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P27316 (L_RVFVZ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismRift valley fever virus (strain ZH-548 M12) (RVFV) [Reference proteome]
Taxonomic identifier11589 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]

Protein attributes

Sequence length2149 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the phlebovirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21492149RNA-directed RNA polymerase L
PRO_0000222023

Regions

Domain975 – 1166192RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P27316 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 8D5739C6079A88D7

FASTA2,149243,591
        10         20         30         40         50         60 
MDSILSKQLV DKTGFVRVPI KHFDCTMLTL ALPTFDVSKM VDRITIDFNL DDIQGASEIG 

        70         80         90        100        110        120 
STLLPSMSID VEDMANFVHD FTFGHLADKT DRLLMREFPM MNDGFDHLSP DMIIKTTSGV 

       130        140        150        160        170        180 
YNIVEFTNFR GDERGAFQAA MIKLAKYEVP CENRSQGRTV VLYVVSAYRA WCMVYLELER 

       190        200        210        220        230        240 
TLKQREMVYR YRLALSVMDE LRTLFPELSS TDEELGKTER ELPAMVSSIQ INWSVTESVF 

       250        260        270        280        290        300 
PPFSREMFDR FRSSPPDSEY ITRIVSRCLI NSQEKLINSS FFAEGNDKAL RFSKNAEECS 

       310        320        330        340        350        360 
LAVERALNQY RAEDNLRDLN DHKSTIQLPP WLSYHDVDGK DLCPLQGLDV RGDHPMCNLW 

       370        380        390        400        410        420 
REVVTSANLE EIERMHDDAA AELEFAFGSK GQARERNRYH RVHLNMGSDV LVYIAALGVN 

       430        440        450        460        470        480 
GKKHKADTLV QQMRDRSKQP FSPDHDVITY LNFSLHALVT CGQQMRTCTA LSLVIRDSVG 

       490        500        510        520        530        540 
SPEDSSAILV RKGFHEIITE HYKFMGSRIG HGCQMVSLIG AELSASVKQH VKPNYFVIKR 

       550        560        570        580        590        600 
LLGSGIFLLI KPTSSKSHIF VSFALSALAG PLISPLPGFS SPTKMLGILL VTDFVSYKLS 

       610        620        630        640        650        660 
KLTNLCKCVS LMESSFSFWA EAFGIQAGTL VGDFVPRSSD SAAMDASYMG KLSLLTLLED 

       670        680        690        700        710        720 
KAATEELQTI ARYIIMEGFV SPPEIPKPHK MTSKFPKVLR SELQVYLLNC LCRTIQRIAG 

       730        740        750        760        770        780 
EPFILKKKDG SISWGGMFNP FSGRPLLDMQ PLISCCYNGY FKNKEEETEP SSLSGMYKKI 

       790        800        810        820        830        840 
IELEHLRPQS DAFLGYKDPE LPRMHEFSVS YLKEACNHAK LVLRSLYGQN FMEQIDNQII 

       850        860        870        880        890        900 
RELSGLTLER LATLKATSNF NENWYVYKDV ADKNYTRDKL LVKMSKYASE GKSLAIQKFE 

       910        920        930        940        950        960 
DCMRQIESQG CMHICLFKKQ QHGGLREIYV MGAEERIVQS VVETIARSIG KFFASDTLCN 

       970        980        990       1000       1010       1020 
PPNKVKIPET HGIRARKQCK GPVWTCATSD DARKWNQGHF VTKFALMLCE FTSPKWWPLI 

      1030       1040       1050       1060       1070       1080 
IRGCSMFTKK RMMMNLNYLK ILDGHRELDI RDDFVMDLFK AYHGEAEVPW AFKGKTYLET 

      1090       1100       1110       1120       1130       1140 
TTGMMQGILH YTSSLLHTIH QEYIRSLSFK IFNLKVAPEM SKSLVCDMMQ GSDDSSMLIS 

