Reviewed,
UniProtKB/Swiss-Prot P27249 (GLND_ECOLI)
Last modified
June 16, 2009.
Version 87.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: [Protein-PII] uridylyltransferase Short name=PII uridylyl-transferase EC=2.7.7.59 Alternative name(s): Uridylyl-removing enzyme UTase | ||||
| Gene names |
| ||||
| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83333 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 890 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein. HAMAP MF_00277 |
| Catalytic activity | UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII]. HAMAP MF_00277 |
| Sequence similarities | Belongs to the glnD family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | [protein-PII] uridylyltransferase activity Inferred from electronic annotation. Source: HAMAP amino acid bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 890 | 890 | [Protein-PII] uridylyltransferase HAMAP MF_00277 | PRO_0000192732 | |||||
Experimental info | |||||||||
| Sequence conflict | 47 | 1 | L → S in AAA23878. Ref.1 | ||||||
| Sequence conflict | 225 | 1 | G → A Ref.3 | ||||||
| Sequence conflict | 357 – 358 | 2 | RG → TR in AAA23878. Ref.1 | ||||||
| Sequence conflict | 523 | 1 | D → H in AAA23878. Ref.1 | ||||||
| Sequence conflict | 703 | 1 | A → R in CAA79887. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and sequencing of gldD, the gene for uridylyl transferase and uridyl removing enzyme of E. coli." Park S.-C., Kim I.H., Rhee S.G. Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12. |
| [2] | "The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli." van Heeswijk W.C., Rabenberg M., Westerhoff H.V., Kahn D.D. Mol. Microbiol. 9:443-458(1993) [PubMed: 8412694] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [3] | "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region." Fujita N., Mori H., Yura T., Ishihama A. Nucleic Acids Res. 22:1637-1639(1994) [PubMed: 8202364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [4] | "Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [5] | "The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [6] | "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
Cross-references
Sequence databases | |
|---|---|
| M96431 Genomic DNA. Translation: AAA23878.1. Z21842 Genomic DNA. Translation: CAA79887.1. U70214 Genomic DNA. Translation: AAB08596.1. U00096 Genomic DNA. Translation: AAC73278.1. AP009048 Genomic DNA. Translation: BAE76045.1. | |
| PIR | G64740. |
| RefSeq | AP_000827.1. NP_414709.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:9779N. |
| IntAct | P27249. 23 interactions. |
Genome annotation databases | |
| GeneID | 944863. |
| GenomeReviews | Gene locus JW0162 in contig AP009048_GR. Gene locus b0167 in contig U00096_GR. |
| KEGG | ecj:JW0162. eco:b0167. |
Organism-specific databases | |
| EchoBASE | EB1383. |
| EcoGene | EG11411. glnD. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P27249. |
| OMA | P27249. MQHDLFH. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:GLND-MON. |
| BRENDA | 2.7.7.59. 246. |
Family and domain databases | |
| HAMAP | MF_00277. [Tree] |
| InterPro | IPR002912. ACT_bd. IPR010043. GlnD_Uridyltrans. IPR003607. Met-dep_phosphohydro_HD. IPR006674. Met-dep_phosphohydro_HD_sub. IPR002934. Nucleotidyltransferase. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view] |
| PANTHER | PTHR13734:SF1. GlnD_Uridyltrans. 1 hit. |
| Pfam | PF01842. ACT. 2 hits. PF08335. GlnD_UR_UTase. 1 hit. PF01966. HD. 1 hit. PF01909. NTP_transf_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF006288. PII_uridyltransf. 1 hit. |
| SMART | SM00471. HDc. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01693. UTase_glnD. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GLND_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P27249 Secondary accession number(s): Q2MCG1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

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