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P27315 (GP_PHV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 2 chains:

  1. Glycoprotein G1
  2. Glycoprotein G2
Gene names
Name:GP
OrganismProspect Hill virus (PHV)
Taxonomic identifier11603 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostMicrotus pennsylvanicus (Meadow vole) [TaxID: 10058]

Protein attributes

Sequence length1142 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Sequence similarities

Belongs to the hantavirus envelope glycoprotein family.

Contains 1 ITAM domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 11421121Envelope glycoprotein
PRO_0000036818
Chain22 – 654633Glycoprotein G1 By similarity
PRO_0000036819
Chain655 – 1142488Glycoprotein G2 By similarity
PRO_0000036820

Regions

Topological domain22 – 489468Lumenal Potential
Transmembrane490 – 51021Helical; Potential
Topological domain511 – 654144Cytoplasmic Potential
Topological domain655 – 1110456Lumenal Potential
Transmembrane1111 – 113121Helical; Potential
Topological domain1132 – 114211Cytoplasmic Potential
Domain617 – 64024ITAM

Sites

Site654 – 6552Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...); by host Potential
Glycosylation3531N-linked (GlcNAc...); by host Potential
Glycosylation4051N-linked (GlcNAc...); by host Potential
Glycosylation9331N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P27315 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: CD3BAD69F078C8B9

FASTA1,142125,686
        10         20         30         40         50         60 
MSKFCLCLSL LGVLLLQVCD TRSLLELKIE CPHTVGLGQG LVIGTVDLNP VPVESVSTLK 

        70         80         90        100        110        120 
LESSCNFDVH TSSATQQAVT KWTWEKKADT AETAKAASTT FQSKSTELNL RGLCVIPTLV 

       130        140        150        160        170        180 
LETANKLRKT VTCYDLSCNQ TACIPTVYLI APIHTCVTTK SCLLGLGTQR IQVTYEKTYC 

       190        200        210        220        230        240 
VSGQLVEGTC FNPIHTMALS QPSHTYDIVT IPVRCFFIAK KTNDDTLKIE KQFETILEKS 

       250        260        270        280        290        300 
GCTAANIKGY YVCFLGATSE PIFVPTMDDF RASQILSDMA ISPHGEDHDS ALSSVSTFRI 

       310        320        330        340        350        360 
AGKLSGKAPS TESSDTVQGV AFSGHPLYTS LSVLASKEDP VYIWSPGIIP ERNHTVCDKK 

       370        380        390        400        410        420 
TLPLTWTGYL PLPGGIEKTT QCTIFCTLAG PGADCEAYSD TGIFNISSPT CLINRVQRFR 

       430        440        450        460        470        480 
GAEQQIKFVC QRVDLDIVVY CNGMKKVILT KTLVIGQCIY TFTSVFSLMP GIAHSLAVEL 

       490        500        510        520        530        540 
CVPGIHGWST IALLATFCFG WLLIPIISLV SIKIMLLFAY MCSKYSNDSK FRLLIEKVKQ 

       550        560        570        580        590        600 
EYQKTMGSMV CEVCQQECEM AKELESHKKS CPNGMCPYCM NPTESTESAL QAHFKVCKLT 

       610        620        630        640        650        660 
TRFQENLRKS LNPYEPKRGC YRTLSVFRYR SRCFVGLVWC ILLVLELVIW AASADTVEIK 

       670        680        690        700        710        720 
TGWTDTAHGA GVIPLKSDLE LDFSLPSSAT YIYRRDLQNP ANEQERIPFH FQLQRQVIHA 

       730        740        750        760        770        780 
EIQNLGHWMD GTFNLKTSFH CYGACEKYAY PWQTAKCFLE KDYEFETGWG CNPGDCPGVG 

       790        800        810        820        830        840 
TGCTACGVYL DKLRSVGKVF KVISLKFTRR VCIQLGSEQS CKTIDSNDCL MTTSVKVCMI 

       850        860        870        880        890        900 
GTVSKFQPGD TLLFLGPLEE GGIIFKQWCT TTCHFGDPGD IMSTPQGMQC PEHTGAFRKK 

       910        920        930        940        950        960 
CAFATMPTCE YDGNTLSGYQ RMLATRDSFQ SFNITEPHIT SNSLEWVDPD SSLKDHINLV 

       970        980        990       1000       1010       1020 
VNRDVSFQDL SENPCQVGVA VSSIDGAWGS GVGFNLVCSV SLTECASFLT SIKACDAAMC 

      1030       1040       1050       1060       1070       1080 
YGATTANLVR GQNTVHILGK GGHSGSKFMC CHSTECSSTG LTAAAPHLDR VTGYNVIDND 

      1090       1100       1110       1120       1130       1140 
KVFDDGSPEC GVHCWFKKSG EWLMGILSGN WMVVAVLVVL LILSIFLFSL CCPRRVVHKK 


SS 

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References

[1]"Molecular characterization of the Prospect Hill virus M RNA segment: a comparison with the M RNA segments of other hantaviruses."
Parrington M.A., Lee P.W., Kang C.Y.
J. Gen. Virol. 72:1845-1854(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55129 mRNA. Translation: CAA38922.1.
PIRGNVUPH. JQ1380.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFPIRSF003945. M_poly_HantaV. 1 hit.
ProDomPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS51056. ITAM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGP_PHV
AccessionPrimary (citable) accession number: P27315
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families