Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipopolysaccharide 1,2-N-acetylglucosaminetransferase

Gene

waaU

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS.

Catalytic activityi

UDP-N-acetyl-alpha-D-glucosamine + [lipopolysaccharide] = UDP + N-acetyl-alpha-D-glucosaminyl-[lipopolysaccharide].

Pathwayi: LPS core biosynthesis

This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

  • ADP-heptose-lipopolysaccharide heptosyltransferase activity Source: GO_Central
  • lipopolysaccharide N-acetylglucosaminyltransferase activity Source: EcoCyc
  • transferase activity, transferring glycosyl groups Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG11423-MONOMER
MetaCyc:EG11423-MONOMER
UniPathwayiUPA00958

Protein family/group databases

CAZyiGT9 Glycosyltransferase Family 9

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide 1,2-N-acetylglucosaminetransferase (EC:2.4.1.56)
Gene namesi
Name:waaU
Synonyms:rfaK, waaK
Ordered Locus Names:b3623, JW3598
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11423 waaU

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000972831 – 357Lipopolysaccharide 1,2-N-acetylglucosaminetransferaseAdd BLAST357

Proteomic databases

PaxDbiP27242
PRIDEiP27242

Interactioni

Protein-protein interaction databases

BioGridi4263305, 249 interactors
DIPiDIP-10672N
IntActiP27242, 7 interactors
STRINGi316385.ECDH10B_3805

Structurei

3D structure databases

ProteinModelPortaliP27242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108XNZ Bacteria
COG0859 LUCA
HOGENOMiHOG000054846
InParanoidiP27242
KOiK03277
OMAiFNTKDHP
PhylomeDBiP27242

Family and domain databases

InterProiView protein in InterPro
IPR002201 Glyco_trans_9
PfamiView protein in Pfam
PF01075 Glyco_transf_9, 1 hit

Sequencei

Sequence statusi: Complete.

P27242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGTFHKKK RFYINKIKIN FLSFLFRNKI NNQITDPAQV KSCLIIHDNN
60 70 80 90 100
KLGDLIVLSS IYRELYSKGV KITLLTNRKG GEFLSNNKNI FEFCIKESTG
110 120 130 140 150
FLEMLTLCKH LRDLQFDIVL DPFETMPSFK HSLILSSLKD SYILGFDHWY
160 170 180 190 200
KRYYSFYHPH DECLKEHMST RAIEILKHIY GEGKFSTNYD LHLPVDVEDK
210 220 230 240 250
IKEFIGDTRI VIINPLGAKK ICRLTFEQIK VIYQEVKTHF ENYRIIFTGL
260 270 280 290 300
PQDLLTIPIL EIETLPFDEF IYTVALTKYS DFVISVDTAL VHIAAAYHKP
310 320 330 340 350
TLAFYPNSRT PEYPSHLIWS PNHHKSIQIV SPTYTVKDID TETLTNSVKR

LSCIDKK
Length:357
Mass (Da):41,729
Last modified:October 1, 1994 - v2
Checksum:i951523B8192616F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293I → M in AAA24523 (PubMed:1624462).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95398 Genomic DNA Translation: AAA24523.1
U00039 Genomic DNA Translation: AAB18600.1
U00096 Genomic DNA Translation: AAC76647.1
AP009048 Genomic DNA Translation: BAE77669.1
PIRiA65163
RefSeqiNP_418080.1, NC_000913.3
WP_001236433.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76647; AAC76647; b3623
BAE77669; BAE77669; BAE77669
GeneIDi948147
KEGGiecj:JW3598
eco:b3623
PATRICifig|511145.12.peg.3743

Similar proteinsi

Entry informationi

Entry nameiWAAU_ECOLI
AccessioniPrimary (citable) accession number: P27242
Secondary accession number(s): Q2M7T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health