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Protein

Phosphate acyltransferase

Gene

plsX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible formation of acyl-phosphate (acyl-PO4) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.UniRule annotation1 Publication

Catalytic activityi

Acyl-[acyl-carrier-protein] + phosphate = acyl-phosphate + [acyl-carrier-protein].UniRule annotation

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • fatty acid biosynthetic process Source: InterPro
  • phospholipid biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG11437-MONOMER
UniPathwayiUPA00085

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acyltransferaseUniRule annotation (EC:2.3.1.n2UniRule annotation)
Alternative name(s):
Acyl-ACP phosphotransacylaseUniRule annotation
Acyl-[acyl-carrier-protein]--phosphate acyltransferaseUniRule annotation
Phosphate-acyl-ACP acyltransferaseUniRule annotation
Gene namesi
Name:plsXUniRule annotation
Ordered Locus Names:b1090, JW5156
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11437 plsX

Subcellular locationi

  • Cytoplasm
  • Note: Associated with the membrane possibly through PlsY.Curated

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001898751 – 356Phosphate acyltransferaseAdd BLAST356

Proteomic databases

PaxDbiP27247
PRIDEiP27247

Interactioni

Subunit structurei

Homodimer. Probably interacts with PlsY.UniRule annotation

Protein-protein interaction databases

BioGridi4261030, 148 interactors
DIPiDIP-10517N
IntActiP27247, 1 interactor
STRINGi316385.ECDH10B_1162

Structurei

3D structure databases

ProteinModelPortaliP27247
SMRiP27247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PlsX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6B Bacteria
COG0416 LUCA
HOGENOMiHOG000154730
InParanoidiP27247
KOiK03621
OMAiDCKPEYL
PhylomeDBiP27247

Family and domain databases

HAMAPiMF_00019 PlsX, 1 hit
InterProiView protein in InterPro
IPR003664 FA_synthesis
IPR012281 Phospholipid_synth_PlsX-like
PANTHERiPTHR30100 PTHR30100, 1 hit
PfamiView protein in Pfam
PF02504 FA_synthesis, 1 hit
PIRSFiPIRSF002465 Phsphlp_syn_PlsX, 1 hit
TIGRFAMsiTIGR00182 plsX, 1 hit

Sequencei

Sequence statusi: Complete.

P27247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRLTLALDV MGGDFGPSVT VPAALQALNS NSQLTLLLVG NSDAITPLLA
60 70 80 90 100
KADFEQRSRL QIIPAQSVIA SDARPSQAIR ASRGSSMRVA LELVKEGRAQ
110 120 130 140 150
ACVSAGNTGA LMGLAKLLLK PLEGIERPAL VTVLPHQQKG KTVVLDLGAN
160 170 180 190 200
VDCDSTMLVQ FAIMGSVLAE EVVEIPNPRV ALLNIGEEEV KGLDSIRDAS
210 220 230 240 250
AVLKTIPSIN YIGYLEANEL LTGKTDVLVC DGFTGNVTLK TMEGVVRMFL
260 270 280 290 300
SLLKSQGEGK KRSWWLLLLK RWLQKSLTRR FSHLNPDQYN GACLLGLRGT
310 320 330 340 350
VIKSHGAANQ RAFAVAIEQA VQAVQRQVPQ RIAARLESVY PAGFELLDGG

KSGTLR
Length:356
Mass (Da):38,214
Last modified:May 30, 2000 - v2
Checksum:i89C6C64C57184DF4
GO

Sequence cautioni

The sequence AAB59064 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96793 Genomic DNA Translation: AAB59064.1 Different initiation.
U00096 Genomic DNA Translation: AAC74174.2
AP009048 Genomic DNA Translation: BAA35898.2
PIRiG64852
RefSeqiNP_415608.2, NC_000913.3
WP_000197597.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74174; AAC74174; b1090
BAA35898; BAA35898; BAA35898
GeneIDi946165
KEGGiecj:JW5156
eco:b1090
PATRICifig|511145.12.peg.1133

Similar proteinsi

Entry informationi

Entry nameiPLSX_ECOLI
AccessioniPrimary (citable) accession number: P27247
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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