P27250 (YJGB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized zinc-type alcohol dehydrogenase-like protein YjgB
EC=1.-.-.-

Gene names

Name:	yjgB
Ordered Locus Names:	b4269, JW5761

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 2 zinc ions per subunit By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.
Sequence caution	The sequence AAA97166.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	alcohol dehydrogenase (NADP+) activity Inferred from direct assay PubMed 22731523PubMed 23093176. Source: EcoCyc cofactor binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from direct assay PubMed 22094925. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Uncharacterized zinc-type alcohol dehydrogenase-like protein YjgB		PRO_0000160894
Sites
	Metal binding	38	1	Zinc 1; catalytic By similarity
	Metal binding	63	1	Zinc 1; catalytic By similarity
	Metal binding	96	1	Zinc 2 By similarity
	Metal binding	99	1	Zinc 2 By similarity
	Metal binding	102	1	Zinc 2 By similarity
	Metal binding	110	1	Zinc 2 By similarity
	Metal binding	152	1	Zinc 1; catalytic By similarity
Experimental info
	Sequence conflict	331 – 339	9	YRVVLKADF → TAWC in AAA72122. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P27250 [UniParc]. Last modified February 1, 1995. Version 2. Checksum: 0854DDEFA16B9EEE	FASTA	339	36,502
	10 20 30 40 50 60 MSMIKSYAAK EAGGELEVYE YDPGELRPQD VEVQVDYCGI CHSDLSMIDN EWGFSQYPLV 70 80 90 100 110 120 AGHEVIGRVV ALGSAAQDKG LQVGQRVGIG WTARSCGHCD ACISGNQINC EQGAVPTIMN 130 140 150 160 170 180 RGGFAEKLRA DWQWVIPLPE NIDIESAGPL LCGGITVFKP LLMHHITATS RVGVIGIGGL 190 200 210 220 230 240 GHIAIKLLHA MGCEVTAFSS NPAKEQEVLA MGADKVVNSR DPQALKALAG QFDLIINTVN 250 260 270 280 290 300 VSLDWQPYFE ALTYGGNFHT VGAVLTPLSV PAFTLIAGDR SVSGSATGTP YELRKLMRFA 310 320 330 ARSKVAPTTE LFPMSKINDA IQHVRDGKAR YRVVLKADF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Pucci M.J., Discotto L.F., Dougherty T.J. Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: B.
[2]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M96355 Genomic DNA. Translation: AAA72122.1. U14003 Genomic DNA. Translation: AAA97166.1. Different initiation. U00096 Genomic DNA. Translation: AAC77226.2. AP009048 Genomic DNA. Translation: BAE78266.1.
PIR	S56495.
RefSeq	NP_418690.4. NC_000913.2. YP_492407.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P27250.
SMR	P27250. Positions 7-335.
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b4269.
Proteomic databases
PaxDb	P27250.
PRIDE	P27250.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC77226; AAC77226; b4269. BAE78266; BAE78266; BAE78266.
GeneID	12934055. 948802.
KEGG	ecj:Y75_p4152. eco:b4269.
PATRIC	32124111. VBIEscCol129921_4400.
Organism-specific databases
EchoBASE	EB1406.
EcoGene	EG11436. yjgB.
Phylogenomic databases
eggNOG	COG1064.
HOGENOM	HOG000294667.
KO	K12957.
OMA	IDNEWGI.
ProtClustDB	CLSK880885.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11436-MONOMER. ECOL316407:JW5761-MONOMER.
Gene expression databases
Genevestigator	P27250.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11695. PTHR11695. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YJGB_ECOLI

Accession

Primary (citable) accession number: P27250
Secondary accession number(s): P76812, Q2M640

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program