Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P27245 (MARR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multiple antibiotic resistance protein MarR
Gene names
Name:marR
Synonyms:cfxB, inaR, soxQ
Ordered Locus Names:b1530, JW5248
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.

Sequence similarities

Contains 1 HTH marR-type DNA-binding domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

gyrAP0AES42EBI-6409744,EBI-547129

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 144144Multiple antibiotic resistance protein MarR
PRO_0000054362

Regions

Domain11 – 144134HTH marR-type

Experimental info

Mutagenesis451V → E: Increased transcription of the region II transcript.
Mutagenesis771R → L: Increased transcription of the region II transcript.
Mutagenesis123 – 14422Missing: Increased transcription of the region II transcript.

Secondary structure

...................... 144
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P27245 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: BE7DF5549E24D1D3

FASTA14416,065
        10         20         30         40         50         60 
MKSTSDLFNE IIPLGRLIHM VNQKKDRLLN EYLSPLDITA AQFKVLCSIR CAACITPVEL 

        70         80         90        100        110        120 
KKVLSVDLGA LTRMLDRLVC KGWVERLPNP NDKRGVLVKL TTGGAAICEQ CHQLVGQDLH 

       130        140 
QELTKNLTAD EVATLEYLLK KVLP 

« Hide

References

« Hide 'large scale' references
[1]"Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli."
Cohen S.P., Haechler H., Levy S.B.
J. Bacteriol. 175:1484-1492(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map."
Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. expand/collapse author list , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:363-377(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli."
Ariza R.R., Cohen S.P., Bachhawat N., Levy S.B., Demple B.
J. Bacteriol. 176:143-148(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli."
Seoane A.S., Levy S.B.
J. Bacteriol. 177:3414-3419(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA binding."
Alekshun M.N., Kim Y.S., Levy S.B.
Mol. Microbiol. 35:1394-1404(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M96235 Genomic DNA. Translation: AAC16394.2.
U00096 Genomic DNA. Translation: AAC74603.2.
AP009048 Genomic DNA. Translation: BAA15220.1.
PIRE64907.
RefSeqNP_416047.4. NC_000913.3.
YP_489793.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JGSX-ray2.30A7-144[»]
3VB2X-ray2.60A/B1-144[»]
3VODX-ray2.60A/B1-144[»]
3VOEX-ray2.60A/B1-144[»]
4JBAX-ray2.50A/B1-144[»]
ProteinModelPortalP27245.
SMRP27245. Positions 7-144.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-10164N.
IntActP27245. 1 interaction.
STRING511145.b1530.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74603; AAC74603; b1530.
BAA15220; BAA15220; BAA15220.
GeneID12930666.
945825.
KEGGecj:Y75_p1505.
eco:b1530.
PATRIC32118358. VBIEscCol129921_1599.

Organism-specific databases

EchoBASEEB1405.
EcoGeneEG11435. marR.

Phylogenomic databases

eggNOGCOG1846.
HOGENOMHOG000221449.
KOK03712.
OMALIVEPEW.
OrthoDBEOG6PGKBH.
PhylomeDBP27245.
ProtClustDBPRK11512.

Enzyme and pathway databases

BioCycEcoCyc:PD00364.
ECOL316407:JW5248-MONOMER.

Gene expression databases

GenevestigatorP27245.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000835. HTH_MarR-typ.
IPR023187. Tscrpt_reg_MarR-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01047. MarR. 1 hit.
[Graphical view]
PRINTSPR00598. HTHMARR.
SMARTSM00347. HTH_MARR. 1 hit.
[Graphical view]
PROSITEPS01117. HTH_MARR_1. 1 hit.
PS50995. HTH_MARR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP27245.
PROP27245.

Entry information

Entry nameMARR_ECOLI
AccessionPrimary (citable) accession number: P27245
Secondary accession number(s): P76882, P77582
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 1, 2000
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene