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P27316

- L_RVFVZ

UniProt

P27316 - L_RVFVZ

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleoside binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
Taxonomic identifieri11589 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]
ProteomesiUP000002477: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21492149RNA-directed RNA polymerase LPRO_0000222023Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini975 – 1166192RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phlebovirus RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFiPIRSF000826. L_PhleboV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27316-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDSILSKQLV DKTGFVRVPI KHFDCTMLTL ALPTFDVSKM VDRITIDFNL
60 70 80 90 100
DDIQGASEIG STLLPSMSID VEDMANFVHD FTFGHLADKT DRLLMREFPM
110 120 130 140 150
MNDGFDHLSP DMIIKTTSGV YNIVEFTNFR GDERGAFQAA MIKLAKYEVP
160 170 180 190 200
CENRSQGRTV VLYVVSAYRA WCMVYLELER TLKQREMVYR YRLALSVMDE
210 220 230 240 250
LRTLFPELSS TDEELGKTER ELPAMVSSIQ INWSVTESVF PPFSREMFDR
260 270 280 290 300
FRSSPPDSEY ITRIVSRCLI NSQEKLINSS FFAEGNDKAL RFSKNAEECS
310 320 330 340 350
LAVERALNQY RAEDNLRDLN DHKSTIQLPP WLSYHDVDGK DLCPLQGLDV
360 370 380 390 400
RGDHPMCNLW REVVTSANLE EIERMHDDAA AELEFAFGSK GQARERNRYH
410 420 430 440 450
RVHLNMGSDV LVYIAALGVN GKKHKADTLV QQMRDRSKQP FSPDHDVITY
460 470 480 490 500
LNFSLHALVT CGQQMRTCTA LSLVIRDSVG SPEDSSAILV RKGFHEIITE
510 520 530 540 550
HYKFMGSRIG HGCQMVSLIG AELSASVKQH VKPNYFVIKR LLGSGIFLLI
560 570 580 590 600
KPTSSKSHIF VSFALSALAG PLISPLPGFS SPTKMLGILL VTDFVSYKLS
610 620 630 640 650
KLTNLCKCVS LMESSFSFWA EAFGIQAGTL VGDFVPRSSD SAAMDASYMG
660 670 680 690 700
KLSLLTLLED KAATEELQTI ARYIIMEGFV SPPEIPKPHK MTSKFPKVLR
710 720 730 740 750
SELQVYLLNC LCRTIQRIAG EPFILKKKDG SISWGGMFNP FSGRPLLDMQ
760 770 780 790 800
PLISCCYNGY FKNKEEETEP SSLSGMYKKI IELEHLRPQS DAFLGYKDPE
810 820 830 840 850
LPRMHEFSVS YLKEACNHAK LVLRSLYGQN FMEQIDNQII RELSGLTLER
860 870 880 890 900
LATLKATSNF NENWYVYKDV ADKNYTRDKL LVKMSKYASE GKSLAIQKFE
910 920 930 940 950
DCMRQIESQG CMHICLFKKQ QHGGLREIYV MGAEERIVQS VVETIARSIG
960 970 980 990 1000
KFFASDTLCN PPNKVKIPET HGIRARKQCK GPVWTCATSD DARKWNQGHF
1010 1020 1030 1040 1050
VTKFALMLCE FTSPKWWPLI IRGCSMFTKK RMMMNLNYLK ILDGHRELDI
1060 1070 1080 1090 1100
RDDFVMDLFK AYHGEAEVPW AFKGKTYLET TTGMMQGILH YTSSLLHTIH
1110 1120 1130 1140 1150
QEYIRSLSFK IFNLKVAPEM SKSLVCDMMQ GSDDSSMLIS FPADDEKVLT
1160 1170 1180 1190 1200
RCKVAAAICF RMKKELGVYL AIYPSEKSTA NTDFVMEYNS EFYFHTQHVR
1210 1220 1230 1240 1250
PTIRWIAACC SLPEVETLVA RQEEASNLMT SVTEGGGSFS LAAIIQQAQC
1260 1270 1280 1290 1300
TLHYMLMGMG VSELFLEYKK AVLKWNDPGL GFFLLDNPYA CGLGGFRFNL
1310 1320 1330 1340 1350
FKAITRTDLQ KLYAFFMKKV KGSAARDWAD EDVTIPETCS VSPGGALILS
1360 1370 1380 1390 1400
SSLKWGSRKK FQKLRDRLNI PENWIELINE NPEVLYRAPR TGPEILLRIA
1410 1420 1430 1440 1450
EKVHSPGVVS SLSSGNAVCK VMASAVYFLS ATIFEDTGRP EFNFLEDSKY
1460 1470 1480 1490 1500
SLLQKMAAYS GFHGFNDMEP EDILFLFPNI EELESLDSIV YNKGEIDIIP
1510 1520 1530 1540 1550
RVNIRDATQT RVTIFNEQKN LRTSPEKLVS DKWFGTQKSR IGKTTFLAEW
1560 1570 1580 1590 1600
EKLKKIVKWL EDAPEATLAH TPLNNHIQVR NFFARMESKP RTVRITGAPV
1610 1620 1630 1640 1650
KKRSGVSKIA MVIRDHFSRM GHLRGVEDLA GFTRSVSAEI LKHFLFCILQ
1660 1670 1680 1690 1700
GPYSESYKLQ LIYRVLSSVS NVEIKESDGK TKTNLIGILQ RFLDGDHVVP
1710 1720 1730 1740 1750
IIEEMGAGTV GGFIKRQQSK VVQNKVVYYG VGIWRGFMDG YQVHLEIEND
1760 1770 1780 1790 1800
IGQPPRLRNV TTNCQSSPWD LSIPIRQWAE DMGVTNNQDY SSKSSRGARY
1810 1820 1830 1840 1850
WMHSFRMQGP SKPFGCPVYI IKGDMSDVIR LRKEEVEMKV RGSTLNLYTK
1860 1870 1880 1890 1900
HHSHQDLHIL SYTASDNDLS PGIFKSISDE GVAQALQLFE REPSNCWVRC
1910 1920 1930 1940 1950
ESVAPKFISA ILEICEGKRQ IKGINRTRLS EIVRICSESS LRSKVGSMFS
1960 1970 1980 1990 2000
FVANVEEAHD VDYDALMDLM IEDAKNNAFS HVVDCIELDV SGPYEMESFH
2010 2020 2030 2040 2050
GRSTLTCTPS TILIRTYTFY LTLHQTMISV QAFQVILDEG VLLIALVNNY
2060 2070 2080 2090 2100
LRGSKANCWV RCESVAPKFI SAILEICEGK RQIKGINRTR LSEIVEFVLN
2110 2120 2130 2140
LPKIKSRIYV LICRQCHGAN FPPISVRRLM LEDIASVARR LIIVASFGS
Length:2,149
Mass (Da):243,591
Last modified:August 1, 1992 - v1
Checksum:i8D5739C6079A88D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56464 Genomic RNA. Translation: CAA39836.1.
PIRiS18676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56464 Genomic RNA. Translation: CAA39836.1 .
PIRi S18676.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view ]
PIRSFi PIRSF000826. L_PhleboV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Rift Valley fever phlebovirus indicates that the L RNA is negative sense and codes for a putative transcriptase-replicase."
    Mueller R., Argentini C., Bouloy M., Prehaud C., Bishop D.H.L.
    Nucleic Acids Res. 19:5433-5433(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_RVFVZ
AccessioniPrimary (citable) accession number: P27316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3