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P27314 (L_SEOU8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismSeoul virus (strain 80-39)
Taxonomic identifier12557 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

Protein attributes

Sequence length2151 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the hantavirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21512151RNA-directed RNA polymerase L
PRO_0000222024

Regions

Domain956 – 1142187RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P27314 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: AA567FF1DBBEE543

FASTA2,151246,664
        10         20         30         40         50         60 
MEKYREIHRD LKEFTINSLT AVECMDYLDR LYAVRHDIVD QMIKHEWSDN KDSEEPISKV 

        70         80         90        100        110        120 
LLFAGIPNNV ITALEKKVIP DHPSGKTLRS FFKMTPDNYR ITGSLIEFVE VTVTADVDKG 

       130        140        150        160        170        180 
IREKKMKYEL GLKYLEQELM TFFHRGELQN PYKITFKVVA VRTDGSNIST QWPSARNDGV 

       190        200        210        220        230        240 
VQYMRLVQAE ISYVREHLVK TEERAALEAM FNLKFNISSL KTQPYFIPEY KGIDLIRPDI 

       250        260        270        280        290        300 
DGLVNYAQSW MSKTQEFSFF EVKGSAVFDC FNENEQGHIV KYPMSRHPRN FLLIQCTVLT 

       310        320        330        340        350        360 
AYKPATILSD QLDSRRACIQ FLNLIPETPA SILAHDMAHR YINLTRDDLL AYYAPRIQFN 

       370        380        390        400        410        420 
PTQNIKEPGT FKLTSNMMRP ESKIMLDMLS QHEPRENLGK SIESLNISSH IVQSDCVSLI 

       430        440        450        460        470        480 
TKILSDLELN ISEPSSHEQI TAKHTHVDTV LDKFFQNETQ KYLIDILKKT TAWHIGHLVR 

       490        500        510        520        530        540 
DITESLIAHS GLRRSKYWSI HAYNNGSVIL FILPSKSLEV AGSFVRFMTA FKLGPGLVDK 

       550        560        570        580        590        600 
DNLDSILADG DILWGVSKIM SLDLNRLLAL NIAFEKALLA TATWFQYYTE DQSQFPLQHS 

       610        620        630        640        650        660 
IRSVFAYHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLVEKLFER PFKSALEVYV 

       670        680        690        700        710        720 
YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGI YPSFMSRVVY KHYKSLISEV 

       730        740        750        760        770        780 
TTCFFLFEKG LHGNVNEEAK IHLETVEWAT KFKEKEDKYG EMLVEHGYTI GELVESSELA 

       790        800        810        820        830        840 
VQQLYCQDAV ELAANELNRV LIAKSQVVAN SILNKYWEEP YFSQTRNISL KGMSGQVQED 

       850        860        870        880        890        900 
GHLSSSTTII EAIRYLSNSR NNPNVLQLYE ETRHQKAQAR IVRKFQRTEA DRGFFITTLP 

       910        920        930        940        950        960 
TRCRLEIIED YYDAISKNVA EEYISYGGER KILCIQAALE KALRWASGES FIELSNGKFI 

       970        980        990       1000       1010       1020 
RMKRKLMYVS ADATKWSPGD NSAKFRRFTA ALHNGLPDDR LKNCVIDALR HVYKTDFYMS 

      1030       1040       1050       1060       1070       1080 
RKLRHYIDSM DTYEPHVRDF LNFFPDGHHG EVRGNWLQGN LNKCSSLFGV AMSLLFKEIW 

      1090       1100       1110       1120       1130       1140 
TRLFPELDCF FEFAHHSDDA LFIYGYLEPA DDGTDWFLFV SQQIQAGKLH WFNVNTEMWK 

      1150       1160       1170       1180       1190       1200 
SMFNLHEHIL LLGSIKISPK KTTLSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 

      1210       1220       1230       1240       1250       1260 
YFDDLAAAQT RCVKAMDLGA SPQISQLAVS LSTSKVERLY GTSIGMVNYP GTYLRTKHSE 

      1270       1280       1290       1300       1310       1320 
TPIPLGGSGA MSIMELSTAG IGMSDKNLLK QALIGYMHKH QKQMSYILGL FKFLMDLSGE 

      1330       1340       1350       1360       1370       1380 
TFQHERLGQF SFIGKVQWKI FTPKSEFEFS DMYSQKFLKV WSEQHPTYDY IIPKGRDNLL 

      1390       1400       1410       1420       1430       1440 
IYLVRKLNDP SIITAMTMQS PLQLRFRMQA KQHMKVCRLD GDWVTFREVL AAANSFAESY 

      1450       1460       1470       1480       1490       1500 
EPSQNDIDLF QTLTSCTFSK EYAWKDFLNN VHCDVIPTKQ VQRAKVARTF TVREKDRIIQ 

      1510       1520       1530       1540       1550       1560 
NSIPAVIGYK FAVTVDEMSD VLDTAKFPDS LAVDLKTMKD GVYRELGLDI SSPDVMKKVA 

      1570       1580       1590       1600       1610       1620 
PMLYKSAKSR VVIVQGNVEG TAEAICAYWL RNMSLIKTIK VKPHKEVLQA VSIFNRKEDI 

      1630       1640       1650       1660       1670       1680 
GQQKDLSALK LCIEVWRWAK ANNAPYRDWF HALWFEDKTF SEWLDRFIRV GVPPIDPEIQ 

      1690       1700       1710       1720       1730       1740 
CAALMIADVK GDRSVLQLQA NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGLDCA 

      1750       1760       1770       1780       1790       1800 
RLEIFWDKKT YILETSITQK HVLKIMMEEV SKELVRCGMR FNTEQVNGVK HLVLFKTDSG 

      1810       1820       1830       1840       1850       1860 
FEWGKPNIPC IVYKNCALRT GLRTNQAINH KFMITIKDDG LRAIAQYDED SPRFLLAHAF 

      1870       1880       1890       1900       1910       1920 
HTIRDVRYQA VDAVSNVWFT HKGIKLYLNP IISSGLLEYF MKNIPAAIPP AAYSLIMNRA 

      1930       1940       1950       1960       1970       1980 
KISVDLFMFN DLLRLINPGN TLDLSGLEIT GEGYSTVNSL SSRLWSEEMS LVDDEEEMDD 

      1990       2000       2010       2020       2030       2040 
EFTIDLQDVD FENIDIEADV EHFLQDESAY TGDLLIMSEE TEVKKMRGII KLLEPVKLIK 

      2050       2060       2070       2080       2090       2100 
SWVSRGLSIE KVYNPVNIIL MTRYISKNFN FSGKQVSLLD PYDLTELESI VKGWGESVVD 

      2110       2120       2130       2140       2150 
QFDSLDLEAQ NLVQKQGIVP EDVIPDSLFS FRHTMVLLRR LFGQDSVSTF Y 

« Hide

References

[1]"Nucleotide sequence and coding capacity of the large (L) genomic RNA segment of Seoul 80-39 virus, a member of the hantavirus genus."
Antic D., Lim B.U., Yong Kang C.
Virus Res. 19:59-66(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56492 Genomic RNA. Translation: CAA39847.1.
PIRS16449.
RefSeqNP_942558.1. NC_005238.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2656409.

Family and domain databases

InterProIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsTIGR04202. capSnatchArena. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_SEOU8
AccessionPrimary (citable) accession number: P27314
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families