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Protein

Multiple antibiotic resistance protein MarR

Gene

marR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.

GO - Molecular functioni

GO - Biological processi

  • cellular response to antibiotic Source: EcoCyc
  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to heat Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processAntibiotic resistance, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00364

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple antibiotic resistance protein MarR
Gene namesi
Name:marR
Synonyms:cfxB, inaR, soxQ
Ordered Locus Names:b1530, JW5248
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11435 marR

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi45V → E: Increased transcription of the region II transcript. 1 Publication1
Mutagenesisi77R → L: Increased transcription of the region II transcript. 1 Publication1
Mutagenesisi123 – 144Missing : Increased transcription of the region II transcript. 1 PublicationAdd BLAST22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000543621 – 144Multiple antibiotic resistance protein MarRAdd BLAST144

Proteomic databases

PaxDbiP27245
PRIDEiP27245

Interactioni

Protein-protein interaction databases

BioGridi4259660, 138 interactors
DIPiDIP-10164N
STRINGi316385.ECDH10B_1661

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 11Combined sources5
Helixi14 – 33Combined sources20
Turni34 – 37Combined sources4
Helixi40 – 52Combined sources13
Beta strandi53 – 55Combined sources3
Helixi57 – 64Combined sources8
Helixi68 – 80Combined sources13
Beta strandi83 – 88Combined sources6
Turni90 – 92Combined sources3
Beta strandi96 – 100Combined sources5
Helixi102 – 124Combined sources23
Turni125 – 130Combined sources6
Helixi132 – 140Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JGSX-ray2.30A7-144[»]
3VB2X-ray2.60A/B1-144[»]
3VODX-ray2.60A/B1-144[»]
3VOEX-ray2.60A/B1-144[»]
4JBAX-ray2.50A/B1-144[»]
5H3RX-ray2.67A/B1-144[»]
ProteinModelPortaliP27245
SMRiP27245
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27245

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 144HTH marR-typePROSITE-ProRule annotationAdd BLAST134

Phylogenomic databases

eggNOGiENOG4108T3F Bacteria
COG1846 LUCA
HOGENOMiHOG000221449
InParanoidiP27245
KOiK03712
OMAiYEATMVT
PhylomeDBiP27245

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000835 HTH_MarR-typ
IPR023187 Tscrpt_reg_MarR-type_CS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01047 MarR, 1 hit
PRINTSiPR00598 HTHMARR
SMARTiView protein in SMART
SM00347 HTH_MARR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS01117 HTH_MARR_1, 1 hit
PS50995 HTH_MARR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P27245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTSDLFNE IIPLGRLIHM VNQKKDRLLN EYLSPLDITA AQFKVLCSIR
60 70 80 90 100
CAACITPVEL KKVLSVDLGA LTRMLDRLVC KGWVERLPNP NDKRGVLVKL
110 120 130 140
TTGGAAICEQ CHQLVGQDLH QELTKNLTAD EVATLEYLLK KVLP
Length:144
Mass (Da):16,065
Last modified:December 1, 2000 - v2
Checksum:iBE7DF5549E24D1D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA Translation: AAC16394.2
U00096 Genomic DNA Translation: AAC74603.2
AP009048 Genomic DNA Translation: BAA15220.1
PIRiE64907
RefSeqiNP_416047.4, NC_000913.3
WP_000843414.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74603; AAC74603; b1530
BAA15220; BAA15220; BAA15220
GeneIDi945825
KEGGiecj:JW5248
eco:b1530
PATRICifig|1411691.4.peg.736

Similar proteinsi

Entry informationi

Entry nameiMARR_ECOLI
AccessioniPrimary (citable) accession number: P27245
Secondary accession number(s): P76882, P77582
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 1, 2000
Last modified: April 25, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health