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P27315

- GP_PHV

UniProt

P27315 - GP_PHV

Protein

Envelope glycoprotein

Gene

GP

Organism
Prospect Hill virus (PHV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei654 – 6552Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. signal transduction Source: InterPro
    3. suppression by virus of host innate immune response Source: UniProtKB-KW
    4. suppression by virus of host TRAF activity Source: UniProtKB-KW
    5. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiProspect Hill virus (PHV)
    Taxonomic identifieri11603 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiMicrotus pennsylvanicus (Meadow vole) [TaxID: 10058]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 11421121Envelope glycoproteinPRO_0000036818Add
    BLAST
    Chaini22 – 654633Glycoprotein G1By similarityPRO_0000036819Add
    BLAST
    Chaini655 – 1142488Glycoprotein G2By similarityPRO_0000036820Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi139 – 1391N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi353 – 3531N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi405 – 4051N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi933 – 9331N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 489468LumenalSequence AnalysisAdd
    BLAST
    Topological domaini511 – 654144CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini655 – 1110456LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1132 – 114211CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei490 – 51021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1111 – 113121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini617 – 64024ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view]
    PfamiPF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
    ProDomiPD001813. Hanta_G2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS51056. ITAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27315-1 [UniParc]FASTAAdd to Basket

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    MSKFCLCLSL LGVLLLQVCD TRSLLELKIE CPHTVGLGQG LVIGTVDLNP     50
    VPVESVSTLK LESSCNFDVH TSSATQQAVT KWTWEKKADT AETAKAASTT 100
    FQSKSTELNL RGLCVIPTLV LETANKLRKT VTCYDLSCNQ TACIPTVYLI 150
    APIHTCVTTK SCLLGLGTQR IQVTYEKTYC VSGQLVEGTC FNPIHTMALS 200
    QPSHTYDIVT IPVRCFFIAK KTNDDTLKIE KQFETILEKS GCTAANIKGY 250
    YVCFLGATSE PIFVPTMDDF RASQILSDMA ISPHGEDHDS ALSSVSTFRI 300
    AGKLSGKAPS TESSDTVQGV AFSGHPLYTS LSVLASKEDP VYIWSPGIIP 350
    ERNHTVCDKK TLPLTWTGYL PLPGGIEKTT QCTIFCTLAG PGADCEAYSD 400
    TGIFNISSPT CLINRVQRFR GAEQQIKFVC QRVDLDIVVY CNGMKKVILT 450
    KTLVIGQCIY TFTSVFSLMP GIAHSLAVEL CVPGIHGWST IALLATFCFG 500
    WLLIPIISLV SIKIMLLFAY MCSKYSNDSK FRLLIEKVKQ EYQKTMGSMV 550
    CEVCQQECEM AKELESHKKS CPNGMCPYCM NPTESTESAL QAHFKVCKLT 600
    TRFQENLRKS LNPYEPKRGC YRTLSVFRYR SRCFVGLVWC ILLVLELVIW 650
    AASADTVEIK TGWTDTAHGA GVIPLKSDLE LDFSLPSSAT YIYRRDLQNP 700
    ANEQERIPFH FQLQRQVIHA EIQNLGHWMD GTFNLKTSFH CYGACEKYAY 750
    PWQTAKCFLE KDYEFETGWG CNPGDCPGVG TGCTACGVYL DKLRSVGKVF 800
    KVISLKFTRR VCIQLGSEQS CKTIDSNDCL MTTSVKVCMI GTVSKFQPGD 850
    TLLFLGPLEE GGIIFKQWCT TTCHFGDPGD IMSTPQGMQC PEHTGAFRKK 900
    CAFATMPTCE YDGNTLSGYQ RMLATRDSFQ SFNITEPHIT SNSLEWVDPD 950
    SSLKDHINLV VNRDVSFQDL SENPCQVGVA VSSIDGAWGS GVGFNLVCSV 1000
    SLTECASFLT SIKACDAAMC YGATTANLVR GQNTVHILGK GGHSGSKFMC 1050
    CHSTECSSTG LTAAAPHLDR VTGYNVIDND KVFDDGSPEC GVHCWFKKSG 1100
    EWLMGILSGN WMVVAVLVVL LILSIFLFSL CCPRRVVHKK SS 1142
    Length:1,142
    Mass (Da):125,686
    Last modified:August 1, 1992 - v1
    Checksum:iCD3BAD69F078C8B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55129 mRNA. Translation: CAA38922.1.
    PIRiJQ1380. GNVUPH.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55129 mRNA. Translation: CAA38922.1 .
    PIRi JQ1380. GNVUPH.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view ]
    Pfami PF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
    ProDomi PD001813. Hanta_G2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS51056. ITAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the Prospect Hill virus M RNA segment: a comparison with the M RNA segments of other hantaviruses."
      Parrington M.A., Lee P.W., Kang C.Y.
      J. Gen. Virol. 72:1845-1854(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGP_PHV
    AccessioniPrimary (citable) accession number: P27315
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3