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Protein

Multiple antibiotic resistance protein MarR

Gene

marR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.

GO - Molecular functioni

GO - Biological processi

  • cellular response to antibiotic Source: EcoCyc
  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to heat Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Antibiotic resistance, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00364.
ECOL316407:JW5248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple antibiotic resistance protein MarR
Gene namesi
Name:marR
Synonyms:cfxB, inaR, soxQ
Ordered Locus Names:b1530, JW5248
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11435. marR.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi45V → E: Increased transcription of the region II transcript. 1 Publication1
Mutagenesisi77R → L: Increased transcription of the region II transcript. 1 Publication1
Mutagenesisi123 – 144Missing : Increased transcription of the region II transcript. 1 PublicationAdd BLAST22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000543621 – 144Multiple antibiotic resistance protein MarRAdd BLAST144

Proteomic databases

PaxDbiP27245.
PRIDEiP27245.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
gyrAP0AES42EBI-6409744,EBI-547129

Protein-protein interaction databases

BioGridi4259660. 138 interactors.
DIPiDIP-10164N.
IntActiP27245. 1 interactor.
STRINGi511145.b1530.

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 33Combined sources20
Turni34 – 37Combined sources4
Helixi40 – 52Combined sources13
Beta strandi53 – 55Combined sources3
Helixi57 – 64Combined sources8
Helixi68 – 80Combined sources13
Beta strandi83 – 88Combined sources6
Turni90 – 92Combined sources3
Beta strandi96 – 100Combined sources5
Helixi102 – 124Combined sources23
Turni125 – 130Combined sources6
Helixi132 – 140Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JGSX-ray2.30A7-144[»]
3VB2X-ray2.60A/B1-144[»]
3VODX-ray2.60A/B1-144[»]
3VOEX-ray2.60A/B1-144[»]
4JBAX-ray2.50A/B1-144[»]
ProteinModelPortaliP27245.
SMRiP27245.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27245.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 144HTH marR-typePROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Contains 1 HTH marR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108T3F. Bacteria.
COG1846. LUCA.
HOGENOMiHOG000221449.
InParanoidiP27245.
KOiK03712.
OMAiYEATMVT.
PhylomeDBiP27245.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR023187. Tscrpt_reg_MarR-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01047. MarR. 1 hit.
[Graphical view]
PRINTSiPR00598. HTHMARR.
SMARTiSM00347. HTH_MARR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS01117. HTH_MARR_1. 1 hit.
PS50995. HTH_MARR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTSDLFNE IIPLGRLIHM VNQKKDRLLN EYLSPLDITA AQFKVLCSIR
60 70 80 90 100
CAACITPVEL KKVLSVDLGA LTRMLDRLVC KGWVERLPNP NDKRGVLVKL
110 120 130 140
TTGGAAICEQ CHQLVGQDLH QELTKNLTAD EVATLEYLLK KVLP
Length:144
Mass (Da):16,065
Last modified:December 1, 2000 - v2
Checksum:iBE7DF5549E24D1D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA. Translation: AAC16394.2.
U00096 Genomic DNA. Translation: AAC74603.2.
AP009048 Genomic DNA. Translation: BAA15220.1.
PIRiE64907.
RefSeqiNP_416047.4. NC_000913.3.
WP_000843414.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74603; AAC74603; b1530.
BAA15220; BAA15220; BAA15220.
GeneIDi945825.
KEGGiecj:JW5248.
eco:b1530.
PATRICi32118358. VBIEscCol129921_1599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA. Translation: AAC16394.2.
U00096 Genomic DNA. Translation: AAC74603.2.
AP009048 Genomic DNA. Translation: BAA15220.1.
PIRiE64907.
RefSeqiNP_416047.4. NC_000913.3.
WP_000843414.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JGSX-ray2.30A7-144[»]
3VB2X-ray2.60A/B1-144[»]
3VODX-ray2.60A/B1-144[»]
3VOEX-ray2.60A/B1-144[»]
4JBAX-ray2.50A/B1-144[»]
ProteinModelPortaliP27245.
SMRiP27245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259660. 138 interactors.
DIPiDIP-10164N.
IntActiP27245. 1 interactor.
STRINGi511145.b1530.

Proteomic databases

PaxDbiP27245.
PRIDEiP27245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74603; AAC74603; b1530.
BAA15220; BAA15220; BAA15220.
GeneIDi945825.
KEGGiecj:JW5248.
eco:b1530.
PATRICi32118358. VBIEscCol129921_1599.

Organism-specific databases

EchoBASEiEB1405.
EcoGeneiEG11435. marR.

Phylogenomic databases

eggNOGiENOG4108T3F. Bacteria.
COG1846. LUCA.
HOGENOMiHOG000221449.
InParanoidiP27245.
KOiK03712.
OMAiYEATMVT.
PhylomeDBiP27245.

Enzyme and pathway databases

BioCyciEcoCyc:PD00364.
ECOL316407:JW5248-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP27245.
PROiP27245.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR023187. Tscrpt_reg_MarR-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01047. MarR. 1 hit.
[Graphical view]
PRINTSiPR00598. HTHMARR.
SMARTiSM00347. HTH_MARR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS01117. HTH_MARR_1. 1 hit.
PS50995. HTH_MARR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMARR_ECOLI
AccessioniPrimary (citable) accession number: P27245
Secondary accession number(s): P76882, P77582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.