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P27315

- GP_PHV

UniProt

P27315 - GP_PHV

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Protein

Envelope glycoprotein

Gene

GP

Organism
Prospect Hill virus (PHV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei654 – 6552Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host innate immune response Source: UniProtKB-KW
  4. suppression by virus of host TRAF activity Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiProspect Hill virus (PHV)
Taxonomic identifieri11603 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiMicrotus pennsylvanicus (Meadow vole) [TaxID: 10058]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 11421121Envelope glycoproteinPRO_0000036818Add
BLAST
Chaini22 – 654633Glycoprotein G1By similarityPRO_0000036819Add
BLAST
Chaini655 – 1142488Glycoprotein G2By similarityPRO_0000036820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi353 – 3531N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi405 – 4051N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi933 – 9331N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 489468LumenalSequence AnalysisAdd
BLAST
Topological domaini511 – 654144CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini655 – 1110456LumenalSequence AnalysisAdd
BLAST
Topological domaini1132 – 114211CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei490 – 51021HelicalSequence AnalysisAdd
BLAST
Transmembranei1111 – 113121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini617 – 64024ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27315-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSKFCLCLSL LGVLLLQVCD TRSLLELKIE CPHTVGLGQG LVIGTVDLNP
60 70 80 90 100
VPVESVSTLK LESSCNFDVH TSSATQQAVT KWTWEKKADT AETAKAASTT
110 120 130 140 150
FQSKSTELNL RGLCVIPTLV LETANKLRKT VTCYDLSCNQ TACIPTVYLI
160 170 180 190 200
APIHTCVTTK SCLLGLGTQR IQVTYEKTYC VSGQLVEGTC FNPIHTMALS
210 220 230 240 250
QPSHTYDIVT IPVRCFFIAK KTNDDTLKIE KQFETILEKS GCTAANIKGY
260 270 280 290 300
YVCFLGATSE PIFVPTMDDF RASQILSDMA ISPHGEDHDS ALSSVSTFRI
310 320 330 340 350
AGKLSGKAPS TESSDTVQGV AFSGHPLYTS LSVLASKEDP VYIWSPGIIP
360 370 380 390 400
ERNHTVCDKK TLPLTWTGYL PLPGGIEKTT QCTIFCTLAG PGADCEAYSD
410 420 430 440 450
TGIFNISSPT CLINRVQRFR GAEQQIKFVC QRVDLDIVVY CNGMKKVILT
460 470 480 490 500
KTLVIGQCIY TFTSVFSLMP GIAHSLAVEL CVPGIHGWST IALLATFCFG
510 520 530 540 550
WLLIPIISLV SIKIMLLFAY MCSKYSNDSK FRLLIEKVKQ EYQKTMGSMV
560 570 580 590 600
CEVCQQECEM AKELESHKKS CPNGMCPYCM NPTESTESAL QAHFKVCKLT
610 620 630 640 650
TRFQENLRKS LNPYEPKRGC YRTLSVFRYR SRCFVGLVWC ILLVLELVIW
660 670 680 690 700
AASADTVEIK TGWTDTAHGA GVIPLKSDLE LDFSLPSSAT YIYRRDLQNP
710 720 730 740 750
ANEQERIPFH FQLQRQVIHA EIQNLGHWMD GTFNLKTSFH CYGACEKYAY
760 770 780 790 800
PWQTAKCFLE KDYEFETGWG CNPGDCPGVG TGCTACGVYL DKLRSVGKVF
810 820 830 840 850
KVISLKFTRR VCIQLGSEQS CKTIDSNDCL MTTSVKVCMI GTVSKFQPGD
860 870 880 890 900
TLLFLGPLEE GGIIFKQWCT TTCHFGDPGD IMSTPQGMQC PEHTGAFRKK
910 920 930 940 950
CAFATMPTCE YDGNTLSGYQ RMLATRDSFQ SFNITEPHIT SNSLEWVDPD
960 970 980 990 1000
SSLKDHINLV VNRDVSFQDL SENPCQVGVA VSSIDGAWGS GVGFNLVCSV
1010 1020 1030 1040 1050
SLTECASFLT SIKACDAAMC YGATTANLVR GQNTVHILGK GGHSGSKFMC
1060 1070 1080 1090 1100
CHSTECSSTG LTAAAPHLDR VTGYNVIDND KVFDDGSPEC GVHCWFKKSG
1110 1120 1130 1140
EWLMGILSGN WMVVAVLVVL LILSIFLFSL CCPRRVVHKK SS
Length:1,142
Mass (Da):125,686
Last modified:August 1, 1992 - v1
Checksum:iCD3BAD69F078C8B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55129 mRNA. Translation: CAA38922.1.
PIRiJQ1380. GNVUPH.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55129 mRNA. Translation: CAA38922.1 .
PIRi JQ1380. GNVUPH.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of the Prospect Hill virus M RNA segment: a comparison with the M RNA segments of other hantaviruses."
    Parrington M.A., Lee P.W., Kang C.Y.
    J. Gen. Virol. 72:1845-1854(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGP_PHV
AccessioniPrimary (citable) accession number: P27315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3