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P27315

- GP_PHV

UniProt

P27315 - GP_PHV

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Protein

Envelope glycoprotein

Gene
GP
Organism
Prospect Hill virus (PHV)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei654 – 6552Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host innate immune response Source: UniProtKB-KW
  4. suppression by virus of host TRAF activity Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiProspect Hill virus (PHV)
Taxonomic identifieri11603 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiMicrotus pennsylvanicus (Meadow vole) [TaxID: 10058]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 489468Lumenal Reviewed predictionAdd
BLAST
Transmembranei490 – 51021Helical; Reviewed predictionAdd
BLAST
Topological domaini511 – 654144Cytoplasmic Reviewed predictionAdd
BLAST
Topological domaini655 – 1110456Lumenal Reviewed predictionAdd
BLAST
Transmembranei1111 – 113121Helical; Reviewed predictionAdd
BLAST
Topological domaini1132 – 114211Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. host cell Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 11421121Envelope glycoproteinPRO_0000036818Add
BLAST
Chaini22 – 654633Glycoprotein G1 By similarityPRO_0000036819Add
BLAST
Chaini655 – 1142488Glycoprotein G2 By similarityPRO_0000036820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi353 – 3531N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi405 – 4051N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi933 – 9331N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini617 – 64024ITAMAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27315-1 [UniParc]FASTAAdd to Basket

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MSKFCLCLSL LGVLLLQVCD TRSLLELKIE CPHTVGLGQG LVIGTVDLNP     50
VPVESVSTLK LESSCNFDVH TSSATQQAVT KWTWEKKADT AETAKAASTT 100
FQSKSTELNL RGLCVIPTLV LETANKLRKT VTCYDLSCNQ TACIPTVYLI 150
APIHTCVTTK SCLLGLGTQR IQVTYEKTYC VSGQLVEGTC FNPIHTMALS 200
QPSHTYDIVT IPVRCFFIAK KTNDDTLKIE KQFETILEKS GCTAANIKGY 250
YVCFLGATSE PIFVPTMDDF RASQILSDMA ISPHGEDHDS ALSSVSTFRI 300
AGKLSGKAPS TESSDTVQGV AFSGHPLYTS LSVLASKEDP VYIWSPGIIP 350
ERNHTVCDKK TLPLTWTGYL PLPGGIEKTT QCTIFCTLAG PGADCEAYSD 400
TGIFNISSPT CLINRVQRFR GAEQQIKFVC QRVDLDIVVY CNGMKKVILT 450
KTLVIGQCIY TFTSVFSLMP GIAHSLAVEL CVPGIHGWST IALLATFCFG 500
WLLIPIISLV SIKIMLLFAY MCSKYSNDSK FRLLIEKVKQ EYQKTMGSMV 550
CEVCQQECEM AKELESHKKS CPNGMCPYCM NPTESTESAL QAHFKVCKLT 600
TRFQENLRKS LNPYEPKRGC YRTLSVFRYR SRCFVGLVWC ILLVLELVIW 650
AASADTVEIK TGWTDTAHGA GVIPLKSDLE LDFSLPSSAT YIYRRDLQNP 700
ANEQERIPFH FQLQRQVIHA EIQNLGHWMD GTFNLKTSFH CYGACEKYAY 750
PWQTAKCFLE KDYEFETGWG CNPGDCPGVG TGCTACGVYL DKLRSVGKVF 800
KVISLKFTRR VCIQLGSEQS CKTIDSNDCL MTTSVKVCMI GTVSKFQPGD 850
TLLFLGPLEE GGIIFKQWCT TTCHFGDPGD IMSTPQGMQC PEHTGAFRKK 900
CAFATMPTCE YDGNTLSGYQ RMLATRDSFQ SFNITEPHIT SNSLEWVDPD 950
SSLKDHINLV VNRDVSFQDL SENPCQVGVA VSSIDGAWGS GVGFNLVCSV 1000
SLTECASFLT SIKACDAAMC YGATTANLVR GQNTVHILGK GGHSGSKFMC 1050
CHSTECSSTG LTAAAPHLDR VTGYNVIDND KVFDDGSPEC GVHCWFKKSG 1100
EWLMGILSGN WMVVAVLVVL LILSIFLFSL CCPRRVVHKK SS 1142
Length:1,142
Mass (Da):125,686
Last modified:August 1, 1992 - v1
Checksum:iCD3BAD69F078C8B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55129 mRNA. Translation: CAA38922.1.
PIRiJQ1380. GNVUPH.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55129 mRNA. Translation: CAA38922.1 .
PIRi JQ1380. GNVUPH.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of the Prospect Hill virus M RNA segment: a comparison with the M RNA segments of other hantaviruses."
    Parrington M.A., Lee P.W., Kang C.Y.
    J. Gen. Virol. 72:1845-1854(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGP_PHV
AccessioniPrimary (citable) accession number: P27315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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