVYLLNC LCRTIQRIAG EPFILKKKDG SISWGGMFNP FSGRPLLDMQ 750
    PLISCCYNGY FKNKEEETEP SSLSGMYKKI IELEHLRPQS DAFLGYKDPE 800
    LPRMHEFSVS YLKEACNHAK LVLRSLYGQN FMEQIDNQII RELSGLTLER 850
    LATLKATSNF NENWYVYKDV ADKNYTRDKL LVKMSKYASE GKSLAIQKFE 900
    DCMRQIESQG CMHICLFKKQ QHGGLREIYV MGAEERIVQS VVETIARSIG 950
    KFFASDTLCN PPNKVKIPET HGIRARKQCK GPVWTCATSD DARKWNQGHF 1000
    VTKFALMLCE FTSPKWWPLI IRGCSMFTKK RMMMNLNYLK ILDGHRELDI 1050
    RDDFVMDLFK AYHGEAEVPW AFKGKTYLET TTGMMQGILH YTSSLLHTIH 1100
    QEYIRSLSFK IFNLKVAPEM SKSLVCDMMQ GSDDSSMLIS FPADDEKVLT 1150
    RCKVAAAICF RMKKELGVYL AIYPSEKSTA NTDFVMEYNS EFYFHTQHVR 1200
    PTIRWIAACC SLPEVETLVA RQEEASNLMT SVTEGGGSFS LAAIIQQAQC 1250
    TLHYMLMGMG VSELFLEYKK AVLKWNDPGL GFFLLDNPYA CGLGGFRFNL 1300
    FKAITRTDLQ KLYAFFMKKV KGSAARDWAD EDVTIPETCS VSPGGALILS 1350
    SSLKWGSRKK FQKLRDRLNI PENWIELINE NPEVLYRAPR TGPEILLRIA 1400
    EKVHSPGVVS SLSSGNAVCK VMASAVYFLS ATIFEDTGRP EFNFLEDSKY 1450
    SLLQKMAAYS GFHGFNDMEP EDILFLFPNI EELESLDSIV YNKGEIDIIP 1500
    RVNIRDATQT RVTIFNEQKN LRTSPEKLVS DKWFGTQKSR IGKTTFLAEW 1550
    EKLKKIVKWL EDAPEATLAH TPLNNHIQVR NFFARMESKP RTVRITGAPV 1600
    KKRSGVSKIA MVIRDHFSRM GHLRGVEDLA GFTRSVSAEI LKHFLFCILQ 1650
    GPYSESYKLQ LIYRVLSSVS NVEIKESDGK TKTNLIGILQ RFLDGDHVVP 1700
    IIEEMGAGTV GGFIKRQQSK VVQNKVVYYG VGIWRGFMDG YQVHLEIEND 1750
    IGQPPRLRNV TTNCQSSPWD LSIPIRQWAE DMGVTNNQDY SSKSSRGARY 1800
    WMHSFRMQGP SKPFGCPVYI IKGDMSDVIR LRKEEVEMKV RGSTLNLYTK 1850
    HHSHQDLHIL SYTASDNDLS PGIFKSISDE GVAQALQLFE REPSNCWVRC 1900
    ESVAPKFISA ILEICEGKRQ IKGINRTRLS EIVRICSESS LRSKVGSMFS 1950
    FVANVEEAHD VDYDALMDLM IEDAKNNAFS HVVDCIELDV SGPYEMESFH 2000
    GRSTLTCTPS TILIRTYTFY LTLHQTMISV QAFQVILDEG VLLIALVNNY 2050
    LRGSKANCWV RCESVAPKFI SAILEICEGK RQIKGINRTR LSEIVEFVLN 2100
    LPKIKSRIYV LICRQCHGAN FPPISVRRLM LEDIASVARR LIIVASFGS 2149
    Length:2,149
    Mass (Da):243,591
    Last modified:August 1, 1992 - v1
    Checksum:i8D5739C6079A88D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56464 Genomic RNA. Translation: CAA39836.1.
    PIRiS18676.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56464 Genomic RNA. Translation: CAA39836.1 .
    PIRi S18676.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR022531. DUF3770.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR014385. RNA-dir_pol_phlebovirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    PF12603. DUF3770. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000826. L_PhleboV. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Rift Valley fever phlebovirus indicates that the L RNA is negative sense and codes for a putative transcriptase-replicase."
      Mueller R., Argentini C., Bouloy M., Prehaud C., Bishop D.H.L.
      Nucleic Acids Res. 19:5433-5433(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiL_RVFVZ
    AccessioniPrimary (citable) accession number: P27316
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3