P27314 (L_SEOU8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-directed RNA polymerase L
Short name=Protein L
EC=2.7.7.48

Alternative name(s):
Large structural protein
Replicase
Transcriptase

Gene names

Name:

L

Organism

Seoul virus (strain 80-39)

Taxonomic identifier

12557 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Bunyaviridae › Hantavirus › Seoul virus

Virus host

Homo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

Protein attributes

Sequence length	2151 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the hantavirus RNA polymerase family. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Biological process	Cap snatching Viral RNA replication
Ligand	Nucleotide-binding
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2151	2151	RNA-directed RNA polymerase L		PRO_0000222024
Regions
	Domain	956 – 1142	187	RdRp catalytic

Sequences

	Sequence		Length	Mass (Da)
	P27314 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: AA567FF1DBBEE543	FASTA	2,151	246,664
	10 20 30 40 50 60 MEKYREIHRD LKEFTINSLT AVECMDYLDR LYAVRHDIVD QMIKHEWSDN KDSEEPISKV 70 80 90 100 110 120 LLFAGIPNNV ITALEKKVIP DHPSGKTLRS FFKMTPDNYR ITGSLIEFVE VTVTADVDKG 130 140 150 160 170 180 IREKKMKYEL GLKYLEQELM TFFHRGELQN PYKITFKVVA VRTDGSNIST QWPSARNDGV 190 200 210 220 230 240 VQYMRLVQAE ISYVREHLVK TEERAALEAM FNLKFNISSL KTQPYFIPEY KGIDLIRPDI 250 260 270 280 290 300 DGLVNYAQSW MSKTQEFSFF EVKGSAVFDC FNENEQGHIV KYPMSRHPRN FLLIQCTVLT 310 320 330 340 350 360 AYKPATILSD QLDSRRACIQ FLNLIPETPA SILAHDMAHR YINLTRDDLL AYYAPRIQFN 370 380 390 400 410 420 PTQNIKEPGT FKLTSNMMRP ESKIMLDMLS QHEPRENLGK SIESLNISSH IVQSDCVSLI 430 440 450 460 470 480 TKILSDLELN ISEPSSHEQI TAKHTHVDTV LDKFFQNETQ KYLIDILKKT TAWHIGHLVR 490 500 510 520 530 540 DITESLIAHS GLRRSKYWSI HAYNNGSVIL FILPSKSLEV AGSFVRFMTA FKLGPGLVDK 550 560 570 580 590 600 DNLDSILADG DILWGVSKIM SLDLNRLLAL NIAFEKALLA TATWFQYYTE DQSQFPLQHS 610 620 630 640 650 660 IRSVFAYHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLVEKLFER PFKSALEVYV 670 680 690 700 710 720 YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGI YPSFMSRVVY KHYKSLISEV 730 740 750 760 770 780 TTCFFLFEKG LHGNVNEEAK IHLETVEWAT KFKEKEDKYG EMLVEHGYTI GELVESSELA 790 800 810 820 830 840 VQQLYCQDAV ELAANELNRV LIAKSQVVAN SILNKYWEEP YFSQTRNISL KGMSGQVQED 850 860 870 880 890 900 GHLSSSTTII EAIRYLSNSR NNPNVLQLYE ETRHQKAQAR IVRKFQRTEA DRGFFITTLP 910 920 930 940 950 960 TRCRLEIIED YYDAISKNVA EEYISYGGER KILCIQAALE KALRWASGES FIELSNGKFI 970 980 990 1000 1010 1020 RMKRKLMYVS ADATKWSPGD NSAKFRRFTA ALHNGLPDDR LKNCVIDALR HVYKTDFYMS 1030 1040 1050 1060 1070 1080 RKLRHYIDSM DTYEPHVRDF LNFFPDGHHG EVRGNWLQGN LNKCSSLFGV AMSLLFKEIW 1090 1100 1110 1120 1130 1140 