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Protein

CD59 glycoprotein

Gene

Cd59

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after the C5b-8 stage of MAC assembly.

GO - Molecular functioni

  • complement binding Source: RGD

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • negative regulation of activation of membrane attack complex Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • positive regulation of T cell proliferation Source: RGD
  • regulation of complement activation Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
CD59 glycoprotein
Alternative name(s):
MAC-inhibitory protein
Short name:
MAC-IP
Membrane attack complex inhibition factor
Short name:
MACIF
Protectin
CD_antigen: CD59
Gene namesi
Name:Cd59
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2311. Cd59.

Subcellular locationi

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: Ensembl
  • cell surface Source: GO_Central
  • compact myelin Source: RGD
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • focal adhesion Source: Ensembl
  • plasma membrane Source: RGD
  • sarcolemma Source: RGD

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000003612423 – 101CD59 glycoproteinAdd BLAST79
PropeptideiPRO_0000036125102 – 126Removed in mature formBy similarityAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 48By similarity
Disulfide bondi28 ↔ 35By similarity
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi41 ↔ 61By similarity
Disulfide bondi67 ↔ 85By similarity
Disulfide bondi86 ↔ 91By similarity
Lipidationi101GPI-anchor amidated asparagineBy similarity1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP27274.
PRIDEiP27274.

PTM databases

iPTMnetiP27274.
PhosphoSitePlusiP27274.
SwissPalmiP27274.

Expressioni

Gene expression databases

BgeeiENSRNOG00000042821.
GenevisibleiP27274. RN.

Interactioni

GO - Molecular functioni

  • complement binding Source: RGD

Protein-protein interaction databases

IntActiP27274. 1 interactor.
STRINGi10116.ENSRNOP00000060967.

Structurei

3D structure databases

ProteinModelPortaliP27274.
SMRiP27274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 110UPAR/Ly6Add BLAST88

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J39P. Eukaryota.
ENOG410ZEQP. LUCA.
GeneTreeiENSGT00390000016309.
HOVERGENiHBG005284.
InParanoidiP27274.
KOiK04008.
OMAiNKAAFSI.
OrthoDBiEOG091G11NF.
PhylomeDBiP27274.

Family and domain databases

InterProiView protein in InterPro
IPR018363. CD59_antigen_CS.
IPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
PANTHERiPTHR10036:SF13. PTHR10036:SF13. 1 hit.
PfamiView protein in Pfam
PF00021. UPAR_LY6. 1 hit.
SMARTiView protein in SMART
SM00134. LU. 1 hit.
PROSITEiView protein in PROSITE
PS00983. LY6_UPAR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARRGFILL LLLAVLCSTG VSLRCYNCLD PVSSCKTNST CSPNLDACLV
60 70 80 90 100
AVSGKQVYQQ CWRFSDCNAK FILSRLEIAN VQYRCCQADL CNKSFEDKPN
110 120
NGAISLLGKT ALLVTSVLAA ILKPCF
Length:126
Mass (Da):13,790
Last modified:November 1, 1997 - v2
Checksum:i54B9C58AB2073005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48255 mRNA. Translation: AAA88909.1.
BC063176 mRNA. Translation: AAH63176.1.
PIRiS53340.
RefSeqiNP_037057.1. NM_012925.1.
UniGeneiRn.1231.

Genome annotation databases

EnsembliENSRNOT00000067085; ENSRNOP00000060967; ENSRNOG00000042821.
GeneIDi25407.
KEGGirno:25407.
UCSCiRGD:2311. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48255 mRNA. Translation: AAA88909.1.
BC063176 mRNA. Translation: AAH63176.1.
PIRiS53340.
RefSeqiNP_037057.1. NM_012925.1.
UniGeneiRn.1231.

3D structure databases

ProteinModelPortaliP27274.
SMRiP27274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP27274. 1 interactor.
STRINGi10116.ENSRNOP00000060967.

PTM databases

iPTMnetiP27274.
PhosphoSitePlusiP27274.
SwissPalmiP27274.

Proteomic databases

PaxDbiP27274.
PRIDEiP27274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067085; ENSRNOP00000060967; ENSRNOG00000042821.
GeneIDi25407.
KEGGirno:25407.
UCSCiRGD:2311. rat.

Organism-specific databases

CTDi966.
RGDi2311. Cd59.

Phylogenomic databases

eggNOGiENOG410J39P. Eukaryota.
ENOG410ZEQP. LUCA.
GeneTreeiENSGT00390000016309.
HOVERGENiHBG005284.
InParanoidiP27274.
KOiK04008.
OMAiNKAAFSI.
OrthoDBiEOG091G11NF.
PhylomeDBiP27274.

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-977606. Regulation of Complement cascade.

Miscellaneous databases

PROiPR:P27274.

Gene expression databases

BgeeiENSRNOG00000042821.
GenevisibleiP27274. RN.

Family and domain databases

InterProiView protein in InterPro
IPR018363. CD59_antigen_CS.
IPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
PANTHERiPTHR10036:SF13. PTHR10036:SF13. 1 hit.
PfamiView protein in Pfam
PF00021. UPAR_LY6. 1 hit.
SMARTiView protein in SMART
SM00134. LU. 1 hit.
PROSITEiView protein in PROSITE
PS00983. LY6_UPAR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCD59_RAT
AccessioniPrimary (citable) accession number: P27274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 1, 1997
Last modified: May 10, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.