P27277 (VGLG_SYNV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spike glycoprotein

Gene names

Name:

G

Organism

Sonchus yellow net virus (SYNV) [Complete proteome]

Taxonomic identifier

11307 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Mononegavirales › Rhabdoviridae › Nucleorhabdovirus

Virus host

Aphis [TaxID: 80764]
Bidens pilosa (Hairy beggarticks) (Cobbler's pegs) [TaxID: 42337]
Lactuca sativa (Garden lettuce) [TaxID: 4236]
Sonchus oleraceus (Common sowthistle) [TaxID: 50207]

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein forms spikes on the surface of the virion. It is responsible both for the binding of the virus to susceptible host cells and for inducing the uptake of the virus by the cell. The interaction between the internal components of the virion and the portion of the glycoprotein exposed on the cytoplasmic face of the plasma membrane probably directs envelopment and virus budding.
Subcellular location	Virion membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the nucleorhabdovirus glycoprotein family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Virus entry into host cell
Cellular component	Membrane Viral envelope protein Virion
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 632	615	Spike glycoprotein		PRO_0000041000
Regions
	Transmembrane	560 – 578	19	Helical; Potential
Amino acid modifications
	Glycosylation	93	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	385	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	501	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	512	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	541	1	N-linked (GlcNAc...); by host Potential

Sequences

	Sequence		Length	Mass (Da)
	P27277 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 05541E78EEA07927	FASTA	632	71,093
	10 20 30 40 50 60 MSHIMNLLVI SFVLAGSSWS LLGYQDDFSS KRSGALASNP TYNLPQDKGY GRDMYQPYYI 70 80 90 100 110 120 CEPDNDGSAL TLPSWHYSCK ESCMGNHLKR VVNITGARWN YVGISIPVFK IVTNEVCYTS 130 140 150 160 170 180 HENVWGYCSQ YQISRPVATQ KSDVSCITSS MWDNDKSPIG SLYNIVNSNE AECDYFSDIT 190 200 210 220 230 240 DCNRDYQIFK REGKLIKRSD DSPLELSIVT DGIRTDPASE YLSLDDVSWF WKLPNNDMSP 250 260 270 280 290 300 PCGWEKTQKL SCSYTDTTDV IKCNSIGYTY NIQGISKKST CAGNIYDTDG PFPFFYDAEE 310 320 330 340 350 360 ALMSTDDACG KAKQGKPDAD IAFIEGVNRA FEDLELTYCS ATCDLFARQG TPNEDHVLDT 370 380 390 400 410 420 PIGTWRYVMR DNLDPALVPC LPTSNWTISD PTTICHGKDH ILVVDTATGH SGSWDTKKDY 430 440 450 460 470 480 IITGEVCNTN NDEMGDDYDG MRDKILRGET IEIKFWTGDI IRMAPPYDNP EWIKGSVLFR 490 500 510 520 530 540 QNPGWFSSVE LNKDMIHTRD NITDLLTVMV QNATAEVMYK RLDPKTMKHI LFAEIVDGVG 550 560 570 580 590 600 NVSGKISGFL TGLFGGFTKA VIIVASLAIC YIVLSVLWKV RLVASIFNSA KKKRVRISDI 610 620 630 LDEEPHRIQQ SRPTLSRKKK TRESIQMLLN DI

References

[1]	"Structure of the glycoprotein gene of sonchus yellow net virus, a plant rhabdovirus." Goldberg K.B., Modrell B., Hillman B.I., Heaton L.A., Choi T.J., Jackson A.O. Virology 185:32-38(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC PV-263.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L32603 mRNA. Translation: AAA50384.1. M73626 Genomic RNA. Translation: AAA47898.1.
PIR	VGVNSY. A40776.
RefSeq	NP_042285.1. NC_001615.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1489881.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

VGLG_SYNV

Accession

Primary (citable) accession number: P27277

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program