TRLFPELDCF FEFAHHSDDA LFIYGYLEPA DDGTDWFLFV SQQIQAGKLH WFNVNTEMWK 1150 1160 1170 1180 1190 1200 SMFNLHEHIL LLGSIKISPK KTTLSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 1210 1220 1230 1240 1250 1260 YFDDLAAAQT RCVKAMDLGA SPQISQLAVS LSTSKVERLY GTSIGMVNYP GTYLRTKHSE 1270 1280 1290 1300 1310 1320 TPIPLGGSGA MSIMELSTAG IGMSDKNLLK QALIGYMHKH QKQMSYILGL FKFLMDLSGE 1330 1340 1350 1360 1370 1380 TFQHERLGQF SFIGKVQWKI FTPKSEFEFS DMYSQKFLKV WSEQHPTYDY IIPKGRDNLL 1390 1400 1410 1420 1430 1440 IYLVRKLNDP SIITAMTMQS PLQLRFRMQA KQHMKVCRLD GDWVTFREVL AAANSFAESY 1450 1460 1470 1480 1490 1500 EPSQNDIDLF QTLTSCTFSK EYAWKDFLNN VHCDVIPTKQ VQRAKVARTF TVREKDRIIQ 1510 1520 1530 1540 1550 1560 NSIPAVIGYK FAVTVDEMSD VLDTAKFPDS LAVDLKTMKD GVYRELGLDI SSPDVMKKVA 1570 1580 1590 1600 1610 1620 PMLYKSAKSR VVIVQGNVEG TAEAICAYWL RNMSLIKTIK VKPHKEVLQA VSIFNRKEDI 1630 1640 1650 1660 1670 1680 GQQKDLSALK LCIEVWRWAK ANNAPYRDWF HALWFEDKTF SEWLDRFIRV GVPPIDPEIQ 1690 1700 1710 1720 1730 1740 CAALMIADVK GDRSVLQLQA NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGLDCA 1750 1760 1770 1780 1790 1800 RLEIFWDKKT YILETSITQK HVLKIMMEEV SKELVRCGMR FNTEQVNGVK HLVLFKTDSG 1810 1820 1830 1840 1850 1860 FEWGKPNIPC IVYKNCALRT GLRTNQAINH KFMITIKDDG LRAIAQYDED SPRFLLAHAF 1870 1880 1890 1900 1910 1920 HTIRDVRYQA VDAVSNVWFT HKGIKLYLNP IISSGLLEYF MKNIPAAIPP AAYSLIMNRA 1930 1940 1950 1960 1970 1980 KISVDLFMFN DLLRLINPGN TLDLSGLEIT GEGYSTVNSL SSRLWSEEMS LVDDEEEMDD 1990 2000 2010 2020 2030 2040 EFTIDLQDVD FENIDIEADV EHFLQDESAY TGDLLIMSEE TEVKKMRGII KLLEPVKLIK 2050 2060 2070 2080 2090 2100 SWVSRGLSIE KVYNPVNIIL MTRYISKNFN FSGKQVSLLD PYDLTELESI VKGWGESVVD 2110 2120 2130 2140 2150 QFDSLDLEAQ NLVQKQGIVP EDVIPDSLFS FRHTMVLLRR LFGQDSVSTF Y

References

[1]	"Nucleotide sequence and coding capacity of the large (L) genomic RNA segment of Seoul 80-39 virus, a member of the hantavirus genus." Antic D., Lim B.U., Yong Kang C. Virus Res. 19:59-66(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56492 Genomic RNA. Translation: CAA39847.1.
PIR	S16449.
RefSeq	NP_942558.1. NC_005238.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2656409.
Family and domain databases
InterPro	IPR026382. CapSnatchArena. IPR016268. RNA-dir_pol_hantavirus. IPR024378. RNA-dir_pol_N_hantavirus. IPR007099. RNA-dir_pol_NSvirus. IPR007322. RNA_pol_bunyavir. [Graphical view]
Pfam	PF04196. Bunya_RdRp. 1 hit. PF12426. DUF3674. 1 hit. [Graphical view]
PIRSF	PIRSF000825. L_HantaV. 1 hit.
TIGRFAMs	TIGR04202. capSnatchArena. 1 hit.
PROSITE	PS50525. RDRP_SSRNA_NEG_SEG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

L_SEOU8

Accession

Primary (citable) accession number: P27314

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program