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P27314

- L_SEOU8

UniProt

P27314 - L_SEOU8

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Seoul virus (strain 80-39)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. cap snatching Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Cap snatching, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiSeoul virus (strain 80-39)
Taxonomic identifieri12557 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21512151RNA-directed RNA polymerase LPRO_0000222024Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1142187RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hantavirus RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFiPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27314-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MEKYREIHRD LKEFTINSLT AVECMDYLDR LYAVRHDIVD QMIKHEWSDN
60 70 80 90 100
KDSEEPISKV LLFAGIPNNV ITALEKKVIP DHPSGKTLRS FFKMTPDNYR
110 120 130 140 150
ITGSLIEFVE VTVTADVDKG IREKKMKYEL GLKYLEQELM TFFHRGELQN
160 170 180 190 200
PYKITFKVVA VRTDGSNIST QWPSARNDGV VQYMRLVQAE ISYVREHLVK
210 220 230 240 250
TEERAALEAM FNLKFNISSL KTQPYFIPEY KGIDLIRPDI DGLVNYAQSW
260 270 280 290 300
MSKTQEFSFF EVKGSAVFDC FNENEQGHIV KYPMSRHPRN FLLIQCTVLT
310 320 330 340 350
AYKPATILSD QLDSRRACIQ FLNLIPETPA SILAHDMAHR YINLTRDDLL
360 370 380 390 400
AYYAPRIQFN PTQNIKEPGT FKLTSNMMRP ESKIMLDMLS QHEPRENLGK
410 420 430 440 450
SIESLNISSH IVQSDCVSLI TKILSDLELN ISEPSSHEQI TAKHTHVDTV
460 470 480 490 500
LDKFFQNETQ KYLIDILKKT TAWHIGHLVR DITESLIAHS GLRRSKYWSI
510 520 530 540 550
HAYNNGSVIL FILPSKSLEV AGSFVRFMTA FKLGPGLVDK DNLDSILADG
560 570 580 590 600
DILWGVSKIM SLDLNRLLAL NIAFEKALLA TATWFQYYTE DQSQFPLQHS
610 620 630 640 650
IRSVFAYHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLVEKLFER
660 670 680 690 700
PFKSALEVYV YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGI
710 720 730 740 750
YPSFMSRVVY KHYKSLISEV TTCFFLFEKG LHGNVNEEAK IHLETVEWAT
760 770 780 790 800
KFKEKEDKYG EMLVEHGYTI GELVESSELA VQQLYCQDAV ELAANELNRV
810 820 830 840 850
LIAKSQVVAN SILNKYWEEP YFSQTRNISL KGMSGQVQED GHLSSSTTII
860 870 880 890 900
EAIRYLSNSR NNPNVLQLYE ETRHQKAQAR IVRKFQRTEA DRGFFITTLP
910 920 930 940 950
TRCRLEIIED YYDAISKNVA EEYISYGGER KILCIQAALE KALRWASGES
960 970 980 990 1000
FIELSNGKFI RMKRKLMYVS ADATKWSPGD NSAKFRRFTA ALHNGLPDDR
1010 1020 1030 1040 1050
LKNCVIDALR HVYKTDFYMS RKLRHYIDSM DTYEPHVRDF LNFFPDGHHG
1060 1070 1080 1090 1100
EVRGNWLQGN LNKCSSLFGV AMSLLFKEIW TRLFPELDCF FEFAHHSDDA
1110 1120 1130 1140 1150
LFIYGYLEPA DDGTDWFLFV SQQIQAGKLH WFNVNTEMWK SMFNLHEHIL
1160 1170 1180 1190 1200
LLGSIKISPK KTTLSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG
1210 1220 1230 1240 1250
YFDDLAAAQT RCVKAMDLGA SPQISQLAVS LSTSKVERLY GTSIGMVNYP
1260 1270 1280 1290 1300
GTYLRTKHSE TPIPLGGSGA MSIMELSTAG IGMSDKNLLK QALIGYMHKH
1310 1320 1330 1340 1350
QKQMSYILGL FKFLMDLSGE TFQHERLGQF SFIGKVQWKI FTPKSEFEFS
1360 1370 1380 1390 1400
DMYSQKFLKV WSEQHPTYDY IIPKGRDNLL IYLVRKLNDP SIITAMTMQS
1410 1420 1430 1440 1450
PLQLRFRMQA KQHMKVCRLD GDWVTFREVL AAANSFAESY EPSQNDIDLF
1460 1470 1480 1490 1500
QTLTSCTFSK EYAWKDFLNN VHCDVIPTKQ VQRAKVARTF TVREKDRIIQ
1510 1520 1530 1540 1550
NSIPAVIGYK FAVTVDEMSD VLDTAKFPDS LAVDLKTMKD GVYRELGLDI
1560 1570 1580 1590 1600
SSPDVMKKVA PMLYKSAKSR VVIVQGNVEG TAEAICAYWL RNMSLIKTIK
1610 1620 1630 1640 1650
VKPHKEVLQA VSIFNRKEDI GQQKDLSALK LCIEVWRWAK ANNAPYRDWF
1660 1670 1680 1690 1700
HALWFEDKTF SEWLDRFIRV GVPPIDPEIQ CAALMIADVK GDRSVLQLQA
1710 1720 1730 1740 1750
NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGLDCA RLEIFWDKKT
1760 1770 1780 1790 1800
YILETSITQK HVLKIMMEEV SKELVRCGMR FNTEQVNGVK HLVLFKTDSG
1810 1820 1830 1840 1850
FEWGKPNIPC IVYKNCALRT GLRTNQAINH KFMITIKDDG LRAIAQYDED
1860 1870 1880 1890 1900
SPRFLLAHAF HTIRDVRYQA VDAVSNVWFT HKGIKLYLNP IISSGLLEYF
1910 1920 1930 1940 1950
MKNIPAAIPP AAYSLIMNRA KISVDLFMFN DLLRLINPGN TLDLSGLEIT
1960 1970 1980 1990 2000
GEGYSTVNSL SSRLWSEEMS LVDDEEEMDD EFTIDLQDVD FENIDIEADV
2010 2020 2030 2040 2050
EHFLQDESAY TGDLLIMSEE TEVKKMRGII KLLEPVKLIK SWVSRGLSIE
2060 2070 2080 2090 2100
KVYNPVNIIL MTRYISKNFN FSGKQVSLLD PYDLTELESI VKGWGESVVD
2110 2120 2130 2140 2150
QFDSLDLEAQ NLVQKQGIVP EDVIPDSLFS FRHTMVLLRR LFGQDSVSTF

Y
Length:2,151
Mass (Da):246,664
Last modified:August 1, 1992 - v1
Checksum:iAA567FF1DBBEE543
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56492 Genomic RNA. Translation: CAA39847.1.
PIRiS16449.
RefSeqiNP_942558.1. NC_005238.1.

Genome annotation databases

GeneIDi2656409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56492 Genomic RNA. Translation: CAA39847.1 .
PIRi S16449.
RefSeqi NP_942558.1. NC_005238.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2656409.

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view ]
PIRSFi PIRSF000825. L_HantaV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and coding capacity of the large (L) genomic RNA segment of Seoul 80-39 virus, a member of the hantavirus genus."
    Antic D., Lim B.U., Yong Kang C.
    Virus Res. 19:59-66(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_SEOU8
AccessioniPrimary (citable) accession number: P27314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3