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P27314

- L_SEOU8

UniProt

P27314 - L_SEOU8

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Seoul virus (strain 80-39)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cap snatching Source: UniProtKB-KW
    2. transcription, DNA-templated Source: InterPro
    3. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Cap snatching, Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiSeoul virus (strain 80-39)
    Taxonomic identifieri12557 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Rattus norvegicus (Rat) [TaxID: 10116]
    Rattus rattus (Black rat) [TaxID: 10117]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21512151RNA-directed RNA polymerase LPRO_0000222024Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini956 – 1142187RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hantavirus RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR026382. CapSnatchArena.
    IPR016268. RNA-dir_pol_hantavirus.
    IPR024378. RNA-dir_pol_N_hantavirus.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    PF12426. DUF3674. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000825. L_HantaV. 1 hit.
    TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27314-1 [UniParc]FASTAAdd to Basket

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    MEKYREIHRD LKEFTINSLT AVECMDYLDR LYAVRHDIVD QMIKHEWSDN     50
    KDSEEPISKV LLFAGIPNNV ITALEKKVIP DHPSGKTLRS FFKMTPDNYR 100
    ITGSLIEFVE VTVTADVDKG IREKKMKYEL GLKYLEQELM TFFHRGELQN 150
    PYKITFKVVA VRTDGSNIST QWPSARNDGV VQYMRLVQAE ISYVREHLVK 200
    TEERAALEAM FNLKFNISSL KTQPYFIPEY KGIDLIRPDI DGLVNYAQSW 250
    MSKTQEFSFF EVKGSAVFDC FNENEQGHIV KYPMSRHPRN FLLIQCTVLT 300
    AYKPATILSD QLDSRRACIQ FLNLIPETPA SILAHDMAHR YINLTRDDLL 350
    AYYAPRIQFN PTQNIKEPGT FKLTSNMMRP ESKIMLDMLS QHEPRENLGK 400
    SIESLNISSH IVQSDCVSLI TKILSDLELN ISEPSSHEQI TAKHTHVDTV 450
    LDKFFQNETQ KYLIDILKKT TAWHIGHLVR DITESLIAHS GLRRSKYWSI 500
    HAYNNGSVIL FILPSKSLEV AGSFVRFMTA FKLGPGLVDK DNLDSILADG 550
    DILWGVSKIM SLDLNRLLAL NIAFEKALLA TATWFQYYTE DQSQFPLQHS 600
    IRSVFAYHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLVEKLFER 650
    PFKSALEVYV YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGI 700
    YPSFMSRVVY KHYKSLISEV TTCFFLFEKG LHGNVNEEAK IHLETVEWAT 750
    KFKEKEDKYG EMLVEHGYTI GELVESSELA VQQLYCQDAV ELAANELNRV 800
    LIAKSQVVAN SILNKYWEEP YFSQTRNISL KGMSGQVQED GHLSSSTTII 850
    EAIRYLSNSR NNPNVLQLYE ETRHQKAQAR IVRKFQRTEA DRGFFITTLP 900
    TRCRLEIIED YYDAISKNVA EEYISYGGER KILCIQAALE KALRWASGES 950
    FIELSNGKFI RMKRKLMYVS ADATKWSPGD NSAKFRRFTA ALHNGLPDDR 1000
    LKNCVIDALR HVYKTDFYMS RKLRHYIDSM DTYEPHVRDF LNFFPDGHHG 1050
    EVRGNWLQGN LNKCSSLFGV AMSLLFKEIW TRLFPELDCF FEFAHHSDDA 1100
    LFIYGYLEPA DDGTDWFLFV SQQIQAGKLH WFNVNTEMWK SMFNLHEHIL 1150
    LLGSIKISPK KTTLSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 1200
    YFDDLAAAQT RCVKAMDLGA SPQISQLAVS LSTSKVERLY GTSIGMVNYP 1250
    GTYLRTKHSE TPIPLGGSGA MSIMELSTAG IGMSDKNLLK QALIGYMHKH 1300
    QKQMSYILGL FKFLMDLSGE TFQHERLGQF SFIGKVQWKI FTPKSEFEFS 1350
    DMYSQKFLKV WSEQHPTYDY IIPKGRDNLL IYLVRKLNDP SIITAMTMQS 1400
    PLQLRFRMQA KQHMKVCRLD GDWVTFREVL AAANSFAESY EPSQNDIDLF 1450
    QTLTSCTFSK EYAWKDFLNN VHCDVIPTKQ VQRAKVARTF TVREKDRIIQ 1500
    NSIPAVIGYK FAVTVDEMSD VLDTAKFPDS LAVDLKTMKD GVYRELGLDI 1550
    SSPDVMKKVA PMLYKSAKSR VVIVQGNVEG TAEAICAYWL RNMSLIKTIK 1600
    VKPHKEVLQA VSIFNRKEDI GQQKDLSALK LCIEVWRWAK ANNAPYRDWF 1650
    HALWFEDKTF SEWLDRFIRV GVPPIDPEIQ CAALMIADVK GDRSVLQLQA 1700
    NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGLDCA RLEIFWDKKT 1750
    YILETSITQK HVLKIMMEEV SKELVRCGMR FNTEQVNGVK HLVLFKTDSG 1800
    FEWGKPNIPC IVYKNCALRT GLRTNQAINH KFMITIKDDG LRAIAQYDED 1850
    SPRFLLAHAF HTIRDVRYQA VDAVSNVWFT HKGIKLYLNP IISSGLLEYF 1900
    MKNIPAAIPP AAYSLIMNRA KISVDLFMFN DLLRLINPGN TLDLSGLEIT 1950
    GEGYSTVNSL SSRLWSEEMS LVDDEEEMDD EFTIDLQDVD FENIDIEADV 2000
    EHFLQDESAY TGDLLIMSEE TEVKKMRGII KLLEPVKLIK SWVSRGLSIE 2050
    KVYNPVNIIL MTRYISKNFN FSGKQVSLLD PYDLTELESI VKGWGESVVD 2100
    QFDSLDLEAQ NLVQKQGIVP EDVIPDSLFS FRHTMVLLRR LFGQDSVSTF 2150
    Y 2151
    Length:2,151
    Mass (Da):246,664
    Last modified:August 1, 1992 - v1
    Checksum:iAA567FF1DBBEE543
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56492 Genomic RNA. Translation: CAA39847.1.
    PIRiS16449.
    RefSeqiNP_942558.1. NC_005238.1.

    Genome annotation databases

    GeneIDi2656409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56492 Genomic RNA. Translation: CAA39847.1 .
    PIRi S16449.
    RefSeqi NP_942558.1. NC_005238.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2656409.

    Family and domain databases

    InterProi IPR026382. CapSnatchArena.
    IPR016268. RNA-dir_pol_hantavirus.
    IPR024378. RNA-dir_pol_N_hantavirus.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    PF12426. DUF3674. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000825. L_HantaV. 1 hit.
    TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and coding capacity of the large (L) genomic RNA segment of Seoul 80-39 virus, a member of the hantavirus genus."
      Antic D., Lim B.U., Yong Kang C.
      Virus Res. 19:59-66(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiL_SEOU8
    AccessioniPrimary (citable) accession number: P27314
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3