Reviewed, UniProtKB/Swiss-Prot P27216 (ANX13_HUMAN)

Names and origin

Protein names

Recommended name:
    Annexin A13
Alternative name(s):
    Annexin-13
    Annexin XIII
    Annexin, intestine-specific
    ISA

Gene names

Name:	ANXA13
Synonyms:	ANX13

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cell membrane. Note: Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.
Tissue specificity	Gut specific.
Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similarities	Belongs to the annexin family. Contains 4 annexin repeats.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Annexin Repeat
Ligand	Calcium Calcium/phospholipid-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell differentiation Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	plasma membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-dependent phospholipid binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P27216-1)

Also known as: Anx13A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P27216-2)

Also known as: Anx13B;

The sequence of this isoform differs from the canonical sequence as follows:
     5-5: H → HSQSYTLSEGSQQLPKGDSQPSTVVQPLSHPSRNGEPEAPQP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 316	315	Annexin A13		PRO_0000067514
Regions
	Repeat	23 – 83	61	Annexin 1
	Repeat	95 – 155	61	Annexin 2
	Repeat	179 – 239	61	Annexin 3
	Repeat	254 – 314	61	Annexin 4
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Ref.1
Natural variations
	Alternative sequence	5	1	H → HSQSYTLSEGSQQLPKGDSQ PSTVVQPLSHPSRNGEPEAP QP in isoform B.		VSP_000291
	Natural variant	86	1	R → H: dbSNP rs2294013.		VAR_055501
	Natural variant	108	1	V → I: dbSNP rs6995099.		VAR_055502
	Natural variant	272	1	V → I: dbSNP rs2294015.		VAR_055503
Experimental info
	Sequence conflict	112	1	F → V in CAC34622. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform A (Anx13A) [UniParc]. Last modified January 23, 2007. Version 2. Checksum: C2DA06B370A95F87	FASTA	316	35,463
	10 20 30 40 50 60 MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY 70 80 90 100 110 120 GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EFLCTRTNKE 130 140 150 160 170 180 IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD 190 200 210 220 230 240 AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV 250 260 270 280 290 300 RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR 310 SDTSGDFRKL LVALLH
	Isoform B (Anx13B). Checksum: 271E15684CBB843A	FASTA	357	39,792
	10 20 30 40 50 60 MGNRHSQSYT LSEGSQQLPK GDSQPSTVVQ PLSHPSRNGE PEAPQPAKAS SPQGFDVDRD 70 80 90 100 110 120 AKKLNKACKG MGTNEAAIIE ILSGRTSDER QQIKQKYKAT YGKELEEVLK SELSGNFEKT 130 140 150 160 170 180 ALALLDRPSE YAARQLQKAM KGLGTDESVL IEFLCTRTNK EIIAIKEAYQ RLFDRSLESD 190 200 210 220 230 240 VKGDTSGNLK KILVSLLQAN RNEGDDVDKD LAGQDAKDLY DAGEGRWGTD ELAFNEVLAK 250 260 270 280 290 300 RSYKQLRATF QAYQILIGKD IEEAIEEETS GDLQKAYLTL VRCAQDCEDY FAERLYKSMK 310 320 330 340 350 GAGTDEETLI RIVVTRAEVD LQGIKAKFQE KYQKSLSDMV RSDTSGDFRK LLVALLH

References

[1]	"A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin." Wice B.M., Gordon J.I. J. Cell Biol. 116:405-422(1992) [PubMed: 1530946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), MYRISTOYLATION AT GLY-2.
[2]	"Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins." Iglesias J.M., Morgan R.O., Jenkins N.A., Copeland N.G., Gilbert D.J., Fernandez M.-P. Mol. Biol. Evol. 19:608-618(2002) [PubMed: 11961095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Tissue: Colon adenocarcinoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z11502 mRNA. Translation: CAA77578.1. AJ306450 mRNA. Translation: CAC34622.1.
IPI	IPI00017337. IPI00465213.
PIR	LUHUIS. A41733.
RefSeq	NP_001003954.1. NP_004297.2.
UniGene	Hs.181107
3D structure databases
HSSP	HSSP built from PDB template 1ANN based on UniProtKB P13214.
ModBase	Search...
Protein-protein interaction databases
STRING	P27216.
Proteomic databases
PRIDE	P27216.
Genome annotation databases
Ensembl	ENST00000262219; ENSP00000262219; ENSG00000104537; Homo sapiens. [Genome view] ENST00000395546; ENSP00000378916; ENSG00000104537; Homo sapiens. [Genome view] ENST00000419625; ENSP00000390809; ENSG00000104537; Homo sapiens. [Genome view]
GeneID	312.
KEGG	hsa:312.
UCSC	uc003yqt.1. human.
Organism-specific databases
CTD	312.
GeneCards	GC08M124762.
HGNC	HGNC:536. ANXA13.
HPA	CAB025135. HPA019569. HPA019650.
MIM	602573. gene.
PharmGKB	PA24826.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P27216.
HOVERGEN	P27216.
Gene expression databases
ArrayExpress	P27216.
Bgee	P27216.
CleanEx	HS_ANXA13.
Genevestigator	P27216.
GermOnline	ENSG00000104537. Homo sapiens.
Family and domain databases
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR009166. AnnexinXIII. [Graphical view]
Gene3D	G3DSA:1.10.220.10. Annexin. 4 hits.
PANTHER	PTHR10502. Annexin. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR01811. ANNEXINXIII.
ProDom	PD000143. Annexin. 4 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00335. ANX. 4 hits. [Graphical view]
PROSITE	PS00223. ANNEXIN. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	1267.
SOURCE	Search...

Entry information

Entry name

ANX13_HUMAN

Accession

Primary (citable) accession number: P27216
Secondary accession number(s): Q9BQR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.