      1150       1160       1170       1180       1190       1200 
FPADDEKVLT RCKVAAAICF RMKKELGVYL AIYPSEKSTA NTDFVMEYNS EFYFHTQHVR 

      1210       1220       1230       1240       1250       1260 
PTIRWIAACC SLPEVETLVA RQEEASNLMT SVTEGGGSFS LAAIIQQAQC TLHYMLMGMG 

      1270       1280       1290       1300       1310       1320 
VSELFLEYKK AVLKWNDPGL GFFLLDNPYA CGLGGFRFNL FKAITRTDLQ KLYAFFMKKV 

      1330       1340       1350       1360       1370       1380 
KGSAARDWAD EDVTIPETCS VSPGGALILS SSLKWGSRKK FQKLRDRLNI PENWIELINE 

      1390       1400       1410       1420       1430       1440 
NPEVLYRAPR TGPEILLRIA EKVHSPGVVS SLSSGNAVCK VMASAVYFLS ATIFEDTGRP 

      1450       1460       1470       1480       1490       1500 
EFNFLEDSKY SLLQKMAAYS GFHGFNDMEP EDILFLFPNI EELESLDSIV YNKGEIDIIP 

      1510       1520       1530       1540       1550       1560 
RVNIRDATQT RVTIFNEQKN LRTSPEKLVS DKWFGTQKSR IGKTTFLAEW EKLKKIVKWL 

      1570       1580       1590       1600       1610       1620 
EDAPEATLAH TPLNNHIQVR NFFARMESKP RTVRITGAPV KKRSGVSKIA MVIRDHFSRM 

      1630       1640       1650       1660       1670       1680 
GHLRGVEDLA GFTRSVSAEI LKHFLFCILQ GPYSESYKLQ LIYRVLSSVS NVEIKESDGK 

      1690       1700       1710       1720       1730       1740 
TKTNLIGILQ RFLDGDHVVP IIEEMGAGTV GGFIKRQQSK VVQNKVVYYG VGIWRGFMDG 

      1750       1760       1770       1780       1790       1800 
YQVHLEIEND IGQPPRLRNV TTNCQSSPWD LSIPIRQWAE DMGVTNNQDY SSKSSRGARY 

      1810       1820       1830       1840       1850       1860 
WMHSFRMQGP SKPFGCPVYI IKGDMSDVIR LRKEEVEMKV RGSTLNLYTK HHSHQDLHIL 

      1870       1880       1890       1900       1910       1920 
SYTASDNDLS PGIFKSISDE GVAQALQLFE REPSNCWVRC ESVAPKFISA ILEICEGKRQ 

      1930       1940       1950       1960       1970       1980 
IKGINRTRLS EIVRICSESS LRSKVGSMFS FVANVEEAHD VDYDALMDLM IEDAKNNAFS 

      1990       2000       2010       2020       2030       2040 
HVVDCIELDV SGPYEMESFH GRSTLTCTPS TILIRTYTFY LTLHQTMISV QAFQVILDEG 

      2050       2060       2070       2080       2090       2100 
VLLIALVNNY LRGSKANCWV RCESVAPKFI SAILEICEGK RQIKGINRTR LSEIVEFVLN 

      2110       2120       2130       2140 
LPKIKSRIYV LICRQCHGAN FPPISVRRLM LEDIASVARR LIIVASFGS 

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References

[1]"Completion of the genome sequence of Rift Valley fever phlebovirus indicates that the L RNA is negative sense and codes for a putative transcriptase-replicase."
Mueller R., Argentini C., Bouloy M., Prehaud C., Bishop D.H.L.
Nucleic Acids Res. 19:5433-5433(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56464 Genomic RNA. Translation: CAA39836.1.
PIRS18676.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFPIRSF000826. L_PhleboV. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_RVFVZ
AccessionPrimary (citable) accession number: P27316
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families