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P27314

- L_SEOU8

UniProt

P27314 - L_SEOU8

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Protein
RNA-directed RNA polymerase L
Gene
L
Organism
Seoul virus (strain 80-39)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. cap snatching Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Cap snatching, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiSeoul virus (strain 80-39)
Taxonomic identifieri12557 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21512151RNA-directed RNA polymerase L
PRO_0000222024Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1142187RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFiPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27314-1 [UniParc]FASTAAdd to Basket

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MEKYREIHRD LKEFTINSLT AVECMDYLDR LYAVRHDIVD QMIKHEWSDN     50
KDSEEPISKV LLFAGIPNNV ITALEKKVIP DHPSGKTLRS FFKMTPDNYR 100
ITGSLIEFVE VTVTADVDKG IREKKMKYEL GLKYLEQELM TFFHRGELQN 150
PYKITFKVVA VRTDGSNIST QWPSARNDGV VQYMRLVQAE ISYVREHLVK 200
TEERAALEAM FNLKFNISSL KTQPYFIPEY KGIDLIRPDI DGLVNYAQSW 250
MSKTQEFSFF EVKGSAVFDC FNENEQGHIV KYPMSRHPRN FLLIQCTVLT 300
AYKPATILSD QLDSRRACIQ FLNLIPETPA SILAHDMAHR YINLTRDDLL 350
AYYAPRIQFN PTQNIKEPGT FKLTSNMMRP ESKIMLDMLS QHEPRENLGK 400
SIESLNISSH IVQSDCVSLI TKILSDLELN ISEPSSHEQI TAKHTHVDTV 450
LDKFFQNETQ KYLIDILKKT TAWHIGHLVR DITESLIAHS GLRRSKYWSI 500
HAYNNGSVIL FILPSKSLEV AGSFVRFMTA FKLGPGLVDK DNLDSILADG 550
DILWGVSKIM SLDLNRLLAL NIAFEKALLA TATWFQYYTE DQSQFPLQHS 600
IRSVFAYHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLVEKLFER 650
PFKSALEVYV YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGI 700
YPSFMSRVVY KHYKSLISEV TTCFFLFEKG LHGNVNEEAK IHLETVEWAT 750
KFKEKEDKYG EMLVEHGYTI GELVESSELA VQQLYCQDAV ELAANELNRV 800
LIAKSQVVAN SILNKYWEEP YFSQTRNISL KGMSGQVQED GHLSSSTTII 850
EAIRYLSNSR NNPNVLQLYE ETRHQKAQAR IVRKFQRTEA DRGFFITTLP 900
TRCRLEIIED YYDAISKNVA EEYISYGGER KILCIQAALE KALRWASGES 950
FIELSNGKFI RMKRKLMYVS ADATKWSPGD NSAKFRRFTA ALHNGLPDDR 1000
LKNCVIDALR HVYKTDFYMS RKLRHYIDSM DTYEPHVRDF LNFFPDGHHG 1050
EVRGNWLQGN LNKCSSLFGV AMSLLFKEIW TRLFPELDCF FEFAHHSDDA 1100
LFIYGYLEPA DDGTDWFLFV SQQIQAGKLH WFNVNTEMWK SMFNLHEHIL 1150
LLGSIKISPK KTTLSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 1200
YFDDLAAAQT RCVKAMDLGA SPQISQLAVS LSTSKVERLY GTSIGMVNYP 1250
GTYLRTKHSE TPIPLGGSGA MSIMELSTAG IGMSDKNLLK QALIGYMHKH 1300
QKQMSYILGL FKFLMDLSGE TFQHERLGQF SFIGKVQWKI FTPKSEFEFS 1350
DMYSQKFLKV WSEQHPTYDY IIPKGRDNLL IYLVRKLNDP SIITAMTMQS 1400
PLQLRFRMQA KQHMKVCRLD GDWVTFREVL AAANSFAESY EPSQNDIDLF 1450
QTLTSCTFSK EYAWKDFLNN VHCDVIPTKQ VQRAKVARTF TVREKDRIIQ 1500
NSIPAVIGYK FAVTVDEMSD VLDTAKFPDS LAVDLKTMKD GVYRELGLDI 1550
SSPDVMKKVA PMLYKSAKSR VVIVQGNVEG TAEAICAYWL RNMSLIKTIK 1600
VKPHKEVLQA VSIFNRKEDI GQQKDLSALK LCIEVWRWAK ANNAPYRDWF 1650
HALWFEDKTF SEWLDRFIRV GVPPIDPEIQ CAALMIADVK GDRSVLQLQA 1700
NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGLDCA RLEIFWDKKT 1750
YILETSITQK HVLKIMMEEV SKELVRCGMR FNTEQVNGVK HLVLFKTDSG 1800
FEWGKPNIPC IVYKNCALRT GLRTNQAINH KFMITIKDDG LRAIAQYDED 1850
SPRFLLAHAF HTIRDVRYQA VDAVSNVWFT HKGIKLYLNP IISSGLLEYF 1900
MKNIPAAIPP AAYSLIMNRA KISVDLFMFN DLLRLINPGN TLDLSGLEIT 1950
GEGYSTVNSL SSRLWSEEMS LVDDEEEMDD EFTIDLQDVD FENIDIEADV 2000
EHFLQDESAY TGDLLIMSEE TEVKKMRGII KLLEPVKLIK SWVSRGLSIE 2050
KVYNPVNIIL MTRYISKNFN FSGKQVSLLD PYDLTELESI VKGWGESVVD 2100
QFDSLDLEAQ NLVQKQGIVP EDVIPDSLFS FRHTMVLLRR LFGQDSVSTF 2150
Y 2151
Length:2,151
Mass (Da):246,664
Last modified:August 1, 1992 - v1
Checksum:iAA567FF1DBBEE543
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56492 Genomic RNA. Translation: CAA39847.1.
PIRiS16449.
RefSeqiNP_942558.1. NC_005238.1.

Genome annotation databases

GeneIDi2656409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56492 Genomic RNA. Translation: CAA39847.1 .
PIRi S16449.
RefSeqi NP_942558.1. NC_005238.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2656409.

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view ]
PIRSFi PIRSF000825. L_HantaV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and coding capacity of the large (L) genomic RNA segment of Seoul 80-39 virus, a member of the hantavirus genus."
    Antic D., Lim B.U., Yong Kang C.
    Virus Res. 19:59-66(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_SEOU8
AccessioniPrimary (citable) accession number: P27314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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